Entry |
|
Name |
pseudolysin;
Pseudomonas elastase;
Pseudomonas aeruginosa neutral metalloproteinase
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Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
|
Reaction(IUBMB) |
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects
|
Comment |
In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage.
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History |
EC 3.4.24.26 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.26
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Orthology |
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Genes |
» show all
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Reference |
1 |
Authors |
Morihara, K. and Tsuzuki, H. |
Title |
Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase. |
Journal |
Agric Biol Chem 39:1123-1128 (1975) |
Reference |
|
Authors |
Nishino N, Powers JC. |
Title |
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand. |
Journal |
J Biol Chem 255:3482-6 (1980) |
Reference |
|
Authors |
Dreyfus LA, Iglewski BH. |
Title |
Purification and characterization of an extracellular protease of Legionella pneumophila. |
Journal |
|
Reference |
|
Authors |
Bever RA, Iglewski BH |
Title |
Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene. |
Journal |
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Sequence |
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Reference |
|
Authors |
Black WJ, Quinn FD, Tompkins LS. |
Title |
Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.24.26 |
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