KEGG   ENZYME: 3.4.24.63Help
Entry
EC 3.4.24.63                Enzyme                                 

Name
meprin B;
meprin-b
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain
Comment
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)
History
EC 3.4.24.63 created 1995
Orthology
K08606  meprin B
Genes
HSA: 4225(MEP1B)
PTR: 468515(MEP1B)
PPS: 100991143(MEP1B)
GGO: 101131682(MEP1B)
PON: 100461703(MEP1B)
NLE: 100587715(MEP1B)
MCC: 707036(MEP1B)
MCF: 102120570(MEP1B)
CSAB: 103222566(MEP1B)
RRO: 104664448(MEP1B)
RBB: 108530921(MEP1B)
CJC: 100406280(MEP1B)
SBQ: 101032707(MEP1B)
MMU: 17288(Mep1b)
MCAL: 110284973(Mep1b)
MPAH: 110333333(Mep1b)
RNO: 25727(Mep1b)
MUN: 110541057(Mep1b)
CGE: 100774490(Mep1b)
NGI: 103730584(Mep1b)
HGL: 101721966(Mep1b)
CCAN: 109700569(Mep1b)
OCU: 100349918(MEP1B)
TUP: 102501249(MEP1B)
CFA: 490497(MEP1B)
VVP: 112918774(MEP1B)
AML: 100474827(MEP1B)
UMR: 103665002(MEP1B)
UAH: 113253198(MEP1B)
ORO: 101362685(MEP1B)
FCA: 101089149(MEP1B)
PTG: 102972887(MEP1B)
PPAD: 109276429(MEP1B)
AJU: 106984962(MEP1B)
BTA: 540701(MEP1B)
BOM: 102277511(MEP1B)
BIU: 109577975(MEP1B)
BBUB: 102394983(MEP1B)
CHX: 102181352(MEP1B)
OAS: 101114072(MEP1B)
SSC: 100516141(MEP1B)
CFR: 102509020(MEP1B)
CDK: 105087045(MEP1B)
BACU: 102999400(MEP1B)
LVE: 103090304(MEP1B)
OOR: 101287646(MEP1B)
DLE: 111181507(MEP1B)
PCAD: 102977401(MEP1B)
ECB: 100052389(MEP1B)
EPZ: 103558347(MEP1B)
EAI: 106833999(MEP1B)
MYB: 102262211(MEP1B)
MYD: 102761324(MEP1B)
MNA: 107524193(MEP1B)
HAI: 109387887(MEP1B)
DRO: 112322891(MEP1B)
PALE: 102878505(MEP1B)
RAY: 107521761(MEP1B)
MJV: 108390781(MEP1B)
LAV: 100656666(MEP1B)
TMU: 101351008
MDO: 100031055(MEP1B)
SHR: 100920095 100920356 100920611(MEP1B)
PCW: 110212554(MEP1B)
OAA: 100084811(MEP1B)
GGA: 421097(MEP1B)
MGP: 100545010(MEP1B)
CJO: 107310133(MEP1B)
NMEL: 110394814
APLA: 101794200(MEP1B)
ACYG: 106038392(MEP1B)
TGU: 100227825(MEP1B)
SCAN: 103816093(MEP1B)
GFR: 102041784(MEP1B)
FAB: 101820401(MEP1B)
PHI: 102106845(MEP1B)
PMAJ: 107200153(MEP1B)
CCAE: 111924898(MEP1B)
CCW: 104690416(MEP1B)
ETL: 114057191(MEP1B)
FPG: 101920674(MEP1B)
FCH: 102052375(MEP1B)
CLV: 102096310(MEP1B)
EGZ: 104126872(MEP1B)
NNI: 104019801(MEP1B)
ACUN: 113476445(MEP1B)
PADL: 103923149(MEP1B)
AAM: 106494484(MEP1B)
ASN: 102371434(MEP1B)
AMJ: 102574106(MEP1B)
PSS: 102456515(MEP1B)
CMY: 102938685(MEP1B)
CPIC: 101930949(MEP1B)
ACS: 100563868(mep1b)
PVT: 110077651(MEP1B)
PBI: 103049257(MEP1B)
PMUA: 114600650(MEP1B)
GJA: 107113251(MEP1B)
XLA: 108695280 108718576 108718577 108718578 108718579
XTR: 100124942(mep1b)
NPR: 108786081(MEP1B) 108786082 108786083
DRE: 100151009(mep1b) 327586(si:ch73-40a17.3)
SRX: 107712835 107714661 107714662 107723382 107725789 107728138 107728528 107754732
SANH: 107657610 107662546 107677797 107685896 107687173
SGH: 107563077 107568554 107571855 107578848 107581493 107581508 107582168 107596174
CCAR: 109055310 109056704 109057735 109068124 109072846 109091953 109092390 109098231 109098394 109105388 109107094 109111380 109112295
IPU: 108258155(mep1b) 108267869 108267871
PHYP: 113545303 113547251 113547287
AMEX: 103035096 103045306(mep1b) 103047091 103047392
EEE: 113582970(mep1b)
TRU: 101073548 101077603
TNG: GSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001
LCO: 104929464 104931537(mep1b) 104939568 104939807 104940145 109140401
NCC: 104947934(mep1b)
MZE: 101464784 101470468(mep1b) 101487076 106674862
ONL: 100696060 100696326 100699674 100705643(mep1b) 100706112 102075759 102080243 109200586
OLA: 101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310
XMA: 102225947(mep1b) 102233350 102236284 106699905
XCO: 114139666 114141730 114142354 114146571(mep1b) 114151483
PRET: 103464018 103477874 103477902 103477905 103479550(mep1b)
CVG: 107082956 107082992 107082993 107083563 107091700 107092415(mep1b)
NFU: 107379407 107379683 107383911(mep1b)
KMR: 108235358 108235371 108235372 108235373 108235546 108235548 108239650(mep1b)
ALIM: 106523730 106532705(mep1b)
AOCE: 111564199 111568694(mep1b)
CSEM: 103389008 103396279(mep1b) 103398781
POV: 109625364 109633072 109633167 109638837 109648090
LCF: 108878817 108883415(mep1b) 108898221 108898236 108898245
SDU: 111231107(mep1b) 111231912 111232045 111235801 111236058
SLAL: 111651130 111657249 111670483(mep1b) 111671948 111671975
HCQ: 109521233(mep1b)
BPEC: 110159506(mep1b) 110174420 110174421 110174422 110174423
MALB: 109954644 109954645 109957740 109972189
SASA: 106569161(mep1b) 106605674 106605676 106605693 106605695
OTW: 112235283 112260582
SALP: 111956379(mep1b) 112081000
ELS: 105018582 105024313 105026400
SFM: 108937645(mep1b)
PKI: 111845993(mep1b)
LCM: 102349308(MEP1B)
CMK: 103191077(mep1b)
RTP: 109932190(mep1b)
BFO: BRAFLDRAFT_102513
CIN: 100179459
BTAB: 109042629 109042937
CLEC: 106668216
ZNE: 110830837
TUT: 107360299
CSCU: 111637773
PTEP: 107446799 107452980
LGI: LOTGIDRAFT_194410
PCAN: 112558985 112573791
CRG: 105317922 105319685 105319686 105319688 105346200
MYI: 110441919 110442536 110452104
OBI: 106872752
NVE: NEMVE_v1g120119
EPA: 110232881 110232943 110233649 110239576 110242500 110246877 110249325 110252250 110254049
ADF: 107331556 107337762 107346411
AMIL: 114955870 114965731 114968599
PDAM: 113665203 113667219 113667374 113680043 113680631 113685879 113686839
SPIS: 111326164 111330406 111336311 111337192 111337305 111345792 111345983
DGT: 114518108
HMG: 100199496 100209222(MP2)
AQU: 109580701
 » show all
Taxonomy
Reference
1  [PMID:1894622]
  Authors
Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.
  Title
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
  Journal
J Biol Chem 266:17350-7 (1991)
  Sequence
[mmu:17288]
Reference
2  [PMID:8407940]
  Authors
Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.
  Title
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
  Journal
J Biol Chem 268:21035-43 (1993)
  Sequence
[mmu:17288]
Reference
3  [PMID:7510289]
  Authors
Johnson GD, Hersh LB.
  Title
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
  Journal
J Biol Chem 269:7682-8 (1994)
Reference
4  [PMID:7674930]
  Authors
Wolz RL, Bond JS.
  Title
Meprins A and B.
  Journal
Methods Enzymol 248:325-45 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.63
IUBMB Enzyme Nomenclature: 3.4.24.63
ExPASy - ENZYME nomenclature database: 3.4.24.63
BRENDA, the Enzyme Database: 3.4.24.63
CAS: 150679-52-0

  All links  
Gene (1773)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (328)   
   KEGG MGENES (72)   
   RefGene (1372)   
Protein sequence (13)   
   UniProt (3)   
   SWISS-PROT (3)   
   RefSeq(pep) (4)   
   PDBSTR (3)   
DNA sequence (5)   
   RefSeq(nuc) (4)   
   GenBank (1)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   InterPro (1)   
All databases (1794)   

Download RDF
DBGET integrated database retrieval system