KEGG   ENZYME: 3.4.23.46
Entry
EC 3.4.23.46                Enzyme                                 
Name
memapsin 2;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment
Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
History
EC 3.4.23.46 created 2003
Orthology
K04521  beta-site APP-cleaving enzyme 1 (memapsin 2)
Genes
HSA23621(BACE1)
PTR451573(BACE1)
PPS100986447(BACE1)
GGO101153063(BACE1)
PON100459804(BACE1)
PPYG129008114(BACE1)
NLE100602656(BACE1)
HMH116476984(BACE1)
SSYN129479708(BACE1)
MCC697694(BACE1)
MCF102116923(BACE1)
MTHB126936330
MNI105476433(BACE1)
CSAB103248553(BACE1)
CATY105582456(BACE1)
PANU101007985(BACE1)
TGE112605654(BACE1)
MLEU105528203(BACE1)
RRO104665556(BACE1)
RBB108536397(BACE1)
TFN117081150(BACE1)
PTEH111540184(BACE1)
CANG105501076(BACE1)
CJC100389332(BACE1)
SBQ101035011(BACE1)
CIMI108300572(BACE1)
ANAN105729569(BACE1)
CSYR103255688(BACE1)
MMUR105876076(BACE1)
LCAT123641536(BACE1)
PCOQ105821602(BACE1)
OGA100943044(BACE1)
MMU23821(Bace1)
MCAL110302110(Bace1)
MPAH110327288(Bace1)
RNO29392(Bace1)
MCOC116073280(Bace1)
ANU117699362(Bace1)
ASYL127689135(Bace1)
MUN110550109(Bace1)
CGE100762079(Bace1)
MAUA101831038(Bace1)
PROB127231646(Bace1)
PLEU114691205(Bace1)
MORG121438362(Bace1)
MFOT126510071
AAMP119809046(Bace1)
NGI103748314(Bace1)
HGL101701890(Bace1)
CPOC100135485(Bace1)
CCAN109701440(Bace1)
DORD105980773(Bace1)
DSP122110421(Bace1)
PLOP125349605(Bace1)
NCAR124958220
MMMA107145827(Bace1)
ITI101977839(Bace1)
OCU100343442
OPI101527966(BACE1)
TUP102484569(BACE1)
GVR103588050(BACE1)
CFA489390(BACE1)
CLUD112671268(BACE1)
VVP112920363(BACE1)
VLG121499483(BACE1)
NPO129496978(BACE1)
AML100475881(BACE1)
UMR103662352(BACE1)
UAH113260016(BACE1)
UAR123792603(BACE1)
ELK111153672
LLV125110272
MPUF101692223(BACE1)
MNP132027802(BACE1)
MLK131836388(BACE1)
NVS122912316(BACE1)
ORO101380754(BACE1)
EJU114211275(BACE1)
ZCA113914790(BACE1)
MLX118013269(BACE1)
NSU110586357(BACE1)
LWW102747265(BACE1)
FCA101086840(BACE1)
PYU121035445(BACE1)
PCOO112864896(BACE1)
PBG122483004(BACE1)
PVIV125176169(BACE1)
LRUF124505653
LGF123600715(BACE1)
AJU106966295
PTG102949291(BACE1)
PPAD109278589(BACE1)
PUC125915353
PLEZ122200929(BACE1)
HHV120229992(BACE1)
BTA614333(BACE1)
BOM102275622(BACE1)
BIU109569448(BACE1)
BBUB102396105(BACE1)
BBIS104981352(BACE1)
CHX102180953(BACE1)
OAS101119667(BACE1)
BTAX128060521(BACE1)
CSUM138092585(BACE1)
ODA120876297(BACE1)
CCAD122449404(BACE1)
MREE136176033(BACE1)
OVR110133029(BACE1)
MBEZ129554366(BACE1)
SSC100511707(BACE1)
CFR102520718(BACE1)
CBAI105067833(BACE1)
CDK105090186(BACE1)
VPC102544872(BACE1)
BACU102997596(BACE1)
BMUS118898898(BACE1)
LVE103069689(BACE1)
OOR101282403(BACE1)
LALB132526335(BACE1)
DLE111166895(BACE1)
PCAD102989318(BACE1)
PSIU116757442(BACE1)
PPHC136127657(BACE1)
NASI112403943(BACE1)
ECB100071137(BACE1)
EPZ103548768(BACE1)
EAI106840262(BACE1)
MYB102247187(BACE1)
MYD102775332(BACE1)
MMYO118664264(BACE1)
MLF102437135(BACE1)
MDT132240517(BACE1)
MYUM139017545(BACE1)
PKL118712837(BACE1)
EFUS103293749(BACE1)
MNA107530812(BACE1)
DRO112314176(BACE1)
SHON118994785(BACE1)
AJM119050778(BACE1)
PDIC114499508(BACE1)
PHAS123819699(BACE1)
MMF118627587(BACE1)
PPAM129085918(BACE1)
HAI109385295(BACE1)
RFQ117030935(BACE1)
PALE102897521(BACE1)
PGIG120622031(BACE1)
PVP105307615(BACE1)
RAY107505049(BACE1)
MJV108402078(BACE1)
TOD119240713(BACE1)
SARA101544672(BACE1)
SFUM130016815(BACE1)
SETR126015593(BACE1)
LAV100675691(BACE1)
TMU101354290
ETF101638317(BACE1)
DNM101427814(BACE1)
MDO100025518(BACE1)
GAS123242093(BACE1)
SHR100927154(BACE1)
AFZ127555032
PCW110210635(BACE1)
TVP118838657(BACE1)
PBRV138154928(BACE1)
OAA100079669(BACE1)
TACU119934275(BACE1)
GGA419768(BACE1)
PCOC116233163(BACE1)
MGP100544363(BACE1)
CJO107324257(BACE1)
TPAI128087562(BACE1)
LMUT125703722(BACE1)
NMEL110387663(BACE1)
APLA101796410(BACE1)
ACYG106039731(BACE1)
CATA118252541(BACE1)
AFUL116497833(BACE1)
TGU101233428(BACE1)
LSR110470414(BACE1)
SCAN103823010(BACE1)
PMOA120508369(BACE1)
OTC121340860(BACE1)
PRUF121348496(BACE1)
ATRC139601029(BACE1)
GFR102034592(BACE1)
FAB101816019(BACE1)
OMA130262537(BACE1)
PHI102108176(BACE1)
PMAJ107214307(BACE1)
CCAE111939226(BACE1)
CCW104692173(BACE1)
CBRC103618614(BACE1)
ACOE138098310(BACE1)
ETL114056290(BACE1)
ZAB102072156(BACE1)
ZLE135457503(BACE1)
ACHL103802433(BACE1)
SVG106858177(BACE1)
MMEA130584707(BACE1)
HRT120762517(BACE1)
SATI136371128 136371129
CCIC134053558(BACE1)
FPG101915520(BACE1)
FCH102053287(BACE1)
NNT104400086(BACE1)
SHAB115616446(BACE1)
TALA116959993(BACE1)
ACHC115344402(BACE1)
HLE104836390(BACE1)
AGEN126038900
HHAR128141641(BACE1)
DPUB104298765(BACE1)
PPUS135191065(BACE1)
EGZ104124578(BACE1)
NNI104020644(BACE1)
PCRI104027818
AFOR103894431(BACE1)
FGA104081441(BACE1)
CBOY140661795(BACE1)
CLV102086831(BACE1)
CNIC135998839(BACE1)
PGUU104461466(BACE1)
CUCA104069026(BACE1)
TEO104379000(BACE1)
BREG104641589(BACE1)
ACAR104527287(BACE1)
CPEA104398744(BACE1)
CVF104295043(BACE1)
RTD128918612(BACE1)
CRID134524969(BACE1)
AAM106497838(BACE1)
AROW112962071(BACE1)
NPD112948073(BACE1)
DNE112991710(BACE1)
SCAM104141019(BACE1)
ASN102373334(BACE1)
AMJ102561132(BACE1)
CPOO109315411(BACE1)
GGN109294053(BACE1)
PSS102457565(BACE1)
CMY102941635(BACE1)
CCAY125625489(BACE1)
DCC119846649(BACE1)
CPIC101937089(BACE1)
TST117868546(BACE1)
CABI116834161(BACE1)
MRV120375855(BACE1)
ACS100560416(bace1)
ASAO132782347(BACE1)
PVT110078970(BACE1)
SUND121934197(BACE1)
PBI103058741(BACE1)
PMUR107284814(BACE1)
CTIG120301962(BACE1)
TSR106540624(BACE1)
PGUT117670213(BACE1)
APRI131204076(BACE1)
PTEX113441881(BACE1)
NSS113420843(BACE1)
VKO123036833(BACE1)
PMUA114585523(BACE1)
PRAF128402326(BACE1)
ZVI118096906(BACE1)
HCG128333953(BACE1)
GJA107124555(BACE1)
STOW125442187(BACE1)
EMC129342103(BACE1)
XLA108696469(bace1.L) 108697592(bace1.S)
XTR779940(bace1)
NPR108792168(BACE1)
RTEM120915183(BACE1)
ACAT141110838(BACE1)
BBUF120996173(BACE1)
BGAR122928924(BACE1)
DTC141097797(BACE1)
PWL138285136(BACE1)
MUO115481650(BACE1)
GSH117347710(BACE1)
DRE403005(bace1)
SRX107720461 107750106
SANH107663735 107663744 107688068
SGH107551225(bace1) 107575425
CCAR109055543 109105034
CAUA113058254 113115451
CGIB127972825
PTET122358761(bace1)
LROH127157587(bace1)
GRF141284746(bace1)
OMC131520901(bace1)
PPRM120464536(bace1)
MAMB125249312(bace1)
CIDE127496263
CERY137005464(bace1)
MASI127422268 127429804
TROS130564426(bace1)
TDW130429119(bace1)
MANU129437596(bace1)
PDAB135771488(bace1)
IPU108280601
IFU128624563(bace1)
PHYP113543364(bace1)
SMEO124403271(bace1)
TVC132849372(bace1)
CGAR128513413(bace1)
NGRA132871542(bace1)
TRN134302727(bace1)
AMEX103025562(bace1)
CMAO118797420(bace1)
EEE113590487
CHAR105901372(bace1)
SPIL134099889(bace1)
TRU101062918(bace1)
TFS130534500(bace1)
TNGGSTEN00026812G001
LCO104930461(bace1)
NCC104965411(bace1)
TBEN117470050(bace1)
CGOB115017977(bace1)
PGEO117457255(bace1)
GACU117537555(bace1)
EMAC134880696 134880824
ELY117260296(bace1)
EFO125889330(bace1)
PLEP121943200(bace1)
SLUC116038983(bace1)
ECRA117942581(bace1)
ESP116674033(bace1)
PFLV114552586(bace1)
GAT120827779(bace1)
PPUG119210831(bace1)
AFB129094869(bace1)
CLUM117741350(bace1)
PSWI130210374(bace1)
CANA137790923(bace1)
CVE137869551(bace1)
MSAM119882543(bace1)
SCHU122878524(bace1)
CUD121515580(bace1)
SPUL138604673(bace1)
LMIX132980154(bace1)
ALAT119007025(bace1)
ASTR137596739(bace1)
MZE101476002(bace1)
ONL100699036(bace1)
OAU116323691(bace1)
OLA101160575(bace1)
OML112136465(bace1)
CSAI133441548(bace1)
XMA102219574(bace1)
XCO114161663(bace1)
XHE116737571(bace1)
PRET103474831(bace1)
PFOR103154619(bace1)
PLAI106964998(bace1)
PMEI106914162(bace1)
GAF122832277(bace1)
PPRL129359014(bace1)
CVG107102687(bace1)
CTUL119775423(bace1)
GMU124884547(bace1)
NFU107374309(bace1)
KMR108244444(bace1)
ALIM106530418(bace1)
NWH119411156(bace1)
AOCE111574516(bace1)
EJA138197066(bace1)
BFRE138623311(bace1)
MCEP125013503(bace1)
CSEM103378268(bace1)
POV109634647(bace1)
SSEN122773895(bace1)
SSOE131462787(bace1)
HHIP117772586(bace1)
HSP118106661(bace1)
PPLT128440719(bace1)
SMAU118299059(bace1)
LCF108890649
SDU111232848(bace1)
SLAL111650653(bace1)
XGL120792540(bace1)
HCQ109529340(bace1)
SSCV125971880(bace1)
SBIA133504549(bace1)
PEE133405511(bace1)
PTAO133482519(bace1)
BPEC110161944(bace1)
ENY140367868(bace1)
MALB109951521(bace1)
BSPL114868159(bace1)
SJO128360484(bace1)
SSCO133980150(bace1)
GMH115560924(bace1)
SASA106580819 106612634
STRU115163134 115206085
OTW112265203 112266844
OMY110503676 110507072
OGO123993969 124006433
ONE115136967 115141623
OKI109905527 109908978
OKE118384607 118397266(bace1)
OMM135546218 135552702
OCLA139383007 139386233
SALP111957101(bace1)
SNH120018647 120029050
CCLU121563654 121567490
ELS105011136(bace1)
OEP134029263(bace1)
SFM108927238(bace1)
PKI111844107(bace1)
AANG118209299(bace1)
AROT135237037(bace1)
CCOG133107976(bace1)
LOC102692585(bace1)
PSPA121304048(bace1)
ARUT117397465 117968465(bace1)
LCM102351539(BACE1)
CMK103188711
CPLA122540618(bace1)
HOC132829577(bace1)
LERI129712345
HAKA140716931(bace1)
PMRN116948102
LRJ133342021
BFO118417244
BBEL109472317
CIN108950261
SCLV120326308
SPU585631(BACE)
LPIC129266346
AJJ139978046
APLC110979364
ARUN117301838
AAMU139951689
AFIL140144662
AJC117124035
SKO100369144
PFLL139126319
BMOR101735766
BMAN114245585
MSEX115441943
BANY112057933
MJU123870408
NIQ126772496
VCD124543173
MCIX123658497
PMAC106719666
PPOT106099307
PXU106122249
BPHI137918344
ZCE119833975
CCRC123696939
LSIN126975213
AAGE121733607
HAW110377490
HZE124633693
TNL113497907
SLIU111357508
OFU114365439
ONU135075857
ATRA106136511
GMW113509734
PXY105392886
PGW126371082
LGLY125229712
CSTB134744990
CFUM141436085
CCRN123301521
FOC113206749
TPAL117641399
ZNE110839383
CSEC111865896
PAME138709439
IEL124154016
HAMR139688238
PVM113812292
PJA122268036
PCHN125043352
PMOO119585109
HAME121876096
PCLA123765497
PTRU123512979
ESN126984283 126984289
MNZ135213589
MRJ136825489
PORN139755346
PPOI119092984 119092989
DSV119455493
RSAN119394381
RMP119172425
CSCU111624250
CVS136980951
PTEP107436221
ABRU129981758
UDV129222508
SDM118189785
LPOL106458042 106460967
LGILOTGIDRAFT_125352
PVUL126830315
PCAN112568263
LSAX138972713
BGT106057145
GAE121386472
HRF124149666
HRJ124288635
HASI137291905
HCRA139458419
CRG105319223
CANU128156889
CVN111126043 111126408
OED125667102
MYI110461765
PMAX117341223
AIRR138317863
MCAF127700851
MMER123561431
RPHI132715611
DPOL127860087
MAEA128234626
OBI106876969
OSN115223424
LJP135470096
LAK106177850
OVIT265_06386
LLON135502114
NVE5510976
EPA110237551 110237936
ATEN116303503
AMIL114955275
MCAZ138028497 138041277
MFOO137982679
PDAM113680920
SPIS111332036
DGT114528123
XEN124447510
HMG100215715
HSY130635893
RES135684481
TADTRIADDRAFT_23825 TRIADDRAFT_55203 TRIADDRAFT_55204
SREPTSG_05615
 » show all
Reference
1  [PMID:11513577]
  Authors
Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J.
  Title
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.
  Journal
Biochemistry 40:10001-6 (2001)
DOI:10.1021/bi015546s
Reference
2  [PMID:12206667]
  Authors
Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J.
  Title
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.
  Journal
Biochemistry 41:10963-7 (2002)
DOI:10.1021/bi026232n
  Sequence
[hsa:23621]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.46
IUBMB Enzyme Nomenclature: 3.4.23.46
ExPASy - ENZYME nomenclature database: 3.4.23.46
BRENDA, the Enzyme Database: 3.4.23.46
CAS: 158736-49-3

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