| Entry |
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| Name |
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
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| Comment |
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
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| History |
EC 3.4.24.21 created 1972 as EC 3.4.99.6, transferred 1992 to EC 3.4.24.21
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| Orthology |
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| Genes |
| PJA: | 122261534 122261535 122261538 122261539 |
| PCHN: | 125026426 125026444 125026591 125026592 |
| PMOO: | 119580291 119580292 119580293 119580294 |
| PCLA: | 123766492 123766493 |
| PTRU: | 123514655 123514656 123514938 |
| ESN: | 126982705 126982706 126994958 |
| CEL: | CELE_C26C6.3(nas-36) CELE_C37H5.9(nas-9) CELE_F40E10.1(hch-1) CELE_F46C5.3(nas-25) CELE_F58A6.4(nas-29) CELE_K04E7.3(nas-33) CELE_T02B11.7(nas-32) CELE_T11F9.3(nas-20) CELE_T23F4.4(nas-27) |
| CBR: | CBG_02333(Cbr-nas-29) CBG_03189(Cbr-nas-25) CBG_05067(Cbr-nas-33) CBG_07102(Cbr-nas-27) CBG_07573(Cbr-hch-1) CBG_08825(Cbr-nas-9) CBG_11886(Cbr-nas-36) CBG_17894(Cbr-nas-32) CBG_21082 CBG_23213 |
| CRQ: | GCK72_000079 GCK72_005609 GCK72_005960 GCK72_008059 GCK72_015340 GCK72_015939 GCK72_016739 GCK72_016740 GCK72_016757 GCK72_019128 GCK72_019334 GCK72_024590 |
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| Reference |
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| Authors |
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H. |
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| Title |
A protease from Astacus fluviatilis as an aid in protein sequencing. |
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| Journal |
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| Reference |
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| Authors |
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R. |
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| Title |
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis. |
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| Journal |
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| Sequence |
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| Reference |
3 |
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| Authors |
Stocker W, Wolz RL, Zwilling R, Strydom DJ, Auld DS. |
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| Title |
Astacus protease, a zinc metalloenzyme. |
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| Journal |
Biochemistry 27:5026-5032 (1988) |
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| Reference |
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| Authors |
Stocker W, Ng M, Auld DS |
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| Title |
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.21 |
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