KEGG   ENZYME: 3.4.24.47Help
Entry
EC 3.4.24.47                Enzyme                                 

Name
horrilysin;
Crotalus horridus metalloendopeptidase;
hemorrhagic proteinase IV;
Crotalus horridus horridus venom hemorrhagic proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of only the single bond Ala14!Leu in the insulin B chain, Ser12!Leu in the A chain, and Ile!Gly, Pro!Ala, and Ser!Trp in melittin
Comment
A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen.
History
EC 3.4.24.47 created 1992
Reference
1  [PMID:6340728]
  Authors
Civello DJ, Duong HL, Geren CR.
  Title
Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom.
  Journal
Biochemistry 22:749-55 (1983)
Reference
2  [PMID:6340729]
  Authors
Civello DJ, Moran JB, Geren CR.
  Title
Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom.
  Journal
Biochemistry 22:755-62 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.47
IUBMB Enzyme Nomenclature: 3.4.24.47
ExPASy - ENZYME nomenclature database: 3.4.24.47
BRENDA, the Enzyme Database: 3.4.24.47
CAS: 84056-81-5

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