Entry
Name
meprin A;
endopeptidase-2;
meprin-a;
meprin;
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase;
PABA-peptide hydrolase;
PPH
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues
Comment
A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC
3.4.24.11 ) (astacin family). Formerly included in EC
3.4.24.11
History
EC 3.4.24.18 created 1992
Orthology
Genes
APLA : 101798272 101798463
ACYG : 106038157 106038159
AFUL : 116487511 116487512
FPG : 101917590 101917757(MEP1A)
PLET : 104618385 104618386
PCRI : 104025808(MEP1A) 104031659
PCAO : 104045507 104045508
ACUN : 113478324 113478900
TALA : 104357816(MEP1A) 104357817
PADL : 103913199 103913259
AFOR : 103906919 103906920
ACHC : 115351123 115351125
HALD : 104316775(MEP1A) 104316848
HLE : 104842152(MEP1A) 104842153
AGEN : 126046369 126046621
CCRI : 104157934(MEP1A) 104157936
EHS : 104505665 104516896(MEP1A)
CMAC : 104483995(MEP1A) 104483996
FGA : 104069347(MEP1A) 104072506
LDI : 104344452(MEP1A) 104344453
ACAR : 104523934(MEP1A) 104523936
AVIT : 104275704(MEP1A) 104275705
CUCA : 104057112 104057122
AAM : 106495190 106495197(MEP1A)
ASN : 102387802 102388049(MEP1A)
AMJ : 102561580(MEP1A) 102561804
CPOO : 109311473(MEP1A) 109312050
SUND : 121918910 121937214
PMUR : 107284262 107284263(MEP1A)
CTIG : 120300341 120300424(MEP1A)
PGUT : 117671091 117671096(MEP1A)
VKO : 123030856 123030857(MEP1A)
STOW : 125438315 125438323
XLA : 100037179(mep1a.L) 447263
DRE : 553530(mep1a.1) 565535(mep1a.2)
SANH : 107696095 107696105
CAUA : 113062851 113062853
CGIB : 127938072 127938608
PPRM : 120493673(mep1a.1) 120494034(mep1a.2)
MAMB : 125278247(mep1a.1) 125278249(mep1a.2)
CIDE : 127502046 127502079
AMEX : 103024428 103025272 103025777
CGOB : 115003558 115028856
ELY : 117270313(mep1a.2) 117270507(mep1a.1)
EFO : 125897369(mep1a.2) 125897374(mep1a.1)
PLEP : 121955203(mep1a.1) 121955454(mep1a.2)
SLUC : 116047013(mep1a.1) 116047020(mep1a.2)
ECRA : 117961258(mep1a.2) 117961261(mep1a.1)
GAT : 120807796(mep1a.1) 120808432(mep1a.2)
PPUG : 119194859(mep1a.2) 119194864(mep1a.1)
MSAM : 119908447(mep1a.1) 119909505(mep1a.2)
CUD : 121520978(mep1a.2) 121521687(mep1a.1)
OAU : 116315447(mep1a.1) 116325156(mep1a.2)
OML : 112157791(mep1a.2) 112158539(mep1a.1)
PRET : 103457752 103457753
PFOR : 103148799 103148801
PLAI : 106944984 106944985
PMEI : 106907790 106907796
GAF : 122825399(mep1a.1) 122825401(mep1a.2)
CTUL : 119772550(mep1a.2) 119772552
GMU : 124881634(mep1a.1) 124882132(mep1a.2)
KMR : 108245453(mep1a.1) 108245473(mep1a.2)
ALIM : 106526863 106526880
AOCE : 111567862 111567866
MCEP : 124999050(mep1a.1) 124999555(mep1a.2)
CSEM : 103398578 103398579
SSEN : 122783724(mep1a.1) 122784416(mep1a.2)
HHIP : 117758021(mep1a.2) 117758022(mep1a.1)
LCF : 108895818 108895821(mep1a.2)
SLAL : 111661366 111661541
XGL : 120788600(mep1a.2) 120789033(mep1a.1)
BPEC : 110154737 110154746
MALB : 109969813 109969814
SASA : 106571460 106571463 106571464
STRU : 115174713 115174714 115174715
OTW : 112250368(mep1a.2) 112250371 112250372
OMY : 110529669(mep1a.2) 110529672 110529673
OGO : 123990813(mep1a.2) 123990815 123990816
ONE : 115107815 115107817 115107818
SALP : 112068748 112068749 112068756
SNH : 120023976 120023977(mep1a.2) 120024576(mep1a.1)
CCLU : 121552375(mep1a.2) 121552377 121552378
ELS : 105017592 105017593 105017596 106024753
SFM : 108920369 108920377 108921075
AANG : 118229714(mep1a.1) 118230345(mep1a.2)
LOC : 102697599(mep1a) 102697789
PSPA : 121315365 121317737(mep1a.2)
ARUT : 117403264(mep1a.1) 117410973(mep1a.2)
PSEX : 120526661 120526662 120526663
SCLV : 120326559 120334903 120338139 120338485
PCHN : 125028033 125040260
PTEP : 107438087 122268366
DPOL : 127868502 127868503
LAK : 106181764 106181780 106181782
» show all
Taxonomy
Reference
Authors
Beynon RJ, Shannon JD, Bond JS.
Title
Purification and characterization of a metallo-endoproteinase from mouse kidney.
Journal
Reference
Authors
Butler PE, McKay MJ, Bond JS.
Title
Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney.
Journal
Reference
Authors
Stephenson SL, Kenny AJ.
Title
The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes.
Journal
Reference
Authors
Sterchi EE, Naim HY, Lentze MJ, Hauri HP, Fransen JA.
Title
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides.
Journal
Reference
Authors
Barnes K, Ingram J, Kenny AJ.
Title
Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.18