Acting on peptide bonds (peptidases);
Degradation of insulin, glucagon and other polypeptides. No action on proteins
A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family).
EC 22.214.171.124 created 1972 as EC 126.96.36.199, transferred 1976 EC 188.8.131.52, transferred 1978 to EC 184.108.40.206, transferred 1993 to to EC 220.127.116.11 (EC 18.104.22.168 created 1992, incorporated 2000)