KEGG   ENZYME: 3.4.24.29
Entry
EC 3.4.24.29                Enzyme                                 
Name
aureolysin;
Staphylococcus aureus neutral proteinase;
Staphylococcus aureus neutral protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus
Comment
A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen).
History
EC 3.4.24.29 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.29
Orthology
K01401  aureolysin
Genes
SDOSD1155_03045
SAUSA2430(aur)
SAVSAV2637(aur)
SAWSAHV_2621(aur)
SAHSaurJH1_2717
SAJSaurJH9_2661
SAMMW2558(aur)
SASSAS2523
SARSAR2716(aur)
SACSACOL2659(aur)
SAXUSA300HOU_2637(aur)
SAASAUSA300_2572(aur)
SAOSAOUHSC_02971
SAENWMN_2536(aur)
SADSAAV_2706(aur)
SUUM013TW_2618(aur)
SUVSAVC_12065
SUESAOV_2686c
SUJSAA6159_02533(aur)
SUKSAA6008_02696(aur)
SUCECTR2_2491
SUTSAT0131_02903
SUQHMPREF0772_10550(aur)
SUZMS7_2642(aur)
SUDST398NM01_2687
SUXSAEMRSA15_25420(aur)
SUWSATW20_27750(aur)
SUGSAPIG2687
SUFSARLGA251_24090(aur)
SAUASAAG_00459
SAUERSAU_002480(aur)
SAUNSAKOR_02638
SAUSSA40_2393(aur)
SAUUSA957_2477(aur)
SAUGSA268_2574(aur)
SAUZSAZ172_2756(aur)
SAUTSAI1T1_2019740(aur)
SAUJSAI2T2_1019750(aur)
SAUKSAI3T3_1019740(aur)
SAUQSAI4T8_1019750(aur)
SAUVSAI7S6_1019740(aur)
SAUWSAI5S5_1019680(aur)
SAUXSAI6T6_1019690(aur)
SAUYSAI8T7_1019720(aur)
SAUFX998_2620
SABSAB2512c(aur)
SUYSA2981_2576(aur)
SAUBC248_2705(aur)
SAUMBN843_26750
SAUCCA347_2715
SAURSABB_04255(aur)
SAUIAZ30_13795
SAUDCH52_05820
SAMSNI36_13265
SUHSAMSHR1132_24610
SERSERP2252(sepA)
SEPSE_2219
SEPPSEB_02220
SEPSDP17_1151(sepA)
SSPSSP1542
SSDSPSINT_2146
SDTSPSE_0326
SDPNCTC12225_00398(aur)
SWAA284_01205
SPASSTP1_1156
SXYBE24_03405
SXLSXYLSMQ121_1581
SXOSXYL_01658
SHUSHYC_09855(aur)
SCAPAYP1020_1844(sepA)
SSCHLH95_01925
SSCZRN70_02240
SAGQEP23_00125
SEQOSE1039_10430
SLZB5P37_04350
SCOHBZ166_12190
SNLBJD96_08540
SKLC7J89_09685
SFQC7J90_00795
SCARDWB96_01280
SCHRDWB92_10010
SARLSAP2_16170
SSHNCTC13712_02592(aur)
SSIMSAMEA4384339_2444(aur)
SLLOISP08_07975
SRAILN051_08840
SPSDJMB28_08605
SSCUCEP64_01805
SFFFOB90_05845
SSTESAMEA4384403_0437(sepA_2)
MVTI6J10_08920
MCLMCCL_1675
MCAKMCCS_05170(sepA_2) MCCS_23430(sepA_3)
MACRBHM04_00285
MBOEHT586_10410
MARYLAU42_10755 LAU42_10760 LAU42_10765
MBRUMGG13_02555 MGG13_09375
MEPIKFV12_11115 KFV12_11980
PBIFKXZ80_15765
PSORRSJ16_08260
 » show all
Reference
1  [PMID:4632563]
  Authors
Arvidson S.
  Title
Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.
  Journal
Biochim Biophys Acta 302:149-57 (1973)
DOI:10.1016/0005-2744(73)90017-X
Reference
2  [PMID:823980]
  Authors
Saheb SA.
  Title
[Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA]
  Journal
Biochimie 58:793-804 (1976)
DOI:10.1016/S0300-9084(76)80310-0
Reference
3  [PMID:711676]
  Authors
Drapeau GR.
  Title
Role of metalloprotease in activation of the precursor of staphylococcal protease.
  Journal
J Bacteriol 136:607-13 (1978)
DOI:10.1128/JB.136.2.607-613.1978
Reference
4  [PMID:2512988]
  Authors
Potempa J, Porwit-Bobr Z, Travis J.
  Title
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.
  Journal
Biochim Biophys Acta 993:301-4 (1989)
DOI:10.1016/0304-4165(89)90181-5
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.29
IUBMB Enzyme Nomenclature: 3.4.24.29
ExPASy - ENZYME nomenclature database: 3.4.24.29
BRENDA, the Enzyme Database: 3.4.24.29
CAS: 39335-13-2

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