| Entry |
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| Name |
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
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| Comment |
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
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| History |
EC 3.4.24.21 created 1972 as EC 3.4.99.6, transferred 1992 to EC 3.4.24.21
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| Orthology |
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| Genes |
| BBEL: | 109464394 109475423 109476583 |
| BCOO: | 119066715 119075049 119083350 119084898 |
| PJA: | 122243963 122244751 122255359 122265394 |
| PCHN: | 125024937 125027847 125028102 125042080 |
| HAME: | 121858615 121870999 121875047 |
| PTRU: | 123498442 123503115 123504388 |
| HAZT: | 108669614 108674308 108678383 108683173 |
| PPOI: | 119090632 119091776 119093077 119093334 119093606 119096273 119096849 119097442 119097443 119097497 119104572 119104728 119105516 119106457 119107750 119107959 |
| RMP: | 119174309 119174310 119174650 119188285 |
| SDM: | 118181404 118185926 118188789 118189731 118192937 118192940 118192941 118192942 118192953 118192954 118196588 118199930 118202013 |
| CEL: | CELE_4R79.1(nas-6) CELE_C07D10.4(nas-7) CELE_C24F3.3(nas-12) CELE_C26C6.3(nas-36) CELE_C34D4.9(nas-8) CELE_C37H5.9(nas-9) CELE_F09E8.6(nas-14) CELE_F38E9.2(nas-39) CELE_F40E10.1(hch-1) CELE_F42A10.8(nas-28) CELE_F45G2.1(nas-1) CELE_F46C5.3(nas-25) CELE_F57C12.1(nas-38) CELE_F58A6.4(nas-29) CELE_K03B8.1(nas-16) CELE_K03B8.2(nas-17) CELE_K03B8.3(nas-18) CELE_K04E7.3(nas-33) CELE_K06A4.1(nas-3) CELE_K09C8.3(nas-10) CELE_T02B11.7(nas-32) CELE_T04G9.2(nas-15) CELE_T11F9.3(nas-20) CELE_T23F4.4(nas-27) CELE_T23H4.3(nas-5) |
| CBR: | CBG_02333(Cbr-nas-29) CBG_03189(Cbr-nas-25) CBG_03849(Cbr-nas-5) CBG_07102(Cbr-nas-27) CBG_07573(Cbr-hch-1) CBG_08147(Cbr-nas-38) CBG_08825(Cbr-nas-9) CBG_11886(Cbr-nas-36) CBG_16363(Cbr-nas-39) CBG_17542(Cbr-nas-10) CBG_17894(Cbr-nas-32) CBG_21082 CBG_23190(Cbr-nas-17) CBG_23213 |
| HRF: | 124117278 124117875 124131685 124132447 124147166 124150973 |
| HRJ: | 124261421 124266475 124276793 124286242 |
| CRG: | 105317300 105320388 105322333 105323497 105324354 105336862 105341269 105342493 105342882 105343588 105348286 |
| PMAX: | 117316612 117333751 117336921 117339095 117344273 |
| ATEN: | 116286289 116287698 116301306 116303373 116308601 116308602 116308605 |
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| Reference |
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| Authors |
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H. |
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| Title |
A protease from Astacus fluviatilis as an aid in protein sequencing. |
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| Journal |
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| Reference |
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| Authors |
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R. |
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| Title |
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis. |
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| Journal |
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| Sequence |
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| Reference |
3 |
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| Authors |
Stocker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S. |
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| Title |
Astacus protease, a zinc metalloenzyme. |
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| Journal |
Biochemistry 27:5026-5032 (1988) |
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| Reference |
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| Authors |
Stocker W, Ng M, Auld DS |
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| Title |
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.21 |
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