| Entry |
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| Name |
memapsin 2;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
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| Reaction(IUBMB) |
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
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| Comment |
Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
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| History |
EC 3.4.23.46 created 2003
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| Orthology |
| K04521 | beta-site APP-cleaving enzyme 1 (memapsin 2) |
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| Genes |
» show all
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| Reference |
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| Authors |
Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J. |
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| Title |
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design. |
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| Journal |
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| Reference |
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| Authors |
Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J. |
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| Title |
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.23.46 |
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