KEGG   ENZYME: 3.4.24.36
Entry
EC 3.4.24.36                Enzyme                                 
Name
leishmanolysin;
promastigote surface endopeptidase;
glycoprotein gp63;
Leishmania metalloproteinase;
surface acid proteinase;
promastigote surface protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr!Leu-Lys-Lys-
Comment
A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100!Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8
History
EC 3.4.24.36 created 1992
Orthology
K01404  leishmanolysin
Genes
ATHAT5G42620
ALY9299837
CRB17875516
CSAT104725219 104760706 104771388
EUSEUTSA_v10022547mg
BRP103828018
BNA106349526 111198782
BOE106342481
RSZ108855134 108855135
THJ104806880 104809128
CPAP110813552
CIT102621178
CICCICLE_v10000250mg
PVY116110659
MINC123202619 123229790
TCC18591336
GRA105769136 105770076 105772974
GHI107904944 107905395 107942010 107942859 107943007 107957561
GAB108453648 108483520 108484368
DZI111312674 111314262 111315379
EGR104416623
GMX100775874 100788818 100807772 100808350
GSJ114384842 114393424 114408661 114414675
PVUPHAVU_001G016500g PHAVU_009G055900g
VRA106762281 106765114
VAR108321514 108343088
VUN114163267 114194477
CCAJ109788373 109805793
APRC113845803 113866404
MTRMTR_1g021950 MTR_3g111630
CAM101501815 101510815
LJALj5g3v2297750.1(Lj5g3v2297750.1) Lj5g3v2297750.2(Lj5g3v2297750.2)
ADU107495963
AIP107605731
AHF112697938 112756242
LANG109337314 109358336
FVE101308254
RCN112172746
PPER18791128
PMUM103320808
PAVI110762610
PDUL117615094
MDM103420931
PXB103954281 103955440
ZJU107420265
MNT21404080
CSV101217702
CMO103487946
BHJ120075623
MCHA111013969
CMAX111491790 111496088
CMOS111454285 111462558
CPEP111798888 111805104
RCU8260940
JCU105633745
HBR110631601 110649111
MESC110606833 110615517
POP18105000 7462916
PEU105120685 105130512
PALZ118028084 118034139
JRE108988633 108991685
QSU112011988
QLO115974277
TWL120009481 120011394
VVI100257368
VRI117906722
SLY101248771
SPEN107017811
SOT102596537
CANN107867059
NTA107793270 107802772
NSY104212740
NTO104091581
NAU109208548
INI109170300
ITR116029615
SIND105159208 105166296
OEU111398027 111408839
EGT105965686
SSPL121755279 121759224 121805584 121809592
HAN110879497 110926717 110936242
ECAD122589553 122608484
LSV111876250 111920667
CCAV112510108 112511776
DCR108219206 108223757
CSIN114315980 114318039
BVG104898653
SOE110785245
CQI110686392 110711242
NNU104595772
MING122073598 122078654
TSS122658609 122661341
PSOM113289294 113296223
NCOL116250202
OSA4334001
DOSAOs03t0731500-01(Os03g0731500)
OBR102704227
BDI100831389
ATS109780249
TDC119286773 119294955
TAES123086986 123090988 123096003
TUA125550516
SBI8059951
ZMA103643963
SITA101779712
SVS117836797
PVIR120649868 120687925
PHAI112874861
PDA103707501
EGU105055836
MUS103978339 103986043 103996181
DCT110100801
PEQ110031986
AOF109822512
ATR18445929
PPP112286782 112292396
DDIDDB_G0286533
DPPDICPUDRAFT_57749
DFADFA_06007(sigB)
EHIEHI_042870(111.t00003) EHI_200230(30.t00006)
EDIEDI_037980
EIVEIN_154240 EIN_174510
ACANACA1_219880
TETTTHERM_00289430 TTHERM_00289510 TTHERM_00289520 TTHERM_00289530 TTHERM_00289540 TTHERM_00289570 TTHERM_00289590 TTHERM_00289600 TTHERM_00290610
PTMGSPATT00012897001 GSPATT00028904001
FCYFRACYDRAFT_195921
TPSTHAPS_263268
PIFPITG_08774
PSOJPHYSODRAFT_317898
SPARSPRG_12195
EHXEMIHUDRAFT_455768
TBRTb10.70.5290 Tb11.02.5310 Tb11.02.5610 Tb11.02.5630 Tb11.02.5640 Tb11.12.0006 Tb927.8.1610 Tb927.8.1620 Tb927.8.1630 Tb927.8.1640
TBGTbgDal_VIII1230 TbgDal_X2960 TbgDal_XI8480 TbgDal_XI8830 TbgDal_XI8840 TbgDal_XI9750
TCR410797.10 505615.10 505989.70 506145.80 506257.50 506321.240 506401.380 506435.370 506867.40 507917.10 507919.10 507993.350 508241.50 508545.40 508609.10 508611.30 508693.100 508699.100 508999.170 509011.80 509205.100 510263.30 510565.150 510657.200 510747.40 510761.80 510873.20 510899.10 511035.10 511151.54 511203.20 511257.60 511277.610 511281.50 511723.10
LMALMJF_10_0460(GP63-1) LMJF_10_0465(GP63-2) LMJF_10_0470(GP63-3) LMJF_10_0480(GP63-4) LMJF_28_0570 LMJF_31_2000
LIFLINJ_10_0490(GP63-1) LINJ_10_0500(GP63-2) LINJ_10_0510(GP63-3) LINJ_10_0520(GP63-3) LINJ_10_0530(GP63-4) LINJ_28_0600 LINJ_28_0610 LINJ_31_2040
LDOLDBPK_280600 LDBPK_312040
LMILMXM_10_0390 LMXM_10_0405 LMXM_10_0460 LMXM_10_0465 LMXM_10_0470 LMXM_28_0570 LMXM_30_2000
LBZLBRM_10_0470(GP63-1) LBRM_10_0480(GP63-2) LBRM_10_0500 LBRM_10_0510(GP63-3) LBRM_10_0520 LBRM_10_0530 LBRM_10_0540 LBRM_10_0550(GP63-2) LBRM_10_0560(GP63-4) LBRM_10_0570(GP63-4) LBRM_10_0580(GP63-4) LBRM_10_0590 LBRM_10_0600 LBRM_10_0610 LBRM_31_2260
LPANLPMP_100410(GP63-1) LPMP_100420(GP63-2) LPMP_100430(GP63-3) LPMP_100440(GP63-4) LPMP_311850
NGRNAEGRDRAFT_74654
TVATVAG_064340 TVAG_223530 TVAG_278480 TVAG_369300
 » show all
Reference
1  [PMID:3346625]
  Authors
Button LL, McMaster WR
  Title
Molecular cloning of the major surface antigen of leishmania.
  Journal
J Exp Med 167:724-9 (1988)
DOI:10.1084/jem.167.2.724
  Sequence
Reference
2  [PMID:2608099]
  Authors
Bouvier J, Bordier C, Vogel H, Reichelt R, Etges R.
  Title
Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase.
  Journal
Mol Biochem Parasitol 37:235-45 (1989)
DOI:10.1016/0166-6851(89)90155-2
Reference
3  [PMID:2708373]
  Authors
Chaudhuri G, Chaudhuri M, Pan A, Chang KP.
  Title
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages.
  Journal
J Biol Chem 264:7483-9 (1989)
Reference
4  [PMID:2271643]
  Authors
Bouvier J, Schneider P, Etges R, Bordier C.
  Title
Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania.
  Journal
Biochemistry 29:10113-9 (1990)
DOI:10.1021/bi00495a015
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.36
IUBMB Enzyme Nomenclature: 3.4.24.36
ExPASy - ENZYME nomenclature database: 3.4.24.36
BRENDA, the Enzyme Database: 3.4.24.36
CAS: 161052-06-8

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