KEGG   ENZYME: 3.4.24.21
Entry
EC 3.4.24.21                Enzyme                                 
Name
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
Comment
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
History
EC 3.4.24.21 created 1972 as EC 3.4.99.6, transferred 1992 to EC 3.4.24.21
Orthology
K08076  astacin
Genes
PVM113819445 113826330
PJA122261534 122261535 122261538 122261539
PCHN125026426 125026444 125026591 125026592
PMOO119580291 119580292 119580293 119580294
PCLA123766492 123766493
CQD128699645 138854347
PTRU123514655 123514656 123514938
ESN126982705 126982706 126994958
MRJ136834610
CELCELE_C26C6.3(nas-36) CELE_C37H5.9(nas-9) CELE_F40E10.1(hch-1) CELE_F46C5.3(nas-25) CELE_F58A6.4(nas-29) CELE_K04E7.3(nas-33) CELE_T02B11.7(nas-32) CELE_T11F9.3(nas-20) CELE_T23F4.4(nas-27)
CBRCBG_02333(Cbr-nas-29) CBG_03189(Cbr-nas-25) CBG_05067(Cbr-nas-33) CBG_07102(Cbr-nas-27) CBG_07573(Cbr-hch-1) CBG_08825(Cbr-nas-9) CBG_11886(Cbr-nas-36) CBG_17894(Cbr-nas-32) CBG_21082 CBG_23213
CRQGCK72_000079 GCK72_005609 GCK72_005960 GCK72_008059 GCK72_015340 GCK72_015939 GCK72_016739 GCK72_016740 GCK72_016757 GCK72_019128 GCK72_019334 GCK72_024590
LJP135463344
EPA110244690
AMIL114957426
SPIS111326758
 » show all
Reference
1  [PMID:7041692]
  Authors
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H.
  Title
A protease from Astacus fluviatilis as an aid in protein sequencing.
  Journal
Anal Biochem 119:153-7 (1982)
DOI:10.1016/0003-2697(82)90679-0
Reference
2  [PMID:3548817]
  Authors
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R.
  Title
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis.
  Journal
Biochemistry 26:222-6 (1987)
DOI:10.1021/bi00375a029
  Sequence
Reference
3
  Authors
Stocker W, Wolz RL, Zwilling R, Strydom DJ, Auld DS.
  Title
Astacus protease, a zinc metalloenzyme.
  Journal
Biochemistry 27:5026-5032 (1988)
Reference
4  [PMID:2261483]
  Authors
Stocker W, Ng M, Auld DS
  Title
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease.
  Journal
Biochemistry 29:10418-25 (1990)
DOI:10.1021/bi00497a018
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.21
IUBMB Enzyme Nomenclature: 3.4.24.21
ExPASy - ENZYME nomenclature database: 3.4.24.21
BRENDA, the Enzyme Database: 3.4.24.21
CAS: 143179-21-9

DBGET integrated database retrieval system