KEGG   ENZYME: 3.4.23.48
Entry
EC 3.4.23.48                Enzyme                                 
Name
plasminogen activator Pla
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Converts human Glu-plasminogen to plasmin by cleaving the Arg560!Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins
Comment
In peptidase family A26. From the bacterium Yersinia pestis that causes plague.
History
EC 3.4.23.48 created 2003
Orthology
K08566  plasminogen activator
Genes
EMA: C1192_04795
ESZ: FEM44_22510
ERUY: OSH18_02400
ENC: ECL_02114
ENL: A3UG_10560
ECLG: EC036_20370
EEC: EcWSU1_02066(pla)
ELG: BH714_06585
ESH: C1N69_10600
ENT: Ent638_1900
EMOR: L6Y89_10175
ESA: ESA_pESA3p05434
CSZ: CSSP291_20538
CUI: AFK65_20100
KPE: KPK_A0239(ompT)
KOX: KOX_19050
KOE: A225_2692
KOY: J415_18580
KOM: HR38_17395
KMI: VW41_22545
KOK: KONIH1_13135
KOC: AB185_21220
KLL: BJF97_13330
KGR: JJJ10_15590
KPAS: LUW96_29085(kop)
RON: TE10_15585
RTG: NCTC13098_03467(pla)
REE: electrica_02648(pla)
CNT: JT31_13365
CEM: LH23_04320
CEN: LH86_04265
CLAP: NCTC11466_00065(pla)
KSA: C813_06220
KOR: AWR26_23415
KRD: A3780_00275
KCO: BWI95_21610
KOT: EH164_06520
LEF: LJPFL01_1950
SYM: K6K13_21715
SGOE: A8O29_010950
YPE: YPPCP1.07(YPPCP1.07)
YPH: YPC_2974(pla2) YPC_4887(pla)
YPA: YPA_PCP0005
YPN: YPN_PCP0005
YPM: YP_pPCP08(pla)
YPG: YpAngola_0009(pla) YpAngola_0023(pla) YpAngola_A1453
YPZ: YPZ3_1132(pla2) YPZ3_pPCP0007(pla)
YPT: A1122_20045 A1122_21777
YPD: YPD4_1093(pla2) YPD4_pPCP0007(pla)
YPX: YPD8_1054(pla2) YPD8_pPCP0007(pla)
YPW: CH59_4484(pla) CH59_613(pla)
YPJ: CH55_1318(pla) CH55_4381(pla)
YPV: BZ15_2325(pla) BZ15_4409(pla)
YPL: CH46_3900(pla) CH46_4426(pla)
YPO: BZ17_1258(pla)
YPY: YPK_2831
YPB: YPTS_1355
YPQ: DJ40_968(pla)
YPU: BZ21_537(pla)
YPR: BZ20_718(pla)
YPC: BZ23_869(pla)
YEP: YE105_C2714
YEY: Y11_02811
YET: CH48_251(pla)
YEF: FORC2_1447
YEE: YE5303_11881
YSI: BF17_15305
YFR: AW19_1805(pla)
YIN: CH53_299(pla)
YKR: CH54_3981
YRO: CH64_1151(pla)
YMA: DA391_15035
YHI: D5F51_07465
YCA: F0T03_09640
YAS: N0H69_12800
SERF: L085_07440
PPAR: A8F97_12040
PEC: W5S_1274
PWS: A7983_01475
PPAV: LOZ86_11775
PCAC: OI450_06520
BRB: EH207_08635
EAY: EAM_P109
EPY: EpC_pEp360230(plaA)
EPR: EPYR_03992(ompT)
ERJ: EJP617_A170(plaA)
ETO: RIN69_11660 RIN69_11685
EGE: EM595_2975(pla)
PLF: PANA5342_0039
PAQ: PAGR_g0037
PVA: Pvag_pPag30480(pgtE)
PAGG: AL522_01215
PAO: Pat9b_2303
PEY: EE896_19205
PJI: KTJ90_19620
KPIE: N5580_19265
PALF: K6R05_18710
XDO: XDD1_1985(pla)
XGR: QL128_11235
VCY: IX92_08020
VCT: JV59_30495
VNP: KW548_09585
PGG: FX982_04856
ALA: BFG52_07125
RVI: RVIR1_11960(pla)
LPH: LPV_2697(pla)
LPO: LPO_2565(pla)
LPU: LPE509_00685
LPM: LP6_2416(pla)
LPA: lpa_03473
LPE: lp12_2380
LLO: LLO_1714
LOK: Loa_01388
LSH: CAB17_13545
LCJ: NCTC11976_01227(pla)
PLG: NCTC10937_01775(pla)
OAN: Oant_1618
OAH: DR92_1102
OCR: HGK82_08350
OCL: GTN27_08660
CDQ: BOQ54_19040
ALP: LPB137_08770
DSF: UWK_00309 UWK_00546
DBK: DGMP_27060(pla)
DOL: Dole_2362
PCU: PC_RS09465
TSU: Tresu_1903
OCK: EXM22_08440
FVA: FV113G1_31430
CSOM: MKD34_00700
 » show all
Reference
1  [PMID:11401715]
  Authors
Kukkonen M, Lahteenmaki K, Suomalainen M, Kalkkinen N, Emody L, Lang H, Korhonen TK
  Title
Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis.
  Journal
Mol Microbiol 40:1097-111 (2001)
DOI:10.1046/j.1365-2958.2001.02451.x
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.48
IUBMB Enzyme Nomenclature: 3.4.23.48
ExPASy - ENZYME nomenclature database: 3.4.23.48
BRENDA, the Enzyme Database: 3.4.23.48
CAS: 101028-08-4

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Gene (154)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (143)   
   RefGene (10)   
Protein sequence (121)   
   UniProt (112)   
   SWISS-PROT (1)   
   PDBSTR (6)   
   PMD (2)   
DNA sequence (355)   
   GenBank (177)   
   EMBL (178)   
3D Structure (3)   
   PDB (3)   
Protein domain (3)   
   InterPro (3)   
All databases (636)   

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