| Entry |
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| Name |
mitochondrial intermediate peptidase;
mitochondrial intermediate precursor-processing proteinase;
MIP
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion
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| Comment |
A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family)
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| History |
EC 3.4.24.59 created 1993
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| Orthology |
| K01410 | mitochondrial intermediate peptidase |
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| Genes |
» show all
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| Reference |
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| Authors |
Isaya G, Kalousek F, Rosenberg LE. |
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| Title |
Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase. |
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| Journal |
J Biol Chem 267:7904-10 (1992) |
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| Reference |
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| Authors |
Isaya G, Kalousek F, Rosenberg LE. |
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| Title |
Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.59 |
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