KEGG   ENZYME: 3.4.24.61
Entry
EC 3.4.24.61                Enzyme                                 
Name
nardilysin;
N-arginine dibasic convertase;
NRD-convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of polypeptides, preferably at -Xaa!Arg-Lys-, and less commonly at -Arg!Arg-Xaa-, in which Xaa is not Arg or Lys
Comment
Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and N-ethylmaleimide. In peptidase family M16 (pitrilysin family)
History
EC 3.4.24.61 created 1995
Orthology
K01411  nardilysin
Genes
HSA4898(NRDC)
PTR456852(NRDC)
PPS100988880(NRDC)
GGO101131269(NRDC)
PON100452780(NRDC)
NLE100601344(NRDC)
MCC106998623(NRDC)
MCF102123458(NRDC)
CSAB103224822(NRDC)
CATY105596050(NRD1)
PANU101003896(NRDC)
TGE112605532(NRDC)
RRO104667840(NRDC)
RBB108531801(NRDC)
TFN117092595(NRDC)
PTEH111523852(NRDC)
CJC100398602(NRDC)
SBQ101038268 101040617(NRD1)
CSYR103263759(NRDC)
MMUR105877540(NRDC)
OGA100947089(NRDC)
MMU230598(Nrd1)
MCAL110292131(Nrdc)
MPAH110322876(Nrdc)
RNO25499(Nrdc)
MCOC116096388(Nrdc)
MUN110563667(Nrdc)
CGE100752575(Nrdc)
MAUA101836888(Nrdc)
PLEU114706407(Nrdc)
MORG121448065(Nrdc)
NGI103730258(Nrdc)
HGL101716146(Nrdc)
CPOC100722594(Nrdc)
CCAN109684273 109693362
DORD105989986(Nrd1)
DSP122106873(Nrdc)
NCAR124982544
OCU100358011(NRDC)
OPI101524179(NRDC)
TUP102500973(NRDC)
CFA475354(NRDC)
VVP112914724(NRDC)
VLG121481630(NRDC)
AML100480818(NRDC)
UMR103670723(NRDC)
UAH113254680(NRDC)
UAR123793703(NRDC)
ELK111142972
LLV125098373
MPUF101669903(NRD1)
ORO101385286(NRD1)
EJU114212093(NRDC)
ZCA113932022(NRDC)
MLX118019417(NRDC)
FCA101088678(NRDC)
PYU121017645(NRDC)
PBG122482162(NRDC)
PTG102958230(NRDC)
PPAD109266886(NRDC)
AJU106973783(NRDC)
HHV120235993(NRDC)
BTA511254(NRDC)
BOM102275032(NRDC)
BIU109556309(NRDC)
BBUB102408119(NRDC)
CHX102168408(NRDC)
OAS101111671(NRDC)
ODA120856123(NRDC)
CCAD122429133(NRDC)
SSC100514906(NRDC)
CFR102510363(NRDC)
CBAI105066459(NRD1)
CDK105092959(NRDC)
VPC102526245(NRDC)
BACU103015976(NRDC)
LVE103070846(NRDC)
OOR101284672(NRD1)
DLE111175802(NRDC)
PCAD102987507(NRDC)
PSIU116763012(NRDC)
ECB100050978(NRDC)
EPZ103550636(NRDC)
EAI106826012(NRDC)
MYB102253301(NRDC)
MYD102760071(NRDC)
MMYO118675367(NRDC)
MLF102425320(NRDC)
MNA107535418(NRDC)
PKL118724209(NRDC)
HAI109372586(NRDC)
DRO112314537(NRDC)
SHON118985000(NRDC)
AJM119051802(NRDC)
PDIC114498125(NRDC)
PHAS123831338(NRDC)
MMF118626585(NRDC)
RFQ117027335(NRDC)
PALE102880364(NRDC)
PGIG120620884(NRDC)
PVP105299010(NRDC)
RAY107497913(NRDC)
MJV108403252
TOD119235151(NRDC)
SARA101544339(NRD1)
LAV100656401(NRDC)
TMU101360391
DNM101440131(NRDC)
MDO100011053(NRDC)
GAS123247540(NRDC)
SHR100924924(NRDC)
PCW110209339(NRDC)
OAA100078629(NRDC)
GGA424635(NRDC)
PCOC116234608(NRDC)
MGP100540908(NRDC)
CJO107317638(NRDC)
NMEL110402355(NRDC)
APLA101803139(NRDC) 101804476
ACYG106032938 106033019(NRD1)
AFUL116491874 116491876(NRDC)
TGU100220278(NRDC)
LSR110469978(NRDC)
SCAN103815013(NRDC)
PMOA120503185(NRDC)
OTC121344960(NRDC)
PRUF121361949(NRDC)
GFR102041804(NRDC)
FAB101806826(NRDC)
PHI102102617(NRDC)
PMAJ107208044(NRDC)
CCAE111932898(NRDC)
CCW104695202(NRDC)
ETL114062596(NRDC)
ZAB102073514(NRDC)
FPG101917899(NRDC)
FCH102059699(NRDC)
CLV102084824(NRDC)
EGZ104131495(NRD1)
NNI104009362(NRD1)
ACUN113482813(NRDC)
TALA104367284(NRDC)
PADL103912457(NRD1)
ACHC115349125(NRDC)
AAM106491058(NRDC) 106491065
AROW112975953 112976070(NRDC)
NPD112943009(NRDC) 112959889
DNE112986008 112986349(NRDC)
ASN102378462 102381928(NRDC)
AMJ102569440 102573951(NRDC)
CPOO109307467(NRDC) 109307489
GGN109286664(NRDC) 109305303
PSS102453754(NRDC) 102458989
CMY102932297 102942086(NRDC)
CPIC101936503(NRDC) 101941153
TST117881398(NRDC) 117881752
CABI116817919(NRDC) 116825217
MRV120370085 120370211(NRDC)
ACS100557559(nrdc) 100563662
PVT110073801 110076154(NRDC)
SUND121928181(NRDC) 121929831
PBI103049165(NRDC) 103052515
PMUR107283057(NRDC) 107293690
TSR106541090(NRD1)
PGUT117664220(NRDC) 117668346
VKO123019048 123023390(NRDC)
PMUA114599009(NRDC) 114601355
ZVI118088717(NRDC) 118090098
GJA107111063(NRDC) 107119142
STOW125433979(NRDC) 125439504
XLA108714316(nrdc.L) 108715597(nrdc.S)
XTR100489182(nrdc)
NPR108783827(NRDC)
RTEM120945920(NRDC)
BBUF120978968(NRDC)
BGAR122943286(NRDC)
DRE557565(nrd1b) 565850(nrd1a)
SRX107706405 107728531 107738192
SANH107659423 107669832 107684410
SGH107558778 107591325(nrdc) 107592727
CCAR109056763 109078041(nrdc)
CAUA113039633 113040108 113045469 113119216
PPRM120480440(nrd1a) 120486552(nrd1b)
MAMB125251352(nrd1a) 125251739(nrd1b)
IPU108268052(nrd1a) 108271269(nrd1b)
PHYP113532048 113540477
SMEO124387311(nrd1a) 124391124(nrd1b)
TFD113647137(nrd1a) 113657794(nrd1b)
AMEX103026065 103040156(nrdc)
EEE113574543(nrdc)
TRU101064303 101079943
TNGGSTEN00010043G001 GSTEN00031930G001
LCO104926594 104938183(nrdc)
NCC104944829 104966241
CGOB115007362 115027503
ELY117254122 117267131
PLEP121941064 121953842(nrd1a)
SLUC116057499 116059138
ECRA117935849(nrd1a) 117950782
PFLV114546866 114561154
GAT120824473 120832784
PPUG119216831 119227364
MSAM119900204 119910291
CUD121512861(nrd1b) 121526494
ALAT119004497 119028816(nrd1b)
MZE101463970 101487937
ONL100693897 100705136
OAU116323240(nrd1b) 116326064
OLA101158595 101160369(nrdc)
OML112137026 112142844(nrd1a)
XMA102226814 102233104
XCO114134205 114141358
XHE116709045 116725615
PRET103458461(nrdc)
PFOR103156364 103156896
PLAI106939079 106959795
PMEI106910101 106929735(nrdc)
GAF122838498(nrd1b) 122846358(nrd1a)
CVG107093038 107100499
CTUL119775610(nrd1a) 119791238(nrd1b)
GMU124855445(nrd1a) 124873244(nrd1b)
NFU107392128(nrdc)
KMR108236583(nrd1a)
ALIM106518483(nrd1) 106537281
NWH119427375 119430362(nrd1b)
AOCE111563171 111567705
CSEM103380052 103399222(nrdc)
POV109636417(nrdc) 109646267
SSEN122780930 122783126
HHIP117756171 117760468
HSP118116556 118120780(nrd1b)
LCF108874942 108883383(nrdc)
SDU111225500 111227509(nrdc)
SLAL111670160 111671724(nrdc)
XGL120790402(nrd1b) 120795466
HCQ109506832 109517479
BPEC110153439 110165601(nrdc)
MALB109965264(nrdc) 109968018
BSPL114848712 114853343(nrd1b)
SASA106574483 106574586 106575437(NRDC) 106613566(NRDC)
OTW112250679 112255133 112266380
OMY110497079 110524082 110528861
OGO123997383(nrd1b) 124007888 124011355
ONE115108122
SALP111975584(nrdc)
SNH120033523 120054645
ELS105006736 105011400(nrdc)
SFM108935237(nrdc)
PKI111838950
AANG118225279(nrd1b) 118228850
LOC102692629(nrdc)
PSPA121326683(nrd1a) 121330705
ARUT117409623 117417124
LCM102357193(NRDC)
CMK103182811
RTP109928327(nrdc)
BFO118431674
BBEL109477516
SCLV120325960
SPU115918983 583323
APLC110977411
SKO100367295
DMEDmel_CG2025(Nrd1)
DER6546142 6551169
DSE6619923
DSIDsimw501_GD15963(Dsim_GD15963) Dsimw501_GD17647(Dsim_GD17647)
DYADyak_GE17590 Dyak_GE19720 Dyak_GE23250
DAN6502198
DSR110187063 110188056
DPODpse_GA15192 Dpse_GA22625 Dpse_GA22690 Dpse_GA25767 Dpse_GA28786 Dpse_GA29049
DPE6589623 6597280 6598118 6602869 6602911
DMN108156889 108160627 108161132 108165171 117185815 117186941 117186944 117186946 117186950 117186966 117191134
DWI6644959 6652825
DGR6565550
DMODmoj_GI13200 Dmoj_GI16413
DAZ108612907 108618868
DNV108652573 108656160
DHE111603014 111604780
DVI6623285 6633454
CCAT101456228
BOD106617198
MDE101901434
SCAC106093313
LCQ111689676 111689678
LSQ119602754 119602760
HIS119654406
AGAAgaP_AGAP010315
ACOZ120959173
AARA120900724
ASTE118517700
AAG5572851
AALB109397745 109428780 115253889
CQUCpipJ_CPIJ002524
CPII120431822
CNS116342296 116350735
BCOO119071058 119084936 119085010
AME552055
ACER108003915
ALAB122717012
BIM100740842
BBIF117217163
BVK117236562
BVAN117154622
BTER100649976
BPYO122576187
CCAL108623354
OBB114876640
MGEN117226915
NMEA116425867
CGIG122401328
SOC105192991
MPHA105830239
AEC105143891 105143897 105143902 105143911 105144350 105148419 105148479 105148691 105149631 105149956 105153016 105153017
ACEP105619096 105619183 105621301 105622483 105626518 105627623 105627624 105627630 105627631 105627632
VEM105569399
HST105191362
DQU106745551
CFO105254177
FEX115238664
LHU105669858
PGC109860275
OBO105275341
PCF106789008
PFUC122514606
VPS122634162
NVI100114249 103316787
CSOL105359784
TPRE106654272 106655552
MDL103571193
CGLO123262107
FAS105268729
AGIF122852005 122860097
CCIN107266405
TCA655191
DPA109544823
SOY115889948
ATD109609595
AGB108915507
LDC111507213
NVL108559150
APLN108743237 108744008
PPYR116175428 116175594
OTU111427127
BMOR101747181
BMAN114246755
MSEX115455658
DPLKGM_207023
BANY112048415
PMAC106714539
PPOT106109232
PXU106117856
PRAP110997357
ZCE119833267
HAW110370817
TNL113503180
SLIU111359948
OFU114350895
PXY105384018
API100574580
DNX107174190
AGS114127077
RMD113554904
BTAB109043031
DCI103507370
CLEC106666326
HHAL106684215
NLU111045936 111063205 120351101
PHUPhum_PHUM248990
FOC113206316 113206324
TPAL117641090
ZNE110833719
FCD110843278 110846927
DPXDAPPUDRAFT_57907
DMK116916625
PVM113810942
PJA122262997
PCHN125032631
HAME121855673
PCLA123747402
PTRU123507439
HAZT108682516
EAF111718116
LSM121123896 121132367
PPOI119108325
ISCIscW_ISCW011140
DSV119430961
RSAN119376181
RMP119176488
VDE111244755 111254068 111254156 111255503
VJA111265935 111265936 111267563 111268613
TUT107365154
DPTE113790980
DFR124496114
HROHELRODRAFT_161568
LGILOTGIDRAFT_233049
PCAN112573820
BGT106066516
GAE121373873
HRF124142854
HRJ124275297
CRG105319154
MYI110465454
PMAX117325498
MMER123524304
OBI106869430
OSN115222306
LAK106157117 106161938
SMMSmp_061510.1 Smp_155220 Smp_156960.1
SHXMS3_0019239
OVIT265_02427 T265_12838
NVE5502422
EPA110231611
ATEN116297118
ADF107354324 107358130
AMIL114963248 114971391
PDAM113676880
SPIS111323106
XEN124438149
HMG100207616
AQU105312649 105313469
ATHAT1G06900
ALY9324600 9328426
CRB17899210
CSAT104730881 104739254 104759101 104773569 104778592
EUSEUTSA_v10006660mg
BRP103836464 103843999 103854597
BNA106362217 106368996 106401128 106402919 106403009
BOE106295394 106310341 106312264
RSZ108805346 108813477 108823061 108833983
THJ104800786
CPAP110823601
CIT102618109
CICCICLE_v10000133mg
PVY116107576
MINC123218369
TCC18591087
GRA105789063
GHI107927136 107963825
GAB108483371
DZI111286756
EGR104434139
GMX100797049 100799924
GSJ114375761 114395976
PVUPHAVU_006G0775000 PHAVU_006G0775001
VRA106752493
VAR108342975
VUN114188153
CCAJ109816878
APRC113848997
MTRMTR_3g466820 MTR_5g095180
CAM101502355 101513223
LJALj0g3v0009849.1(Lj0g3v0009849.1) Lj4g3v1983560.1(Lj4g3v1983560.1) Lj6g3v0315180.1(Lj6g3v0315180.1) Lj6g3v0315180.2(Lj6g3v0315180.2)
ADU107473923
AIP107641648
AHF112719891 112793976
LANG109329693
FVE101297043 101304082 101304372 101308581
RCN112164565 112164566 112164859 112168412 112176718
PPER18772714 18774999
PMUM103340273
PAVI110750804
PDUL117632102
MDM103418044 103447270
PXB103945922 103963300
ZJU107411437
MNT21393960
CSV101207129
CMO103502959
BHJ120088179
MCHA111018034
CMAX111484420
CMOS111448618
CPEP111777374
RCU8279155
JCU105638720
HBR110663554
MESC110609104
POP7464726
PEU105123206
PALZ118054006
JRE108996935
QSU112024965
QLO115984675
TWL120001473
VVI100251821
VRI117915652
SLY101261473
SPEN107011183
SOT102584781
CANN107842726
NTA107765001 107776904
NSY104229059
NTO104090844
NAU109229213
INI109156361
ITR116025313
SIND105163864
OEU111377179 111390541
EGT105961748
SSPL121743847 121811589
HAN110873396
ECAD122607136 122607278
LSV111876522
CCAV112518115
DCR108204298
CSIN114301594
BVG104900286
SOE110797389
CQI110684222 110684645
NNU104594500
MING122083631
TSS122670679
PSOM113310161 113322082
NCOL116254307
OSA4332762
DOSAOs03t0336300-01(Os03g0336300)
OBR102715651
BDI100824526
ATS109761452
TDC119285602 119296220
TAES123085800 123092204
TUA125551397
SBI8082333
ZMA103639163
SITA101756486
SVS117836775
PVIR120652443 120687973
PHAI112875002
PDA103702128
EGU105044814
MUS103996967
DCT110104695
PEQ110022009
AOF109850836
ATR18432284
SMOSELMODRAFT_154839 SELMODRAFT_157708
PPP112279591 112282358
VCNVOLCADRAFT_94734
MNGMNEG_4161
CSLCOCSUDRAFT_27509
CVRCHLNCDRAFT_138430
APROF751_0466
OLUOSTLU_45399
OTAOT_ostta04g00870
BPGBathy14g01200
MISMICPUN_55952
MPPMICPUCDRAFT_16352
MBRMONBRDRAFT_34450
SREPTSG_01878
SMINv1.2.017618.t1(symbB.v1.2.017618.t1)
PTIPHATRDRAFT_47929
FCYFRACYDRAFT_195622
TPSTHAPSDRAFT_263431
PIFPITG_01569 PITG_16759
PSOJPHYSODRAFT_491157 PHYSODRAFT_496885
SPARSPRG_02713 SPRG_02716
 » show all
Reference
1  [PMID:3897221]
  Authors
Gomez S, Gluschankof P, Morel A, Cohen P.
  Title
The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes.
  Journal
J Biol Chem 260:10541-5 (1985)
Reference
2  [PMID:2885328]
  Authors
Gluschankof P, Gomez S, Morel A, Cohen P.
  Title
Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex.
  Journal
J Biol Chem 262:9615-20 (1987)
Reference
3  [PMID:8294457]
  Authors
Chesneau V, Pierotti AR, Barre N, Creminon C, Tougard C, Cohen P.
  Title
Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues.
  Journal
J Biol Chem 269:2056-61 (1994)
Reference
4  [PMID:8016118]
  Authors
Pierotti AR, Prat A, Chesneau V, Gaudoux F, Leseney AM, Foulon T, Cohen P.
  Title
N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.
  Journal
Proc Natl Acad Sci U S A 91:6078-82 (1994)
DOI:10.1073/pnas.91.13.6078
  Sequence
[rno:25499]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.61
IUBMB Enzyme Nomenclature: 3.4.24.61
ExPASy - ENZYME nomenclature database: 3.4.24.61
BRENDA, the Enzyme Database: 3.4.24.61
CAS: 292850-69-2

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