KEGG   ENZYME: 3.4.24.56
Entry
EC 3.4.24.56                Enzyme                                 
Name
insulysin;
insulinase;
insulin-degrading enzyme;
insulin protease;
insulin proteinase;
insulin-degrading neutral proteinase;
insulin-specific protease;
insulin-glucagon protease;
metalloinsulinase;
IDE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Degradation of insulin, glucagon and other polypeptides. No action on proteins
Comment
A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family).
History
EC 3.4.24.56 created 1972 as EC 3.4.99.10, transferred 1976 EC 3.4.22.11, transferred 1978 to EC 3.4.99.45, transferred 1993 to to EC 3.4.24.56 (EC 3.4.99.46 created 1992, incorporated 2000)
Orthology
K01408  insulysin
Genes
HSA3416(IDE)
PTR450608(IDE)
PPS100987046(IDE)
GGO101141069(IDE)
PON100434053(IDE)
NLE100593040(IDE)
MCC698640(IDE)
MCF102128252(IDE)
CSAB103216264(IDE)
CATY105587124(IDE)
PANU101009890(IDE)
TGE112632174(IDE)
RRO104676500(IDE)
RBB108532590(IDE)
TFN117091736(IDE)
PTEH111552174(IDE)
CJC100385143(IDE)
SBQ101050161(IDE)
CSYR103266025(IDE)
MMUR105872121(IDE)
OGA100942657(IDE)
MMU15925(Ide)
MCAL110285640(Ide)
MPAH110336819(Ide)
RNO25700(Ide)
MCOC116103790(Ide)
MUN110545280(Ide)
CGE100763752(Ide)
PLEU114702447(Ide)
NGI103747266(Ide)
HGL101706921(Ide)
CPOC100719651(Ide)
CCAN109688019(Ide)
DORD105999378(Ide)
DSP122115756(Ide)
NCAR124984747
OCU100341888(IDE)
OPI101524552(IDE)
TUP102491829(IDE)
CFA477768(IDE)
VVP112913877(IDE)
VLG121484354(IDE)
AML100482236(IDE)
UMR103667958(IDE)
UAH113243168(IDE)
UAR123800276(IDE)
ELK111144834
LLV125084532
MPUF101675890(IDE)
ORO101380916(IDE)
EJU114205152(IDE)
ZCA113921843(IDE)
MLX118023736(IDE)
FCA101093646(IDE)
PYU121036995(IDE)
PBG122493029(IDE)
PTG102971779(IDE)
PPAD109264657(IDE)
AJU106965844(IDE)
HHV120230595(IDE)
BTA523752(IDE)
BOM102265572(IDE)
BIU109552990(IDE)
BBUB102390944(IDE)
CHX102173809(IDE)
OAS101104194(IDE)
ODA120873693(IDE)
CCAD122446143(IDE)
SSC100155309(IDE)
CFR102505022(IDE)
CBAI105081901(IDE)
CDK105084233(IDE)
VPC102525212(IDE)
BACU103000770(IDE)
LVE103074682(IDE)
OOR101275790(IDE)
DLE111172492(IDE)
PCAD102984672(IDE) 114486076
PSIU116741559(IDE)
ECB100071303(IDE)
EPZ103559075(IDE)
EAI106845083(IDE)
MYB102263187(IDE)
MYD102758781(IDE)
MMYO118669958(IDE)
MLF102419916(IDE)
MNA107543320(IDE)
PKL118719293(IDE)
HAI109380938(IDE)
DRO112307411(IDE)
SHON118987983(IDE) 118993304
AJM119057724(IDE)
PDIC114496167(IDE)
PHAS123828774(IDE)
MMF118632197(IDE)
RFQ117036165(IDE)
PALE102895302(IDE)
PGIG120609305(IDE)
PVP105293081(IDE)
RAY107514007(IDE)
MJV108398048(IDE)
TOD119234348(IDE)
SARA101546541(IDE)
LAV100655439(IDE)
TMU101340940
DNM101431307(IDE)
MDO100024067(IDE)
GAS123238218(IDE)
SHR100919889(IDE)
PCW110192735(IDE)
OAA100074945(IDE)
GGA423814(IDE)
PCOC116231760(IDE)
MGP100542747(IDE)
CJO107315974(IDE)
NMEL110399870(IDE)
APLA101796419(IDE)
ACYG106039786(IDE)
AFUL116491502(IDE)
TGU100232369(IDE)
LSR110473710(IDE)
SCAN103813910(IDE)
PMOA120502213(IDE)
OTC121341944(IDE)
PRUF121350290(IDE)
GFR102044722(IDE)
FAB101813235(IDE)
PHI102107945(IDE)
PMAJ107206642(IDE)
CCAE111931199(IDE)
CCW104696227(IDE)
ETL114071272(IDE)
ZAB102067409(IDE)
FPG101918348(IDE)
FCH102053322(IDE)
CLV102093029(IDE)
EGZ104129064(IDE)
NNI104013845(IDE)
ACUN113481458(IDE)
TALA116962475(IDE)
PADL103916353(IDE)
ACHC115348011(IDE)
AAM106491518(IDE)
NPD112957530(IDE)
DNE112979712(IDE)
ASN102372742(IDE)
AMJ102565114(IDE)
CPOO109323847(IDE)
GGN109287505(IDE)
PSS102457580(IDE)
CMY102939264(IDE)
CPIC101951441(IDE)
TST117880881(IDE)
CABI116832421(IDE)
MRV120409254(IDE)
ACS100562442(ide) 103282118
PVT110073578(IDE)
SUND121926347(IDE)
PBI103064318(IDE)
PMUR107283394(IDE)
TSR106540499
PGUT117673198(IDE)
VKO123018500(IDE)
PMUA114597338(IDE)
ZVI118096665(IDE)
GJA107106472(IDE) 107110237
STOW125437528(IDE)
XLA108696126(ide.L) 108697399(ide.S)
XTR100490154(ide)
NPR108788832(IDE)
RTEM120946945(IDE)
BBUF121005991(IDE)
BGAR122939988(IDE)
DRE561390(ide)
SRX107719220(ide) 107747278
SANH107665588 107676380
SGH107549153 107586078
CCAR109067563 109100554
CAUA113092350 113112434
PPRM120479378(ide)
MAMB125276696(ide)
IPU108263145(ide)
PHYP113538031(ide)
SMEO124399439(ide)
TFD113660997(ide)
AMEX103033253(ide)
EEE113579898(ide)
TRU101066029(ide)
TNGGSTEN00003718G001
LCO104921911(ide)
NCC104941703
CGOB115020494(ide)
ELY117248183(ide)
PLEP121954332(ide)
SLUC116047860(ide)
ECRA117960925(ide)
PFLV114572292(ide)
GAT120820385(ide)
PPUG119214047(ide)
MSAM119917161(ide)
CUD121510815(ide)
MZE101464415 101465473
ONL100692389 100706901
OAU116309660 116318769(ide)
OLA101157559 101158223 101163025
OML112141524 112145324 112145325(ide)
XCO114137656(ide)
XHE116713150 116713643
PRET103477096(ide)
PFOR103148263(ide)
PLAI106939392
PMEI106930457(ide)
GAF122842242(ide)
CVG107088202(ide)
CTUL119782902(ide)
GMU124858728(ide)
NFU107375781(ide)
KMR108247174(ide)
ALIM106526539(ide)
NWH119410718(ide)
AOCE111572830(ide)
CSEM103387481(ide)
POV109633847(ide)
SSEN122781693(ide)
HHIP117775830(ide)
LCF108886288(ide)
SDU111220621(ide)
SLAL111669525(ide)
XGL120796443(ide)
HCQ109523193(ide)
BPEC110161080(ide)
MALB109959169(ide)
SASA106576795 106604847
OTW112252831 112252932
OMY110502301 110526671(ide)
OGO124038134 124041415
ONE115113359 115135279
SALP111951795 111977826
SNH120017537 120046482
ELS105005727(ide)
SFM108925811(ide)
PKI111850359(ide)
AANG118217913(ide)
LOC102686331(ide)
PSPA121321877 121325232
ARUT117415575 117418117
LCM102363186(IDE)
CMK103180581(ide)
RTP109912130(ide)
BFO118413042
BBEL109478554
CIN100177319
SCLV120340145
SPU574555 591315
APLC110981248
SKO102806877
DMEDmel_CG5517(Ide)
DER6544553
DSE6616289
DSIDsimw501_GD12197(Dsim_GD12197)
DYADyak_GE22411
DAN6506778
DSR110184656
DPODpse_GA18943
DPE6603355
DMN108152750
DWI6638788
DGR6557764
DMODmoj_GI13481
DNV108650229
DHE111592276
DVI6624225
CCAT101459832
BOD106619491
MDE101899568
SCAC106096173
LCQ111677349
AGAAgaP_AGAP010351
ACOZ120956720
AARA120902153
AAG110678158 5575268
AALB109413566
CQUCpipJ_CPIJ006153
CPII120424413
CNS116337890
AME413539
ACER107992697
ALAB122715613
BIM100740682
BBIF117208070
BVK117240265
BVAN117164496
BTER100644699
BPYO122576116
CCAL108631858
OBB114879359
MGEN117220685
NMEA116428662
CGIG122396037
SOC105205327
MPHA105830806 105839814
AEC105152472 105152492
ACEP105620850
PBAR105425760 105425777 105425778 105425798 105425799 105427238
VEM105563049 105565695 105567598
HST105185119 105189706
DQU106741566 106742500 106750535
CFO105249060 105258460
FEX115233687 115246321
LHU105667811 105671329
PGC109858418 109858911 109859391
OBO105274769
PCF106786397
PFUC122521368
VPS122637713
NVI100114345
CSOL105363243
TPRE106657989
MDL103576120 103579756
CGLO123272463
FAS105271942 105273032
DAM107041090
AGIF122858899
CCIN107271454
TCA660586
DPA109543947
SOY115881971
ATD109605259
CSET123317796
AGB108917873
LDC111509946
NVL108562427
APLN108741211
PPYR116163380
OTU111416099
BMOR101745525
BMAN114246172
MSEX115454235
DPLKGM_211055A KGM_211055B
BANY112045690
PMAC106716963
PPOT106107646
PXU106116140 106119243 106120466
PRAP110998472
ZCE119839051
HAW110375755 110383325
TNL113505516
SLIU111351395
OFU114355000
PXY105396216 105396278 105398789
API100167928
DNX107173966
AGS114126529 114128610
RMD113548808 113557884
BTAB109037866
DCI103512936
CLEC106666217
HHAL106680575
NLU111058304
PHUPhum_PHUM003750
FOC113210134
ZNE110833158
CSEC111864772 117282033
FCD110845618 110846814 110850482 110854575 110856794 110856939 110857492 110860916 110862143
DPXDAPPUDRAFT_305640
DMK116926288
PVM113821673
PJA122262577
PCHN125029568
HAME121854243
PCLA123764112
PTRU123502918
HAZT108668955
EAF111706311 111706459
LSM121118111 121129636
DSV119457502
RSAN119379410
RMP119175663
VDE111242942 111243342 111244578 111245308 111246384 111249273 111255291
VJA111258856 111260626 111263062 111265757 111266466 111266586 111269255
DPTE113790375
DFR124492350
CSCU111634626
PTEP107436385
SDM118194410
CELCELE_C02G6.2(C02G6.2) CELE_F44E7.4(F44E7.4) CELE_Y70C5C.1(Y70C5C.1)
CBRCBG_09322 CBG_17023
BMYBM_BM13793(Bm13793)
LOALOAG_08082
NAINECAME_12077
TSPTsp_00424
HROHELRODRAFT_109371
LGILOTGIDRAFT_232210
PCAN112564175
BGT106059917
GAE121383266 121384415
HRF124117264 124143872
HRJ124258429 124259345
CRG105329003
MYI110455364 110459151
PMAX117339419 117339446
MMER123544538 123546540
OBI106875967
OSN115219912
LAK106168930 106180939
SMMSmp_011100 Smp_146010
OVIT265_04051
EGLEGR_05548
NVE5509246
EPA110231484
ATEN116308795
ADF107350280
AMIL114961712
PDAM113669966
SPIS111324398
DGT114515965
XEN124444752
HMG100205092 101236769
TADTRIADDRAFT_28404
AQU100632301 105314756
ATHAT2G41790 AT3G57470
ALY9314222 9314223 9316021
CRB17885035 17886354 17889182 17889511
CSAT104699389 104712420 104712421 104713937 104715299 104752120 104784127 104785199 104792037 109124581
EUSEUTSA_v10005770mg EUTSA_v10016187mg
BRP103841652 103863042 103866587
BNA106396187 106410876 106445196 106450648 106451568 111214975
BOE106300306 106312439 106321110 106336575
RSZ108813078 108814401 108829670 108829672 108863355
THJ104802114 104824443
CPAP110811224
CIT102625307 102629343
CICCICLE_v10004240mg CICLE_v10004250mg
MINC123224732
TCC18598933 18598935 18598944
GRA105785350 105785352
GHI107921220 107921627 107922017 121213639
GAB108481936 108481937
DZI111294450 111311511 111311512 111311513
EGR104414623 104445012 104445029
GMX100788622 100804856
GSJ114400184 114406717
PVUPHAVU_001G1332000
VRA106757584
VAR108328969
VUN114179662
CCAJ109797247
APRC113861524
MTRMTR_7g091590
CAM101508744
LJALj0g3v0331639.1(Lj0g3v0331639.1) Lj0g3v0331639.2(Lj0g3v0331639.2)
ADU107492618
AIP107645485
AHF112696027 112755426
LANG109340850 109356953
FVE101297565
RCN112193461 112193462 112193625
PPER18771330
PMUM103322039 103322040
PAVI110773385
PDUL117633672 117633792
MDM103400282 103454415
PXB103946506 103946507 103968020
ZJU107431720
MNT21388248
CSV101207568 101207811
CMO103486819
BHJ120091708
MCHA111021555
CMAX111481567
CMOS111441824
CPEP111790335
RCU8286299 8286300
JCU105645230 105645231 105645233
HBR110643838 110648272 110660413 110661319 110662163 110673582
MESC110620723 110622746 110622795
POP7473617
PEU105142229
PALZ118053175 118053176 118053177
JRE108987792 109003515 109004639
QSU111983721 111994875 112027923 112034313
QLO115953732
TWL119991175
VVI100241851 100246976
VRI117920111 117920763
SLY101244763 543773(ide)
SPEN107017808 107017877
SOT102606094 102606434
CANN107870070 107870071
NTA107764696 107769755 107821603 107825793
NSY104231856 104244490
NTO104115258 104121323
NAU109239863 109239864
INI109181420 109181421 109181820
ITR116006578 116006692
SIND105159756
OEU111365873
EGT105949356
SSPL121746983 121748336 121752292 121790165
HAN110884632
ECAD122606886
LSV111879375
CCAV112517896
DCR108227588
CSIN114318147
BVG104889352
SOE110779098
CQI110691497 110707281
NNU104597372 104597374
MING122065322
TSS122642097
PSOM113307965 113310373 113321620
NCOL116256933
OSA4326432 4343659 4343660 9266542
DOSAOs01t0778800-01(Os01g0778800) Os01t0779100-00(Os01g0779100) Os07t0570100-01(Os07g0570100) Os07t0570300-01(Os07g0570300) Os07t0570500-01(Os07g0570500)
OBR102700359 102709753 102720094
BDI100828166 100843556 100846895
ATS109743057 109775769
TDC119269204 119277197 119354072 119363262
TAES123044489 123052352 123062240 123070990 123079370 123188197
SBI110432528 8054706
ZMA103633315 103636601 103651144
SITA101755850 101776553
SVS117844527 117856992
PVIR120650747 120661731 120673615 120692205 120708262
PHAI112880219 112893810
PDA103717655
EGU105046510
MUS103975260
PEQ110029154
AOF109833714
ATR18428917 18428919
SMOSELMODRAFT_183357 SELMODRAFT_447027
PPP112282066 112287795 112291094 112293272
CRECHLRE_09g386113v5
VCNVOLCADRAFT_105585 VOLCADRAFT_94765
MNGMNEG_3943
CSLCOCSUDRAFT_30601
CVRCHLNCDRAFT_35384
APROF751_6272
CMECYME_CMO219C
GSLGasu_10170
CCPCHC_T00006291001
SCEYLR389C(STE23)
SEUBDI49_3889
SPAOSPAR_L03980
AGOAGOS_AER053C
ERCEcym_3273
KLAKLLA0_E05105g
KMXKLMA_70067(STE23)
LTHKLTH0D14278g
VPOKpol_1055p83
ZROZYRO0B12320g
CGRCAGL0H06457g
NCSNCAS_0J01470(NCAS0J01470)
NDINDAI_0J02240(NDAI0J02240)
TPFTPHA_0B02260(TPHA0B02260)
TBLTBLA_0A08050(TBLA0A08050) TBLA_0I02940(TBLA0I02940)
TDLTDEL_0E01250(TDEL0E01250)
TGBHG536_0E01660
KAFKAFR_0A05970(KAFR0A05970)
KNGKNAG_0B06080(KNAG0B06080)
ZMKHG535_0B06380
PPAPAS_chr1-4_0511
DHADEHA2A05192g
PICPICST_56651
PGUPGUG_00170
SPAASPAPADRAFT_143847
LELLELG_04953
CALCAALFM_C602860WA(STE23)
CTPCTRG_02123 CTRG_05751 CTRG_05771
COTCORT_0H02160
CDUCD36_63250
CTENCANTEDRAFT_99150
YLIYALI0E17831g YALI0F25091g
CLUCLUG_02178
CLUSA9F13_02g01221
CAURCJI97_005353
SLBAWJ20_816(STE23)
PKZC5L36_0B12870
BNNFOA43_004812
BBRXBRETT_001915
OPAHPODL_01967
NCRNCU00481
NTENEUTE1DRAFT82494(NEUTE1DRAFT_82494)
SMPSMAC_12071
PANPODANSg5055
TTTTHITE_2118447
MTMMYCTH_2304722
MGRMGG_13149
TMNUCRPA7_6437
SSCKSPSK_06929
FGRFGSG_06911
FPUFPSE_11749
FVRFVEG_14030
FOXFOXG_01908 FOXG_06921 FOXG_12571 FOXG_12622 FOXG_13969 FOXG_16289 FOXG_17054
NHENECHADRAFT_68465
TRETRIREDRAFT_73809
TRRM419DRAFT_139701
MAWMAC_03112
MAJMAA_05780 MAA_11828
CMTCCM_02661
VALVDBG_06702
VDAVDAG_05762
CHIGCH63R_02500
SAPOSAPIO_CDS5364
ELAUCREL1_6314
PFYPFICI_07549 PFICI_10843
SSLSS1G_08876
BFUBCIN_16g02680
MBEMBM_00273
PSCOLY89DRAFT_581710 LY89DRAFT_588283 LY89DRAFT_766505
GLZGLAREA_05982
ANIAN8044.2
AFMAFUA_5G02010
ACTACLA_003260
NFINFIA_040110
AORAO090003001317
ANGANI_1_1920064(An07g06490) ANI_1_262144(An16g01860)
AFVAFLA_000361
ALUCAKAW2_70152S(IDE1)
ACHEACHE_51053A(IDE1)
APUUAPUU_41509S(IDE1)
PCSPc21g14590
PDPPDIP_47890
TMFPMAA_039700
TRGTRUGW13939_02639
CIMCIMG_06411
CPWCPC735_029100
UREUREG_03995
PBLPAAG_04661
PBNPADG_07053 PADG_11423(PADG_02421)
ABEARB_00823
TVETRV_07483
AJEHCAG_00321
BGHBDBG_01567
PNOSNOG_11020
PTEPTT_06680
BZECOCCADRAFT_8266
BSCCOCSADRAFT_83803
BORCOCMIDRAFT_9183
AALTCC77DRAFT_948948
ZTRMYCGRDRAFT_110531
PFJMYCFIDRAFT_165332
FFUCLAFUR5_07226
BCOMBAUCODRAFT_75180
NPAUCRNP2_1990
TMLGSTUM_00003807001
SPOSPACUNK4.12c(mug138)
CNECNL05710
CNBCNBI1120
CNGCNAG_07805
CGICGB_D1300C
TMSTREMEDRAFT_73292
TASAA1Q1_07495
TVSTRAVEDRAFT_66168 TRAVEDRAFT_70638
DSQDICSQDRAFT_132271 DICSQDRAFT_172476
PCOPHACADRAFT_249147 PHACADRAFT_255847
SHSSTEHIDRAFT_118845
HIRHETIRDRAFT_31896
PSQPUNSTDRAFT_53482
ADLAURDEDRAFT_110880
FMEFOMMEDRAFT_109506 FOMMEDRAFT_113079 FOMMEDRAFT_149732 FOMMEDRAFT_156520 FOMMEDRAFT_160675 FOMMEDRAFT_160677 FOMMEDRAFT_160684 FOMMEDRAFT_160691 FOMMEDRAFT_160811 FOMMEDRAFT_164257 FOMMEDRAFT_170571 FOMMEDRAFT_170573 FOMMEDRAFT_20973 FOMMEDRAFT_73398 FOMMEDRAFT_74907 FOMMEDRAFT_75209 FOMMEDRAFT_84908 FOMMEDRAFT_94441 FOMMEDRAFT_94516
GTRGLOTRDRAFT_119876
LBCLACBIDRAFT_244036
MRRMoror_14816 Moror_16162 Moror_8369
MOREE1B28_006704 E1B28_009124 E1B28_009207
CCICC1G_01115
SCMSCHCODRAFT_65338
ABPAGABI1DRAFT68291(AGABI1DRAFT_68291)
ABVAGABI2DRAFT199158(AGABI2DRAFT_199158)
CPUTCONPUDRAFT_69841
SLASERLADRAFT_363280 SERLADRAFT_363284
WSEWALSEDRAFT_60480
WICJ056_002957
UMAUMAG_11953
PFPPFL1_05557
MGLMGL_1347
MRTMRET_4013
MSYMMSY001_0310
PGRPGTG_21124
MLRMELLADRAFT_39801
ECUECU06_0750
EINEint_060670
EHEEHEL_060690
EROEROM_060680
DDIDDB_G0287851
DPPDICPUDRAFT_151903 DICPUDRAFT_47068
DFADFA_01586
ACANACA1_074110
CPVcgd1_1680 cgd1_3840 cgd2_4270 cgd2_920 cgd2_930 cgd3_4170 cgd3_4180 cgd3_4200 cgd3_4210 cgd3_4220 cgd3_4240 cgd3_4250 cgd3_4260 cgd3_4270 cgd3_4280 cgd6_5520
CHOChro.10431 Chro.20103 Chro.20104 Chro.20459 Chro.30469 Chro.30474 Chro.30475
TGOTGME49_257010 TGME49_269885(TLN1)
TETTTHERM_000181089 TTHERM_00101300 TTHERM_00277260 TTHERM_00300360 TTHERM_00302040 TTHERM_00590330 TTHERM_00624110 TTHERM_00939020 TTHERM_01108740 TTHERM_01165230
PTMGSPATT00000195001 GSPATT00000651001 GSPATT00001153001 GSPATT00002867001 GSPATT00003529001 GSPATT00003618001 GSPATT00006701001 GSPATT00011043001 GSPATT00016702001 GSPATT00021051001 GSPATT00021367001 GSPATT00025091001 GSPATT00025546001 GSPATT00030786001 GSPATT00036196001 GSPATT00036837001 PTMB.304c
SMINv1.2.006079.t1(symbB.v1.2.006079.t1) v1.2.019310.t1(symbB.v1.2.019310.t1) v1.2.033058.t1(symbB.v1.2.033058.t1) v1.2.037748.t1(symbB.v1.2.037748.t1) v1.2.038222.t1(symbB.v1.2.038222.t1)
PTIPHATRDRAFT_18335 PHATRDRAFT_47985 PHATRDRAFT_50598
FCYFRACYDRAFT_201763 FRACYDRAFT_206890 FRACYDRAFT_209078 FRACYDRAFT_248059 FRACYDRAFT_263926
TPSTHAPSDRAFT_2118 THAPSDRAFT_262412
NGDNGA_0335320(IDE) NGA_0415400(IDE)
AAFAURANDRAFT_62143 AURANDRAFT_71803
PIFPITG_08991 PITG_17057
PSOJPHYSODRAFT_261837 PHYSODRAFT_519509
SPARSPRG_02382 SPRG_05446 SPRG_05468
EHXEMIHUDRAFT_110328 EMIHUDRAFT_449448 EMIHUDRAFT_449760 EMIHUDRAFT_461074 EMIHUDRAFT_471473 EMIHUDRAFT_65626 EMIHUDRAFT_74243 EMIHUDRAFT_74380 EMIHUDRAFT_97098
GTTGUITHDRAFT_106094 GUITHDRAFT_45298 GUITHDRAFT_70428
TBRTb927.8.7020
TBGTbgDal_VIII7240
TCR507389.70 509911.90
LMALMJF_31_3090(SCG5)
LIFLINJ_31_3210(SCG5)
LDOLDBPK_313210
LMILMXM_30_3090
LBZLBRM_31_3470(SCG5) LBRM_31_3520(SCG5)
LPANLPMP_312970(SCG5)
NGRNAEGRDRAFT_35474 NAEGRDRAFT_80868
PSHISAMEA2665130_0904(ptrA_1)
ALIGNCTC10568_02300(ptrA_2)
PPRPBPRA0963(SO3083)
PGBH744_2c1169
PDSCAY62_03750
PGHFH974_04225
GHOAL542_05190
SALYE8E00_03275
SKSFCN78_09570
SCOTHBA18_10055
MAQMaqu_2509
MHCMARHY2431
MADHP15_1211
MBSMRBBS_1376
MSRAU15_14415
MPQABA45_06415
MARIACP86_17050
MLQASQ50_03800
MSQBKP64_08400
MARAD0851_19455
MARJMARI_06460(ptrA)
SLOShew_2420
SSESsed_1634
SPLSpea_2592
SHLShal_2664
SWDSwoo_3021
SWPswp_3134
SVOSVI_2900
SPSWSps_01787
SMAVCFF01_07205
SBKSHEWBE_2214
ILOIL0991
ILIK734_04980
IPICEW91_08330
IDICWC33_01200
IDTC5610_03895
IABK5X84_04220
COMCMT41_05070
COZA3Q34_14970
COLWA3Q33_04075
COLADBO93_03930
COVEKO29_16380
CBERB5D82_02070
LSDEMK97_04385 EMK97_16295
THTE2K93_02625
THAPFNC98_10735
PHAPSHAa0972
PTNPTRA_a1117
PATPatl_1666
PSMPSM_A1042
PSEOOM33_07330
PIAPI2015_1017
PPHEPP2015_996
PBWD172_005810
PRRAT705_06700
PLZS4054249_05800
PALNB0W48_19665
PPISB1L02_02910
PEAPESP_a1256
PSPOPSPO_a0942
PARTPARC_a2780
PTUPTUN_a4060
PNGPNIG_a1176
PTDPTET_a1180
PSENPNC201_14055(ptrA1)
PDJD0907_05125
PAGAPAGA_a2651
PCARPC2016_0983
PMAACPA52_11170
PXIJ5O05_05815
PVBJ5X90_18335
PDVFFU37_10285
PSYMJ1N51_13485
AMCMADE_000001020955
AMACMASE_05820
AMBAMBAS45_06035
AMGAMEC673_05890
AMKAMBLS11_05880
ALTambt_12335
ASQAVL57_10035
AAWAVL56_09180
ALEAV939_09050
ALZAV940_08830
APELCA267_003210
SALMD0Y50_05675
GAGGlaag_2665
GPSC427_1902
PMESFX988_00965
LALAT746_06315
SALHHMF8227_01901
HMIsoil367_05960
FBLFbal_2625
FESHER31_10220
MVSMVIS_1042
MYAMORIYA_1941
MMAAFR932_12630
CJACJA_1334
CEBB0D95_01785
CELLCBR65_07700
CEKD0B88_09925
CEGD0C16_09115
TTUTERTU_1027
SAGAM5M_05838
SPOIIMCC21906_02681
ZALAZF00_11475
OSGBST96_15065
HJABST95_08460
HALCEY643_14320
KIMG3T16_13685
AFUSEYZ66_04525
MEINmethR_P0490
HCHHCH_02204 HCH_05001
HAHEENC22_07900
CSACsal_3023
HELHELO_3870
HCSFF32_08470
HAKKO116_03848
HAMHALO4126
HCOLOKO_03289(ptrA)
HSIBOX17_09635
HALOBWR19_01915
HHHCLM76_03365
HBEBEI_3284
HAGBB497_01400
HAFC8233_12560
HALKCUU95_03715
HVNEI420_02215
HMDCTT34_02525
HAXIHAALTHF_02350n
HTTHZS52_01715
HCAMI4484_02265
HPIZGYM47_02410
HSXHNO51_02180
HSVHNO53_02095
ZPLZBT109_0442
HAAA5892_18955
CMAIBFX80_01250
CAMHLCW13_15960
KUSB9G99_03100
KMAB9H00_12050
PAURFGL86_01425
MMWMmwyl1_2863
MPCMar181_1207
MPRIMP3633_1344
MARDIBG28_07535
MFOIJSY38_16220
TOLTOL_1037
TORR615_12240
OAIOLEAN_C23490
MARSA8C75_05415
MGEOCFI10_06685
BSANCHH28_17255
NCUF0U83_04670
NJPNEJAP_0991
NIKF5I99_13530
BMARHF888_11370
AJPAMJAP_0942
RFOREIFOR_02437
OMEOLMES_3488
LLPGH975_03325
AHAAHA_1997
AHYAHML_12920
AHDAI20_07215
AHRV428_13350
AHPV429_13370
AHJV469_09735
AHHRY45_12685
AHIVU14_09610
AAJBOQ57_12505
ASAASA_1875
AEOO23A_p1165
AVRB565_2232
AVOAMS64_10920
AMEDB224_2593
ASRWL1483_1605
ADHCK627_13850
AEMCK911_08195
AEAC2U39_09745
AESC2U30_04000
AELNCTC12917_01886(ptrA_2)
ASIMFE240_08940
AALLI6G90_03890
AJDI6H43_20265
ARIVKYK33_10450
TAUTola_2184
TBNTBH_C0846
CTRCT_806(ptr)
CTDCTDEC_0806(ptr)
CTFCTDLC_0806(ptr)
CTRDSOTOND1_00862
CTROSOTOND5_00860
CTRTSOTOND6_00860
CTACTA_0878(ptr)
CTYCTR_8111(ptr)
CRACTO_0878
CTRQA363_00869
CTRXA5291_00868
CTRZA7249_00867
CTRPL11322_00856
CTLJL1115_00856
CTLXL1224_00857
CTLLL1440_00859
CTBCTL0175(ptr)
CTRRL225667R_00857
CTLFCTLFINAL_00940
CTLICTLINITIAL_00940
CTLCTLon_0176(ptr)
CTRUL2BUCH2_00856
CTRLL2BLST_00856
CTRVL2BCV204_00856
CTRML2BAMS1_00856
CTLAL2BAMS2_00856
CTLML2BAMS3_00856
CTLSL2BAMS4_00856
CTLZL2BAMS5_00857
CTLCL2BCAN1_00857
CTLNL2BCAN2_00855
CTLBL2B795_00856
CTLQL2B8200_00856
CTOCTL2C_538
CTRNL3404_00855
CTJJALI_8121(ptr)
CTZCTB_8121(ptr)
CTGE11023_04280
CTKE150_04315
CTRBBOUR_00864
CTRESOTONE4_00859
CTRSSOTONE8_00864
CTECEC599_8481(ptr)
CTFWSWFP_8861(ptr)
CTRFSOTONF3_00860
CTCHO173_04510
CTNG11074_04270
CTQG11222_04305
CTVCTG9301_04285
CTWG9768_04275
CTRGSOTONG1_00861
CTRHSOTONIA1_00863
CTRJSOTONIA3_00863
CTRKSOTONK1_00860
CTJTCTJTET1_04470
CTCFCTRC69_04305
CTFSCTRC342_04500
CTHFCTRC852_04515
CTCJCTRC943_04275
CTHJCTRC953_04260
CTMJCTRC966_04285
CTTJCTRC971_04285
CTJSCTRC122_04415
CTRCCTRC55_04285
CTRWCTRC3_04320
CTRYCTRC46_04290
CTCTCTW3_04525
CMUTC_0190
CMURY015_01005
CMNBB17_01025
CMMNC80_00960
CMGNC81_00975
CMXDNC_00975
CMZTAC_01005
CPNCPn_0957(ide)
CPACP_0903
CPJide(ide)
CPTCpB0994
CLPCPK_ORF00372
CPMG5S_0078
CPECCPE3_0772
CPEOCPE1_0771(ide)
CPERCPE2_0772
CHPCPSIT_0862
CHBG5O_0851
CHSCPS0A_0881
CHICPS0B_0868
CHTCPS0D_0878
CHCCPS0C_0880
CHRCpsi_7971
CPSCB711_0929
CPSNB712_0871
CPSBB595_0929 B595_0930
CPSGB598_0867
CPSMB602_0872
CPSIB599_0867
CPSVB600_0926
CPSWB603_0871
CPSTB601_0870
CPSDBN356_8001
CAVM832_05800
CCACCA_00812(ide)
CABCAB782
CABOAB7_8631
CFECF0202(ide1) CF0203(ide2)
CGZM787_000880
CHLAC834K_0834(ptrA)
CSUIChls_210(ptr)
CBUEHBN95_01505
CSEEC10C_0930(ptrA)
PNLPNK_0535
PUVPUV_02500(IDE)
NEYNCS13_1_0125
WCHwcw_0398(ide)
SNGSNE_A18560
OBGVerru16b_00710(ptrA_1)
CECCE557_732
NLIG3M70_17290
 » show all
Reference
1  [PMID:3061785]
  Authors
Duckworth WC.
  Title
Insulin degradation: mechanisms, products, and significance.
  Journal
Endocr Rev 9:319-45 (1988)
DOI:10.1210/edrv-9-3-319
Reference
2  [PMID:2293021]
  Authors
Affholter JA, Hsieh CL, Francke U, Roth RA
  Title
Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
  Journal
Mol Endocrinol 4:1125-35 (1990)
DOI:10.1210/mend-4-8-1125
  Sequence
[hsa:3416]
Reference
3  [PMID:1689296]
  Authors
Duckworth WC, Hamel FG, Bennett R, Ryan MP, Roth RA.
  Title
Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.
  Journal
J Biol Chem 265:2984-7 (1990)
Reference
4  [PMID:2126597]
  Authors
Kuo WL, Gehm BD, Rosner MR
  Title
Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
  Journal
Mol Endocrinol 4:1580-91 (1990)
DOI:10.1210/mend-4-10-1580
  Sequence
Reference
5  [PMID:1733942]
  Authors
Ding L, Becker AB, Suzuki A, Roth RA.
  Title
Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III.
  Journal
J Biol Chem 267:2414-20 (1992)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.56
IUBMB Enzyme Nomenclature: 3.4.24.56
ExPASy - ENZYME nomenclature database: 3.4.24.56
BRENDA, the Enzyme Database: 3.4.24.56
CAS: 9013-83-6

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