KEGG   ENZYME: 3.4.23.42
Entry
EC 3.4.23.42                Enzyme                                 
Name
thermopsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1'
Comment
From the thermophilic archaeon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 _degree_C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5.
History
EC 3.4.23.42 created 1992 as EC 3.4.99.43, transferred 2000 to EC 3.4.23.42
Orthology
K01385  thermopsin
Genes
SAI: Saci_1714(thpS)
SACN: SacN8_08325
SACR: SacRon12I_08340
SACS: SUSAZ_08125
MSE: Msed_1230
MEMJ: MJ1HA_1429
MPRU: DFR88_00205
MJN: MjAS7_2249
SAHS: HS7_12910 HS7_15670
Reference
1  [PMID:7674919]
  Authors
Lin X, Tang J.
  Title
Thermopsin.
  Journal
Methods Enzymol 248:156-68 (1995)
DOI:10.1016/0076-6879(95)48013-7
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.42
IUBMB Enzyme Nomenclature: 3.4.23.42
ExPASy - ENZYME nomenclature database: 3.4.23.42
BRENDA, the Enzyme Database: 3.4.23.42
CAS: 126125-05-1

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Gene (11)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10)   
Protein sequence (47)   
   UniProt (45)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (91)   
   RefSeq(nuc) (56)   
   GenBank (17)   
   EMBL (18)   
Protein domain (1)   
   InterPro (1)   
All databases (150)   

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