KEGG   ENZYME: 3.4.24.52Help
Entry
EC 3.4.24.52                Enzyme                                 

Name
trimerelysin I;
Trimeresurus metalloendopeptidase I;
hemorrhagic proteinase HR1A;
hemorrhagic metalloproteinase HR1A;
metalloproteinase HR1A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of only two bonds His10!Leu and Ala14!Leu in the insulin B chain
Comment
A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family)
History
EC 3.4.24.52 created 1992
Orthology
K21897  trimerelysin I
Reference
1  [PMID:518906]
  Authors
Omori-Satoh T, Sadahiro S.
  Title
Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts.
  Journal
Biochim Biophys Acta 580:392-404 (1979)
DOI:10.1016/0005-2795(79)90151-X
Reference
2  [PMID:3284004]
  Authors
Yamakawa Y, Omori-Satoh T.
  Title
The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis).
  Journal
Toxicon 26:227-31 (1988)
Reference
3  [PMID:2398046]
  Authors
Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S.
  Title
The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis.
  Journal
J Biol Chem 265:16068-73 (1990)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.52
IUBMB Enzyme Nomenclature: 3.4.24.52
ExPASy - ENZYME nomenclature database: 3.4.24.52
BRENDA, the Enzyme Database: 3.4.24.52
CAS: 151125-16-5

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