EC                Enzyme                                 

thimet oligopeptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
Acting on peptide bonds (peptidases);
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
EC created 1984 (EC created 1989 and EC created 1978 both incorporated 1992)
K01392  thimet oligopeptidase
HSA: 7064(THOP1)
PTR: 750162(THOP1)
PPS: 100985112(THOP1)
GGO: 101143234(THOP1)
PON: 100455971(THOP1)
NLE: 100583449(THOP1)
MCC: 721578(THOP1)
MCF: 102117812(THOP1)
CSAB: 103233658(THOP1)
RRO: 104665465(THOP1)
RBB: 108537535(THOP1)
CJC: 100385317(THOP1)
SBQ: 101028985(THOP1)
MMU: 50492(Thop1)
MCAL: 110303835(Thop1)
MPAH: 110326403(Thop1)
RNO: 64517(Thop1)
MUN: 110555611(Thop1)
CGE: 100764672(Thop1)
NGI: 103737278(Thop1)
HGL: 101714143(Thop1)
CCAN: 109691048(Thop1) 109702423
TUP: 102500342(THOP1)
CFA: 476748(THOP1)
VVP: 112935469(THOP1)
AML: 100471700(THOP1)
UMR: 103681807(THOP1)
UAH: 113242770(THOP1)
ORO: 101362401(THOP1)
ELK: 111161713
FCA: 101083746(THOP1)
PTG: 102964477(THOP1)
PPAD: 109260811(THOP1)
AJU: 106982145(THOP1)
BTA: 510889(THOP1)
BOM: 102265369(THOP1)
BIU: 109561783(THOP1)
BBUB: 102413536(THOP1)
CHX: 102178165(THOP1)
OAS: 101119557(THOP1)
SSC: 397442(THOP1)
CFR: 102508107(THOP1)
CDK: 105106052(THOP1)
BACU: 103019210(THOP1)
LVE: 103090843(THOP1)
OOR: 101287363(THOP1)
DLE: 111170481(THOP1)
PCAD: 102992430(THOP1)
ECB: 100059667(THOP1)
EPZ: 103540477(THOP1)
EAI: 106834154(THOP1)
MYB: 102262534(THOP1)
MYD: 102774039(THOP1)
MNA: 107534611(THOP1)
HAI: 109390675(THOP1)
DRO: 112312636(THOP1)
PALE: 102886786(THOP1)
RAY: 107520132(THOP1)
MJV: 108393267(THOP1)
LAV: 100665776
TMU: 101346830
MDO: 100020499(THOP1)
SHR: 100924623(THOP1)
PCW: 110223381(THOP1)
OAA: 100076730(THOP1)
GGA: 426398(THOP1)
MGP: 100545913(THOP1)
CJO: 107325439(THOP1)
NMEL: 110388975(THOP1)
APLA: 101804753(THOP1)
ACYG: 106048201(THOP1)
TGU: 100231983(THOP1)
LSR: 110483736(THOP1)
SCAN: 103822058(THOP1)
GFR: 102032301(THOP1)
FAB: 101805763(THOP1)
PHI: 102110662(THOP1)
PMAJ: 107215455(THOP1)
CCAE: 111940251(THOP1)
CCW: 104697073(THOP1)
ETL: 114066386(THOP1)
FPG: 101913462(THOP1)
FCH: 102053721(THOP1)
CLV: 102095097(THOP1)
EGZ: 104132299(THOP1)
NNI: 104016288(THOP1)
ACUN: 113489333(THOP1)
PADL: 103925937(THOP1)
AAM: 106486695(THOP1)
ASN: 102383675(THOP1)
AMJ: 102558370(THOP1)
PSS: 102457370(THOP1)
CMY: 102940710(THOP1)
CPIC: 101943510(THOP1)
PVT: 110079254(THOP1)
PBI: 103051765(THOP1)
PMUR: 107296844(THOP1)
TSR: 106544855(THOP1)
PMUA: 114588367(THOP1)
GJA: 107105512(THOP1)
XLA: 108706839(thop1.S) 397806(thop1.L)
XTR: 779863(thop1)
NPR: 108802730
DRE: 436628(thop1)
SANH: 107658499
CCAR: 109087313
IPU: 108271294(thop1)
PHYP: 113535897(thop1)
AMEX: 103038939(thop1)
EEE: 113568245(thop1)
TRU: 101069017
LCO: 104935746(thop1)
MZE: 101464999(thop1)
ONL: 100703187
OLA: 101157763(thop1)
XMA: 102222331(thop1)
XCO: 114141368(thop1)
PRET: 103463257(thop1)
CVG: 107085901(thop1)
NFU: 107395897(thop1)
KMR: 108228871(thop1)
ALIM: 106532164
AOCE: 111563975(thop1)
CSEM: 103396631(thop1)
POV: 109642545
SDU: 111231825(thop1)
SLAL: 111671759(thop1)
HCQ: 109506833(thop1)
BPEC: 110167856(thop1)
MALB: 109965204(thop1)
SASA: 100194867(mepd) 106613599(MEPD)
ELS: 105011365(thop1)
SFM: 108935234
PKI: 111840410
LCM: 102357708(THOP1)
CMK: 103181955(thop1)
RTP: 109912733(thop1)
BFO: 118426054
CIN: 100183579
SPU: 585276
APLC: 110987267
SKO: 100373471
AALB: 115261885
FCD: 110858459
PVM: 113824454
PTEP: 107452832
PCAN: 112573585
MYI: 110466585
OBI: 106883272
LAK: 106165041
NVE: 5520300
EPA: 110233802
AMIL: 114975087
PDAM: 113674458
SPIS: 111336744
DGT: 114526239
HMG: 100212290
ATH: AT1G67690
ALY: 9324680
CRB: 17894312
THJ: 104825527
CPAP: 110811640
CIT: 102612794
TCC: 18609680
GRA: 105794549
GAB: 108461139
DZI: 111282553
EGR: 104433638
GSJ: 114394812
VRA: 106755630
VAR: 108327003
VUN: 114176336
CCAJ: 109809646
CAM: 101492891
LJA: Lj2g3v1402690.2(Lj2g3v1402690.2)
ADU: 107468942
AIP: 107623713
LANG: 109327233
FVE: 101295009
RCN: 112198397
PPER: 18789331
PMUM: 103321960
PAVI: 110753096
PXB: 103949886
ZJU: 107428397
CSV: 101203244
CMO: 103487749
MCHA: 111004893
CMAX: 111491781
CMOS: 111462816
CPEP: 111805736
RCU: 8278432
JCU: 105644751
HBR: 110640451
MESC: 110628853
POP: 7460043
PEU: 105138030
JRE: 108982025
QSU: 112015579
VVI: 100251085
SLY: 101244701
SPEN: 107030536
SOT: 102581011
CANN: 107878381
NSY: 104236568
NTO: 104101862
NAU: 109240158
INI: 109172014
SIND: 105168364
OEU: 111401948
HAN: 110895102
LSV: 111887622
CCAV: 112524158
DCR: 108197056
BVG: 104897646
SOE: 110793856
NNU: 104591627
OSA: 4325012
DOSA: Os01t0902200-01(Os01g0902200)
OBR: 102721983
BDI: 100821906
ATS: 109754044(LOC109754044)
SBI: 8056125
ZMA: 100280152(si683006e11)
SITA: 101785951
PDA: 103713620
EGU: 105053005
MUS: 103994127
DCT: 110099372
PEQ: 110021067
AOF: 109836686
ATR: 18441855
DFA: DFA_04384
SPAR: SPRG_12685
PSUW: WQ53_10275
ACB: A1S_1610
ABN: AB57_1834
ABB: ABBFA_01863(prlC_2)
ABX: ABK1_2095
ABH: M3Q_1989
ABAD: ABD1_15970
ABAZ: P795_9225
ABAU: IX87_18875
ABAA: IX88_09965
ACC: BDGL_000980(thoP1)
AGU: AS4_08040(prlC)
CJA: CJA_2059
SDE: Sde_2026
TBN: TBH_C0772
MPT: Mpe_A1779
CFU: CFU_3179
CARE: LT85_1318
OFO: BRW83_0121(prlC_1)
BBAG: E1O_22950
DEU: DBW_3398(prlC)
ADE: Adeh_0397
CCX: COCOR_00293(prlC) COCOR_06341(prlC1)
SCL: sce4462(prlC1)
HOH: Hoch_5061
ADO: A6F68_02348(prlC)
MTS: MTES_0996
LMOI: VV02_11660
CFI: Celf_0358
NCA: Noca_4613
NDK: I601_3548(prlC)
NBE: Back2_18900(thoP1)
PSIM: KR76_26405
OBG: Verru16b_00587(prlC)
ACA: ACP_2228
SUS: Acid_7278
FSN: GS03_01802(prlC_2)
DPB: BABL1_gene_25(prlC)
MPI: Mpet_2495
MBN: Mboo_2053
MPL: Mpal_0768
 » show all
1  [PMID:3244563]
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC.
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.
Peptides 9:945-55 (1988)
2  [PMID:2803255]
Orlowski M, Reznik S, Ayala J, Pierotti AR.
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.
Biochem J 261:951-8 (1989)
3  [PMID:2123097]
Barrett AJ, Brown MA.
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.
Biochem J 271:701-6 (1990)
4  [PMID:2261476]
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.
Molecular cloning and primary structure of rat testes metalloendopeptidase EC
Biochemistry 29:10323-9 (1990)
5  [PMID:2185743]
Tisljar U, Barrett AJ.
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.
Biochem J 267:531-3 (1990)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 110639-28-6

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