KEGG   ENZYME: 3.4.24.59
Entry
EC 3.4.24.59                Enzyme                                 
Name
mitochondrial intermediate peptidase;
mitochondrial intermediate precursor-processing proteinase;
MIP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion
Comment
A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family)
History
EC 3.4.24.59 created 1993
Orthology
K01410  mitochondrial intermediate peptidase
Genes
HSA4285(MIPEP)
PTR467228(MIPEP)
PPS100984556(MIPEP)
GGO101137911(MIPEP)
PON100171586(MIPEP)
NLE100606156(MIPEP)
MCC707131(MIPEP)
MCF101865693
MTHB126940868
CSAB103249000(MIPEP)
CATY105591907(MIPEP)
PANU101015337(MIPEP)
TGE112611005(MIPEP)
RRO104669088(MIPEP)
RBB108531177(MIPEP)
TFN117098528(MIPEP)
PTEH111525023(MIPEP)
CANG105523796(MIPEP)
CJC100393887(MIPEP)
SBQ101049620(MIPEP)
CSYR103262397(MIPEP)
MMUR105855732(MIPEP)
LCAT123648841
PCOQ105814783(MIPEP)
OGA100966279(MIPEP)
MMU70478(Mipep)
MCAL110309115(Mipep)
MPAH110325414(Mipep)
RNO81684(Mipep)
MCOC116084555(Mipep)
MUN110556381(Mipep)
CGE100762716(Mipep)
MAUA101825843
PLEU114684073 114693826
MORG121435118
MFOT126507620
AAMP119800376
NGI103727184(Mipep)
HGL101696293(Mipep)
CPOC100717132(Mipep)
CCAN109682365
DORD105983366(Mipep)
DSP122112809
NCAR124985516
OCU100355371
OPI101515988
TUP102494013(MIPEP)
GVR103597803(MIPEP)
CFA477338(MIPEP)
CLUD112669526
VVP112918614(MIPEP)
VLG121497195
AML100466665(MIPEP)
UMR103664393(MIPEP)
UAH113251186(MIPEP)
UAR123791971
ELK111159900
LLV125096190
MPUF101679652(MIPEP)
ORO101377428(MIPEP)
EJU114212761(MIPEP)
ZCA113919171
MLX118009580(MIPEP)
NSU110570250
LWW102726046(MIPEP)
FCA101084847(MIPEP)
PYU121012737
PBG122480630
LRUF124510979
PTG102960672(MIPEP)
PPAD109266165(MIPEP)
AJU106988936(MIPEP)
HHV120247187
BTA517531(MIPEP)
BOM102279227(MIPEP)
BIU109566845(MIPEP)
BBUB102406548
BBIS104996857(MIPEP)
CHX102169023(MIPEP)
OAS101116412
ODA120882949
CCAD122447150
SSC100155148(MIPEP)
CFR102507392(MIPEP)
CBAI105066268(MIPEP)
CDK105096410(MIPEP)
VPC102544034(MIPEP)
BACU103011954(MIPEP)
LVE103089766(MIPEP)
OOR101290249(MIPEP)
DLE111175165(MIPEP)
PCAD102977708(MIPEP)
PSIU116743146(MIPEP)
ECB100058095(MIPEP)
EPZ103543675 103565839
EAI106832449
MYB102251949(MIPEP)
MYD102764825(MIPEP)
MMYO118650845
MLF102436308(MIPEP)
MNA107526928(MIPEP)
PKL118729008
HAI109387502(MIPEP)
DRO112313629(MIPEP)
SHON118994846
AJM119037293
PDIC114508689
PHAS123818903
MMF118622623
RFQ117021774(MIPEP)
PALE102893175(MIPEP)
PGIG120610643
PVP105293303(MIPEP)
RAY107520897
MJV108409083(MIPEP)
TOD119258775
SARA101556245(MIPEP)
LAV100676057(MIPEP)
TMU101348130
ETF101650395
DNM101437796(MIPEP)
MDO100024478(MIPEP)
GAS123240602
SHR100923419(MIPEP)
PCW110215608(MIPEP)
OAA100089996
GGA418942(MIPEP)
PCOC116244281(MIPEP)
MGP100548274
CJO107308297(MIPEP)
NMEL110389270(MIPEP)
APLA101800508(MIPEP)
ACYG106040392
AFUL116491099(MIPEP)
TGU100217619(MIPEP)
LSR110470754(MIPEP)
SCAN103827321(MIPEP)
PMOA120506736
OTC121342031
PRUF121364246
GFR102041723(MIPEP)
FAB101808582(MIPEP)
PHI102104433(MIPEP)
PMAJ107202032(MIPEP)
CCAE111923549(MIPEP)
CCW104690098
CBRC103613251(MIPEP)
ETL114057639(MIPEP)
ZAB102073516(MIPEP)
ACHL103810574(MIPEP)
FPG101912013(MIPEP)
FCH102050134(MIPEP)
CLV102093974(MIPEP)
EGZ104131696(MIPEP)
NNI104023098(MIPEP)
PLET104616398(MIPEP)
PCAO104047401
ACUN113485274(MIPEP)
TALA104366465
PADL103920198(MIPEP)
AFOR103908014(MIPEP)
ACHC115353343
HLE104835021(MIPEP)
AGEN126048260
GCL127026507
CCRI104167474(MIPEP)
EHS104516659(MIPEP)
CMAC104486989(MIPEP)
MUI104536330(MIPEP)
GSTE104262446(MIPEP)
LDI104345804
OHA104337322(MIPEP)
NNT104407524(MIPEP)
DPUB104307745(MIPEP)
ACAR104530581(MIPEP)
CPEA104392500(MIPEP)
CVF104291411(MIPEP)
CUCA104064221(MIPEP)
BRHI104488887(MIPEP)
AAM106500405(MIPEP)
AROW112966134(MIPEP)
NPD112956306(MIPEP)
TGT104578317(MIPEP)
DNE112988343(MIPEP)
SCAM104151606(MIPEP)
ASN102387822(MIPEP)
AMJ102565859(MIPEP)
CPOO109306656(MIPEP)
GGN109302225(MIPEP)
PSS102448704(MIPEP)
CMY102932805
CPIC101931175
TST117871104(MIPEP)
CABI116819323(MIPEP)
MRV120387781
ACS100565494(mipep)
PVT110088650(MIPEP)
SUND121925514
PBI103051948(MIPEP)
PMUR107288414(MIPEP)
CTIG120313877
TSR106549849(MIPEP)
PGUT117661491(MIPEP)
VKO123029280
PMUA114589709 114595732(MIPEP)
ZVI118084966(MIPEP)
GJA107117273(MIPEP)
STOW125431845
XLA108708717(mipep.L) 108709016(mipep.S)
XTR100497804(mipep)
NPR108800063(MIPEP)
RTEM120929225
BGAR122931395
DRE100005953(mipep) 557349(si:ch73-1a9.4)
SRX107724959 107743467
SANH107679518 107699841(mipep)
SGH107565260 107592667
CCAR109058308(mipep)
CAUA113054514 113058749(mipep)
PPRM120478648(mipepa) 120482510(mipepb)
MAMB125248214(mipepa) 125262273(mipepb)
IPU108277681(mipepa)
PHYP113539081(mipep)
SMEO124394429(mipepa)
TFD113643509(mipepa)
AMEX103023218(mipep)
EEE113578643
TRU101077714(mipep)
TNGGSTEN00008730G001
LCO104921133(mipep)
CGOB115017311(mipep)
ELY117260108
EFO125889387(mipepb)
PLEP121943405
SLUC116043867
ECRA117941789
ESP116679956(mipep)
PFLV114552445(mipep)
GAT120829019
PPUG119210095
MSAM119883095
CUD121520345(mipepa)
ALAT119010273
MZE101479497(mipep)
ONL100692688(mipep)
OAU116330413
OLA101155870(mipep)
OML112153360
XMA102233165(mipep)
XCO114133335(mipep)
XHE116708068(mipep)
PRET103474376(mipep)
PFOR103154586(mipep)
PLAI106945119(mipep)
PMEI106915095(mipep)
GAF122832619
CVG107103504(mipep)
CTUL119784018
GMU124883819
NFU107380675(mipep)
KMR108238157(mipepa)
ALIM106533599(mipep)
NWH119411201(mipepa)
AOCE111588941(mipep)
MCEP125013397
CSEM103377613(mipep)
POV109634593(mipep)
SSEN122773484
HHIP117773468
HSP118105885
LCF108873787
SDU111239092(mipep)
SLAL111654557(mipep)
XGL120791561
HCQ109512836(mipep)
BPEC110171875(mipep)
MALB109960392(mipep)
BSPL114867844
SASA106567911 106581117
STRU115148927 115163509
OTW112257800(mipepb) 112265591
OMY110507837(mipepa) 110537429(mipepb)
OGO123992671 123998737(mipepb)
ONE115105590 115136678
SALP111981387 112080734
SNH120018147 120045167
CCLU121558721 121573601
ELS105007223 105019419(mipep)
SFM108932349(mipep)
PKI111844852(mipep)
AANG118210434 118235986
LOC102693278(mipep)
PSPA121302843(mipepa)
ARUT117406361 117407539
PSEX120523821
LCM102353862(MIPEP)
CMK103183271
RTP109921485(mipep)
BFO118427438
BBEL109484994
CIN100179312 113473986
SCLV120338927
SPU585883
APLC110988415
AJC117100500
SKO102800854
DMEDmel_CG7791(CG7791)
DER6542312
DSE6619128
DSIDsimw501_GD10350(Dsim_GD10350)
DYADyak_GE19442
DAN6496673
DSR110189357
DPO4804848
DPE6602133
DMN108158705 117192990
DWI6652527
DGR6560244
DMODmoj_GI19399
DAZ108615426
DNV108654463
DHE111597721
DVI6625531
CCAT101451366
BOD106627878
RZE108357159 108379930
MDE101891459
SCAC106089823
LCQ111680043
LSQ119612023
HIS119646320
AGAAgaP_AGAP007728
ACOZ120947579
AARA120904105
ASTE118510146
AAG110675343 5578217
AALB109410006
CQUCpipJ_CPIJ010570
CPII120422860
CNS116340058
BCOO119073842
AME412784
ACER108000241
ALAB122713472
BIM100740934
BBIF117207790
BVK117238229
BVAN117160058
BTER100642335
BPYO122570881
CCAL113463795
OBB114874010
MGEN117225146
NMEA116429862
CGIG122404035
SOC105201761
MPHA105840584
AEC105151479
ACEP105619885
PBAR105425223
VEM105566279
HST105187249
DQU106741274
CFO105252786
FEX115238890
LHU105679570
PGC109857877
OBO105287520
PCF106790038
PFUC122518205
VPS122630953
NVI100119769
CSOL105367870
TPRE106651627
MDL103577148
CGLO123261594
FAS105271480
DAM107046011
AGIF122854251 122855278
CINS118065965
LHT122508292
CCIN107264064
TCA662652
SOY115885731
ATD109595159
CSET123311354
AGB108916402
LDC111502186
NVL108569082
PPYR116175054
OTU111418009
BMOR101741797
BMAN114247457
MSEX115448447
DPLKGM_215726
BANY112050122
NIQ126770007
PMAC106715991
PPOT106099348
PXU106124437
PRAP111001867
PBX123714557
PNAP125059945
ZCE119838763
CCRC123694816
HAW110372900
HZE124645541
TNL113502054
SLIU111353344
OFU114354254 114360438
PXY105395962
CFEL113376917
API100159686
DNX107166347
AGS114121186
RMD113550179
BTAB109041203
DCI103514916
CLEC106672676
HHAL106683881
NLU111049265 120355320
PHUPhum_PHUM381090
FOC113209011
ZNE110840240
CSEC111868515
SGRE126356844
FCD110858809
DPXDAPPUDRAFT_107701
DMK116934371
DPZ124321139
PVM113810986
PJA122247222
PCHN125024901
HAME121873300
PCLA123756908
PTRU123509795
HAZT108666201
LSM121119021
PPOI119096805
ISCIscW_ISCW016804
DSV119441521
RSAN119386678
RMP119178257
VDE111245339
VJA111271513
TUT107366416
DPTE113789202
DFR124491471
CSCU111628542
PTEP107438074
SDM118182111
CELCELE_Y67H2A.7(Y67H2A.7)
CBRCBG_01792
BMYBM_BM7010(Bm7010)
LOALOAG_02623
NAINECAME_02371
TSPTsp_03383
HROHELRODRAFT_161462
LGILOTGIDRAFT_198714
PCAN112555701
BGT106061390
GAE121372889
HRF124130913
HRJ124281138
CRG105341064
MYI110466918
PMAX117343026
MMER123555212
OBI106879897
OSN115209842
LAK106152488 106164240
SMMSmp_075220.1
SHXMS3_00004308
OVIT265_11166
EGLEGR_01229
NVE5514962
EPA110240373
ATEN116306357
ADF107331392
AMIL114960754
PDAM113686917
SPIS111319500
DGT114519994
XEN124442352
HMG100203118
TADTRIADDRAFT_51263
AQU105313764
ATHAT5G51540
ALY9301940
CRB17874842
CSAT104725663 104726278 104761154
EUSEUTSA_v10012823mg
BRP103857178
BNA106345886 106387932
BOE106329452
RSZ108844096
THJ104811515
CPAP110823525
CIT102620869
CICCICLE_v10004402mg
PVY116124236
MINC123197777
TCC18605385
GRA105801745
GHI107904641 121209573
GAB108454428
DZI111289717
EGR104424338
GMX100794972
GSJ114409373
PVUPHAVU_005G006700g
VRA106762665
VAR108334127
VUN114186551
CCAJ109813038
APRC113846714
MTR11417823
CAM101509522
PSAT127086060
LJALj0g3v0319349.1(Lj0g3v0319349.1) Lj0g3v0319349.2(Lj0g3v0319349.2)
ADU107491534
AIP107641590
AHF112752052 112803108
LANG109328828
FVE101314141
RCN112173522
PPER18787218
PMUM103333334 103333437
PAVI110764650
PDUL117619326
MDM103439650
PXB103959845 103961971
ZJU107414304 107414694
MNT21387870
CSV101210211
CMO103483995
BHJ120085149
MCHA111011592
CMAX111471087
CMOS111446997
CPEP111782043
RCU8266048
JCU105648591
HBR110648092
MESC110600246
POP7481823
PEU105137609
PALZ118056340
JRE109014092
CILL122307717
QSU111984144 112020495 112030514
QLO115960099
TWL120004067
VVI100262804
VRI117933773
SLY101249800
SPEN107015509
SOT102584257
SSTN125860177
CANN107863420
NTA107811967 107815534
NSY104225794
NTO104111565
NAU109205949
INI109193780
ITR116000478
SIND105160579
OEU111406064
EGT105971680
SSPL121779652 121782611 121782651
APAN127256274
HAN110872840
ECAD122585903
LSV111904041
CCAV112502199
DCR108223767
CSIN114256931
BVG104888673
SOE110782383
CQI110692985 110697259
NNU104611543
MING122086741
TSS122664154
PSOM113297122
OSA4341884
DOSAOs06t0686500-01(Os06g0686500)
OBR102717808
BDI100825697
ATS109780722
TDC119331284 119340839
TAES123148916 123159030 123165915
TUA125531096
LPER127326680
SBI8061641
ZMA100384686
SITA101782826
SVS117851525
PVIR120668537 120704280
PHAI112888941
PDA103698068
EGU105043263
MUS103983048
ZOF121981434 121985311
DCT110100890
PEQ110031231
AOF109837777
NCOL116253536
ATR18444248
SMOSELMODRAFT_416778 SELMODRAFT_420134
PPP112293047
CRECHLRE_02g073400v5
VCNVOLCADRAFT_88756
MNGMNEG_0600
CSLCOCSUDRAFT_65943
CVRCHLNCDRAFT_28509
APROF751_3907
OLUOSTLU_625
OTAOT_ostta10g00160
BPGBathy11g00610
MISMICPUN_84836
MPPMICPUCDRAFT_54794
CMECYME_CMS132C
GSLGasu_00790
CCPCHC_T00003664001
SCEYKL134C(OCT1)
SEUBDI49_3245
SPAOSPAR_K00830
AGOAGOS_AFR198W
ERCEcym_6099
KLAKLLA0_B12397g
KMXKLMA_30114(OCT1)
LTHKLTH0D04730g
VPOKpol_297p8
ZROZYRO0G20130g
CGRCAGL0D02112g
NCSNCAS_0A04280(NCAS0A04280)
NDINDAI_0E02010(NDAI0E02010)
TPFTPHA_0G02390(TPHA0G02390)
TBLTBLA_0I00710(TBLA0I00710)
TGBHG536_0A03640
TDLTDEL_0A02080(TDEL0A02080)
KAFKAFR_0D02950(KAFR0D02950)
KNGKNAG_0A06200(KNAG0A06200)
ZMKHG535_0D02930
PPAPAS_chr2-1_0435
DHADEHA2G04928g
PICPICST_89481(OCT1)
PGUPGUG_02947
SPAASPAPADRAFT_73048
LELLELG_04645
CALCAALFM_C600340CA(CaO19.1195)
CTPCTRG_03003
COTCORT_0F04490
CDUCD36_60290
CTENCANTEDRAFT_128793
YLIYALI0A09988g
CLUCLUG_01559
CLUSA9F13_06g03850
CAURCJI97_000525
SLBAWJ20_321(OCT1)
PKZC5L36_0D04260
BNNFOA43_000659
BBRXBRETT_003277
OPAHPODL_00478
SLUDSCDLUD_003991
NCRNCU02063
NTENEUTE1DRAFT149413(NEUTE1DRAFT_149413)
SMPSMAC_04958
PANPODANSg5754
TTTTHITE_2113856
MTMMYCTH_2295923
CTHRCTHT_0053100
MGRMGG_00487
PPEIPpBr36_08682
TMNUCRPA7_4786
SSCKSPSK_02243
FGRFGSG_06865
FPUFPSE_11800
FVRFVEG_05121
FOXFOXG_01961
NHENECHADRAFT_37934
TRETRIREDRAFT_76502
TRRM419DRAFT_97114
MAWMAC_01004
MAJMAA_05729
CMTCCM_02324
PLJVFPFJ_05375
VDAVDAG_04118
CFJCFIO01_13233
CLUPCLUP02_05607
CHIGCH63R_00726
PFYPFICI_01843
SSLSS1G_01296
BFUBCIN_11g05560
MBEMBM_01310
PSCOLY89DRAFT_499062
GLZGLAREA_02057
AFMAFUA_6G08640
ACTACLA_083770
NFINFIA_054290
AORAO090001000525
ANGANI_1_762094(An11g05710)
AFVAFLA_012647
ALUCAKAW2_80504S(OCT1)
ACHEACHE_80654A(OCT1)
APUUAPUU_40466S(OCT1)
PCSPc12g11360
PDPPDIP_79610
TMFPMAA_029760
TRGTRUGW13939_05941
CIMCIMG_01084
CPWCPC735_052840
UREUREG_01022
PBLPAAG_01110
PBNPADG_03721
ABEARB_04967
TVETRV_06295
AJEHCAG_03742
BGHBDBG_05514
PNOSNOG_15771
PTEPTT_01260
BZECOCCADRAFT_80567
BSCCOCSADRAFT_33610
BORCOCMIDRAFT_34128
AALTCC77DRAFT_1016661
ZTRMYCGRDRAFT_49589
PFJMYCFIDRAFT_33481
FFUCLAFUR5_12809
BCOMBAUCODRAFT_63450
NPAUCRNP2_3116
TMLGSTUM_00006809001
SPOSPAC1F3.10c(oct1)
CNECNB02140 CNC03660
CNBCNBB3570 CNBC3550
CNGCNAG_02741 CNAG_03718
CGICGB_B5340C CGB_C5520C
TMSTREMEDRAFT_71704
TASAA1Q1_06138
PPLPOSPLDRAFT_115378(mip) POSPLDRAFT_43376
TVSTRAVEDRAFT_138945
DSQDICSQDRAFT_95687
PCOPHACADRAFT_214439 PHACADRAFT_214974
SHSSTEHIDRAFT_70842
HIRHETIRDRAFT_59033
PSQPUNSTDRAFT_79927
ADLAURDEDRAFT_82840
FMEFOMMEDRAFT_105679(mip)
GTRGLOTRDRAFT_52549
LBCLACBIDRAFT_181082(mip)
CCICC1G_01835
ABPAGABI1DRAFT67360(mip)
ABVAGABI2DRAFT213738(AGABI2DRAFT_213738)
MPRMPER_11852
MRRMoror_317
MOREE1B28_001422(OCT1)
SCMSCHCO_02684301(SCHCODRAFT_02684301)
CPUTCONPUDRAFT_161656
SLASERLADRAFT_444624(mip1)
WSEWALSEDRAFT_51823
WICJ056_003994
UMAUMAG_02435
PFPPFL1_01578
MGLMGL_3874
MRTMRET_3777
MSYMMSY001_2285
PGRPGTG_11819
MLRMELLADRAFT_36998
MBRMONBRDRAFT_33521
DDIDDB_G0295743
DPPDICPUDRAFT_96831
DFADFA_04512
ACANACA1_390930
PFAPF3D7_1337000
PFHPFHG_02938
PREIPRSY57_1336000
PGABPGSY75_1337000
PYOPY17X_1355900
PCBPCHAS_1355400
PBEPBANKA_1350800
PVVPVVCY_1305350
PKNPKNH_1264300
PVXPVX_082780
PCYPCYB_122580
TANTA20475
TPVTP01_0515
TOTTOT_010001186
BEQBEWA_002700
BBOBBOV_III002610
BMICBMR1_03g00560
BBIGBBBOND_0304270
TGOTGME49_272670
TETTTHERM_00152030
SMINv1.2.007151.t2(symbB.v1.2.007151.t2) v1.2.007151.t4(symbB.v1.2.007151.t4) v1.2.007151.t5(symbB.v1.2.007151.t5)
PTIPHATRDRAFT_24006
FCYFRACYDRAFT_136715
TPSTHAPSDRAFT_263784
NGDNGA_0478710
PIFPITG_08197
PSOJPHYSODRAFT_565255
SPARSPRG_00112
GTTGUITHDRAFT_75461
TBRTb10.6k15.0490
TBGTbgDal_X11990
TCR504147.80
LMALMJF_36_4450
LIFLINJ_36_4670
LDOLDBPK_364670
LMILMXM_36_4450
LBZLBRM_35_4690
LPANLPMP_354560
NGRNAEGRDRAFT_71343 NAEGRDRAFT_80457
 » show all
Reference
1  [PMID:1560019]
  Authors
Isaya G, Kalousek F, Rosenberg LE.
  Title
Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase.
  Journal
J Biol Chem 267:7904-10 (1992)
Reference
2  [PMID:1518864]
  Authors
Isaya G, Kalousek F, Rosenberg LE.
  Title
Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue.
  Journal
Proc Natl Acad Sci U S A 89:8317-21 (1992)
DOI:10.1073/pnas.89.17.8317
  Sequence
[rno:81684]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.59
IUBMB Enzyme Nomenclature: 3.4.24.59
ExPASy - ENZYME nomenclature database: 3.4.24.59
BRENDA, the Enzyme Database: 3.4.24.59
CAS: 136447-30-8

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