KEGG   ENZYME: 3.4.24.34
Entry
EC 3.4.24.34                Enzyme                                 
Name
neutrophil collagenase;
matrix metalloproteinase 8;
PMNL collagenase;
MMP-8
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I
Comment
Similar to interstitial collagenase in specificity, but the product of a different gene and highly glycosylated. Stored in the specific granules of neutrophil leukocytes. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.7
History
EC 3.4.24.34 created 1992
Orthology
K01402  matrix metalloproteinase-8 (neutrophil collagenase)
Genes
HSA4317(MMP8)
PTR740516(MMP8)
PPS100967517(MMP8)
GGO101130698(MMP8)
PON100459562(MMP8)
NLE100590326(MMP8)
MCC703536(MMP8)
MCF102141209(MMP8)
CSAB103248338(MMP8)
CATY105588776(MMP8)
PANU100999640(MMP8)
TGE112606698(MMP8)
RRO104674673(MMP8)
RBB108514067(MMP8)
TFN117080307(MMP8)
PTEH111540072(MMP8)
CJC100392602(MMP8)
SBQ101052201(MMP8)
CSYR103258290(MMP8)
MMUR105874593(MMP8)
LCAT123641889(MMP8)
OGA100950955(MMP8)
MMU17394(Mmp8)
MCAL110301722(Mmp8)
MPAH110327350(Mmp8)
RNO63849(Mmp8)
MCOC116071920(Mmp8)
MUN110541844(Mmp8)
CGE100759953(Mmp8)
MAUA110342247(Mmp8)
PLEU114708010(Mmp8)
MORG121451292(Mmp8)
MFOT126513688
AAMP119809252(Mmp8)
NGI103731673(Mmp8)
HGL101716969(Mmp8)
CPOC100724670(Mmp8)
CCAN109689288(Mmp8)
DORD105980682(Mmp8)
DSP122110395(Mmp8)
NCAR124958966
OCU100339790(MMP8)
OPI101527137(MMP8)
TUP102491284(MMP8)
CFA489429(MMP8)
CLUD112671440(MMP8)
VVP112925873(MMP8)
VLG121500257(MMP8)
AML100480934(MMP8)
UMR103662456(MMP8)
UAH113260136(MMP8)
UAR123792503(MMP8)
ELK111153789
LLV125078736
MPUF106003374(MMP8)
ORO101369890(MMP8)
EJU114211389(MMP8)
ZCA113915035(MMP8)
MLX118013052(MMP8)
NSU110586173(MMP8)
FCA101080995(MMP8)
PYU121020773(MMP8)
PBG122482891(MMP8)
LRUF124504839
PTG102970860(MMP8)
PPAD109257533(MMP8)
AJU106976490(MMP8)
HHV120219699(MMP8)
BTA100336575(MMP8)
BOM102264685(MMP8)
BBUB102400184(MMP8)
CHX102172738(MMP8)
OAS101120601(MMP8)
ODA120876081(MMP8)
CCAD122450162(MMP8)
SSC100523811(MMP8)
CFR102517300(MMP8)
CBAI105067596(MMP8)
CDK105087170(MMP8)
VPC102529148(MMP8)
BACU103009475(MMP8)
LVE103088779(MMP8)
OOR101271219(MMP8)
DLE111167575(MMP8)
PCAD102995095(MMP8)
PSIU116757860(MMP8)
ECB100069005(MMP8)
EPZ103552634(MMP8)
EAI106843116(MMP8)
MYB102243196(MMP8)
MYD102770824(MMP8)
MMYO118664464(MMP8)
MLF102426192(MMP8)
MNA107532388(MMP8)
PKL118713422(MMP8)
HAI109376359(MMP8)
DRO112317541(MMP8)
SHON118975723(MMP8)
AJM119054060(MMP8)
PHAS123805580(MMP8)
MMF118627934(MMP8)
RFQ117031318(MMP8)
PALE102885648(MMP8)
PGIG120614285(MMP8)
PVP105309854(MMP8)
RAY107504636(MMP8)
MJV108400679(MMP8)
TOD119240914(MMP8)
SARA101545653(MMP8)
LAV100656135(MMP8)
TMU101342032
DNM101432739(MMP8)
MDO100012425(MMP8)
GAS123238993(MMP8)
SHR100914807(MMP8)
PCW110215021(MMP8)
OAA100079007
XMA106699854
XCO114153708
PRET103476142
CVG107091375
SDU111222299
SLAL111663528
OBO105274441
PPYR116160097
 » show all
Reference
1  [PMID:3038863]
  Authors
Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG.
  Title
The collagen substrate specificity of human neutrophil collagenase.
  Journal
J Biol Chem 262:10048-52 (1987)
Reference
2  [PMID:2164002]
  Authors
Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL
  Title
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
  Journal
J Biol Chem 265:11421-4 (1990)
  Sequence
[hsa:4317]
Reference
3  [PMID:2159879]
  Authors
Knauper V, Kramer S, Reinke H, Tschesche H.
  Title
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms.
  Journal
Eur J Biochem 189:295-300 (1990)
DOI:10.1111/j.1432-1033.1990.tb15489.x
  Sequence
[hsa:4317]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.34
IUBMB Enzyme Nomenclature: 3.4.24.34
ExPASy - ENZYME nomenclature database: 3.4.24.34
BRENDA, the Enzyme Database: 3.4.24.34
CAS: 9001-12-1

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