KEGG ENZYME: 3.4.24.66

ENZYME: 3.4.24.66

Entry

EC 3.4.24.66                Enzyme

Name

choriolysin L;
teleost hatching enzyme (component);
low choriolytic enzyme (LCE)

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr!7-(4-methyl)coumarylamide

Comment

Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin H. A 24 kDa peptidase family M12 (astacin family)

History

EC 3.4.24.66 created 1995

Orthology

K18542

choriolysin L

Genes

TRU:	777973(fglce)

TFS:

130515853

TNG:	GSTEN00020735G001

LCO:

104940076

TBEN:

117498620

CGOB:

115028844

PGEO:

139433033

GACU:

117554268

EMAC:

134877187

ELY:

117270808

EFO:

125897303

PLEP:

121955371

SLUC:

116066133

ECRA:

117961966

ESP:

116706235

GAT:	100190865(galce)

PPUG:

119195387 119195388 119195389

AFB:

129106750

CLUM:

117727261

PSWI:

130202346

CANA:

137785487

CVE:

137870833

MSAM:

119908817 119908820

SCHU:

122863640

CUD:

121521303

SPUL:

138611245

LMIX:

132984568

ALAT:

119012390

ASTR:

137613804

MZE:	101476186 106676582

ONL:

100703510

OAU:	116332236 116332252

OLA:	100049451(lce)

OML:

112157895

CSAI:

133464367

PLAI:

106949868

CVG:

107090859

CTUL:

119773101

GMU:

124882439

NFU:

107378082

KMR:

108231855

ALIM:

106518582

NWH:	119418488 119418489

AOCE:

111573796

EJA:

138203715

BFRE:

138631315

MCEP:

124999041

CSEM:

103381002

POV:

109632545

SSEN:

122783655

SSOE:

131443361 131460606

HHIP:

117758503

HSP:

118099633

PPLT:

128460584

SMAU:

118290208

LCF:

108896859

SDU:

111235837

SLAL:

111672534

XGL:

120789184

HCQ:

109531019

SSCV:

125989906

SBIA:

133496427

PEE:

133416905

PTAO:

133468636

BPEC:

110168286

ENY:

140362929

MALB:

109962249

SJO:

128376671

SSCO:

133997350

GMH:

115534436

SASA:

100302417 106613193

STRU:

115163983 115204953

OTW:	112243681 112266172

OMY:	100359378(rblce) 110503164 118944670

OGO:	123993888 124005757

ONE:	115119784 115142216

OKI:	109906117 109909581

OKE:	118376818 127909009 127909010

OMM:	135551553 135551554

OCLA:

139382410 139385593 139385604

SALP:

111949951 111960782

SNH:	120018727 120028779

CCLU:

121567210

ELS:

105023563

PSPA:

121308983

AALI:

118459483

ACOS:

131260105

AAG:

5574405

AALB:

109419214

ASUA:

134219155

CQU:	CpipJ_CPIJ013386

CPII:

120425610

CBRI:

134826998

API:

100574746

BTAB:

109044757

ZNE:

110827431

PAME:

138715350

BROR:

134532670

PVM:

138864982

PCHN:

125036433

HAME:

121855840

PORN:

139753599 139753993 139754473

CSCU:

111631999

PTEP:

107441045 139425175

UDV:	129226400 129226573 129227006

LPOL:

106476015

AIRR:

138332175

» show all

Reference

Authors

Yasumasu S, Iuchi I, Yamagami K.

Title

Medaka hatching enzyme consists of two kinds of proteases which act cooperatively.

Journal

Zool Sci 5:191-195 (1988)

Reference

2 [PMID:2656665]

Authors

Yasumasu S, Iuchi I, Yamagami K.

Title

Isolation and some properties of low choriolytic enzyme (LCE), a component of the hatching enzyme of the teleost, Oryzias latipes.

Journal

J Biochem (Tokyo) 105:212-8 (1989)
DOI:10.1093/oxfordjournals.jbchem.a122641

Reference

3 [PMID:1730389]

Authors

Yasumasu S, Katow S, Hamazaki TS, Iuchi I, Yamagami K.

Title

Two constituent proteases of a teleostean hatching enzyme: concurrent syntheses and packaging in the same secretory granules in discrete arrangement.

Journal

Dev Biol 149:349-56 (1992)
DOI:10.1016/0012-1606(92)90290-W

Reference

4 [PMID:1397682]

Authors

Yasumasu S, Yamada K, Akasaka K, Mitsunaga K, Iuchi I, Shimada H, Yamagami K

Title

Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development.

Journal

Dev Biol 153:250-8 (1992)
DOI:10.1016/0012-1606(92)90110-3

Sequence

[ola:100049451]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.66

IUBMB Enzyme Nomenclature:

3.4.24.66

ExPASy - ENZYME nomenclature database:

3.4.24.66

BRENDA, the Enzyme Database:

3.4.24.66

CAS:	177529-15-6

All links

Gene (1)   
   MGENES (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (4)   
   InterPro (4)   
All databases (9)   

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