KEGG   ENZYME: 3.4.24.21
Entry
EC 3.4.24.21                Enzyme                                 
Name
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
Comment
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
History
EC 3.4.24.21 created 1972 as EC 3.4.99.6, transferred 1992 to EC 3.4.24.21
Orthology
K08076  astacin
Genes
MSAM119890445
BBEL109464394 109475423 109476583
ASTE118507312
CNS116351062
BCOO119066715 119075049 119083350 119084898
HHAL106682334
PJA122243963 122244751 122255359 122265394
PCHN125024937 125027847 125028102 125042080
HAME121858615 121870999 121875047
PCLA123767545
PTRU123498442 123503115 123504388
HAZT108669614 108674308 108678383 108683173
PPOI119090632 119091776 119093077 119093334 119093606 119096273 119096849 119097442 119097443 119097497 119104572 119104728 119105516 119106457 119107750 119107959
DSV119460739 119461498
RMP119174309 119174310 119174650 119188285
VDE111250350 111253240
VJA111267846 111269178
DFR124497161
SDM118181404 118185926 118188789 118189731 118192937 118192940 118192941 118192942 118192953 118192954 118196588 118199930 118202013
CELCELE_4R79.1(nas-6) CELE_C07D10.4(nas-7) CELE_C24F3.3(nas-12) CELE_C26C6.3(nas-36) CELE_C34D4.9(nas-8) CELE_C37H5.9(nas-9) CELE_F09E8.6(nas-14) CELE_F38E9.2(nas-39) CELE_F40E10.1(hch-1) CELE_F42A10.8(nas-28) CELE_F45G2.1(nas-1) CELE_F46C5.3(nas-25) CELE_F57C12.1(nas-38) CELE_F58A6.4(nas-29) CELE_K03B8.1(nas-16) CELE_K03B8.2(nas-17) CELE_K03B8.3(nas-18) CELE_K04E7.3(nas-33) CELE_K06A4.1(nas-3) CELE_K09C8.3(nas-10) CELE_T02B11.7(nas-32) CELE_T04G9.2(nas-15) CELE_T11F9.3(nas-20) CELE_T23F4.4(nas-27) CELE_T23H4.3(nas-5)
CBRCBG_02333(Cbr-nas-29) CBG_03189(Cbr-nas-25) CBG_03849(Cbr-nas-5) CBG_07102(Cbr-nas-27) CBG_07573(Cbr-hch-1) CBG_08147(Cbr-nas-38) CBG_08825(Cbr-nas-9) CBG_11886(Cbr-nas-36) CBG_16363(Cbr-nas-39) CBG_17542(Cbr-nas-10) CBG_17894(Cbr-nas-32) CBG_21082 CBG_23190(Cbr-nas-17) CBG_23213
TSPTsp_00923
GAE121383576 121388382
HRF124117278 124117875 124131685 124132447 124147166 124150973
HRJ124261421 124266475 124276793 124286242
CRG105317300 105320388 105322333 105323497 105324354 105336862 105341269 105342493 105342882 105343588 105348286
PMAX117316612 117333751 117336921 117339095 117344273
OSN115232428
NVE5512699
EPA110244690
ATEN116286289 116287698 116301306 116303373 116308601 116308602 116308605
AMIL114957426
SPIS111326758
DGT114525285
 » show all
Reference
1  [PMID:7041692]
  Authors
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H.
  Title
A protease from Astacus fluviatilis as an aid in protein sequencing.
  Journal
Anal Biochem 119:153-7 (1982)
DOI:10.1016/0003-2697(82)90679-0
Reference
2  [PMID:3548817]
  Authors
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R.
  Title
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis.
  Journal
Biochemistry 26:222-6 (1987)
DOI:10.1021/bi00375a029
  Sequence
Reference
3
  Authors
Stocker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S.
  Title
Astacus protease, a zinc metalloenzyme.
  Journal
Biochemistry 27:5026-5032 (1988)
Reference
4  [PMID:2261483]
  Authors
Stocker W, Ng M, Auld DS
  Title
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease.
  Journal
Biochemistry 29:10418-25 (1990)
DOI:10.1021/bi00497a018
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.21
IUBMB Enzyme Nomenclature: 3.4.24.21
ExPASy - ENZYME nomenclature database: 3.4.24.21
BRENDA, the Enzyme Database: 3.4.24.21
CAS: 143179-21-9

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