Entry |
|
Name |
neurolysin;
neurotensin endopeptidase;
endopeptidase 24.16;
endo-oligopeptidase B (proline-endopeptidase)
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
|
Reaction(IUBMB) |
Preferential cleavage in neurotensin: Pro10!Tyr
|
Comment |
No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family)
|
History |
EC 3.4.24.16 created 1989
|
Orthology |
|
Genes |
» show all
|
Reference |
|
Authors |
Checler F, Vincent JP, Kitabgi P. |
Title |
Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes. |
Journal |
J Biol Chem 261:11274-81 (1986) |
Reference |
|
Authors |
Barelli H, Vincent JP, Checler F. |
Title |
Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum. |
Journal |
|
Reference |
|
Authors |
Checler F, Barelli H, Vincent JP. |
Title |
Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.24.16 |
|