KEGG ENZYME: 3.4.24.63

ENZYME: 3.4.24.63

Entry

EC 3.4.24.63 Enzyme

Name

meprin B;
meprin-b

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain

Comment

A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)

History

EC 3.4.24.63 created 1995

Orthology

K08606

meprin B

Genes

HSA:	4225(MEP1B)

PTR:	468515(MEP1B)

PPS:	100991143(MEP1B)

GGO:	101131682(MEP1B)

PON:	100461703(MEP1B)

NLE:	100587715(MEP1B)

MCC:	707036(MEP1B)

MCF:	102120570(MEP1B)

CSAB:

103222566(MEP1B)

CATY:

105592602(MEP1B)

PANU:

101001403(MEP1B)

RRO:	104664448(MEP1B)

RBB:	108530921(MEP1B)

TFN:	117064003(MEP1B)

CJC:	100406280(MEP1B)

SBQ:	101032707(MEP1B)

MMUR:

105881102(MEP1B)

MMU:	17288(Mep1b)

MCAL:

110284973(Mep1b)

MPAH:

110333333(Mep1b)

RNO:	25727(Mep1b)

MCOC:

116087559(Mep1b)

MUN:	110541057(Mep1b)

CGE:	100774490(Mep1b)

PLEU:

114704981(Mep1b)

NGI:	103730584(Mep1b)

HGL:	101721966(Mep1b)

CCAN:

109700569(Mep1b)

OCU:	100349918(MEP1B)

TUP:	102501249(MEP1B)

CFA:	490497(MEP1B)

VVP:	112918774(MEP1B)

VLG:	121500881(MEP1B)

AML:	100474827(MEP1B)

UMR:	103665002(MEP1B)

UAH:	113253198(MEP1B)

ORO:	101362685(MEP1B)

ELK:

111142409

MPUF:

101687936(MEP1B)

EJU:	114204991(MEP1B)

MLX:	118004459(MEP1B)

FCA:	101089149(MEP1B)

PTG:	102972887(MEP1B)

PPAD:

109276429(MEP1B)

AJU:	106984962(MEP1B)

HHV:	120246841(MEP1B)

BTA:	540701(MEP1B)

BOM:	102277511(MEP1B)

BIU:	109577975(MEP1B)

BBUB:

102394983(MEP1B)

CHX:	102181352(MEP1B)

OAS:	101114072(MEP1B)

ODA:	120881181(MEP1B)

SSC:	100516141(MEP1B)

CFR:	102509020(MEP1B)

CDK:	105087045(MEP1B)

BACU:

102999400(MEP1B)

LVE:	103090304(MEP1B)

OOR:	101287646(MEP1B)

DLE:	111181507(MEP1B)

PCAD:

102977401(MEP1B)

ECB:	100052389(MEP1B)

EPZ:	103558347(MEP1B)

EAI:	106833999(MEP1B)

MYB:	102262211(MEP1B)

MYD:	102761324(MEP1B)

MMYO:

118663201(MEP1B)

MNA:	107524193(MEP1B)

HAI:	109387887(MEP1B)

DRO:	112322891(MEP1B)

SHON:

118980342(MEP1B)

AJM:	119055550(MEP1B)

MMF:	118619263(MEP1B)

PALE:

102878505(MEP1B)

RAY:	107521761(MEP1B)

MJV:	108390781(MEP1B)

LAV:	100656666(MEP1B)

TMU:

101351008

MDO:	100031050 100031055(MEP1B)

SHR:	100920095 100920356 100920611

PCW:	110212554(MEP1B)

OAA:	100084811(MEP1B)

GGA:	421097(MEP1B)

PCOC:

MGP:

CJO:

NMEL:

APLA:

101794200(MEP1B)

ACYG:

106038392(MEP1B)

TGU:	100227825(MEP1B)

SCAN:

103816093(MEP1B)

PMOA:

120499951(MEP1B)

GFR:	102041784(MEP1B)

FAB:	101820401(MEP1B)

PHI:	102106845(MEP1B)

PMAJ:

107200153(MEP1B)

CCAE:

111924898(MEP1B)

CCW:	104690416(MEP1B)

ETL:	114057191(MEP1B)

FPG:	101920674(MEP1B)

FCH:	102052375(MEP1B)

CLV:	102096310(MEP1B)

EGZ:	104126872(MEP1B)

NNI:	104019801(MEP1B)

ACUN:

113476445(MEP1B)

PADL:

103923149(MEP1B)

AAM:	106494484(MEP1B)

ASN:	102371434(MEP1B)

AMJ:	102574106(MEP1B)

CPOO:

109314699(MEP1B)

GGN:	109304248(MEP1B)

PSS:	102456515(MEP1B)

CMY:

102938685

CPIC:

101930949(MEP1B)

TST:	117871643(MEP1B)

CABI:

116816221(MEP1B)

ACS:	100563868(mep1b)

PVT:	110077651(MEP1B)

PBI:	103049257(MEP1B)

PMUA:

114600650(MEP1B)

ZVI:	118089951(MEP1B)

GJA:	107113251(MEP1B)

XLA:	108695280(mep1b.S) 108718576 108718577 108718578 108718579

XTR:	100124942(mep1b)

NPR:	108786081(MEP1B) 108786082 108786083

DRE:	100151009(mep1ba) 327586(si:ch73-40a17.3)

SRX:	107714661 107714662 107723382 107725789

SANH:

107657610 107662546 107677797 107687173

SGH:	107563077 107568554 107571855 107581493 107581508 107596174

CCAR:

109055310 109057735 109091953 109098231 109098394 109105388 109107094 109111380 109112295

CAUA:

113039431 113059708 113060240 113063711 113084155 113084156 113084159 113102986 113102988 113102990 113113425 113116738 113119132 113121069

IPU:	108258155(mep1b) 108267869 108267871

PHYP:

113545303 113547251 113547287

AMEX:

103035096 103045306(mep1b) 103047091 103047392

EEE:	113582970(mep1b)

TRU:	101073548 101077603

TNG:	GSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001

LCO:	104929464 104931537(mep1b) 104939568 104939807 109140401

NCC:	104947934(mep1b)

ELY:	117253373 117253635 117253862 117264509 117265345 117266095 117271857(si:ch73-40a17.3)

PLEP:

121938414(mep1bb) 121941335 121945197

SLUC:

116039641 116046032(si:ch73-40a17.3)

GAT:	120810384 120811183 120815780 120823774

MSAM:

119887102 119887252 119901238 119901240 119901373 119902973

CUD:	121512490(mep1ba) 121514163 121514164 121519949(mep1bb)

MZE:	101464784 101470468(mep1b) 101487076 106674862

ONL:	100696060 100696326 100699674 100705643(mep1b) 100706112 102075759 102080243

OAU:	116309517 116309518 116309519 116309947(mep1ba) 116313761 116318670(mep1bb) 120442723

OLA:	101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310

OML:	112138238 112143593 112143793 112143796 112147067(si:ch73-40a17.3) 112150446 118599840

XMA:	102225947(mep1b) 102233350 102236284 106699905

XCO:	114139666 114141730 114142354 114146571(mep1b) 114151483

XHE:	116716359 116716808 116716810 116717206 116721700(mep1b) 116726251

PRET:

103464018 103477874 103477902 103477905 103479550(mep1b)

CVG:	107082956 107082992 107082993 107083563 107091700 107092415(mep1b)

NFU:	107379407 107379683 107383911(mep1b)

KMR:	108235358 108235371 108235372 108235373 108235546 108235548 108239650(si:ch73-40a17.3)

ALIM:

106532705(mep1b)

AOCE:

111564199 111568694(mep1b)

CSEM:

103389008 103396279(mep1b) 103398781

POV:	109625364 109633072 109633167 109638837 109648090

LCF:	108878817 108883415(mep1b) 108898221 108898236 108898245

SDU:	111231107(mep1b) 111231912 111232045 111235801 111236058

SLAL:

111651130 111657249 111670483(mep1b) 111671975

XGL:	120784491 120798892(mep1bb)

HCQ:	109521233(mep1b)

BPEC:

110159506(mep1b) 110174420 110174421 110174422 110174423

MALB:

109954644 109954645 109957740

SASA:

106569161(mep1b) 106605693 106605695

OTW:	112235283 112260582

OMY:	110524649(mep1b) 110530435(si:ch73-40a17.3)

SALP:

111956379(mep1b) 112081000

ELS:	105018582 105024313 105026400

SFM:	108937645(mep1b)

PKI:	111845993(mep1b)

LOC:	102698182(mep1b)

PSPA:

121309460

ARUT:

117399984

LCM:	102349308(MEP1B)

CMK:	103191077(mep1b)

RTP:	109932190(mep1b)

BFO:	118414382 118428956

CIN:	100175318 100179459

SCLV:

120326385 120335019 120335037 120336056 120337642 120344001 120346510

SKO:

BTAB:

DCI:

CLEC:

NLU:	111043633 111045362

ZNE:

CSEC:

FCD:

HAME:

CSCU:

PTEP:

LGI:	LOTGIDRAFT_194410

PCAN:

112573791

GAE:

121380046

CRG:	105317922 105319685 105319686 105319688 105340289 105346200

MYI:	110441919 110452104

PMAX:

117332549 117338499 117342714

OBI:

106872752

LAK:

106174443

NVE:	5500840 5504038 5507767 5516561 5522136 5522147

EPA:	110232881 110232943 110233649 110235540 110236447 110236451 110239576 110243849 110252250 110252268 110253148 110253171 110254049

ATEN:

116287249 116289314 116290639 116293897 116299167 116302414 116303370 116306718 116308851

ADF:	107327597 107331556 107337681 107337762 107346411 107355954

AMIL:

114955870 114956355 114957630 114958349 114965731 114968599

PDAM:

113665203 113667219 113667374 113667665 113680043 113680631 113685877 113685879

SPIS:

111325461 111326164 111330142 111330143 111336311 111337192 111337305 111345792 111345983

DGT:	114518108 114525564 114528385 114541320

HMG:	100199496 100200172 100209222(MP2)

AQU:

109580701

» show all

Reference

1 [PMID:1894622]

Authors

Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.

Title

Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.

Journal

J Biol Chem 266:17350-7 (1991)

Sequence

[mmu:17288]

Reference

2 [PMID:8407940]

Authors

Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.

Title

Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.

Journal

J Biol Chem 268:21035-43 (1993)

Sequence

[mmu:17288]

Reference

3 [PMID:7510289]

Authors

Johnson GD, Hersh LB.

Title

Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.

Journal

J Biol Chem 269:7682-8 (1994)

Reference

4 [PMID:7674930]

Authors

Wolz RL, Bond JS.

Title

Meprins A and B.

Journal

Methods Enzymol 248:325-45 (1995)
DOI:10.1016/0076-6879(95)48022-6

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.63

IUBMB Enzyme Nomenclature:

3.4.24.63

ExPASy - ENZYME nomenclature database:

3.4.24.63

BRENDA, the Enzyme Database:

3.4.24.63

CAS:	150679-52-0

All links

Gene (1902)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (452)   
   KEGG MGENES (77)   
   RefGene (1372)   
Protein sequence (22)   
   UniProt (6)   
   SWISS-PROT (3)   
   RefSeq(pep) (4)   
   PDBSTR (9)   
DNA sequence (5)   
   RefSeq(nuc) (4)   
   GenBank (1)   
3D Structure (4)   
   PDB (4)   
Protein domain (11)   
   InterPro (11)   
All databases (1944)   

Download RDF

DBGET integrated database retrieval system