KEGG   ENZYME: 3.4.24.17
Entry
EC 3.4.24.17                Enzyme                                 
Name
stromelysin 1;
matrix metalloproteinase 3;
proteoglycanase;
collagenase activating protein;
procollagenase activator;
transin;
MMP-3;
neutral proteoglycanase;
stromelysin;
collagen-activating protein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Preferential cleavage where P1', P2' and P3' are hydrophobic residues
Comment
An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.17 created 1990
Orthology
K01394  matrix metalloproteinase-3 (stromelysin 1, progelatinase)
Genes
HSA4314(MMP3)
PTR451511(MMP3)
PPS100995831(MMP3)
GGO101131989(MMP3)
PON100461529(MMP3)
NLE100583082(MMP3)
MCC703762(MMP3)
MCF102142651(MMP3)
MTHB126936369
CSAB103248344(MMP3)
CATY105588770(MMP3)
PANU101000789(MMP3)
TGE112607314(MMP3)
RRO104674668(MMP3)
RBB108514072(MMP3)
TFN117081262(MMP3)
PTEH111540075(MMP3)
CANG105500946(MMP3)
CJC100396218(MMP3)
SBQ101051562(MMP3)
CSYR103277140
MMUR105874563
LCAT123641885
PCOQ105822157 105822245
OGA100952217
MMU17392(Mmp3)
MCAL110301975
MPAH110327820
RNO171045(Mmp3)
MCOC116072442
MUN110558090
CGE100754565(Mmp3)
MAUA101834647
PLEU114708015
MORG121451850
MFOT126493288
AAMP119810022
NGI103731587(Mmp3)
HGL101702569 101716622(Mmp3)
CPOC100729101(Mmp3)
CCAN109689285
DORD105980671
DSP122110302(Mmp3)
NCAR124958931
OCU100009111(MMP3)
OPI101528146
TUP102489067(MMP3)
GVR103600379(MMP3)
CFA403445(MMP3)
CLUD112671545
VVP112925877
VLG121500272(MMP3)
AML100477912 100478420
UMR103662452 103662454
UAH113259796 113259798
UAR123792353 123792355
ELK111153872
LLV125078732 125078733
MPUF101688701
ORO101368994(MMP3)
EJU114211354(MMP3)
ZCA113914358
MLX118013056(MMP3)
NSU110586166
LWW102733397 102734593
FCA101081492
PYU121020779
PBG122482892
LRUF124504841
PTG102970292
PPAD109257540
AJU106976485
HHV120223085
BTA281309(MMP3)
BOM102288330(MMP3)
BIU109569248
BBUB102413066(MMP3)
BBIS104987808(MMP3)
CHX102170893(MMP3)
OAS101118895(MMP3)
ODA120876149(MMP3)
CCAD122450308
SSC396769(MMP3)
CFR102516794(MMP3)
CBAI105067594(MMP3)
CDK105087168(MMP3)
VPC102528182(MMP3)
BACU103010042(MMP3)
LVE103089307(MMP3)
OOR101270746
DLE111167570
PCAD102983506
PSIU116758766
ECB100034195(MMP3)
EPZ103552637(MMP3)
EAI106843118
MYB102252870 102254078
MYD102770528(MMP3)
MMYO118664459
MLF102427039
MNA107532386
PKL118713270
DRO112317540
SHON118975721
AJM119054055
PDIC114499511 114500132
PHAS123805510
MMF118628226
RFQ117031216 117031218
PALE102886139
PGIG120599686
PVP105297467
RAY107504635
MJV108385898
TOD119240915
SARA101545129
LAV100660303
TMU101341271
ETF101656613 101657229
DNM101447627
MDO100011059(MMP3)
GAS123238995
SHR100934169
PCW110214977
OAA100077197
GGA418981(MMP10) 428086(MMP3)
PCOC116230607 116230616
MGP100544485 100544642
CJO107308380 107308400
NMEL110389860 110389866
APLA101794349 101798488
ACYG106034136 106034139
AFUL116493125 116501848
TGU100221422 100227226
LSR110470043 110470055
SCAN103812522 103827285
PMOA120506631 120506743
OTC121342518 121342531
PRUF121364175 121364179
GFR102045216 102045385
FAB101805628 101805825
PHI102111122 102111311
PMAJ107199793 107213689
CCAE111924322 111924329
CCW104690061 104690062
CBRC103617949 103617950
ETL114067039
ZAB102069814 102069989
ACHL103811760 103811761
FPG101924760(MMP3)
FCH102050939
CLV102089434 102089618
EGZ104128904 104128911
NNI104023068
PLET104617149
PCRI104025174 104025526
PCAO104045435
ACUN113476996 113477018
TALA104369555 104369556
PADL103915451
AFOR103895109 103895110
ACHC115353566 115353567
HALD104314245 104314246
HLE104828448 104828449
AGEN126048148 126048150
GCL127021506 127021519
CCRI104159689 104163036
CSTI104549815 104556371
EHS104506190
CMAC104474429 104474600
MUI104535899 104537560
FGA104070480 104081957
GSTE104255839 104261779
LDI104351208 104351209
MNB103781317
OHA104333034 104333059
NNT104404383
DPUB104296910 104296911
PGUU104468646
ACAR104532861
CPEA104390272 104390273
AVIT104268312 104280485
CVF104290311 104290323
CUCA104055008 104064703
TEO104370475 104370765
BRHI104489342
AAM106495497 106495502
AROW112971953 112971954
NPD112943711 112943717
TGT104571781 104571785
DNE112988744 112988745
SCAM104151759 104151760
ASN102380481 102386892
AMJ102567265 102567499
CPOO109305541
GGN109302216 109303444
PSS102447500 102447922
CMY102939197 102940374 102940592
CPIC101931498 101931780 101932067
TST117871171 117871173 117871798
CABI116814903 116837660 116837662
MRV120375066 120395683 120407101
ACS100552454 100552651 100561433
PVT110089066 110089069 110089074
SUND121925768 121926153 121926847
PBI103067400 103067634
PMUR107286365 107286366
CTIG120313881 120313882
TSR106552777
PGUT117664145 117664152
VKO123029183 123029242 123029250
PMUA114595297 114595661 114595664
ZVI118084935 118084937
GJA107119161 107119164 107119165
STOW125430820 125431172 125431542
XLA108707763 108707764 108707765 108708732 108709141 108709142 446898(mmp3.L) 495372(mmp8.S)
XTR100489571 100489735 100491214 100491547 100494588(mmp8)
NPR108786934 108786935
RTEM120929026 120929033 120929034 120929035
BBUF120996397 120996398
BGAR122930903 122931173
IPU108276913(mmp30)
PHYP113544863
AMEX103038016
TRU101068697
LCO104930317
ALIM106512532
CSEM103377668
POV109628507 109634382
LCF108893128(mmp30)
SDU111222196 111233417
SLAL111663517
XGL120791805 120802392(mmp30)
HCQ109512887
MALB109972892
LOC102685380
ARUT117406493
CMK103177428 103177583
BBEL109482489
FOC113213637
PDAM113674030
 » show all
Reference
1  [PMID:2995374]
  Authors
Chin JR, Murphy G, Werb Z.
  Title
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.
  Journal
J Biol Chem 260:12367-76 (1985)
Reference
2  [PMID:3095317]
  Authors
Okada Y, Nagase H, Harris ED Jr.
  Title
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
  Journal
J Biol Chem 261:14245-55 (1986)
Reference
3  [PMID:2197998]
  Authors
Docherty AJ, Murphy G.
  Title
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
  Journal
Ann Rheum Dis 49:469-79 (1990)
Reference
4  [PMID:2165861]
  Authors
Emonard H, Grimaud JA.
  Title
Matrix metalloproteinases. A review.
  Journal
Cell Mol Biol 36:131-53 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.17
IUBMB Enzyme Nomenclature: 3.4.24.17
ExPASy - ENZYME nomenclature database: 3.4.24.17
BRENDA, the Enzyme Database: 3.4.24.17
CAS: 79955-99-0

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