KEGG   ENZYME: 3.4.24.67
Entry
EC 3.4.24.67                Enzyme                                 
Name
choriolysin H;
teleost hatching enzyme (component);
high choriolytic enzyme (HCE)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr!7-(4-methyl)coumarylamide
Comment
Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin L. A 25.5 kDa peptidase in family M12 (astacin family)
History
EC 3.4.24.67 created 1995
Orthology
K18543  choriolysin H
Genes
DRE407971(he1.2) 569018(he1.1) 792176(he1.3)
SRX107715261 107739316 107739317 107739318 107751463 107751483 107751488 107756160
SANH107653533 107653536 107653568 107653569 107653570 107653608 107653609 107669394 107687862 107687863 107687881 107687887 107699967
SGH107548229 107559407 107565490 107565491 107565492 107571701 107571702 107600986 107600988
CCAR109045988 109047084 109047085 109060047 109061795 109061816 109061828 109061829 109061830 109091756
CAUA113038526 113040175 113040180 113040182 113064352 113064641 113064804 113064806 113064807 113064808 113064809 113064810 113064811 113064812 113064813 113064816 113077243 113077245
PPRM120486804(he1.3) 120486805 120486806 120486807 120486808 120494495
MAMB125250914 125252131 125254227 125254236(he1.3) 125262138 125262139
IPU108259525 108259527
SMEO124379750 124379924 124379925 124386720 124387887 124387889
TFD113649231 113649232 113649233 113649234 113649238 125139112 125145185 125145498 125145501
AMEX111191931 111197482 111197483
TRU101077206 101079794 115246833 115246835 115247008 115247009 115247010 115247011 778019(fghce)
TNGGSTEN00012859G001
LCO104919773 104927714 109137006 109141327 109141329
NCC104948368 104953081 104953510
CGOB115026318 115026711 115026787 115026796
ELY117257233 117257378 117257397 117257403 117257451
EFO125881443 125881459 125881474 125898857 125902834
PLEP121940717 121942931 121958941 121959635
SLUC116044373 116056362 116056363 116056365 116056381 116057007 116057374 116062345
ECRA117940759 117944512 117948693
ESP116688470 116692169 116692676
PFLV114546703 114546744 114554616 114565874 114565876 114565877 114565878 114565879 114565880 114565881 114566058 114566059
GAT100190864(gahce1) 120813666 120813668 120819747 120819882 120819884 120835840
PPUG119212977 119213351 119220303 119220317 119221149
MSAM119889894 119889895 119889896 119890360 119890371 119890396 119890401 119890407 119918809 119918810 119918894 119918896
CUD121509763 121509793 121509811 121509818 121509840 121509906 121524950
ALAT119006925 119007471 119007472 119007474 119017506 119018142 119018151 119018153 119018600 119029579
MZE101468145 101472880
ONL100696428 100706991
OAU116321903
OLA100049314(mahce) 100049452(hceb) 100529164(hce) 101172803 105358676 111946254 111947172
OML112161182 112161183 112161184 112161185 112161186
XCO114143236
PRET103462301
CVG107085049 107085050
CTUL119773600 119773610 119773611 119773612
GMU124867241 124867243
NFU107372897 107373641
KMR108241581 108241582
ALIM106524262 106524264
NWH119423789 119423801
AOCE111563322 111563324 111563328
MCEP125004953 125004955 125005404 125005462 125005465 125005466 125005726
CSEM103379239 103379240 103379241 103379289 103390327 103398455 103399268
POV109642494 109646984
SSEN122767788 122771902 122771903 122771906 122771993 122772520 122772528 122772533 122772537 122772542
HHIP117753222 117753227 117753241 117753251 117753261 117759067 117772120
HSP118098197 118109589
LCF108890560 108897657 108897663 108897664 108897665 108897666 108897667 108897668 108897669 108897671 108897672
SDU111218600 111218609 111218615 111222275 111222281 111235434
SLAL111646196 111654950 111669431 111672327 111672329
XGL120790522 120790782 120790901
HCQ109509944
BPEC110159557
MALB109969927
SASA106564462 106588013 106588019 106588108 106589398 106597512
STRU115147389 115190072 115203561 115203566 115203567 115203568
OTW112238529 112238694 112239921
OMY100359379(rbhce2) 100359380(rbhce1) 110485531 110485534 110489520 110489522 110515482 110516712 118936259
OGO124017570 124020943 124021150 124028577 124028579 124030320 124034977 124035466 124035467 124035468
ONE115119423 115120296 115128072
SALP112078632
SNH120032786 120036640 120043459
CCLU121548181 121548182 121554027 121557539
ELS105016656 105021097 105026484 106024615 114828779 114829424 114841033
SFM108925328
PKI111834979
AANG118222533 118222535 118222538 118222546 118222547 118223735 118223743 118224304 118224305 118224306
PSPA121310331
BCOO119083314 119083797
FCD110857742
PCHN125026592
HAZT108680154
LSM121114261 121124430 121124516 121125300 121125545 121130878 121131539
RSAN119377398 119390118 119390201
RMP119163096 119163097
CSCU111617083 111621123 111621124 111621126 111621128 111621136 111621141 111628084 111629557 111629563 111629564 111629853
PTEP107441038 107441041 107441058 107441485 107446534
SDM118185823 118192947 118199931 118202551
NAINECAME_05955 NECAME_13810
LGILOTGIDRAFT_209446
EPA110235532
TADTRIADDRAFT_26557
 » show all
Reference
1  [PMID:4652273]
  Authors
Yamagami K.
  Title
Isolation of a choriolytic enzyme (hatching enzyme) of the teleost, Oryzias latipes.
  Journal
Dev Biol 29:343-8 (1972)
DOI:10.1016/0012-1606(72)90074-7
Reference
2  [PMID:2656664]
  Authors
Yasumasu S, Iuchi I, Yamagami K.
  Title
Purification and partial characterization of high choriolytic enzyme (HCE), a component of the hatching enzyme of the teleost, Oryzias latipes.
  Journal
J Biochem (Tokyo) 105:204-11 (1989)
DOI:10.1093/oxfordjournals.jbchem.a122640
Reference
3  [PMID:2751672]
  Authors
Yasumasu S, Katow S, Umino Y, Iuchi I, Yamagami K.
  Title
A unique proteolytic action of HCE, a constituent protease of a fish hatching enzyme: tight binding to its natural substrate, egg envelope.
  Journal
Biochem Biophys Res Commun 162:58-63 (1989)
DOI:10.1016/0006-291X(89)91961-X
Reference
4  [PMID:1397682]
  Authors
Yasumasu S, Yamada K, Akasaka K, Mitsunaga K, Iuchi I, Shimada H, Yamagami K
  Title
Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development.
  Journal
Dev Biol 153:250-8 (1992)
DOI:10.1016/0012-1606(92)90110-3
  Sequence
Reference
5  [PMID:8112467]
  Authors
Lee KS, Yasumasu S, Nomura K, Iuchi I.
  Title
HCE, a constituent of the hatching enzymes of Oryzias latipes embryos, releases unique proline-rich polypeptides from its natural substrate, the hardened chorion.
  Journal
FEBS Lett 339:281-4 (1994)
DOI:10.1016/0014-5793(94)80431-1
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.67
IUBMB Enzyme Nomenclature: 3.4.24.67
ExPASy - ENZYME nomenclature database: 3.4.24.67
BRENDA, the Enzyme Database: 3.4.24.67
CAS: 177529-16-7

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