Entry
Name
vibriolysin;
Aeromonas proteolytica neutral proteinase;
aeromonolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of bonds with bulky hydrophobic groups in P2 and P1'. Phe at P1' is the most favoured residue, which distinguished this enzyme from thermolysin
Comment
Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin [1]. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC
3.4.24.4
History
EC 3.4.24.25 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.25, modified 1997
Orthology
Genes
LAB : LA76x_2473(nprV) LA76x_2475
LAQ : GLA29479_1171(empA) GLA29479_1174(hap)
LCP : LC55x_2887(nprV) LC55x_2889 LC55x_2891
LGU : LG3211_2739 LG3211_2741(nprV) LG3211_4445
LEZ : GLE_2741(nprV) GLE_2743(nprV)
LYA : RDV84_18675 RDV84_18680
FSG : LQ771_02990 LQ771_09765 LQ771_13930
FED : LQ772_03675 LQ772_11020 LQ772_15560
RTH : LRK53_06130 LRK53_12690
VHA : VIBHAR_02509 VIBHAR_05515
VCA : M892_00890 M892_23945
VOW : A9237_15790 A9237_19765
VAU : VANGNB10_cII0919c(empA)
VCY : IX92_04640 IX92_17695 IX92_22445
VCT : JV59_17150 JV59_21375 JV59_34105
VQI : CCZ37_14020 CCZ37_14710
VCC : FAZ90_06635 FAZ90_18460
VAQ : FIV01_09435(hap2) FIV01_17270(nprV1) FIV01_19305(nprV2)
VKA : BTD91_00265 BTD91_17540
VGI : MID13_09035 MID13_15870
VSL : LTQ54_15765 LTQ54_16510 LTQ54_21280
VPL : SA104470976_03599(hap)
VCRA : IS519_00895 IS519_16885
VNP : KW548_13075 KW548_18330 KW548_21875
VLE : ISX51_08050 ISX51_19380 ISX51_22605
GKD : K6Q96_22635 K6Q96_23505
SALY : E8E00_07740 E8E00_14545
SKS : FCN78_05640 FCN78_13840
SCOT : HBA18_05895 HBA18_14490
SPRO : N7E60_06120 N7E60_16375
SPSW : Sps_01606 Sps_02676 Sps_03413 Sps_03524
SHEW : CKQ84_10610 CKQ84_19125
SKH : STH12_00210(hap_1) STH12_00763(lasB) STH12_04148(hap_2)
SLIT : JQC75_02050 JQC75_05895
SCYP : JYB88_01960 JYB88_06140
SSEM : JYB85_02135 JYB85_06435
SZH : K0H63_02290 K0H63_06520
THAT : H3N35_00170 H3N35_00175
TACT : SG35_000160 SG35_000165 SG35_029565
TVD : SG34_029320 SG34_029325 SG34_032645
PPHE : PP2015_3255 PP2015_3842
PBW : D172_014080 D172_014110 D172_019810
PRR : AT705_01970 AT705_21455 AT705_23865 AT705_23895 AT705_24095
PLZ : S4054249_19905 S4054249_21035 S4054249_21745
PPIS : B1L02_19675 B1L02_23455 B1L02_23510
PTU : PTUN_a1933 PTUN_b0532
PSEN : PNC201_18505(empA) PNC201_22380(hap)
PXI : J5O05_00755 J5O05_21200
PVB : J5X90_00010 J5X90_18620 J5X90_20530 J5X90_22665 J5X90_22945 J5X90_22950
PSAZ : PA25_02030 PA25_34250
PFLI : CTT31_18695 CTT31_20005
MVS : MVIS_1898(empA) MVIS_2920(empA)
MYA : MORIYA_1508(nprV) MORIYA_2361(nprV)
MOQ : HWV03_05935 HWV03_07230
MII : BTJ40_13250 BTJ40_13270
LSH : CAB17_00130 CAB17_04525
LCJ : NCTC11976_00699(hap)
LWA : SAMEA4504053_0021(hap) SAMEA4504053_0892(nprV)
LSS : NCTC12082_01281(hap)
HAHE : ENC22_11265 ENC22_12285
GSN : YC6258_00785 YC6258_04970
RFO : REIFOR_01115 REIFOR_01121 REIFOR_02033
PLEI : Q9312_13695 Q9312_17865
AEL : NCTC12917_00828(nprV)
GKN : PVT67_03015 PVT67_09445
CARI : FNU76_01840 FNU76_12870
MSD : MYSTI_02756 MYSTI_03758 MYSTI_06723
MFB : MFUL124B02_15035 MFUL124B02_35290 MFUL124B02_41125
CCX : COCOR_00680(fibA1) COCOR_05260(empA) COCOR_05722(nprV) COCOR_06634(fibA)
AGE : AA314_01740 AA314_04229 AA314_05554 AA314_07697
AVM : JQX13_06230 JQX13_18330 JQX13_21325 JQX13_29500 JQX13_29505 JQX13_35000
MBD : MEBOL_000619 MEBOL_004242 MEBOL_006291
CFUS : CYFUS_001067 CYFUS_005706 CYFUS_006155 CYFUS_006373 CYFUS_007200 CYFUS_007262 CYFUS_007593 CYFUS_007667 CYFUS_009809
SCOR : J3U87_04665 J3U87_18630 J3U87_25030 J3U87_34815
» show all
Taxonomy
Reference
Authors
Holmquist B, Vallee BL.
Title
Esterase activity of zinc neutral proteases.
Journal
Reference
Authors
Wilkes SH, Prescott JM.
Title
Aeromonas neutral protease.
Journal
Reference
Authors
Bayliss ME, Wilkes SH, Prescott JM.
Title
Aeromonas neutral protease: specificity toward extended substrates.
Journal
Reference
Authors
Wilkes SH, Bayliss ME, Prescott JM.
Title
Critical ionizing groups in Aeromonas neutral protease.
Journal
J Biol Chem 263:1821-5 (1988)
Reference
Authors
David VA, Deutch AH, Sloma A, Pawlyk D, Ally A, Durham DR
Title
Cloning, sequencing and expression of the gene encoding the extracellular neutral protease, vibriolysin, of Vibrio proteolyticus.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.25