Acting on peptide bonds (peptidases);
Preferential cleavage of bonds with hydrophobic residues in P1'
The enzyme has been characterized from the bacteria Streptomyces griseus, Streptomyces naraensis, and Streptomyces cacaoi. Specificity is similar to that of thermolysin, but the enzyme is much more sensitive to inhibition by sulfanylacetyl-Phe-Leu. Little structural similarity to other bacterial metalloendopeptidases. Type example of peptidase family M5.
EC 18.104.22.168 created 1972 as EC 22.214.171.124, part transferred 1992 to EC 126.96.36.199