KEGG ENZYME: 3.4.24.19

ENZYME: 3.4.24.19

Entry

EC 3.4.24.19                Enzyme

Name

procollagen C-endopeptidase;
procollagen C-terminal proteinase;
carboxyprocollagen peptidase;
procollagen C-terminal peptidase;
procollagen C-proteinase;
procollagen carboxypeptidase;
procollagen carboxy-terminal proteinase;
procollagen peptidase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Cleavage of the C-terminal propeptide at Ala!Asp in type I and II procollagens and at Arg!Asp in type III

Comment

A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family)

History

EC 3.4.24.19 created 1992

Orthology

K05502

bone morphogenetic protein 1

Genes

HSA:

649(BMP1)

PTR:	464042(BMP1)

PPS:	100979179(BMP1)

GGO:	101145590(BMP1)

PON:	100453093(BMP1)

PPYG:

129042614(BMP1)

NLE:	100596014(BMP1)

HMH:	116462103(BMP1)

SSYN:

129491377(BMP1)

MCC:	707596(BMP1)

MCF:	135964483(BMP1)

MTHB:

126961255

MNI:	105482085(BMP1)

CSAB:

103215447(BMP1)

CATY:

105579280(BMP1)

PANU:

101024113(BMP1)

TGE:	112630026(BMP1)

MLEU:

105531047(BMP1)

RRO:	104663959(BMP1)

RBB:	108521321(BMP1)

TFN:	117093121(BMP1)

PTEH:

111545679(BMP1)

CJC:	118146757(BMP1)

SBQ:	101042414(BMP1)

CIMI:

108318550(BMP1)

ANAN:

105705308(BMP1)

CSYR:

103265922(BMP1)

MMUR:

105857139(BMP1)

LCAT:

123626474(BMP1)

ERUF:

138393608(BMP1)

PCOQ:

105825281(BMP1)

OGA:	100943028(BMP1)

MMU:	12153(Bmp1)

MCAL:

110308919(Bmp1)

MPAH:

110325211(Bmp1)

RNO:	83470(Bmp1)

MCOC:

116084242(Bmp1)

ANU:	117704933(Bmp1)

ASYL:

127691331(Bmp1)

MUN:	110551677(Bmp1)

CGE:	100751120(Bmp1)

MAUA:

101840264(Bmp1)

PROB:

127230201(Bmp1)

PLEU:

114698807(Bmp1)

PMAV:

102921790(Bmp1)

MORG:

121460618(Bmp1)

AAMP:

119800314(Bmp1)

CNL:	130884854(Bmp1)

NGI:	103748138(Bmp1)

HGL:	101713810(Bmp1)

CPOC:

100729039(Bmp1)

CCAN:

109690450(Bmp1)

DORD:

105999409(Bmp1)

DSP:	122096636(Bmp1)

DMER:

138823344(Bmp1)

PLOP:

125339331(Bmp1)

NCAR:

124982304

MMMA:

107153833(Bmp1)

ITI:	101959062(Bmp1)

OCU:

100356758

OPI:	101523216(BMP1)

OCZ:	121150400(BMP1)

TUP:	102480045(BMP1)

GVR:	103593966 103610307

CFA:	100856514(BMP1)

CLUD:

112669764(BMP1)

VVP:	112926748(BMP1)

VLG:	121497269(BMP1)

NPO:	129523315(BMP1)

AML:	100477539(BMP1)

UMR:	103673342(BMP1)

UAH:	113270006(BMP1)

UAR:	123777385(BMP1)

ELK:

111156717

LLV:

125092852

MPUF:

101690300(BMP1)

MNP:	131998975(BMP1)

MLK:	131834202(BMP1)

NVS:	122889786(BMP1)

ORO:	101382533(BMP1)

EJU:	114217518(BMP1)

ZCA:	113924525(BMP1)

MLX:	118022074(BMP1)

MANO:

123848015(BMP1)

NSU:	110588445(BMP1)

FCA:	101093350(BMP1)

PYU:	121039873(BMP1)

PCOO:

112869835(BMP1)

PBG:	122472468(BMP1)

PVIV:

125163833(BMP1)

LRUF:

124521210

LGF:	123587662(BMP1)

AJU:

106981094

PTG:	102972893(BMP1)

PPAD:

109277354(BMP1)

PUC:

125923323

PLEZ:

122217537(BMP1)

HHV:	120239461(BMP1)

CCRU:

144233639(BMP1)

BTA:	510360(BMP1)

BOM:	102266088(BMP1)

BIU:	109562539 109562540

BJV:	133253318(BMP1)

BBUB:

102396219(BMP1)

BKE:	129650333(BMP1)

BBIS:

104992571(BMP1)

CHX:	102179476(BMP1)

OAS:	101122334(BMP1)

OCAN:

138432606(BMP1)

BTAX:

128052219(BMP1)

CSUM:

138081488(BMP1)

ODA:	120865419(BMP1)

CCAD:

122431644(BMP1)

MREE:

136176664(BMP1)

OVR:	110141185(BMP1)

MBEZ:

129556880(BMP1)

SSC:	100156461(BMP1)

CFR:	102521071(BMP1)

CBAI:

105068985(BMP1)

CDK:	105103080(BMP1)

VPC:	102540876(BMP1)

BACU:

103005385(BMP1)

BMUS:

118896848(BMP1)

LVE:	103091450(BMP1)

OOR:	101269303(BMP1)

LALB:

132523843(BMP1)

GMF:	115840109(BMP1)

DDP:	132427540(BMP1)

DLE:	111169000(BMP1)

PCAD:

102978081(BMP1)

PSIU:

116755449(BMP1)

PPHC:

136124102(BMP1)

NASI:

112401445(BMP1)

ECB:	100056914(BMP1)

EPZ:	103566261(BMP1)

EAI:	106847695(BMP1)

MYB:	102239069(BMP1)

MYD:	102754055(BMP1)

MMYO:

118658390(BMP1)

MLF:	102427373(BMP1)

MDT:	132234733(BMP1)

MYUM:

139011191(BMP1)

PKL:	118725839(BMP1)

EFUS:

103295142(BMP1)

MNA:	107536087(BMP1)

DRO:	112305145(BMP1)

SHON:

118975002(BMP1)

AJM:	119054656(BMP1)

PDIC:

114502433(BMP1)

PHAS:

123828254(BMP1)

MMF:	118615271(BMP1)

PPAM:

129075007(BMP1)

HAI:	109382422(BMP1)

RFQ:	117038285(BMP1)

PALE:

102887209(BMP1)

PGIG:

120606621(BMP1)

PVP:	105296659(BMP1)

RAY:	107509198(BMP1)

MJV:	108393179(BMP1)

TOD:	119234842(BMP1)

SARA:

101558249(BMP1)

SFUM:

130028243(BMP1)

SETR:

126003286(BMP1)

LAV:	100673680(BMP1)

TMU:

101359122

ETF:	101638386(BMP1)

DNM:	101418313(BMP1)

MDO:	100033098(BMP1)

GAS:	123236955(BMP1)

SHR:	100932831(BMP1)

AFZ:

127548320

PCW:	110200409(BMP1)

TVP:	118843711(BMP1)

PBRV:

138152045(BMP1)

MLAO:

141504240(BMP1)

OAA:	100087374(BMP1)

TACU:

119928261(BMP1)

APLA:

101795070(BMP1)

AACU:

137845365(BMP1)

ACYG:

106049199(BMP1)

CATA:

118256038(BMP1)

AFUL:

116499461(BMP1)

TGU:	115498187(BMP1)

LSR:	110479426(BMP1)

VMC:	128820134(BMP1)

VCHA:

128800919(BMP1)

AIB:	137463332(BMP1)

SCAN:

103824949(BMP1)

PMOA:

120497192(BMP1)

OTC:	121346808(BMP1)

PRUF:

121366000(BMP1)

ATRC:

139603835(BMP1)

MATE:

118695254 118695343(BMP1)

MAEN:

136567538(BMP1)

GFR:	102040585(BMP1)

FAB:	101807676(BMP1)

OMA:	130262016(BMP1)

PHI:	102099474(BMP1)

PMAJ:

107213953(BMP1)

CCAE:

111938758(BMP1)

CCW:	120411161(BMP1)

CBRC:

103615057(BMP1)

ACOE:

138121747(BMP1)

ETL:	114070072(BMP1)

ZLE:	135457039(BMP1)

SVG:	106863470(BMP1)

MMEA:

130584542(BMP1)

HRT:	120764003(BMP1)

SATI:

136372610(BMP1)

CFAI:

136302842 136304271

CCIC:

134054659(BMP1)

FPG:	101918385(BMP1)

FCH:	102051643(BMP1)

FRS:	119140393(BMP1)

SHAB:

115618554(BMP1)

ANOC:

141971252(BMP1)

SURA:

141935667(BMP1)

TALA:

116962217(BMP1)

ACHC:

115350281(BMP1)

HLE:	104828986(BMP1)

AGEN:

126051411

HHAR:

128150254(BMP1)

BBUT:

142038261(BMP1)

CSTI:

104556827

PPUS:

135192470(BMP1)

EGZ:	104127935(BMP1)

NNI:	104016031(BMP1)

PARX:

142048153(BMP1)

AFOR:

103904678(BMP1)

CBOR:

142093437(BMP1)

CBOY:

140643955(BMP1)

MAME:

142420018(BMP1)

CLV:	102094799(BMP1)

CNIC:

135998430(BMP1)

CUCA:

104068546(BMP1)

PCUR:

138731568(BMP1)

GAME:

129196744(BMP1)

RTD:	128900084(BMP1)

CRID:

134526547(BMP1)

LMIC:

141733363(BMP1)

NARQ:

141475820(BMP1)

AAM:	106499973(BMP1)

AROW:

112973614(BMP1)

NPD:	112949870(BMP1)

DNE:	112996692(BMP1)

ASN:	102376631(BMP1)

AMJ:	102574594(BMP1)

PSS:	102460646(BMP1)

CIZ:	142004209(BMP1)

CMY:	102937822(BMP1)

CCAY:

125626460(BMP1)

LKP:	140903702(BMP1)

NDS:	141978331(BMP1)

DCC:	119848786(BMP1)

CPIC:

101938610(BMP1)

TST:	117872976(BMP1)

EOB:	135873392(BMP1)

CABI:

116836917(BMP1)

MRV:	120397967(BMP1)

ACS:	100568138(bmp1)

ASAO:

132782495

PVT:	110072169(BMP1)

SUND:

121933497(BMP1)

PBI:	103064624(BMP1)

PMUR:

107289251(BMP1)

CTIG:

120312917(BMP1)

TSR:

106549316

PCAE:

139323024(BMP1)

APRI:

131203782(BMP1)

PTEX:

113445633 113445685

NSS:	113420965(BMP1)

VKO:	123027064(BMP1)

PMUA:

114585596(BMP1)

PRAF:

128403102(BMP1)

ZVI:	118096805(BMP1)

HCG:	128333705(BMP1)

GJA:	107113015(BMP1)

STOW:

125441651(BMP1)

EMC:	129342150(BMP1)

XLA:	397872(bmp1.L) 399093(bmp1.S)

XTR:	733960(bmp1)

NPR:	108798464(BMP1)

RTEM:

120933137(BMP1)

ACAT:

141133120(BMP1)

PADS:

140323081(BMP1)

BBUF:

120986284(BMP1)

BGAR:

122927308(BMP1)

DTC:	141100445(BMP1)

PCOB:

134936651(BMP1)

PWL:	138265859(BMP1)

MUO:	115469401(BMP1)

GSH:	117362595(BMP1)

DRE:	559877(bmp1b) 572452(bmp1a)

SRX:	107710833 107728365 107746216 107758677

SANH:

107658580 107661342 107678424 107688986

SGH:	107553124 107558131 107562633 107583398

CCAR:

109091465(bmp1b) 109104348 109109073 109110675

CAUA:

113039693 113054539 113054592 113107433 113110278

CGIB:

127962864 127966608 128018254 128020934

PTET:

122350078(bmp1a) 122353046(bmp1b)

LROH:

127169954(bmp1a) 127172368(bmp1b)

GRF:	141286633(bmp1a) 141299077(bmp1b)

OMC:	131545377(bmp1a) 131548782(bmp1b)

PPRM:

120472226(bmp1b) 120489014(bmp1a)

RKG:	130078416(bmp1b) 130082081(bmp1a)

MAMB:

125262307(bmp1b) 125280362(bmp1a)

CIDE:

127517082 127520718

CERY:

137027336(bmp1a) 137028597(bmp1b)

MASI:

127415112 127423956 127432219

TROS:

130546304(bmp1b) 130567763(bmp1a)

TDW:	130406983(bmp1a) 130411540(bmp1b)

MANU:

129413643(bmp1a) 129446601(bmp1b)

PDAB:

135729821(bmp1a) 135743684(bmp1b)

IPU:	108265517(bmp1a) 108276587(bmp1b)

IFU:	128607430(bmp1a) 128620577(bmp1b)

PHYP:

113533637(bmp1) 113544093

SMEO:

124393991 124399606(bmp1a)

TFD:	113639248 113645712(bmp1a)

TVC:	132853605(bmp1a) 132863522

CGAR:

128529833(bmp1a) 128545762(bmp1b)

NGRA:

132873234(bmp1b) 132892857(bmp1a)

TRN:	134318413(bmp1a)

AMEX:

103024888(bmp1a) 103045069(bmp1b)

CMAO:

118813274(bmp1a) 118824943(bmp1b)

EEE:

113578135

CHAR:

105902772(bmp1a) 105907038

SPIL:

134088575(bmp1a) 134101159

ASAD:

121679806 121714751(bmp1a)

TRU:	101068949(bmp1) 101072844

TFS:	130517431 130525420(bmp1a)

TNG:	GSTEN00017307G001 GSTEN00020449G001

LCO:	104923815 104931147

NCC:	104948155 104964464

TBEN:

117476299 117496873(bmp1a)

CGOB:

115013854 115016494

PGEO:

117451922(bmp1a) 117455874

GACU:

117558123 117561017(bmp1a)

EMAC:

134868912 134873860(bmp1a)

ELY:	117252445(bmp1a) 117269816

EFO:	125890614(bmp1a) 125906171

PLEP:

121945014(bmp1a) 121959616

SLUC:

116035078 116053872(bmp1a)

SVIT:

144518722(bmp1a) 144531504

ECRA:

117944235(bmp1a) 117959405

ESP:	116690182(bmp1)

PFLV:

114555701 114571340

PFLT:

120545361 120561227(bmp1a)

GAT:	120830810(bmp1a) 120832220

PPUG:

119224547(bmp1a) 119226498

AFB:	129100753(bmp1a) 129102150

CLUM:

117735826(bmp1a) 117740183

PSWI:

130196425(bmp1a) 130205349 130205684

CANA:

137783483 137804969(bmp1a)

CVE:	137866727(bmp1a) 137868973

AMIR:

142947465 142964480(bmp1a)

MSAM:

119891092(bmp1a) 119914448

SCHU:

122865346 122876957(bmp1a)

EARM:

139283655(bmp1a) 139300959

CUD:	121509636(bmp1a) 121525241

SPUL:

138601909 138610189(bmp1a)

LMIX:

132974062(bmp1a) 132992440

HTC:	141789943(bmp1a) 141805298

ALAT:

119018975(bmp1a) 119029853

ASTR:

137592389(bmp1a) 137608074

PKLU:

139203800(bmp1a) 139219179

MZE:	101474919(bmp1a) 101478248

ONL:	100695027 100704448

OAU:	116310222(bmp1a) 116322545

OLA:	100125511 100125512

OML:	112148425(bmp1a) 112163076

CSAI:

133450350(bmp1a) 133454666

XMA:	102230322 102234545

XCO:	114149315 114155249

XHE:	116724780 116729501(bmp1)

PRET:

103470513 103473707

PFOR:

103145852 103148700

PLAI:

106938060(bmp1) 106962456

PMEI:

106914985(bmp1) 106925500

GAF:	122819389 122827965(bmp1a)

PPRL:

129366463 129372196(bmp1a)

CVG:	107092678 107093872(bmp1)

CTUL:

119783946(bmp1a) 119789025

GMU:	124873014 124877173(bmp1a)

NFU:	107373116 107393753(bmp1)

KMR:	108232606 108236587(bmp1a)

ALIM:

106514493 106534203

NWH:	119413999(bmp1a) 119424806

AOCE:

111567679 111579811(bmp1a)

EJA:	138191895(bmp1a) 138207355

BFRE:

138621635(bmp1a) 138623088

MCEP:

124997122 125011806(bmp1a)

CSEM:

103390498 103397185 103398239

POV:	109625957 109633812

SSEN:

122769038(bmp1a) 122781938

SSOE:

131445836 131464123(bmp1a)

HHIP:

117768039(bmp1a) 117771850

HSP:	118115130(bmp1a) 118125450

PPLT:

128424954 128438896(bmp1a)

SMAU:

118284608 118314230(bmp1a)

LCF:	108878376(bmp1a) 108879830

SDU:	111227713 111234202

SLAL:

111645016 111655191

XGL:	120805554(bmp1a) 120806693

HCQ:	109523580 109525229

SSCV:

125980039 125993568(bmp1a)

SBIA:

133490833 133498843(bmp1a)

PEE:	133400023(bmp1a) 133413618

PTAO:

133475040(bmp1a) 133490064

BPEC:

110160651 110169815

ENY:	140347003(bmp1a) 140368403

MALB:

109956973 109963495

BSPL:

114863150(bmp1a) 114866769

SJO:	128364218(bmp1a) 128380562

SSCO:

133979745(bmp1a) 133994824

TTY:	137170740 137194711(bmp1a)

GMH:	115541278 115545008(bmp1)

SASA:

100380312(bmp1) 106579847 106585594

STRU:

115149159 115164536 115200112

OTW:	112248466 112257596 112262929(bmp1a)

OMY:	110525648 110536019(bmp1a) 110537216

OGO:	123999447 124034333 124036289

ONE:	115105800 115111587 115140028

OKI:	109879433 109892542 109895878

OKE:	118358326 118375825 118393191

OMM:	135514116 135541451 135548358

OCLA:

139389587 139410896 139422906

SALP:

111957729 111973946 111981226

SNH:	120017819 120045043 120063226

SFON:

129815129 129826292 129853553

CCLU:

121530881 121573785 121584832

ELS:	105014263(bmp1) 105014870

OEP:	134011869(bmp1a) 134038458

SFM:	108923610 108929473

PKI:	111838614(bmp1) 111857333

AANG:

118213089 118237278(bmp1a)

AROT:

135239071 135261245(bmp1a)

CCOG:

133140782(bmp1a) 133142484

LOC:	102688693(bmp1)

PSPA:

121302323 121303148

ARUT:

117397969 117966448

PSEX:

120539492(bmp1a)

LCM:	102357697(BMP1)

CMK:

103190854

RTP:

109911454

CPLA:

122543176

CPUN:

140459761

HOC:

132837035

SCAU:

119957338

LERI:

129713367

HAKA:

140735902

BFO:	118405444 118414260

BBEL:

109471399 109471402 109483296 109485679

SPU:	115923379 373360(BMP1)

AJJ:

139974915

ARUN:

117298250

MDL:

103573542

CSCU:

111613782 111613783 111613784

BGT:	106054907 106060224

HRF:

124117380

LLON:

135491030

NVE:

5522383

EPA:

110254476

ADF:

107347397

PDAM:

113665761 113670912 113678110 113680396

SPIS:

111322335 111329169 111338165 111341484

DGT:

114521449

XEN:

124446666

HSY:

130653824

RES:

135686546

» show all

Reference

1 [PMID:3905801]

Authors

Hojima Y, van der Rest M, Prockop DJ.

Title

Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization.

Journal

J Biol Chem 260:15996-6003 (1985)

Reference

2 [PMID:2689170]

Authors

Kessler E, Adar R.

Title

Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein.

Journal

Eur J Biochem 186:115-21 (1989)
DOI:10.1111/j.1432-1033.1989.tb15184.x

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.19

IUBMB Enzyme Nomenclature:

3.4.24.19

ExPASy - ENZYME nomenclature database:

3.4.24.19

BRENDA, the Enzyme Database:

3.4.24.19

CAS:	68651-95-6

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Gene (1284)   
   MGENES (349)   
   RefGene (935)   
Protein sequence (34)   
   UniProt (12)   
   SWISS-PROT (2)   
   RefSeq(pep) (5)   
   PDBSTR (13)   
   PMD (2)   
DNA sequence (22)   
   RefSeq(nuc) (10)   
   GenBank (12)   
3D Structure (8)   
   PDB (8)   
All databases (1348)   

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