Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein

Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.

EC 3.4.23.46 created 2003

1  [PMID:11513577]

Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J.

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

Biochemistry 40:10001-6 (2001)
DOI:10.1021/bi015546s

2  [PMID:12206667]

Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J.

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.

Biochemistry 41:10963-7 (2002)
DOI:10.1021/bi026232n

[hsa:23621]