KEGG ENZYME: 3.4.24.14

ENZYME: 3.4.24.14

Entry

EC 3.4.24.14                Enzyme

Name

procollagen N-endopeptidase;
procollagen N-terminal peptidase;
procollagen aminopeptidase;
aminoprocollagen peptidase;
aminoterminal procollagen peptidase;
procollagen aminoterminal protease;
procollagen N-terminal proteinase;
type I/II procollagen N-proteinase;
type III procollagen

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Cleaves the N-propeptide of collagen chain alpha1(I) at Pro!Gln and of alpha1(II) and alpha2(I) at Ala!Gln

Comment

Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family)

History

EC 3.4.24.14 created 1984

Orthology

K08618

a disintegrin and metalloproteinase with thrombospondin motifs 2

Genes

HSA:	9509(ADAMTS2)

PTR:	462325(ADAMTS2)

PPS:	100979430(ADAMTS2)

PON:	100447800(ADAMTS2)

NLE:	100589584(ADAMTS2)

HMH:	116471937(ADAMTS2)

MCC:	713532(ADAMTS2)

MCF:	102133312(ADAMTS2)

MTHB:

126957057

MNI:	105484013(ADAMTS2)

CSAB:

103245099(ADAMTS2)

CATY:

105590398(ADAMTS2)

PANU:

101013940(ADAMTS2)

TGE:	112626399(ADAMTS2)

MLEU:

105537289(ADAMTS2)

RRO:	104676210(ADAMTS2)

RBB:	108539415(ADAMTS2)

TFN:	117065425(ADAMTS2)

PTEH:

111527441(ADAMTS2)

CANG:

105524777(ADAMTS2)

CJC:	100395899(ADAMTS2)

SBQ:	101039904(ADAMTS2)

CIMI:

108295092(ADAMTS2)

CSYR:

103250957(ADAMTS2)

MMUR:

105885208(ADAMTS2)

LCAT:

123621815(ADAMTS2)

PCOQ:

105814857(ADAMTS2)

OGA:	100952453(ADAMTS2)

MMU:	216725(Adamts2)

MCAL:

110304829(Adamts2)

MPAH:

110332142(Adamts2)

RNO:	287899(Adamts2)

MCOC:

116077301(Adamts2)

ANU:	117710558(Adamts2)

MUN:	110559099(Adamts2)

CGE:

100769264

MAUA:

101827047(Adamts2)

PROB:

127219328(Adamts2)

PLEU:

114687569(Adamts2)

MORG:

121456511(Adamts2)

MFOT:

126511450

AAMP:

119811499(Adamts2)

NGI:	103749380(Adamts2)

HGL:	101711463(Adamts2)

CPOC:

100721564(Adamts2)

CCAN:

109688447

DORD:

105996709(Adamts2)

DSP:	122115390(Adamts2)

PLOP:

125342031(Adamts2)

NCAR:

124987305

OCU:

100345799

OPI:	101523012(ADAMTS2)

TUP:	102485420(ADAMTS2)

GVR:	103600910(ADAMTS2)

CFA:	481453(ADAMTS2)

CLUD:

112659598(ADAMTS2)

VVP:	112932465(ADAMTS2)

VLG:	121494899(ADAMTS2)

NPO:	129494885(ADAMTS2)

AML:	100470520(ADAMTS2)

UMR:	103680011(ADAMTS2)

UAH:	113261565(ADAMTS2)

UAR:	123790484(ADAMTS2)

ELK:

111158889

LLV:

125100375

MPUF:

101679681(ADAMTS2)

MNP:	132027416(ADAMTS2)

NVS:	122915874(ADAMTS2)

ORO:	101380933(ADAMTS2)

EJU:	114200461(ADAMTS2)

ZCA:	113928750(ADAMTS2)

MLX:	118026517(ADAMTS2)

NSU:	110581209(ADAMTS2)

FCA:	101096945(ADAMTS2)

PYU:	121010528(ADAMTS2)

PCOO:

112860887(ADAMTS2)

PBG:	122486077(ADAMTS2)

LRUF:

124514780

PTG:	102955026(ADAMTS2)

PPAD:

109278957(ADAMTS2)

PUC:

125935367

AJU:

106970137

HHV:	120245693(ADAMTS2)

BTA:	282401(ADAMTS2)

BOM:	102267134(ADAMTS2)

BIU:	109561344(ADAMTS2)

BBUB:

102394919(ADAMTS2)

BBIS:

104981758(ADAMTS2)

CHX:	102182397(ADAMTS2)

OAS:	101120574(ADAMTS2)

BTAX:

128050539(ADAMTS2)

ODA:	120864344(ADAMTS2)

CCAD:

122440593(ADAMTS2)

MBEZ:

129558237(ADAMTS2)

SSC:	100521434(ADAMTS2)

CFR:	102506510(ADAMTS2)

CBAI:

105062077(ADAMTS2)

CDK:	105100636(ADAMTS2)

VPC:	102529194(ADAMTS2)

BACU:

103012078(ADAMTS2)

LVE:	103071192(ADAMTS2)

OOR:	101284632(ADAMTS2)

DLE:	111169280(ADAMTS2)

PCAD:

102987989(ADAMTS2)

PSIU:

116752121(ADAMTS2)

NASI:

112413191(ADAMTS2)

ECB:	100630632(ADAMTS2)

EPZ:	103559965(ADAMTS2)

EAI:	106843705(ADAMTS2)

MYB:	102255495(ADAMTS2)

MYD:	102760485(ADAMTS2)

MMYO:

118658136(ADAMTS2)

MLF:	102434655(ADAMTS2)

MNA:	107529862(ADAMTS2)

PKL:	118725906(ADAMTS2)

EFUS:

103295017(ADAMTS2)

HAI:	109392749(ADAMTS2)

DRO:	112304979(ADAMTS2)

SHON:

118994088(ADAMTS2)

AJM:	119039501(ADAMTS2)

PDIC:

114515193(ADAMTS2)

PHAS:

123826538(ADAMTS2)

MMF:	118615359(ADAMTS2)

RFQ:	117016661(ADAMTS2)

PALE:

102883520(ADAMTS2)

PGIG:

120616631(ADAMTS2)

PVP:	105300007(ADAMTS2)

RAY:

107512278

MJV:	108395040(ADAMTS2)

TOD:	119236684(ADAMTS2)

SARA:

101546229(ADAMTS2)

LAV:	100674486(ADAMTS2)

TMU:

101348900

ETF:	123521038(ADAMTS2)

DNM:	101436855(ADAMTS2)

MDO:	100029340(ADAMTS2)

GAS:	123237521(ADAMTS2)

SHR:	100920081(ADAMTS2)

AFZ:

127550101

PCW:	110192839(ADAMTS2)

OAA:	100074059(ADAMTS2)

GGA:	416291(ADAMTS2)

PCOC:

116232170(ADAMTS2)

MGP:	100538388(ADAMTS2)

CJO:	107320100(ADAMTS2)

TPAI:

128083868(ADAMTS2)

LMUT:

125700030(ADAMTS2)

NMEL:

110405507(ADAMTS2)

APLA:

101799569(ADAMTS2)

ACYG:

106032808(ADAMTS2)

CATA:

118254991(ADAMTS2)

AFUL:

116494689(ADAMTS2)

TGU:	100224296(ADAMTS2)

LSR:	110482726(ADAMTS2)

SCAN:

103817477(ADAMTS2)

PMOA:

120498711(ADAMTS2)

OTC:	121332489(ADAMTS2)

PRUF:

121361443(ADAMTS2)

GFR:	102038616(ADAMTS2)

FAB:	101819965(ADAMTS2)

OMA:	130258979(ADAMTS2)

PHI:	102107776(ADAMTS2)

PMAJ:

107210556(ADAMTS2)

CCAE:

111935404(ADAMTS2)

CCW:	104689702(ADAMTS2)

CBRC:

103611513(ADAMTS2)

ETL:	114065205(ADAMTS2)

ZAB:	102063232(ADAMTS2)

ACHL:

103798671(ADAMTS2)

SVG:	106859561(ADAMTS2)

MMEA:

130577954

HRT:	120759319(ADAMTS2)

FPG:	101917429(ADAMTS2)

FCH:	102056156(ADAMTS2)

CLV:	102084652(ADAMTS2)

EGZ:	104128442(ADAMTS2)

NNI:	104018458(ADAMTS2)

PLET:

104620862(ADAMTS2)

EHS:	104509693(ADAMTS2)

PCAO:

104052073

ACUN:

113485120(ADAMTS2)

TALA:

104366838(ADAMTS2)

PADL:

103915832(ADAMTS2)

AFOR:

103904568(ADAMTS2)

ACHC:

115333980(ADAMTS2)

HALD:

104323494(ADAMTS2)

HLE:	104839085(ADAMTS2)

AGEN:

126051006

GCL:

127022129

CCRI:

104166892(ADAMTS2)

CSTI:

104560916(ADAMTS2)

CMAC:

104481080(ADAMTS2)

MUI:	104543930(ADAMTS2)

BREG:

104632731

FGA:

104069974

GSTE:

104257300(ADAMTS2)

LDI:

104348639

MNB:	103780385(ADAMTS2)

OHA:	104326913(ADAMTS2)

NNT:	104412370(ADAMTS2)

SHAB:

115616055(ADAMTS2)

DPUB:

104310321(ADAMTS2)

PGUU:

104466302

CPEA:

104386919(ADAMTS2)

AVIT:

104279902(ADAMTS2)

CVF:	104293143(ADAMTS2)

RTD:	128916306(ADAMTS2)

CUCA:

104059861(ADAMTS2)

TEO:	104372326(ADAMTS2)

BRHI:

104499695(ADAMTS2)

AAM:	106493433(ADAMTS2)

AROW:

112964788(ADAMTS2)

NPD:	112954368(ADAMTS2)

TGT:

104567759

DNE:	112996944(ADAMTS2)

SCAM:

104142576(ADAMTS2)

ASN:	102383052(ADAMTS2)

AMJ:	102569690(ADAMTS2)

CPOO:

109310141(ADAMTS2)

GGN:	109289911(ADAMTS2)

PSS:

102456107

CMY:	102943314(ADAMTS2)

CCAY:

125641359(ADAMTS2)

DCC:	119860591(ADAMTS2)

CPIC:

101950216(ADAMTS2)

TST:	117881356(ADAMTS2)

CABI:

116837700(ADAMTS2)

MRV:	120370964(ADAMTS2)

ACS:	100557740(adamts2)

PVT:	110073478(ADAMTS2)

SUND:

121923827(ADAMTS2)

PBI:

103060599

PMUR:

107285860(ADAMTS2)

CTIG:

120306848(ADAMTS2)

TSR:	106548108(ADAMTS2)

PGUT:

117655506(ADAMTS2)

APRI:

131193544(ADAMTS2)

PTEX:

113433787(ADAMTS2)

VKO:	123035719(ADAMTS2)

PMUA:

114591323(ADAMTS2)

PRAF:

128407933(ADAMTS2)

ZVI:	118080400(ADAMTS2)

HCG:	128345756(ADAMTS2)

GJA:	107123236(ADAMTS2)

STOW:

125429559(ADAMTS2)

EMC:	129328074(ADAMTS2)

XLA:	108710899(adamts2.L) 108713291(adamts2.S)

XTR:	100492431(adamts2)

NPR:

108798945

RTEM:

120932444

BBUF:

121009531

BGAR:

122928255

MUO:

115475753

GSH:	117351661(ADAMTS2)

DRE:	101883894 571682(adamts2)

SRX:	107749938 107756425 107756799 107758566

SANH:

107665532 107667595 107680579 107689184

SGH:	107566216 107566696 107590100 107594866

CCAR:

109053459 109060242 109063876 109078251 109102812

CAUA:

113038411 113057586 113064000 113114025 113114095

CGIB:

127941719 127947077 127971636 127986404 128026965

PTET:

122326824(adamts2a) 122358235

LROH:

127152442(adamts2a) 127176524

OMC:	131528339(adamts2a) 131553632

PPRM:

120460902 120494725(adamts2a)

MAMB:

125252346(adamts2a) 125259363

CIDE:

127494526 127503175

MASI:

127413031 127418324 127429398 127431107

TROS:

130563861 130570343(adamts2a)

MANU:

129422029 129423200(adamts2a)

IPU:	108269222 108278612(adamts2a)

IFU:	128612029 128622246(adamts2a)

PHYP:

113541621 113542831

SMEO:

124386140 124397813(adamts2a)

TFD:	113646004 113646917(adamts2a)

AMEX:

103038015 103047851

CMAO:

118807006 118819984(adamts2)

EEE:	113571274 113581513

CHAR:

105904583(adamts2a) 105906701

TRU:	101061361 101063894

TFS:	130531189 130537159

TNG:	GSTEN00007373G001 GSTEN00008314G001 GSTEN00014566G001

LCO:	104919456 104927075

NCC:	104942672 104949504

CGOB:

115014490 115019154

ELY:	117260823 117269398(adamts2)

EFO:	125894516 125899052(adamts2a)

PLEP:

121948056(adamts2a) 121952195

SLUC:

116064073 116064304

ECRA:

117952083

ESP:	116678813 116697403

PFLV:

114562491 114566537

GAT:	120817843 120821596

PPUG:

119210760 119215718

AFB:	129090029 129113069

CLUM:

117738063 117743048

MSAM:

119883032 119888589 119895121

SCHU:

122880386 122888268(adamts2a)

CUD:	121515900 121518824

ALAT:

119007986 119030957

MZE:	101478756 101481373

ONL:	100693470 100711611

OAU:	116329068(adamts2a) 116336128

OLA:	101157151 101157225

OML:	112136875(adamts2) 112153355

XMA:	102230281 102234845

XCO:	114139055 114152804

XHE:	116712654 116714359 116728255

PRET:

103459894 103471261

PFOR:

103135534 103141078

PLAI:

106948561 106964884

PMEI:

106918556 106920872

GAF:	122837360 122844809

CVG:	107102010 107103400

CTUL:

119792493 119793474(adamts2)

GMU:	124860390 124876446

NFU:	107375858 107387186

KMR:	108228995 108240586(adamts2)

ALIM:

106517507 106532992

NWH:	119408792 119420750(adamts2a)

AOCE:

111569503(adamts2) 111575726

MCEP:

125008074 125021579(adamts2a)

CSEM:

103391033 103395597

POV:	109643920(adamts2) 109644389

SSEN:

122778359 122779339

HHIP:

117769153 117774665

HSP:	118112375 118122070(adamts2a)

LCF:	108873642 108899249

SDU:	111226437 111239490

SLAL:

111646645 111669318

XGL:	120785567 120802164(adamts2a)

HCQ:	109518787 109528916

SSCV:

125981959 125983042

BPEC:

110157629 110174988

MALB:

109955091 109973159

BSPL:

114864077 114869115

SASA:

106563724 106563762 106602921 106604833 106611949

STRU:

115154901 115174484 115204532 115205406

OTW:	112220757 112229028 112230691(adamts2a) 112257039

OMY:	110488609 110504815 110510203 110533139

OGO:	123993252 124005646 124006932 124010832

ONE:	115129144 115130523 115135444 115146820

OKI:	109864977 109872731 109878722 109882118

OKE:	118374579 118384013 118384930 118390561

SALP:

111950346 111964411 111964771

SNH:	120021778 120048200 120057349 120062196

CCLU:

121541970 121544674 121578962 121579666(adamts2a)

ELS:	105024906 109614569

SFM:	108934149 108936843

PKI:	111850411 111855482

AANG:

118223260 118235729

LOC:	102688577(adamts2)

PSPA:

121297237 121324257

ARUT:

117413282(adamts2)

PSEX:

120542905

LCM:	102351758(ADAMTS2)

CMK:

103186476

RTP:

109916643

CPLA:

122556645

LERI:

129701736

LHU:	105667396 105667397 105668524 105668553 105668554 105668556 105669605 105671190 105671217 105671304 105671442 105671444 105671517 105672340 105673466 105675067 105676683 105676684

PCF:

106784434

PFUC:

122519369

VPS:

122630820

VCRB:

124424434

NVI:

100677889

CSOL:

105367742

TPRE:

106648540

CGLO:

123271517

FAS:

105268093

VCAN:

122410062

SOY:

115881319

LDC:

111502885

PPYR:

116163207

OTU:

111428109

DPX:	DAPPUDRAFT_191143

DMK:

116916027

HAME:

121856460

LGI:	LOTGIDRAFT_127898

BGT:

106072148

OVI:	T265_01650

ADF:

107356636

AMIL:

114976548

PDAM:

113677815

SPIS:

111321308

DGT:

114520911

XEN:

124438887

» show all

Reference

1 [PMID:4204204]

Authors

Kohn LD, Isersky C, Zupnik J, Lenaers A, Lee G, Lapiere CM.

Title

Calf tendon procollagen peptidase: its purification and endopeptidase mode of action.

Journal

Proc Natl Acad Sci U S A 71:40-4 (1974)
DOI:10.1073/pnas.71.1.40

Reference

2 [PMID:2500439]

Authors

Hojima Y, McKenzie JA, van der Rest M, Prockop DJ.

Title

Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.

Journal

J Biol Chem 264:11336-45 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.14

IUBMB Enzyme Nomenclature:

3.4.24.14

ExPASy - ENZYME nomenclature database:

3.4.24.14

BRENDA, the Enzyme Database:

3.4.24.14

CAS:	68651-94-5

DBGET integrated database retrieval system