Entry
Name
bacillolysin;
Bacillus metalloendopeptidase;
Bacillus subtilis neutral proteinase;
anilozyme P 10;
Bacillus metalloproteinase;
Bacillus neutral proteinase;
megateriopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar, but not identical, to that of thermolysin
Comment
Variants of this enzyme have been found in species of Bacillus including B. subtilis [1,6], B. amyloliquefaciens [5], B. megaterium (megateriopeptidase, [2]), B. mesentericus [10], B. cereus [3,8,9] and B. stearothermophilus [7]. In peptidase family M4 (thermolysin family). Formerly included in EC
3.4.24.4
History
EC 3.4.24.28 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.28
Orthology
Genes
MSD : MYSTI_00607 MYSTI_01772 MYSTI_03187
MFB : MFUL124B02_03455 MFUL124B02_09985 MFUL124B02_17365 MFUL124B02_41865
CCX : COCOR_00799(npr) COCOR_01296(nprM) COCOR_05687(nprS) COCOR_06712(nprM1)
MFU : LILAB_21525 LILAB_34165
SUR : STAUR_1693 STAUR_4897(fibA) STAUR_7158 STAUR_7459
AGE : AA314_00679 AA314_02845 AA314_04696 AA314_05742 AA314_05743 AA314_08228 AA314_09142
AVM : JQX13_06110 JQX13_20980 JQX13_22835 JQX13_37405 JQX13_47940
MBD : MEBOL_000603 MEBOL_003411 MEBOL_004624 MEBOL_007739 MEBOL_007740
CFUS : CYFUS_000044 CYFUS_000703 CYFUS_002522 CYFUS_003038 CYFUS_004891 CYFUS_005614 CYFUS_009605
PAUU : E8A73_004680 E8A73_026080 E8A73_026085 E8A73_034725 E8A73_040880
LLU : AKJ09_05311 AKJ09_06197
BAZ : BAMTA208_09795(nprE)
BAX : H9401_0571 H9401_2444
BANS : BAPAT_0578 BAPAT_2463
BANV : DJ46_1349 DJ46_5058(npr)
BCZ : BCE33L0511(npr) pE33L466_0375(npr)
BCR : BCAH187_A0727 BCAH187_C0042
BCG : BCG9842_B4700 BCG9842_B5478
BCQ : BCQ_0665(npr) BCQ_PI139
BCY : Bcer98_0515 Bcer98_1599 Bcer98_2213
BTL : BALH_0539(nprE) BALH_2915(npr)
BTC : CT43_CH0522 CT43_CH5391
BTG : BTB_c06140(npr1) BTB_c55530(nprS)
BTN : BTF1_00720 BTF1_25250
BTHT : H175_ch0525 H175_ch5482
BTHU : YBT1518_03175 YBT1518_33971
BMYC : DJ92_2128(nprB) DJ92_3204(npr) DJ92_5598(nprM)
BPAC : LMD38_23075 LMD38_27735
BPAN : NLJ82_03225 NLJ82_27195
BALU : QRY64_05350 QRY64_18545
BACA : FAY30_02370 FAY30_05135
BHAI : KJK41_01910 KJK41_10320 KJK41_12900 KJK41_19665
PKS : IE339_12435 IE339_20820
HHD : HBHAL_4199(npr2) HBHAL_4829(npr4)
HNZ : P9989_08705 P9989_19385 P9989_19920
HSHI : MUO14_10110 MUO14_21605
VIR : X953_07045 X953_16635
VIL : CFK37_04370 CFK37_17250
FPN : ABE65_001600 ABE65_005430 ABE65_019890
FAR : ABE41_001575 ABE41_018950
FEC : QNH15_06615 QNH15_13415 QNH15_24905
BSJ : UP17_08785 UP17_22480
NMK : CHR53_02870 CHR53_05275
NNV : QNH39_05250 QNH39_15655
BVQ : FHE72_02230 FHE72_20120
GAJ : MY490_06060 MY490_08035
MJO : FOF60_01945 FOF60_12185
ECTO : MUG87_10505 MUG87_15830
PHJ : LC071_06515 LC071_15730 LC071_17970
PPOL : X809_36325 X809_36330
PPQ : PPSQR21_040810(lasB)
PMS : KNP414_01081 KNP414_07799(npr)
PMQ : PM3016_1408 PM3016_7319
PTA : HPL003_01080 HPL003_01085 HPL003_01090
PLV : ERIC2_c17790(npr1) ERIC2_c23330(npr2) ERIC2_c25850(npr3)
PPEO : ABE82_20240 ABE82_20245
PBV : AR543_13480 AR543_13485
PKB : B4V02_05125 B4V02_05130 B4V02_05135
PAIH : ASL14_17665 ASL14_17675 ASL14_17680
PCHI : PC41400_03940 PC41400_09065
TUM : CBW65_00785 CBW65_05655 CBW65_05660 CBW65_05665 CBW65_05670 CBW65_05675 CBW65_05680 CBW65_19395 CBW65_21440
TAB : CIG75_01505 CIG75_01510 CIG75_08200
PRT : AUC31_02165 AUC31_11445
PMAR : B0X71_00070 B0X71_15875
PPLA : BBI15_03570 BBI15_10550
PMAT : BBI11_08725 BBI11_16155
PDEC : H1Q58_07885 H1Q58_15395
PLAY : DNR44_005865 DNR44_011600
LFB : C1X05_02975 C1X05_02980
CAC : CA_C2290(nprE) CA_C2517(nrpE)
CAE : SMB_G2324 SMB_G2552(nprE)
CBA : CLB_1466(npr-1) CLB_1467(npr-2) CLB_1468(npr-3) CLB_1470(npr-5) CLB_1471(npr-6)
CBH : CLC_1478(npr-1) CLC_1479(npr-2) CLC_1480(npr-3) CLC_1482(npr-5) CLC_1483(npr-6)
CBY : CLM_1605(npr) CLM_1606(npr) CLM_1607(npr) CLM_1608(npr) CLM_1609
CBL : CLK_0923(npr) CLK_0924(npr) CLK_0925(npr) CLK_0926(npr) CLK_0927
CBB : CLD_3104 CLD_3105(npr) CLD_3107(npr) CLD_3108(npr)
CBI : CLJ_B1544(npr_1) CLJ_B1545(npr_2) CLJ_B1547(npr_4) CLJ_B1548(npr_5)
CBF : CLI_1525(npr-1) CLI_1526(npr-2) CLI_1527(npr-3) CLI_1529(npr-5) CLI_1530
CBM : CBF_1504 CBF_1508 CBF_1509
CBJ : H04402_01511 H04402_01512 H04402_01514 H04402_01515
CLD : CLSPO_c14710(nprM3) CLSPO_c14720(nprM4) CLSPO_c14730(nprM2)
CARG : RSJ17_11665 RSJ17_11670
OCW : OW730_08215 OW730_18760
THYR : P4S50_12385 P4S50_14195
MSP : Mspyr1_21870 Mspyr1_42680
MAUU : NCTC10437_03546(npr)
MHOL : K3U96_05650 K3U96_23380
NAH : F5544_13935 F5544_30865
NOI : FCL41_09745 FCL41_16365
NDP : E2C04_10300 E2C04_10305 E2C04_17015
KAL : KALB_3559 KALB_3827 KALB_8710 KALB_8711
KUT : JJ691_16160(hly) JJ691_78810 JJ691_96900
SCOR : J3U87_02535 J3U87_19455
PGIN : FRZ67_11380 FRZ67_21095
SMON : AWR27_02055 AWR27_15695
SPIB : G8759_24660 G8759_33635
HYG : AUC43_07375 AUC43_07380
HRS : HER32_08900 HER32_08905 HER32_15885
FUA : LVD17_04755 LVD17_06625
FCO : FCOL_02025 FCOL_08450
ASL : Aeqsu_1324 Aeqsu_2324
KAN : IMCC3317_26790(nprT) IMCC3317_45780(npr)
FBU : UJ101_00424(nprB) UJ101_00425
CIO : CEQ15_09780 CEQ15_14585
CHRY : CEY12_00875 CEY12_10630 CEY12_10635
CPIP : CJF12_18165 CJF12_18170
CGLE : NCTC11432_02515(npr)
CORA : N0B40_10915 N0B40_19620
CGAM : PFY09_04510 PFY09_08800
CJG : NCTC13459_00235(nprM_1) NCTC13459_00589(nprM_2) NCTC13459_02696(npr)
CANT : NCTC13489_01559(npr)
» show all
Taxonomy
Reference
Authors
Morihara K, Tsuzuki H, Oka T.
Title
Comparison of the specificities of various neutral proteinases from microorganisms.
Journal
Reference
Authors
Millet J, Acher R.
Title
[Specificity of megateriopeptidase: an amino-endopeptidase with hydrophobic characteristics]
Journal
Reference
Authors
Feder J, Keay L, Garrett LR, Cirulis N, Moseley MH, Wildi BS.
Title
Bacillus cereus neutral protease.
Journal
Reference
Authors
Holmquist B, Vallee BL.
Title
Esterase activity of zinc neutral proteases.
Journal
Reference
Authors
Vasantha N, Thompson LD, Rhodes C, Banner C, Nagle J, Filpula D
Title
Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein.
Journal
Sequence
Reference
Authors
Yang MY, Ferrari E, Henner DJ
Title
Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation.
Journal
Sequence
Reference
Authors
Takagi M, Imanaka T, Aiba S
Title
Nucleotide sequence and promoter region for the neutral protease gene from Bacillus stearothermophilus.
Journal
Sequence
Reference
Authors
Sidler W, Niederer E, Suter F, Zuber H
Title
The primary structure of Bacillus cereus neutral proteinase and comparison with thermolysin and Bacillus subtilis neutral proteinase.
Journal
Sequence
Reference
Authors
Pauptit RA, Karlsson R, Picot D, Jenkins JA, Niklaus-Reimer AS, Jansonius JN.
Title
Crystal structure of neutral protease from Bacillus cereus refined at 3.0 A resolution and comparison with the homologous but more thermostable enzyme thermolysin.
Journal
Sequence
Reference
Authors
Stoeva S, Kleinschmidt T, Mesrob B, Braunitzer G.
Title
Primary structure of a zinc protease from Bacillus mesentericus strain 76.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.28