KEGG   ENZYME: 3.4.23.4
Entry
EC 3.4.23.4                 Enzyme                                 
Name
chymosin;
rennin (but this should be avoided since it leads to confusion with renin)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105!Met-Ala bond in kappa-chain of casein
Comment
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)
History
EC 3.4.23.4 created 1961 as EC 3.4.4.3, transferred 1972 to EC 3.4.23.4, modified 1986
Orthology
K01378  chymosin
Genes
GGO101141938
NLE100595848
CSAB103224246
CATY105594369
PANU101006467
TGE112609313
RBB108528004
PTEH111556034
CJC100411198(CYM)
SBQ101040593
CSYR103270996
MMUR105863963
OGA100965584
MMU229697(Cym)
MCAL110291784
MPAH110320931
RNO56825(Cym)
MCOC116094247
MUN110545485
CGE100759177(Chymosin)
PLEU114685263
NGI103747813
CCAN109702561
DORD105997458
DSP122110765
OCU100354542
OPI101520081
TUP102496533
CFA100856000
VVP112918404
VLG121488227
AML100478363
UMR103675019
UAH113244905
UAR123794945
ELK111143434
LLV125098235
MPUF101677169
ORO101386303
EJU114208054
ZCA113909436
MLX118020155
FCA101083355
PYU121018674
PBG122479629
PTG102969814
PPAD109272185
AJU106978180
HHV120244546
BTA529879(CYM)
BOM102277564
BIU109557034
BBUB102390023
CHX100861166(CYM)
OAS443399(CYM)
ODA120856706
CCAD122427526
SSC396864(CYM)
CFR102515505
CBAI105063671
CDK105085668
VPC102531735
BACU103001873
LVE103074375
OOR101282938
DLE111179917
PCAD102977326
PSIU116756719
ECB100062192
MYB102241708
MYD102769611
MMYO118673417
MLF102420033
MNA107545283
PKL118727185
HAI109371566
DRO112313827
SHON118981981
AJM119054501
PDIC114489204
PHAS123804452
MMF118637815
RFQ117015073
PALE102896975
PGIG120584954
PVP105298061
RAY107516113
MJV108399923
TOD119236017
SARA101550639
LAV100669186
TMU101354650
DNM101438928
MDO100030263
GAS123247153
SHR100932628
PCW110218419
OAA100077212
GGA395926(PGA3)
PCOC116237051
MGP100539842
CJO107324766
NMEL110388081
ACYG106048442
AFUL116498872
TGU100225946
LSR110469175
SCAN103822342
PMOA120502256
OTC121345619
PRUF121365451
GFR102031903
PHI102113955
PMAJ107214827
CCAE111939876
CCW104692428
ZAB102066044
FPG101920610
FCH102052516
EGZ104131419
NNI104018420
ACUN113489003
TALA104369246
PADL103925930
ACHC115335393
AAM106484398
AROW112961443
DNE112990309
ASN102383357 102383620 102383868 102384109
AMJ102570248 102570484 102570713 102575145
CPOO109317477 109317478 109317479 109317529 109317530
GGN109295192 109295194 109295195 109295416
ACS100555068
SUND121928824
PBI103048622
PMUR107286264
TSR106542676
PGUT117664335
VKO123029828
PMUA114598349 114598449 114598450
ZVI118077562 118089109 118089401
GJA107106443
 » show all
Reference
1  [PMID:5330666]
  Authors
Foltmann B.
  Title
A review on prorennin and rennin.
  Journal
C R Trav Lab Carlsberg 35:143-231 (1966)
Reference
2  [PMID:6283469]
  Authors
Harris TJ, Lowe PA, Lyons A, Thomas PG, Eaton MA, Millican TA, Patel TP, Bose CC, Carey NH, Doel MT.
  Title
Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.
  Journal
Nucleic Acids Res 10:2177-87 (1982)
DOI:10.1093/nar/10.7.2177
  Sequence
[bta:529879]
Reference
3  [PMID:3128264]
  Authors
Visser S, Slangen CJ, van Rooijen PJ.
  Title
Peptide substrates for chymosin (rennin). Interaction sites in kappa-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.
  Journal
Biochem J 244:553-8 (1987)
DOI:10.1042/bj2440553
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.4
IUBMB Enzyme Nomenclature: 3.4.23.4
ExPASy - ENZYME nomenclature database: 3.4.23.4
BRENDA, the Enzyme Database: 3.4.23.4
CAS: 9001-98-3

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