Entry |
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Name |
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
|
Reaction(IUBMB) |
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
|
Comment |
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
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History |
EC 3.4.24.21 created 1972 as EC 3.4.99.6, transferred 1992 to EC 3.4.24.21
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Orthology |
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Genes |
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Reference |
|
Authors |
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H. |
Title |
A protease from Astacus fluviatilis as an aid in protein sequencing. |
Journal |
|
Reference |
|
Authors |
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R. |
Title |
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis. |
Journal |
|
Sequence |
|
Reference |
3 |
Authors |
Stocker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S. |
Title |
Astacus protease, a zinc metalloenzyme. |
Journal |
Biochemistry 27:5026-5032 (1988) |
Reference |
|
Authors |
Stocker W, Ng M, Auld DS |
Title |
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.24.21 |
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