KEGG   ENZYME: 3.4.24.15
Entry
EC 3.4.24.15                Enzyme                                 
Name
thimet oligopeptidase;
Pz-peptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
Comment
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
History
EC 3.4.24.15 created 1984 (EC 3.4.22.19 created 1989 and EC 3.4.99.31 created 1978 both incorporated 1992)
Orthology
K01392  thimet oligopeptidase
Genes
HSA7064(THOP1)
PTR750162(THOP1)
PPS100985112(THOP1)
GGO101143234(THOP1)
PON100455971(THOP1)
PPYG129020261(THOP1)
NLE100583449(THOP1)
HMH116483102(THOP1)
SSYN129465293(THOP1)
MCC721578(THOP1)
MCF102117812(THOP1)
MTHB126942541
MNI105485733(THOP1)
CSAB103233658(THOP1)
CATY105591760(THOP1)
PANU101016285(THOP1)
TGE112613114(THOP1)
MLEU105551973(THOP1)
RRO104665465(THOP1)
RBB108537535(THOP1)
TFN117074290(THOP1)
PTEH111520680(THOP1)
CANG105527655(THOP1)
CJC100385317(THOP1)
SBQ101028985(THOP1)
CIMI108288502(THOP1)
ANAN105706088(THOP1)
CSYR103265974(THOP1)
MMUR105873975(THOP1)
LCAT123633237(THOP1)
PCOQ105811943(THOP1)
OGA100947655(THOP1)
MMU50492(Thop1)
MCAL110303835(Thop1)
MPAH110326403(Thop1)
RNO64517(Thop1)
MCOC116076209(Thop1)
ANU117696806(Thop1)
ASYL127670930(Thop1)
MUN110555611(Thop1)
CGE100764672(Thop1)
MAUA101823587(Thop1)
PROB127216546(Thop1)
PLEU114688124(Thop1)
MORG121459922(Thop1)
MFOT126489301
AAMP119800920(Thop1)
NGI103737278(Thop1)
HGL101714143(Thop1)
CPOC100731879(Thop1)
CCAN109691048(Thop1) 109702423
DORD105990473(Thop1)
DSP122099291(Thop1)
PLOP125348632(Thop1)
NCAR124969480
MMMA107157425(Thop1)
ITI101963829(Thop1)
OPI101521830(THOP1)
TUP102500342(THOP1)
GVR103605472(THOP1)
CFA476748(THOP1)
CLUD112666240(THOP1)
VVP112935469(THOP1)
VLG121494789(THOP1)
NPO129521739(THOP1)
AML100471700(THOP1)
UMR103681807(THOP1)
UAH113242770(THOP1)
UAR123793979(THOP1)
ELK111161713
LLV125086980
MPUF101675322(THOP1)
MNP132010756(THOP1)
MLK131823254(THOP1)
NVS122909904(THOP1)
ORO101362401(THOP1)
EJU114226166(THOP1)
ZCA113916363(THOP1)
MLX118005518(THOP1)
NSU110593679(THOP1)
LWW102733859(THOP1)
FCA101083746(THOP1)
PYU121021304(THOP1)
PBG122486659(THOP1)
PVIV125160661(THOP1)
LRUF124524840
LGF123605068(THOP1)
AJU106982145
PTG102964477(THOP1)
PPAD109260811(THOP1)
PUC125930507
PLEZ122213730(THOP1)
HHV120242394(THOP1)
BTA510889(THOP1)
BOM102265369(THOP1)
BIU109561783(THOP1)
BBUB102413536(THOP1)
BBIS105005586(THOP1)
CHX102178165(THOP1)
OAS101119557(THOP1)
BTAX128050814(THOP1)
CSUM138085918(THOP1)
ODA120864781(THOP1)
CCAD122440188(THOP1)
MREE136166968(THOP1)
OVR110138372(THOP1)
MBEZ129559136(THOP1)
SSC397442(THOP1)
CFR102508107(THOP1)
CBAI105078170(THOP1)
CDK105106052(THOP1)
VPC102539590(THOP1)
BACU103019210(THOP1)
BMUS118892444(THOP1) 118892597
LVE103090843(THOP1)
OOR101287363(THOP1)
LALB132517825(THOP1) 132522667 132529986
DLE111170481(THOP1)
PCAD102992430(THOP1)
PSIU116751758(THOP1) 116761195
NASI112396373(THOP1)
ECB100059667(THOP1)
EPZ103540477(THOP1)
EAI106834154(THOP1)
MYB102262534(THOP1)
MYD102774039(THOP1)
MMYO118658947(THOP1)
MLF102426538(THOP1)
MDT132235224(THOP1)
MYUM139009763(THOP1)
PKL118731308(THOP1)
EFUS103294259(THOP1)
MNA107534611(THOP1)
DRO112312636(THOP1)
SHON118984464(THOP1)
AJM119063770(THOP1)
PDIC114502924(THOP1)
PHAS123814089(THOP1)
MMF118615985(THOP1)
PPAM129081319(THOP1)
HAI109390675(THOP1)
RFQ117038291(THOP1)
PALE102886786(THOP1)
PGIG120583743(THOP1)
PVP105300464(THOP1)
RAY107520132(THOP1)
MJV108393267
TOD119240546(THOP1)
SARA101543766(THOP1)
SFUM130022145(THOP1)
SETR126031140(THOP1)
LAV100665776
TMU101346830
ETF101649445(THOP1)
DNM101436326(THOP1)
MDO100020499(THOP1)
GAS123256779(THOP1)
SHR100924623(THOP1)
AFZ127545129
PCW110223381(THOP1)
TVP118846412(THOP1)
PBRV138172283(THOP1)
OAA100076730(THOP1)
TACU119919678(THOP1)
GGA426398(THOP1)
PCOC116235780(THOP1)
MGP100545913(THOP1)
CJO107325439(THOP1)
TPAI128088932(THOP1)
LMUT125685058(THOP1)
NMEL110388975(THOP1)
APLA101804753(THOP1)
ACYG106048201(THOP1)
CATA118260844(THOP1)
AFUL116499110(THOP1)
TGU100231983(THOP1)
LSR110483736(THOP1)
SCAN103822058(THOP1)
PMOA120513634(THOP1)
OTC121342122(THOP1)
PRUF121360908
ATRC139602321(THOP1)
GFR102032301(THOP1)
FAB101805763(THOP1)
OMA130264551(THOP1)
PHI102110662(THOP1)
PMAJ107215455(THOP1)
CCAE111940251(THOP1)
CCW104697073(THOP1)
CBRC103622198
ACOE138099691(THOP1)
ETL114066386(THOP1)
ZAB102062983(THOP1)
ZLE135458833(THOP1)
ACHL103804792(THOP1)
SVG106857154(THOP1)
MMEA130580196(THOP1)
SATI136371853(THOP1)
CCIC134054481(THOP1)
FPG101913462(THOP1)
FCH102053721(THOP1)
CCRI104165370(THOP1)
NNT104413388(THOP1)
SHAB115618044(THOP1)
ACUN113489333(THOP1)
TALA104363459(THOP1)
ACHC115348846(THOP1)
HALD104319119
HLE104829105(THOP1)
AGEN126041611
HHAR128148128(THOP1)
GCL127025543
CSTI104554122
LDI104342201
MNB103780001(THOP1)
DPUB104299056(THOP1)
PPUS135192001(THOP1)
AVIT104279925(THOP1)
EGZ104132299(THOP1)
NNI104016288(THOP1)
PCRI104035619(THOP1)
PCAO104042347(THOP1)
PADL103925937(THOP1)
AFOR103899398(THOP1)
FGA104084170(THOP1)
GSTE104260085(THOP1)
CBOY140643516(THOP1)
CLV102095097(THOP1)
MUI104539560(THOP1)
PGUU104471466(THOP1)
PLET104621712(THOP1)
EHS104513053(THOP1)
CMAC104474322(THOP1)
CUCA104065758(THOP1)
TEO104378215(THOP1)
BREG104641176(THOP1)
OHA104327957(THOP1)
ACAR104523453
CPEA104395609(THOP1)
CVF104285119(THOP1)
RTD128900752(THOP1)
CRID134526249(THOP1)
AAM106486695(THOP1)
AROW112965657(THOP1)
NPD112946888(THOP1)
TGT104568357(THOP1)
DNE112992759(THOP1)
SCAM104139383(THOP1)
ASN102383675(THOP1)
AMJ102558370(THOP1)
CPOO109312321(THOP1)
GGN109294955(THOP1)
PSS102457370(THOP1)
CMY102940710(THOP1)
CCAY125627075(THOP1)
DCC119848370(THOP1)
CPIC101943510(THOP1)
TST117868787(THOP1)
CABI116831649(THOP1)
MRV120391749(THOP1)
ASAO132780866(THOP1)
PVT110079254(THOP1)
SUND121936693(THOP1)
PBI103051765(THOP1)
PMUR107296844(THOP1)
CTIG120299507(THOP1)
TSR106544855(THOP1)
PGUT117670577(THOP1)
APRI131188456(THOP1)
PTEX113451175(THOP1)
NSS113426270(THOP1)
VKO123017592
PMUA114588367(THOP1)
PRAF128405630(THOP1)
ZVI118087077(THOP1)
HCG128344541(THOP1)
GJA107105512(THOP1)
STOW125433653(THOP1)
EMC129330744(THOP1)
XLA108706839(thop1.S) 397806(thop1.L)
XTR779863(thop1)
NPR108802730
RTEM120912800(THOP1)
BBUF120989474(THOP1)
BGAR122919913(THOP1)
PWL138266980(THOP1)
MUO115480489(THOP1)
GSH117365613(THOP1)
DRE436628(thop1)
SRX107726548 107730481 107751012
SANH107658499
SGH107568058 107592556
CCAR109071551 109087313
CAUA113054995 113069380
CGIB127968090 128022613
PTET122354205(thop1)
LROH127173375(thop1)
OMC131549863(thop1)
PPRM120464244(thop1)
RKG130100915(thop1)
MAMB125256422(thop1)
CIDE127522016
CERY137021698(thop1)
MASI127426443 127427641
TROS130571149(thop1)
TDW130410790(thop1)
MANU129427250(thop1)
PDAB135719230(thop1)
IPU108271294
IFU128614035(thop1)
PHYP113535897(thop1)
SMEO124391613(thop1)
TFD113657854(thop1)
TVC132851924(thop1)
CGAR128542523(thop1)
NGRA132899615(thop1)
TRN134331189(thop1)
AMEX103038939(thop1)
CMAO118819360(thop1)
EEE113568245(thop1)
CHAR105896439(thop1)
SPIL134101649(thop1)
TRU101069017
TFS130528297(thop1)
TNGGSTEN00006269G001
LCO104935746(thop1)
TBEN117491064(thop1)
CGOB115006745(thop1)
PGEO117445633(thop1)
GACU117534328(thop1)
EMAC134869686(thop1)
ELY117254224(thop1)
EFO125895982(thop1)
PLEP121941066(thop1)
SLUC116066747(thop1)
ESP116679471
PFLV114552158(thop1)
GAT120823858(thop1)
PPUG119216330(thop1)
AFB129094302(thop1)
CLUM117730033(thop1)
PSWI130193560(thop1)
CANA137794750(thop1)
CVE137870491(thop1)
MSAM119888385 119888386
SCHU122877413(thop1)
CUD121511696(thop1)
SPUL138606759(thop1)
LMIX132967216(thop1)
ALAT119029193(thop1)
ASTR137599129(thop1)
MZE101464999(thop1)
ONL100703187
OAU116323245(thop1)
OLA101157763(thop1)
OML112136800(thop1)
CSAI133458331(thop1)
XMA102222331(thop1)
XCO114141368(thop1)
XHE116725751
PRET103463257(thop1)
PFOR103155047(thop1)
PLAI106941416(thop1)
PMEI106927773(thop1)
GAF122838058(thop1)
PPRL129378906(thop1)
CVG107085901(thop1)
CTUL119791252(thop1)
GMU124873733(thop1)
NFU107395897(thop1)
KMR108228871(thop1)
ALIM106532164
NWH119430462(thop1)
AOCE111563975(thop1)
EJA138193759(thop1)
BFRE138635096(thop1)
MCEP125009784(thop1)
CSEM103396631(thop1)
POV109642545
SSEN122780778(thop1)
SSOE131465520(thop1)
HHIP117760170(thop1)
HSP118121258(thop1)
PPLT128447974(thop1)
SMAU118318066(thop1)
LCF108882357(thop1) 108892667
SDU111231825(thop1)
SLAL111671759(thop1)
XGL120790957(thop1)
HCQ109506833(thop1)
SSCV125975091(thop1)
SBIA133503286(thop1)
PEE133406741(thop1)
PTAO133481261(thop1)
BPEC110167856(thop1)
ENY140353378(thop1)
MALB109965204(thop1)
BSPL114854329
SJO128362053(thop1)
SSCO133985330(thop1)
GMH115556075(thop1)
SASA100194867(mepd) 106613599(MEPD)
STRU115151639 115158073
OTW112250709 112252097
OMY110489937 110524109
OGO123997264(thop1) 123997863
ONE115108147 115109114
OKI109889094 109902350
OKE118387838 118401487
OMM135512623 135524681
OCLA139367769 139409042
SALP111952854 111975950
SNH120053694 120054667
CCLU121533688 121576477(thop1)
ELS105011365(thop1)
OEP134012970(thop1)
SFM108935234
PKI111840410
AANG118225034(thop1)
AROT135252824(thop1)
CCOG133126547(thop1)
LOC102698056
PSPA121300806
ARUT117401455 117966344
PSEX120537589(thop1)
LCM102357708(THOP1)
CMK103181955
RTP109912733
CPLA122557939 122565420
HOC132821387 132828857
LERI129711114(thop1)
PMRN116942290(THOP1)
LRJ133359165
BFO118426054
BBEL109463730
CIN100183579
SCLV120345308
SPU585276
LPIC129271765 129271768
AJJ139985189
APLC110987267
ARUN117297591
AAMU139946087
AFIL140148021
AJC117106427
SKO100373471
PFLL139139265
BCOO119080155 119080156
FCD110858459
AFRA136031299
PVM113824454
PJA122251371
PCHN125027779
PMOO119572960
HAME121868559
PCLA123762978 138361025
CQD128695031
PTRU123517768
ESN127005818
MNZ135195550
MRJ136855927
PORN139763452
HAZT108669727
EAF111710536
TCF131886280
PPOI119101446
DSV119433527
RSAN119405166 119405167
RMP119181934
CSCU111634737 111637553 111642625
CVS136970947
PTEP107452832
ABRU129975725
UDV129216964
SDM118187678 118200824
LPOL106458305
LGILOTGIDRAFT_178669
PVUL126819247
PCAN112573585
LSAX138966031
BGT106064971
GAE121376297 121376298
HRF124113096
HRJ124258522
HASI137290825
HCRA139478904
CRG105326160 117684168 136270347
CANU128164619
CVN111117774 111122414
OED125668093 125668094
MYI110466585
PMAX117325603
AIRR138325912
MCAF127735844
MMER123524249
RPHI132719648
DPOL127833413
MAEA128214654
OBI106883272
OSN115222172
LJP135470521
LAK106165041
SMMSmp_029470 Smp_029500
SHXMS3_00004895(THOP1_1) MS3_00004897(THOP1_2)
OVIT265_02526
LLON135486227
NVE5520300
EPA110233802
ATEN116297513
AMIL114975087
MCAZ138024102
MFOO137974260
PDAM113674458
SPIS111336744
DGT114526239
XEN124436297
HMG100212290
RES135684349
TADTRIADDRAFT_22587
ATHAT1G67690
ALY9324680
CRB17894312
CSAT104704713 104750568 104787784
EUSEUTSA_v10018203mg
BRP103831014 103831191
BNA106353963 106410390 106436805 106454291
BOE106300211 106300276
RSZ108817546 108817732
THJ104825527
CPAP110811640
CIT102612794
CICCICLE_v10033657mg
PVY116128487
MINC123214879
TCC18609680
GRA105794549
GHI107886507 107909759
GAB108461139
HSYR120134494
DZI111282553
EGR104433638
RARG115749342
GMX100793518 100796889
GSJ114394812
PVU137815220
VRA106755630
VAR108327003
VUN114176336
VUM124840004
CCAJ109809646
APRC113850421
MTR11446411
TPRA123910196
CAM101492891
PSAT127083060
VVO131661506 131661518
LJA130724453
ADU107468942
AIP107623713
AHF112715069 112783859
LANG109327233
PCIN129293194
QSAO6P43_023901
FVE101295009
AANS126791342
RCN112198397
PPER18789331
PMUM103321960
PAVI110753096
PDUL117616153
MDM103450130 103452091
MSYL126597794 126608737
PXB103949886
PCOX137732286 137738096
ZJU107428397
MNT21410202
CSAV115717346
CSV101203244
CMO103487749
BHJ120076088
MCHA111004893
CMAX111491781
CMOS111462816
CPEP111805736
RCU8278432
MEAN126656372
JCU105644751
HBR110640451
MESC110628853
POP7460043
PEU105138030
PALZ118048831
PNZ133696130
JRE108982025
CILL122314418
CAVE132179893
AGLU133865328
QSU112015579
QLO115982332
TWL119992207
VVI100251085
VRI117922528
SLY101244701
SPEN107030536
SOT102581011
SSTN125870859
SDUL129882459
CANN107878381
LBB132631303
NTA107776157 107805230
NSY104236568
NTO104101862
NAU109240158
INI109172014
ITR116024900
SIND105168364
OEU111401948
EGT105970919
SSPL121794523
SMIL130995561
SHIS125205300
APAN127241511
HAN110895102
ECAD122607332
LSV111887622
CCAV112524158
DCR108197056
CSIN114318340
RVL131311514
AEW130772416
DLT127797587
BVG104897646
SOE110793856
CQI110710335 110712431
ATRI130809249
MOF131144688
NNU104591627
MING122078158
TSS122671950
PSOM113298209 113302654
OSA4325012
DOSAOs01g0902200
OBR102721983
OGL127780107
BDI100821906
ATS109754044
TDC119269828 119277834
TAES123062821 123071663 123080010
TUA125545482
LPER127344991
LRD124661406
SBI8056125
ZMA100280152
MFLO136450901 136456993
SITA101785951
SVS117857165
PVIR120676599 120708956
PHAI112891681
PAUA133909396
PDA103713620
EGU105053005
MUS135583018
ZOF122041905 122046429
DCT110099372
PEQ110021067
AOF109836686
MSIN131246242
ACAK137962710
NCOL116250655
ATR18441855
CJF131071469
SMOSELMODRAFT_113618 SELMODRAFT_164651
PPP112295568 112295983
MNGMNEG_12125
OLUOSTLU_46518
OTAOT_ostta09g02980
BPGBathy10g01530
CMECYME_CMS446C
ZTRMYCGRDRAFT_107351
MBRMONBRDRAFT_25656
SREPTSG_13259
DDIDDB_G0292362
DPPDICPUDRAFT_54379
DFADFA_04384
AAFAURANDRAFT_72404
PIFPITG_08599
PSOJPHYSODRAFT_329905
SPARSPRG_12685
TBRTb927.7.190
TBGTbgDal_VII70
TCR506411.10 511237.10
LMALMJF_26_1570
LIFLINJ_26_1550
LDOLDBPK_261550
LMILMXM_26_1570
LMAT92514198(LSCM1_04165)
LBZLBRM_26_1590
LPANLPMP_261550
LOI92361047(LSCM4_05143)
LEIS94180563(GH5_05161)
LENR94171148(CUR178_03912)
LEIN94188723(JIQ42_05078)
PHET94290252(JKF63_04182) 94290260(JKF63_04190)
NGRNAEGRDRAFT_36811
GTTGUITHDRAFT_166948
 » show all
Reference
1  [PMID:3244563]
  Authors
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC.
  Title
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.
  Journal
Peptides 9:945-55 (1988)
DOI:10.1016/0196-9781(88)90072-1
Reference
2  [PMID:2803255]
  Authors
Orlowski M, Reznik S, Ayala J, Pierotti AR.
  Title
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.
  Journal
Biochem J 261:951-8 (1989)
DOI:10.1042/bj2610951
Reference
3  [PMID:2123097]
  Authors
Barrett AJ, Brown MA.
  Title
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.
  Journal
Biochem J 271:701-6 (1990)
DOI:10.1042/bj2710701
Reference
4  [PMID:2261476]
  Authors
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL
  Title
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.
  Journal
Biochemistry 29:10323-9 (1990)
DOI:10.1021/bi00497a006
  Sequence
[rno:64517]
Reference
5  [PMID:2185743]
  Authors
Tisljar U, Barrett AJ.
  Title
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.
  Journal
Biochem J 267:531-3 (1990)
DOI:10.1042/bj2670531
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.15
IUBMB Enzyme Nomenclature: 3.4.24.15
ExPASy - ENZYME nomenclature database: 3.4.24.15
BRENDA, the Enzyme Database: 3.4.24.15
CAS: 110639-28-6

DBGET integrated database retrieval system