KEGG   ENZYME: 3.4.24.17Help
Entry
EC 3.4.24.17                Enzyme                                 

Name
stromelysin 1;
matrix metalloproteinase 3;
proteoglycanase;
collagenase activating protein;
procollagenase activator;
transin;
MMP-3;
neutral proteoglycanase;
stromelysin;
collagen-activating protein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage where P1', P2' and P3' are hydrophobic residues
Comment
An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.17 created 1990
Orthology
K01394  matrix metalloproteinase-3 (stromelysin 1, progelatinase)
Genes
HSA: 4314(MMP3)
PTR: 451511(MMP3)
PPS: 100995831(MMP3)
GGO: 101131989(MMP3)
PON: 100461529(MMP3)
NLE: 100583082(MMP3)
MCC: 703762(MMP3)
MCF: 102142651(MMP3)
CSAB: 103248344(MMP3)
RRO: 104674668(MMP3)
RBB: 108514072(MMP3)
CJC: 100396218(MMP3)
SBQ: 101051562(MMP3)
MMU: 17392(Mmp3)
MCAL: 110301975
MPAH: 110327820
RNO: 171045(Mmp3)
MUN: 110558090
CGE: 100754565
NGI: 103731587(Mmp3)
HGL: 101702569 101716622(Mmp3)
CCAN: 109689285
OCU: 100009111(MMP3)
TUP: 102489067(MMP3)
CFA: 403445(MMP3)
VVP: 112925877
AML: 100478420
ORO: 101368994(MMP3)
ELK: 111153872
FCA: 101081492
PTG: 102970292
PPAD: 109257540
AJU: 106976485
BTA: 281309(MMP3)
BOM: 102288330(MMP3)
BIU: 109569248
BBUB: 102413066(MMP3)
CHX: 102170893(MMP3)
OAS: 101118895
SSC: 396769(MMP3)
CFR: 102516794(MMP3)
CDK: 105087168(MMP3)
BACU: 103010042(MMP3)
LVE: 103089307(MMP3)
OOR: 101270746
DLE: 111167570
PCAD: 102983506
ECB: 100034195(MMP3)
EPZ: 103552637(MMP3)
EAI: 106843118(MMP3)
MYD: 102770528(MMP3)
MNA: 107532386
DRO: 112317540
PALE: 102886139
RAY: 107504635
MJV: 108385898
LAV: 100660303
TMU: 101341271
MDO: 100011059(MMP3)
SHR: 100934169
PCW: 110214977
OAA: 100077197
GGA: 418981(MMP10) 428086(MMP3)
ETL: 114067039
FPG: 101924760(MMP3)
FCH: 102050939
NNI: 104023068
PADL: 103915451
CMY: 102940374 102940592(MMP3)
CPIC: 101931780 101932067(MMP3)
IPU: 108276913
PHYP: 113544863
AMEX: 103038016
TRU: 101068697
LCO: 104930317
ALIM: 106512532
CSEM: 103377668
POV: 109634382
LCF: 108893128
SLAL: 111663517
HCQ: 109512887
MALB: 109972892
 » show all
Taxonomy
Reference
1  [PMID:2995374]
  Authors
Chin JR, Murphy G, Werb Z.
  Title
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.
  Journal
J Biol Chem 260:12367-76 (1985)
Reference
2  [PMID:3095317]
  Authors
Okada Y, Nagase H, Harris ED Jr.
  Title
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
  Journal
J Biol Chem 261:14245-55 (1986)
Reference
3  [PMID:2197998]
  Authors
Docherty AJ, Murphy G.
  Title
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
  Journal
Ann Rheum Dis 49:469-79 (1990)
Reference
4  [PMID:2165861]
  Authors
Emonard H, Grimaud JA.
  Title
Matrix metalloproteinases. A review.
  Journal
Cell Mol Biol 36:131-53 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.17
IUBMB Enzyme Nomenclature: 3.4.24.17
ExPASy - ENZYME nomenclature database: 3.4.24.17
BRENDA, the Enzyme Database: 3.4.24.17
CAS: 79955-99-0

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