| Entry |
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| Name |
oligopeptidase A;
68000-M signalpeptide hydrolase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly!Gly-Pro-Ala is cleaved, but not Z-(Gly)5 [4]
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| Comment |
Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase, in peptidase family M3 (thimet oligopeptidase family), but differs from thimet oligopeptidase in lack of thiol-activation
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| History |
EC 3.4.24.70 created 1996
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Novak P, Dev IK. |
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| Title |
Degradation of a signal peptide by protease IV and oligopeptidase A. |
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| Journal |
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| Reference |
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| Authors |
Conlin CA, Vimr ER, Miller CG. |
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| Title |
Oligopeptidase A is required for normal phage P22 development. |
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| Journal |
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| Reference |
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| Authors |
Conlin CA, Trun NJ, Silhavy TJ, Miller CG. |
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| Title |
Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Conlin CA, Miller CG. |
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| Title |
Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.70 |
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