Entry
Name
procollagen N-endopeptidase;
procollagen N-terminal peptidase;
procollagen aminopeptidase;
aminoprocollagen peptidase;
aminoterminal procollagen peptidase;
procollagen aminoterminal protease;
procollagen N-terminal proteinase;
type I/II procollagen N-proteinase;
type III procollagen
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves the N-propeptide of collagen chain alpha1(I) at Pro!Gln and of alpha1(II) and alpha2(I) at Ala!Gln
Comment
Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family)
History
EC 3.4.24.14 created 1984
Orthology
K08618 a disintegrin and metalloproteinase with thrombospondin motifs 2
Genes
XLA : 108710899(adamts2.L) 108713291(adamts2.S)
DRE : 101883894 571682(adamts2a)
SRX : 107749938 107756425 107756799 107758566
SANH : 107665532 107667595 107680579 107689184
SGH : 107566216 107566696 107590100 107594866
CCAR : 109053459 109060242 109063876 109078251 109102812
CAUA : 113038411 113057586 113064000 113114025 113114095
CGIB : 127941719 127947077 127971636 127986404 128026965
PTET : 122326824(adamts2a) 122358235
LROH : 127152442(adamts2a) 127176524
OMC : 131528339(adamts2a) 131553632
PPRM : 120460902 120494725(adamts2a)
RKG : 130089729 130095379(adamts2a)
MAMB : 125252346(adamts2a) 125259363
CIDE : 127494526 127503175
CERY : 137012115(adamts2a) 137031122
MASI : 127413031 127418324 127429398 127431107
TROS : 130563861 130570343(adamts2a)
TDW : 130407710(adamts2a) 130438375
MANU : 129422029 129423200(adamts2a)
IPU : 108269222 108278612(adamts2a)
IFU : 128612029 128622246(adamts2a)
PHYP : 113541621 113542831
SMEO : 124386140 124397813(adamts2a)
TFD : 113646004 113646917(adamts2a)
TVC : 132855952 132859698(adamts2a)
TRN : 134318701 134330263(adamts2a)
AMEX : 103038015(adamts2a)
CMAO : 118807006 118819984(adamts2)
CHAR : 105904583(adamts2a) 105906701
SPIL : 134068639 134080380(adamts2a)
TNG : GSTEN00007373G001 GSTEN00008314G001 GSTEN00014566G001
TBEN : 117471179 117490555
CGOB : 115014490 115019154
GACU : 117551341 117556018 117560375
EMAC : 134860200 134872420
ELY : 117260823 117269398(adamts2)
EFO : 125894516 125899052(adamts2a)
PLEP : 121948056(adamts2a) 121952195
SLUC : 116064073 116064304
PFLV : 114562491 114566537
PPUG : 119210760 119215718
CLUM : 117738063 117743048
PSWI : 130191754 130193510 130209279
CANA : 137787399 137791325
MSAM : 119883032 119888589 119895121
SCHU : 122880386 122888268(adamts2a)
SPUL : 138598128 138601848
LMIX : 132981810 132988399
ALAT : 119007986 119030957
ASTR : 137602389 137605949
OAU : 116329068(adamts2a) 116336128
OML : 112136875(adamts2) 112153355
CSAI : 133446931 133460011
XHE : 116712654 116714359 116728255
PRET : 103459894 103471261
PFOR : 103135534 103141078
PLAI : 106948561 106964884
PMEI : 106918556 106920872
PPRL : 129362513 129370559
CTUL : 119792493 119793474(adamts2)
KMR : 108228995 108240586(adamts2)
ALIM : 106517507 106532992
NWH : 119408792 119420750(adamts2a)
AOCE : 111569503(adamts2) 111575726
BFRE : 138631499 138633636(adamts2a)
MCEP : 125008074 125021579(adamts2a)
CSEM : 103391033 103395597
POV : 109643920(adamts2) 109644389
SSEN : 122778359 122779339
HHIP : 117769153 117774665
HSP : 118112375 118122070(adamts2a)
PPLT : 128446449 128456588
SMAU : 118301259 118319704
SLAL : 111646645 111669318
XGL : 120785567 120802164(adamts2a)
SSCV : 125981959 125983042
SBIA : 133492083 133508486
PTAO : 133467035 133484550
BPEC : 110157629 110174988
MALB : 109955091 109973159
BSPL : 114864077 114869115
SSCO : 133985609 133993698
SASA : 106563724 106563762 106602921 106604833 106611949
STRU : 115154901 115174484 115204532 115205406
OTW : 112220757 112229028 112230691(adamts2a) 112257039
OMY : 110488609 110504815 110510203 110533139
OGO : 123993252 124005646 124006932 124010832
ONE : 115129144 115130523 115135444 115146820
OKI : 109864977 109872731 109878722 109882118
OKE : 118374579 118384013 118384930 118390561
OMM : 135526222 135545726 135550232
SALP : 111950346 111964411 111964771
SNH : 120021778 120048200 120057349 120062196
CCLU : 121541970 121544674 121578962 121579666(adamts2a)
AANG : 118223260 118235729
AROT : 135249695 135263622
CCOG : 133124742 133132672
PSPA : 121297237 121324257
LHU : 105667396 105667397 105668524 105668553 105668554 105668556 105668557 105668558 105669512 105669605 105670542 105671190 105671217 105671304 105671306 105671442 105671444 105671448 105671517 105672340 105673439 105673466 105673467 105673468 105675067 105676683 105676684 136996849 136998917 136998918 136998919 137000536 137000655
» show all
Taxonomy
Reference
Authors
Kohn LD, Isersky C, Zupnik J, Lenaers A, Lee G, Lapiere CM.
Title
Calf tendon procollagen peptidase: its purification and endopeptidase mode of action.
Journal
Reference
Authors
Hojima Y, McKenzie JA, van der Rest M, Prockop DJ.
Title
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.
Journal
J Biol Chem 264:11336-45 (1989)
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.14