KEGG   ENZYME: 3.4.24.11
Entry
EC 3.4.24.11                Enzyme                                 

Name
neprilysin;
neutral endopeptidase;
endopeptidase 24.11;
kidney-brush-border neutral peptidase;
enkephalinase (misleading);
endopeptidase-2;
CALLA (common acute lymphoblastic leukemia-associated) antigens;
CALLA antigen;
endopeptidase;
membrane metalloendopeptidase;
kidney-brush-border neutral endopeptidase;
kidney-brush-border neutral proteinase;
endopeptidase-2;
CALLA glycoprotein;
CALLA;
common acute lymphoblastic leukemia antigen;
CALLA glycoproteins;
common acute lymphoblastic leukemia-associated antigens;
neutral metallendopeptidase;
membrane metalloendopeptidase;
NEP;
neutral endopeptidase 24.11;
CD10;
neutral endopeptidase;
acute lymphoblastic leukemia antigen
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Comment
A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13
History
EC 3.4.24.11 created 1978, modified 1989
Orthology
K01389  neprilysin
K08635  neprilysin
Genes
HSA: 4311(MME) 79258(MMEL1)
PTR: 460792(MME) 744165(MMEL1)
PPS: 100985033(MMEL1) 100985469(MME)
GGO: 101130840(MME) 101134609(MMEL1)
PON: 100173750(MME) 100437958(MMEL1)
NLE: 100587997(MME) 100598660(MMEL1)
MCC: 698525(MMEL1) 707667(MME)
MCF: 101925772(MME) 102135493(MMEL1)
CSAB: 103225750(MMEL1) 103241443(MME)
RRO: 104664576(MMEL1) 104668763(MME)
RBB: 108512221(MME) 108535990(MMEL1)
CJC: 100387438(MME) 100397773(MMEL1)
SBQ: 101038182(MMEL1) 101046081(MME)
MMU: 17380(Mme) 27390(Mmel1)
MCAL: 110290750(Mme) 110292659(Mmel1)
MPAH: 110319726(Mme) 110323148(Mmel1)
RNO: 24590(Mme) 313755(Mmel1)
MUN: 110553985(Mme) 110559788(Mmel1)
CGE: 100755223(Mmel1) 100756999(Mme)
NGI: 103726236 103740089(Mme) 103749779(Mmel1)
HGL: 101715828(Mme) 101723792(Mmel1)
CCAN: 109691458(Mmel1) 109693062(Mme)
OCU: 100009251(MME)
TUP: 102478575(MME) 102489583(MMEL1)
CFA: 477120(MME) 489617(MMEL1)
VVP: 112911327(MME) 112924717(MMEL1)
AML: 100473810(MMEL1) 100474251(MME)
UMR: 103677644(MME) 103678454(MMEL1)
UAH: 113254091(MME) 113270601(MMEL1)
ORO: 101369234(MME) 101378951(MMEL1)
FCA: 101087516(MME) 101090372(MMEL1)
PTG: 102951476(MMEL1) 102956005(MME)
PPAD: 109261526(MME) 109273858(MMEL1)
AJU: 106974867(MME) 106984649(MMEL1)
BTA: 536741(MME) 616991(MMEL1)
BOM: 102276645(MME) 102283443(MMEL1)
BIU: 109559100(MME) 109570270(MMEL1)
BBUB: 102389157(MME) 102399163(MMEL1)
CHX: 102184743(MMEL1) 102184949(MME)
OAS: 101112618(MME) 101120510(MMEL1)
SSC: 100511536(MME) 100512286(MMEL1)
CFR: 102510634(MME) 102523064(MMEL1)
CDK: 105094476(MME) 105105598(MMEL1)
BACU: 103000572(MMEL1) 103006902(MME)
LVE: 103081551(MMEL1) 103088815
OOR: 101279513(MME) 101285184(MMEL1)
DLE: 111179330(MME) 111187249(MMEL1)
PCAD: 102991612(MME) 102995381(MMEL1)
ECB: 100053541(MME) 100054362(MMEL1)
EPZ: 103543853(MMEL1) 103551466(MME)
EAI: 106836570(MME) 106844278(MMEL1)
MYB: 102238816(MMEL1) 102259140(MME)
MYD: 102755226(MMEL1) 102757655(MME)
MNA: 107542025(MMEL1) 107544695(MME)
HAI: 109373662(MME) 109391186(MMEL1)
DRO: 112299625(MMEL1) 112306866(MME)
PALE: 102890893(MMEL1) 102892831(MME)
RAY: 107507593(MME) 107510643(MMEL1)
MJV: 108397799(MMEL1) 108409423(MME)
LAV: 100672246(MMEL1) 100676161(MME)
MDO: 100012497(MME) 100028021(MMEL1)
SHR: 100920293(MME) 100934084(MMEL1)
PCW: 110200369(MMEL1) 110210116(MME)
OAA: 100092983(MME) 100680636(MMEL1)
GGA: 425031(MME) 770671(MMEL1)
MGP: 100544190(MME) 100549748(MMEL1)
CJO: 107318419(MME) 107323445(MMEL1)
NMEL: 110397630(MME) 110408637(MMEL1)
APLA: 101798722(MMEL1) 101804711(MME)
ACYG: 106043555(MME) 106044618(MMEL1)
TGU: 100224600(MME) 100227361(MMEL1)
LSR: 110470358(MMEL1) 110476117(MME)
SCAN: 103815257(MME) 103820813(MMEL1)
GFR: 102034360(MMEL1) 102042553(MME)
FAB: 101806893(MME) 101819314(MMEL1)
PHI: 102110334(MME) 102114308(MMEL1)
PMAJ: 107208825(MME) 107213763(MMEL1)
CCAE: 111933263(MME) 111938618(MMEL1)
CCW: 104688087(MME) 104693288(MMEL1)
ETL: 114062920(MME) 114063165(MMEL1)
FPG: 101920007(MMEL1) 101924415(MME)
FCH: 102049235(MMEL1) 102059406(MME)
CLV: 102083516(MMEL1) 102083559(MME)
EGZ: 104122315(MME) 104134553(MMEL1)
NNI: 104008934(MMEL1) 104011554(MME)
ACUN: 113483299(MME) 113487987(MMEL1)
PADL: 103913949(MMEL1) 103925256(MME)
AAM: 106485740(MMEL1) 106497060(MME)
ASN: 102381364(MME) 102381946(MMEL1)
AMJ: 102564695(MME) 102569761(MMEL1)
PSS: 102443820(MME) 102456133(MMEL1)
CMY: 102934442(MMEL1) 102942442(MME)
CPIC: 101932856(MME) 101934228(MMEL1)
ACS: 100558527(mme)
PVT: 110073080(MME) 110088237(MMEL1)
PBI: 103057528(MME)
PMUR: 107288042(MME)
TSR: 106538527(MME)
PMUA: 114597903(MME) 114602570(MMEL1)
GJA: 107110349(MMEL1) 107114156(MME)
XLA: 108696635(mmel1.L) 108697711(mmel1.S) 108716217(mme.L)
XTR: 100145721(mmel1) 101734885(mme)
NPR: 108783691(MMEL1)
DRE: 560703(mmel1)
IPU: 108264737(mme) 108281002(mmel1)
PHYP: 113534432(mme) 113537948(mmel1)
AMEX: 103025396(mmel1) 103041883(mme) 103042961
EEE: 113582009(mmel1) 113589488(mme)
TRU: 101064577(mmel1) 101067932(mme)
LCO: 104919374(mmel1) 104927644(mme)
NCC: 104955274(mmel1) 104957651
MZE: 101467767(mmel1) 101488070(mme)
ONL: 100691568(mme) 100710821(mmel1)
OLA: 101170860(mme) 101173139(mmel1)
XMA: 102217091(mme) 102217344 102226632(mmel1)
XCO: 114135768(mmel1) 114161465(mme) 114161469
PRET: 103464469(mmel1) 103474711(mme) 103474713
CVG: 107081874(mme) 107087515(mmel1)
NFU: 107380056(mme) 107385266(mmel1)
KMR: 108231717(mmel1) 108240951(mme)
ALIM: 106513840(mmel1) 106519429(mme)
AOCE: 111588020(mmel1) 111589102(mme)
CSEM: 103378377(mme) 103385681(mmel1)
POV: 109630371(mme) 109638466(mmel1)
LCF: 108899894 108900938(mme)
SDU: 111224000(mmel1) 111239768(mme)
SLAL: 111652234(mme) 111657920(mmel1)
HCQ: 109518499(mme) 109529231(mmel1)
BPEC: 110163663(mme) 110166955(mmel1)
MALB: 109959067(mmel1)
ELS: 105017395(mmel1) 105029340(mme)
PKI: 111849128(mme) 111856982(mmel1)
LCM: 102360975(MME) 102362087(MMEL1)
CMK: 103176796(mme) 103184200(mmel1)
RTP: 109917036 109918227(mme)
CIN: 100184420
DME: Dmel_CG14527(Nepl20) Dmel_CG3775(Nep6) Dmel_CG4058(Nep4) Dmel_CG5905(Nep1) Dmel_CG8358(Nepl12) Dmel_CG9565(Nep3) Dmel_CG9761(Nep2)
DSI: Dsimw501_GD16783(Dsim_GD16783) Dsimw501_GD17088(Dsim_GD17088) Dsimw501_GD18636(Dsim_GD18636) Dsimw501_GD19662(Dsim_GD19662) Dsimw501_GD20045(Dsim_GD20045) Dsimw501_GD20688(Dsim_GD20688) Dsimw501_GD21386(Dsim_GD21386) Dsimw501_GD21387(Dsim_GD21387)
CEL: CELE_F18A12.8(nep-11) CELE_T05A8.4(nep-2) CELE_T16A9.4(nep-21) CELE_ZK20.6(nep-1)
HMG: 100198564
PXB: 103942785
 » show all
Reference
1  [PMID:6190172]
  Authors
Matsas R, Fulcher IS, Kenny AJ, Turner AJ.
  Title
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
  Journal
Proc Natl Acad Sci U S A 80:3111-5 (1983)
DOI:10.1073/pnas.80.10.3111
Reference
2  [PMID:3555489]
  Authors
Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ.
  Title
Molecular cloning and amino acid sequence of rat enkephalinase.
  Journal
Biochem Biophys Res Commun 144:59-66 (1987)
DOI:10.1016/S0006-291X(87)80475-8
  Sequence
[rno:24590]
Reference
3  [PMID:2971756]
  Authors
Letarte M, Vera S, Tran R, Addis JB, Onizuka RJ, Quackenbush EJ, Jongeneel CV, McInnes RR.
  Title
Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.
  Journal
J Exp Med 168:1247-53 (1988)
DOI:10.1084/jem.168.4.1247
  Sequence
[hsa:4311]
Reference
4  [PMID:2521610]
  Authors
Erdos EG, Skidgel RA.
  Title
Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones.
  Journal
FASEB J 3:145-51 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.11
IUBMB Enzyme Nomenclature: 3.4.24.11
ExPASy - ENZYME nomenclature database: 3.4.24.11
BRENDA, the Enzyme Database: 3.4.24.11
CAS: 82707-54-8

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