KEGG   ENZYME: 3.4.24.63
Entry
EC 3.4.24.63                Enzyme                                 
Name
meprin B;
meprin-b
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain
Comment
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)
History
EC 3.4.24.63 created 1995
Orthology
K08606  meprin B
Genes
HSA4225(MEP1B)
PTR468515(MEP1B)
PPS100991143(MEP1B)
GGO101131682(MEP1B)
PON100461703(MEP1B)
NLE100587715(MEP1B)
MCC707036(MEP1B)
MCF102120570(MEP1B)
CSAB103222566(MEP1B)
CATY105592602(MEP1B)
PANU101001403(MEP1B)
TGE112611509(MEP1B)
RRO104664448(MEP1B)
RBB108530921(MEP1B)
TFN117064003(MEP1B)
PTEH111539602(MEP1B)
CJC100406280(MEP1B)
SBQ101032707(MEP1B)
CSYR103252712(MEP1B)
MMUR105881102(MEP1B)
LCAT123621712(MEP1B)
OGA100954479(MEP1B)
MMU17288(Mep1b)
MCAL110284973(Mep1b)
MPAH110333333(Mep1b)
RNO25727(Mep1b)
MCOC116087559(Mep1b)
MUN110541057(Mep1b)
CGE100774490(Mep1b)
MAUA101835986(Mep1b)
PLEU114704981(Mep1b)
MORG121441844 121441893 121453336 121453586
MFOT126497086 126497087
AAMP119815303 119815304
NGI103730584(Mep1b)
HGL101721966(Mep1b)
CPOC100733995(Mep1b)
CCAN109700569(Mep1b)
DORD105984574(Mep1b)
DSP122104256(Mep1b)
NCAR124965368
OCU100349918(MEP1B)
OPI101535433(MEP1B)
TUP102501249(MEP1B)
CFA490497(MEP1B)
CLUD112648180(MEP1B)
VVP112918774(MEP1B)
VLG121500881(MEP1B)
AML100474827(MEP1B)
UMR103665002(MEP1B)
UAH113253198(MEP1B)
UAR123782011(MEP1B)
ELK111142409
LLV125082546
MPUF101687936(MEP1B)
ORO101362685(MEP1B)
EJU114204991(MEP1B)
ZCA113912268(MEP1B)
MLX118004459(MEP1B)
NSU110576950(MEP1B)
FCA101089149(MEP1B)
PYU121033031(MEP1B)
PBG122469999(MEP1B)
LRUF124517538
PTG102972887(MEP1B)
PPAD109276429(MEP1B)
AJU106984962(MEP1B)
HHV120246841(MEP1B)
BTA540701(MEP1B)
BOM102277511(MEP1B)
BIU109577975(MEP1B)
BBUB102394983(MEP1B)
CHX102181352(MEP1B)
OAS101114072(MEP1B)
ODA120881181(MEP1B)
CCAD122425832(MEP1B)
SSC100516141(MEP1B)
CFR102509020(MEP1B)
CBAI105062611(MEP1B)
CDK105087045(MEP1B)
VPC102545555(MEP1B)
BACU102999400(MEP1B)
LVE103090304(MEP1B)
OOR101287646(MEP1B)
DLE111181507(MEP1B)
PCAD102977401(MEP1B)
PSIU116739028(MEP1B)
ECB100052389(MEP1B)
EPZ103558347(MEP1B)
EAI106833999(MEP1B)
MYB102262211(MEP1B)
MYD102761324(MEP1B)
MMYO118663201(MEP1B)
MLF102438631(MEP1B)
MNA107524193(MEP1B)
PKL118707419(MEP1B)
HAI109387887(MEP1B)
DRO112322891(MEP1B)
SHON118980342(MEP1B)
AJM119055550(MEP1B)
PDIC114505982(MEP1B)
PHAS123826198(MEP1B)
MMF118619263(MEP1B)
RFQ117038642(MEP1B)
PALE102878505(MEP1B)
PGIG120587130(MEP1B)
PVP105293718(MEP1B)
RAY107521761(MEP1B)
MJV108390781(MEP1B)
TOD119242794(MEP1B)
SARA101550583(MEP1B)
LAV100656666(MEP1B)
TMU101351008
DNM101420233(MEP1B)
MDO100031050 100031055(MEP1B)
GAS123253669 123253691(MEP1B)
SHR100920095 100920356 100920611
PCW110212554(MEP1B)
OAA100084811(MEP1B)
GGA421097(MEP1B)
PCOC116242218
MGP100545010
CJO107310133
NMEL110394814
APLA101794200(MEP1B)
ACYG106038392(MEP1B)
AFUL116485636(MEP1B)
TGU100227825(MEP1B)
SCAN103816093(MEP1B)
PMOA120499951(MEP1B)
OTC121333145(MEP1B)
PRUF121358992(MEP1B)
GFR102041784(MEP1B)
FAB101820401(MEP1B)
PHI102106845(MEP1B)
PMAJ107200153(MEP1B)
CCAE111924898(MEP1B)
CCW104690416(MEP1B)
CBRC103625520(MEP1B)
ETL114057191(MEP1B)
ZAB102072756(MEP1B)
ACHL103800971(MEP1B)
FPG101920674(MEP1B)
FCH102052375(MEP1B)
CLV102096310(MEP1B)
EGZ104126872(MEP1B)
NNI104019801(MEP1B)
PLET104626166(MEP1B)
PCRI104030433(MEP1B)
ACUN113476445(MEP1B)
TALA104358761(MEP1B)
PADL103923149(MEP1B)
AFOR103904245(MEP1B)
ACHC115340816(MEP1B)
HALD104323620(MEP1B)
CCRI104168754(MEP1B)
CSTI104552830(MEP1B)
EHS104511128(MEP1B)
CMAC104474731(MEP1B)
MUI104547578(MEP1B)
FGA104082673(MEP1B)
GSTE104258902(MEP1B)
LDI104343138(MEP1B)
MNB103773824(MEP1B)
OHA104329165(MEP1B)
NNT104400505(MEP1B)
DPUB104309119(MEP1B)
PGUU104459469(MEP1B)
ACAR104527222(MEP1B)
AVIT104271511(MEP1B)
AAM106494484(MEP1B)
AROW112969480(MEP1B)
NPD112957848(MEP1B)
TGT104576541(MEP1B)
DNE112994919(MEP1B)
SCAM104149447(MEP1B)
ASN102371434(MEP1B)
AMJ102574106(MEP1B)
CPOO109314699(MEP1B)
GGN109304248(MEP1B)
PSS102456515(MEP1B)
CMY102938685
CPIC101930949(MEP1B)
TST117871643(MEP1B)
CABI116816221(MEP1B)
MRV120398349(MEP1B)
ACS100563868(mep1b)
PVT110077651(MEP1B)
SUND121929122(MEP1B)
PBI103049257(MEP1B)
VKO123020526(MEP1B)
PMUA114600650(MEP1B)
ZVI118089951(MEP1B)
GJA107113251(MEP1B)
STOW125439438(MEP1B)
XLA108695280(mep1b.S) 108718576 108718577 108718578 108718579
XTR100124942(mep1b)
NPR108786081(MEP1B) 108786082 108786083
RTEM120940955 120940956
BBUF121002163 121002434 121002435
BGAR122938859(MEP1B) 122939334 122939336
DRE100151009(mep1ba) 327586(si:ch73-40a17.3)
SRX107714661 107714662 107723382 107725789
SANH107657610 107662546 107677797 107687173
SGH107563077 107568554 107571855 107581493 107581508 107596174
CCAR109055310 109057735 109091953 109098231 109098394 109105388 109107094 109111380 109112295
CAUA113039431 113059708 113060240 113063711 113084155 113084156 113084159 113102986 113102988 113102990 113113425 113116738 113119132 113121069
PPRM120468741 120468742 120478367 120478369 120478370 120484792 120494197(mep1ba)
MAMB125243202 125243203 125243205 125246280 125250500(mep1bb)
IPU108258155(mep1ba) 108267869 108267871
PHYP113545303 113547251 113547287
SMEO124376696(mep1ba) 124387068(mep1bb)
TFD113662331(mep1bb) 113664000(mep1ba)
AMEX103035096 103045306(mep1b) 103047091 103047392
EEE113582970(mep1b)
TRU101073548 101077603
TNGGSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001
LCO104929464 104931537(mep1b) 104939568 104939807 109140401
NCC104947934(mep1b)
CGOB115020985 115022332
ELY117253373 117253635 117253862 117264509 117265345 117266095 117271857(si:ch73-40a17.3)
EFO125882232 125893314 125895297(mep1ba) 125896421 125896422 125902215(mep1bb)
PLEP121938414(mep1bb) 121941335 121945197
SLUC116039641 116046032(si:ch73-40a17.3)
ECRA117953861(si:ch73-40a17.3)
ESP116695328 116698780(mep1b)
PFLV114545668 114565580(mep1b) 114573819 114573835
GAT120810384 120811183 120815780 120823774
PPUG119197311 119209164(si:ch73-40a17.3) 119216184(mep1b)
MSAM119887102 119887252 119901238 119901240 119901373 119902973
CUD121512490(mep1ba) 121514163 121514164 121519949(mep1bb)
ALAT119005322 119006195 119010835(si:ch73-40a17.3) 119028193
MZE101464784 101470468(mep1b) 101487076 106674862
ONL100696060 100696326 100699674 100705643(mep1b) 100706112 102075759 102080243
OAU116309517 116309518 116309519 116309947(mep1ba) 116313761 116318670(mep1bb) 120442723
OLA101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310
OML112138238 112143593 112143793 112143796 112147067(si:ch73-40a17.3) 112150446 118599840
XMA102225947(mep1b) 102233350 102236284 106699905
XCO114139666 114141730 114142354 114146571(mep1b) 114151483
XHE116716359 116716808 116716810 116717206 116721700(mep1b) 116726251
PRET103464018 103477874 103477902 103477905 103479550(mep1b)
PFOR103135811(mep1b) 103139244 103139245 103139249 103139250 103141591 103143062 103146697
PLAI106938467 106948617(mep1b) 106959843 106960215 106960224 106960439
PMEI106908512 106910742 106912957 106917662 106917670 106917671 106917675 106925930(mep1b)
GAF122830739 122831136 122831277 122838892 122841237(mep1bb)
CVG107082956 107082992 107082993 107083563 107091700 107092415(mep1b)
CTUL119777433 119777434 119777435 119787670(mep1b) 119795659(si:ch73-40a17.3) 119797871
GMU124866050 124866085 124866137 124869902(mep1bb)
NFU107379407 107379683 107383911(mep1b)
KMR108235358 108235371 108235372 108235373 108235546 108235548 108239650(si:ch73-40a17.3)
ALIM106532705(mep1b)
NWH119409678 119409679 119414561(mep1bb)
AOCE111564199 111568694(mep1b)
MCEP125009142 125009184 125009186 125009187 125009188 125010423(mep1bb) 125015817 125016027 125016492 125016949 125016950 125016951 125016952
CSEM103389008 103396279(mep1b) 103398781
POV109625364 109633072 109633167 109638837 109648090
SSEN122759880 122766408 122769155(mep1bb) 122780674
HHIP117759756(mep1b) 117776987 117776988 117778189(si:ch73-40a17.3)
HSP118113559 118113878 118118073(mep1bb) 118121443
LCF108878817 108883415(mep1bb) 108898236
SDU111231107(mep1b) 111231912 111232045 111235801 111236058
SLAL111651130 111657249 111670483(mep1b) 111671975
XGL120784491 120798892(mep1bb)
HCQ109521233(mep1b)
BPEC110159506(mep1b) 110174420 110174421 110174422 110174423
MALB109954644 109954645 109957740
BSPL114845085(mep1bb)
SASA106569161(mep1b) 106605693 106605695
STRU115157135 115158625 115183202 115183212 115183265
OTW112235283 112251615(mep1ba) 112260582(mep1bb)
OMY110524649(mep1b) 110530435(si:ch73-40a17.3)
OGO123997327 124009135(mep1bb)
ONE115114525(mep1b) 115142125
SALP111956379(mep1b) 112081000
SNH120047228 120054335(mep1b) 120055310(si:ch73-40a17.3)
CCLU121533893(mep1ba) 121535317(mep1bb) 121543802 121586152
ELS105018582 105024313 105026400
SFM108937645(mep1b)
PKI111845993(mep1b)
AANG118225776(mep1b) 118233073
LOC102698182(mep1b)
PSPA121309460
ARUT117399984
LCM102349308(MEP1B)
CMK103191077
RTP109932190(mep1b)
BFO118428956
BBEL109472514 109481933 109485440
CIN100175318 100179459
SCLV120326385 120335019 120335037 120337642 120344001 120346510
BTAB109042629 109042937
DCI103519147
CLEC106668216
NLU111043633 111045362
FOC113209580
TPAL117646662
ZNE110830837
CSEC111867104
FCD110861175
PJA122260941 122263524 122264039
PCHN125028342
HAME121853292
PCLA123774647
PPOI119091472 119095627 119095634
CSCU111637773
PTEP107446799 122268285
LGILOTGIDRAFT_194410
PCAN112573791
GAE121380046
HRF124130203 124137440 124137450 124137456 124137461 124137468 124139988 124140217 124140234 124140252
HRJ124266673
CRG105317110 105317922 105319685 105319686 105319688 105343632 117681556 117683148
MYI110441919 110452104
PMAX117332549 117338499 117342714
MMER123534631 123536726 123563485 123564247 123564248
OBI106867426 106872752
OSN118764515
LAK106174443
NVE5500840 5504038 5507767 5516561 5522136 5522147
EPA110232881 110232943 110233649 110235540 110236447 110236451 110239576 110243849 110252250 110252268 110253148 110253171 110254049
ATEN116287249 116289314 116290639 116293897 116299167 116302414 116303370 116306718 116308851
ADF107327597 107331556 107337681 107337762 107346411 107355954
AMIL114955870 114956355 114957630 114958349 114965731 114968599
PDAM113665203 113667219 113667374 113667665 113680043 113680631 113685877 113685879
SPIS111325461 111326164 111330142 111330143 111336311 111337192 111337305 111345792 111345983
DGT114518108 114525564 114541320
HMG100199496 100209222
AQU109580701
 » show all
Reference
1  [PMID:1894622]
  Authors
Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.
  Title
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
  Journal
J Biol Chem 266:17350-7 (1991)
  Sequence
[mmu:17288]
Reference
2  [PMID:8407940]
  Authors
Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.
  Title
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
  Journal
J Biol Chem 268:21035-43 (1993)
  Sequence
[mmu:17288]
Reference
3  [PMID:7510289]
  Authors
Johnson GD, Hersh LB.
  Title
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
  Journal
J Biol Chem 269:7682-8 (1994)
Reference
4  [PMID:7674930]
  Authors
Wolz RL, Bond JS.
  Title
Meprins A and B.
  Journal
Methods Enzymol 248:325-45 (1995)
DOI:10.1016/0076-6879(95)48022-6
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.63
IUBMB Enzyme Nomenclature: 3.4.24.63
ExPASy - ENZYME nomenclature database: 3.4.24.63
BRENDA, the Enzyme Database: 3.4.24.63
CAS: 150679-52-0

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