EC                Enzyme                                 

neutral endopeptidase;
endopeptidase 24.11;
kidney-brush-border neutral peptidase;
enkephalinase (misleading);
CALLA (common acute lymphoblastic leukemia-associated) antigens;
CALLA antigen;
membrane metalloendopeptidase;
kidney-brush-border neutral endopeptidase;
kidney-brush-border neutral proteinase;
CALLA glycoprotein;
common acute lymphoblastic leukemia antigen;
CALLA glycoproteins;
common acute lymphoblastic leukemia-associated antigens;
neutral metallendopeptidase;
membrane metalloendopeptidase;
neutral endopeptidase 24.11;
neutral endopeptidase;
acute lymphoblastic leukemia antigen
Acting on peptide bonds (peptidases);
BRITE hierarchy
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13
EC created 1978, modified 1989
K01389  neprilysin
K08635  neprilysin
HSA: 4311(MME) 79258(MMEL1)
PTR: 460792(MME) 744165(MMEL1)
PPS: 100985033(MMEL1) 100985469(MME)
GGO: 101130840(MME) 101134609(MMEL1)
PON: 100173750(MME) 100437958(MMEL1)
NLE: 100587997(MME) 100598660(MMEL1)
MCC: 698525(MMEL1) 707667(MME)
MCF: 101925772(MME) 102135493(MMEL1)
CSAB: 103225750(MMEL1) 103241443(MME)
RRO: 104664576(MMEL1) 104668763(MME)
RBB: 108512221(MME) 108535990(MMEL1)
CJC: 100387438(MME) 100397773(MMEL1)
SBQ: 101038182(MMEL1) 101046081(MME)
MMU: 17380(Mme) 27390(Mmel1)
MCAL: 110290750(Mme) 110292659(Mmel1)
MPAH: 110319726(Mme) 110323148(Mmel1)
RNO: 24590(Mme) 313755(Mmel1)
MUN: 110553985(Mme) 110559788(Mmel1)
CGE: 100755223(Mmel1) 100756999(Mme)
NGI: 103726236 103740089(Mme) 103749779(Mmel1)
HGL: 101715828(Mme) 101723792(Mmel1)
CCAN: 109691458(Mmel1) 109693062(Mme)
OCU: 100009251(MME)
TUP: 102478575(MME) 102489583(MMEL1)
CFA: 477120(MME) 489617(MMEL1)
VVP: 112911327(MME) 112924717(MMEL1)
AML: 100473810(MMEL1) 100474251(MME)
UMR: 103677644(MME) 103678454(MMEL1)
UAH: 113254091(MME) 113270601(MMEL1)
ORO: 101369234(MME) 101378951(MMEL1)
FCA: 101087516(MME) 101090372(MMEL1)
PTG: 102951476(MMEL1) 102956005(MME)
AJU: 106974867(MME) 106984649(MMEL1)
BTA: 536741(MME) 616991(MMEL1)
BOM: 102276645(MME) 102283443(MMEL1)
BIU: 109559100(MME) 109570270(MMEL1)
BBUB: 102389157(MME) 102399163(MMEL1)
PHD: 102315885(MME) 102339029(MMEL1)
CHX: 102184743(MMEL1) 102184949(MME)
OAS: 101112618(MME) 101120510(MMEL1)
SSC: 100511536(MME) 100512286(MMEL1)
CFR: 102510634(MME) 102523064(MMEL1) 106731199
CDK: 105094476(MME) 105105598(MMEL1) 105106650
BACU: 103000572(MMEL1) 103006902(MME)
LVE: 103081551(MMEL1) 103088815
OOR: 101279513(MME) 101285184(MMEL1)
DLE: 111179330(MME) 111187249(MMEL1)
PCAD: 102991612(MME) 102995381(MMEL1) 114485394
ECB: 100053541(MME) 100054362(MMEL1)
EPZ: 103543853(MMEL1) 103551466(MME)
EAI: 106836570(MME) 106844278(MMEL1)
MYB: 102238816(MMEL1) 102259140(MME)
MYD: 102755226(MMEL1) 102757655(MME) 102762380
MNA: 107542025(MMEL1) 107544695(MME)
HAI: 109373662(MME) 109391186(MMEL1)
RSS: 109447536(MME) 109461135(MMEL1)
DRO: 112299625(MMEL1) 112306866(MME)
PALE: 102890893(MMEL1) 102892831(MME)
RAY: 107507593(MME) 107510643(MMEL1)
LAV: 100672246(MMEL1) 100676161(MME)
MDO: 100012497(MME) 100028021(MMEL1)
SHR: 100920293(MME) 100934084(MMEL1)
PCW: 110200369(MMEL1) 110210116(MME)
OAA: 100092983(MME) 100680636(MMEL1)
GGA: 425031(MME) 770671(MMEL1)
MGP: 100544190(MME) 100549748(MMEL1)
CJO: 107318419(MME) 107323445(MMEL1)
NMEL: 110397630(MME) 110408637(MMEL1)
APLA: 101798722(MMEL1) 101804711(MME)
ACYG: 106043555(MME) 106044618(MMEL1)
TGU: 100224600(MME) 100227361(MMEL1)
LSR: 110470358(MMEL1) 110476117(MME)
SCAN: 103815257(MME) 103820813(MMEL1)
GFR: 102034360(MMEL1) 102042553(MME)
FAB: 101806893(MME) 101819314(MMEL1)
PHI: 102110334(MME) 102114308(MMEL1)
PMAJ: 107208825(MME) 107213763(MMEL1)
CCAE: 111933263(MME) 111938618(MMEL1) 111943355
CCW: 104688087(MME) 104693288(MMEL1)
ETL: 114062920(MME) 114063165(MMEL1)
FPG: 101920007(MMEL1) 101924415(MME)
FCH: 102049235(MMEL1) 102059406(MME)
CLV: 102083516(MMEL1) 102083559(MME)
EGZ: 104122315(MME) 104134553(MMEL1)
NNI: 104008934(MMEL1) 104011554(MME)
ACUN: 113483299(MME) 113487987(MMEL1)
PADL: 103913949(MMEL1) 103925256(MME)
AAM: 106485740(MMEL1) 106497060(MME)
ASN: 102381364(MME) 102381946(MMEL1)
AMJ: 102564695(MME) 102569761(MMEL1)
PSS: 102443820(MME) 102456133(MMEL1)
CMY: 102934442(MMEL1) 102942442(MME)
CPIC: 101932856(MME) 101934228(MMEL1)
ACS: 100558527(mme)
PVT: 110073080(MME) 110088237(MMEL1)
PBI: 103057528(MME)
PMUR: 107288042(MME)
GJA: 107110349(MMEL1) 107114156(MME)
XLA: 108696635(mmel1.L) 108697711(mmel1.S) 108716217(mme.L)
XTR: 100145721(mmel1) 101734885(mme)
NPR: 108783691(MMEL1)
DRE: 560703(mmel1)
IPU: 108264737(mme) 108281002(mmel1)
PHYP: 113534432(mme) 113537948(mmel1)
AMEX: 103025396(mmel1) 103041883(mme) 103042961
EEE: 113582009(mmel1) 113589488(mme)
TRU: 101064577(mmel1) 101067932(mme)
LCO: 104919374(mmel1) 104927644(mme)
MZE: 101467767(mmel1) 101488070(mme)
OLA: 101170860(mme) 101173139(mmel1)
XMA: 102217091(mme) 102217344 102226632(mmel1)
XCO: 114135768(mmel1) 114161465(mme) 114161469
PRET: 103464469(mmel1) 103474711(mme) 103474713
NFU: 107380056(mme) 107385266(mmel1)
KMR: 108231717(mmel1) 108240951(mme)
AOCE: 111588020(mmel1) 111589102(mme)
CSEM: 103378377(mme) 103385681(mmel1)
POV: 109630371(mme) 109638466(mmel1)
LCF: 108899894 108900938(mme)
SDU: 111224000(mmel1) 111239768(mme)
HCQ: 109518499(mme) 109529231(mmel1)
BPEC: 110163663(mme) 110166955(mmel1)
ELS: 105017395(mmel1) 105029340(mme)
PKI: 111849128(mme) 111856982(mmel1)
LCM: 102357522 102360975(MME) 102362087(MMEL1)
CMK: 103176796(mme) 103184200(mmel1)
CIN: 100184420
SPU: 575956(mmel1) 580975
DME: Dmel_CG14527(Nepl20) Dmel_CG3775(Nep6) Dmel_CG4058(Nep4) Dmel_CG5905(Nep1) Dmel_CG8358(Nepl12) Dmel_CG9565(Nep3) Dmel_CG9761(Nep2)
DSI: Dsimw501_GD16783(Dsim_GD16783) Dsimw501_GD17088(Dsim_GD17088) Dsimw501_GD18636(Dsim_GD18636) Dsimw501_GD19662(Dsim_GD19662) Dsimw501_GD20045(Dsim_GD20045) Dsimw501_GD20688(Dsim_GD20688) Dsimw501_GD21386(Dsim_GD21386) Dsimw501_GD21387(Dsim_GD21387) Dsimw501_GD24059(Dsim_GD24059)
CEL: CELE_F18A12.8(nep-11) CELE_T05A8.4(nep-2) CELE_T16A9.4(nep-21) CELE_ZK20.6(nep-1)
CBR: CBG02837(Cbr-nep-1) CBG04739 CBG17774 CBG19565(Cbr-nep-2)
EPA: 110239805
SPIS: 111332678
PXB: 103942785
 » show all
1  [PMID:6190172]
Matsas R, Fulcher IS, Kenny AJ, Turner AJ.
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
Proc Natl Acad Sci U S A 80:3111-5 (1983)
2  [PMID:3555489]
Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ.
Molecular cloning and amino acid sequence of rat enkephalinase.
Biochem Biophys Res Commun 144:59-66 (1987)
3  [PMID:2971756]
Letarte M, Vera S, Tran R, Addis JB, Onizuka RJ, Quackenbush EJ, Jongeneel CV, McInnes RR.
Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.
J Exp Med 168:1247-53 (1988)
4  [PMID:2521610]
Erdos EG, Skidgel RA.
Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones.
FASEB J 3:145-51 (1989)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 82707-54-8

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