KEGG   ENZYME: 3.4.24.63Help
Entry
EC 3.4.24.63                Enzyme                                 

Name
meprin B;
meprin-b
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain
Comment
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)
History
EC 3.4.24.63 created 1995
Orthology
K08606  meprin B
Genes
HSA: 4225(MEP1B)
PTR: 468515(MEP1B)
PPS: 100991143(MEP1B)
GGO: 101131682(MEP1B)
PON: 100461703(MEP1B)
NLE: 100587715(MEP1B)
MCC: 707036(MEP1B)
MCF: 102120570(MEP1B)
CSAB: 103222566(MEP1B)
RRO: 104664448(MEP1B)
RBB: 108530921(MEP1B)
CJC: 100406280(MEP1B)
SBQ: 101032707(MEP1B)
MMU: 17288(Mep1b)
RNO: 25727(Mep1b)
CGE: 100774490(Mep1b)
NGI: 103730584(Mep1b)
HGL: 101721966(Mep1b)
CCAN: 109700569(Mep1b)
OCU: 100349918(MEP1B)
TUP: 102501249(MEP1B)
CFA: 490497(MEP1B)
AML: 100474827(MEP1B)
UMR: 103665002(MEP1B)
ORO: 101362685(MEP1B)
FCA: 101089149(MEP1B)
PTG: 102972887(MEP1B)
AJU: 106984962(MEP1B)
BTA: 540701(MEP1B)
BOM: 102277511(MEP1B)
BIU: 109577975(MEP1B)
PHD: 102342891(MEP1B)
CHX: 102181352(MEP1B)
OAS: 101114072(MEP1B)
SSC: 100516141(MEP1B)
CFR: 102509020(MEP1B)
CDK: 105087045(MEP1B)
BACU: 102999400(MEP1B)
LVE: 103090304(MEP1B)
OOR: 101287646(MEP1B)
ECB: 100052389(MEP1B)
EPZ: 103558347(MEP1B)
EAI: 106833999(MEP1B)
MYB: 102262211(MEP1B)
MYD: 102761324(MEP1B)
HAI: 109387887(MEP1B)
RSS: 109435906(MEP1B)
PALE: 102878505(MEP1B)
LAV: 100656666(MEP1B)
TMU: 101351008
MDO: 100031055(MEP1B)
OAA: 100084811(MEP1B)
GGA: 421097(MEP1B)
MGP: 100545010(MEP1B)
CJO: 107310133(MEP1B)
APLA: 101794200(MEP1B)
ACYG: 106038392(MEP1B)
TGU: 100227825(MEP1B)
GFR: 102041784(MEP1B)
FAB: 101820401(MEP1B)
PHI: 102106845(MEP1B)
PMAJ: 107200153(MEP1B)
CCW: 104690416(MEP1B)
FPG: 101920674(MEP1B)
FCH: 102052375(MEP1B)
CLV: 102096310(MEP1B)
EGZ: 104126872(MEP1B)
AAM: 106494484(MEP1B)
ASN: 102371434(MEP1B)
AMJ: 102574106(MEP1B)
PSS: 102456515(MEP1B)
CMY: 102938685(MEP1B)
CPIC: 101930949(MEP1B)
ACS: 100563868(mep1b)
PVT: 110077651(MEP1B)
PBI: 103049257(MEP1B)
GJA: 107113251(MEP1B)
XTR: 100124942(mep1b)
DRE: 100151009(mep1b) 327586(si:ch73-40a17.3)
NCC: 104947934(mep1b)
HCQ: 109521233(mep1b)
SFM: 108937645(mep1b)
LCM: 102349308(MEP1B)
CMK: 103191077(mep1b)
CIN: 100179459
ZNE: 110830837
TUT: 107360299
OBI: 106872752
HMG: 100199496 100209222(MP2)
AQU: 109580701
 » show all
Taxonomy
Reference
1  [PMID:1894622]
  Authors
Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.
  Title
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
  Journal
J Biol Chem 266:17350-7 (1991)
  Sequence
[mmu:17288]
Reference
2  [PMID:8407940]
  Authors
Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.
  Title
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
  Journal
J Biol Chem 268:21035-43 (1993)
  Sequence
[mmu:17288]
Reference
3  [PMID:7510289]
  Authors
Johnson GD, Hersh LB.
  Title
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
  Journal
J Biol Chem 269:7682-8 (1994)
Reference
4  [PMID:7674930]
  Authors
Wolz RL, Bond JS.
  Title
Meprins A and B.
  Journal
Methods Enzymol 248:325-45 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.63
IUBMB Enzyme Nomenclature: 3.4.24.63
ExPASy - ENZYME nomenclature database: 3.4.24.63
BRENDA, the Enzyme Database: 3.4.24.63
CAS: 150679-52-0

DBGET integrated database retrieval system