| Entry |
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| Name |
neurolysin;
neurotensin endopeptidase;
endopeptidase 24.16;
endo-oligopeptidase B (proline-endopeptidase)
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Preferential cleavage in neurotensin: Pro10!Tyr
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| Comment |
No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family)
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| History |
EC 3.4.24.16 created 1989
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Checler F, Vincent JP, Kitabgi P. |
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| Title |
Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes. |
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| Journal |
J Biol Chem 261:11274-81 (1986) |
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| Reference |
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| Authors |
Barelli H, Vincent JP, Checler F. |
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| Title |
Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum. |
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| Journal |
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| Reference |
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| Authors |
Checler F, Barelli H, Vincent JP. |
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| Title |
Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies. |
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| Journal |
Biochem J 257:549-54 (1989) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.16 |
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