KEGG ENZYME: 3.4.24.80

ENZYME: 3.4.24.80

Entry

EC 3.4.24.80 Enzyme

Name

membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain

Comment

In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

History

EC 3.4.24.80 created 2003

Orthology

K07763

matrix metalloproteinase-14 (membrane-inserted)

Genes

HSA:	4323(MMP14)

PTR:	742887(MMP14)

PPS:	100990208(MMP14)

GGO:	101142469(MMP14)

PON:	100171646(MMP14)

NLE:	100606407(MMP14)

MCC:	712429(MMP14)

MCF:	102132205(MMP14)

CSAB:

103231446(MMP14)

RRO:	104674133(MMP14)

RBB:	108523596(MMP14)

CJC:	100389088(MMP14)

SBQ:	101041075(MMP14)

MMU:	17387(Mmp14)

MCAL:

110309210(Mmp14)

MPAH:

110325048(Mmp14)

RNO:	81707(Mmp14)

MUN:	110550039(Mmp14)

CGE:	100689336(Mmp14)

NGI:	103739479(Mmp14)

HGL:	101723795(Mmp14)

CCAN:

109685808(Mmp14) 109689717

OCU:	100009598(MMP14)

TUP:	102468813(MMP14)

CFA:	403823(MMP14)

VVP:	112926491(MMP14)

AML:	100468621(MMP14)

UMR:	103681059(MMP14)

UAH:	113246072(MMP14)

ORO:	101369821(MMP14)

ELK:

111158421

FCA:	101089776(MMP14)

PTG:	102953674(MMP14)

PPAD:

109255047(MMP14)

AJU:	106988210(MMP14)

BTA:	281915(MMP14)

BOM:	102281987(MMP14)

BIU:	109564819(MMP14)

BBUB:

102413520(MMP14)

CHX:	100861171(MMP14)

OAS:	443116(MMP14)

SSC:	397471(MMP14)

CFR:	102513570 102524386(MMP14)

CDK:	105096970(MMP14)

BACU:

103003307(MMP14)

LVE:	103081188(MMP14)

OOR:	101284790(MMP14)

DLE:	111164185(MMP14)

PCAD:

102987825(MMP14)

ECB:	100034170(MMP14)

EPZ:	103556751(MMP14)

EAI:	106840662(MMP14)

MYB:	102240202(MMP14)

MYD:	102761559(MMP14)

MNA:	107531691(MMP14)

HAI:	109393698(MMP14)

DRO:	112301504(MMP14)

PALE:

102887003(MMP14)

RAY:	107498042(MMP14)

MJV:	108400026(MMP14)

LAV:	100671131(MMP14)

TMU:

101345768

MDO:	100030382(MMP14)

SHR:	100932143(MMP14)

PCW:	110223023(MMP14)

OAA:	100091029(MMP14)

TGU:

115493029

LSR:

110481924

PHI:	102107021(MMP14)

ASN:	102368749(MMP14)

AMJ:	102558609(MMP14)

CMY:

102943947

CPIC:

101945719(MMP14)

ACS:	100553534(mmp14)

PVT:	110087815(MMP14)

PBI:	103064383(MMP14)

PMUR:

107295092(MMP14)

TSR:	106550394(MMP14)

PMUA:

114581663(MMP14)

GJA:	107109121(MMP14)

XLA:	108707025 407753(mmp14.L)

XTR:	594950(mmp14)

NPR:	108786770(MMP14)

DRE:	373882(mmp14a) 566945(mmp14b)

SRX:	107706348 107738136 107753930

SANH:

107668983 107669100 107691938 107704286

SGH:	107557973 107562471(mmp14) 107588203 107591383

CCAR:

109060080 109064679 109111707 109111713

IPU:	108267723 108267832 108267934(mmp14)

PHYP:

113525614 113540329

AMEX:

103024760(mmp14) 103041213

EEE:	113578328 113589197(mmp14)

TRU:	101061607 101073560

TNG:	GSTEN00015140G001 GSTEN00025878G001

LCO:	104927972 104932902

NCC:	104952609 104956583

MZE:	101464934 101486213

ONL:	100691693 100695964

OLA:	100125428(mmp14) 101171699

XMA:	102236291 102236856

XCO:	114146537 114157472

PRET:

103475992 103478877

CVG:	107087725 107101469(mmp14)

NFU:	107377284(mmp14) 107384247

KMR:	108238671(mmp14) 108245890

ALIM:

106517892 106526432 106535469

AOCE:

111577984 111587803

CSEM:

103388226(mmp14) 103396588

POV:	109640512 109641241

LCF:	108883931 108903045

SDU:	111223843 111235670

SLAL:

111647186 111666536

HCQ:	109508489 109512811

BPEC:

110170349 110172013

MALB:

109962674 109974431

SASA:

106569443 106577791 106600280 106608848

OTW:	112214636 112226707 112235598 112260764

SALP:

111953232 111956641 111979299 112080231

ELS:	105020567 105021572

SFM:	108930930 108937864(mmp14) 114911942

PKI:	111837704 111854546

LCM:	102355301(MMP14)

CMK:	103179997(prg4)

BFO:	BRAFLDRAFT_110778 BRAFLDRAFT_121872 BRAFLDRAFT_121873 BRAFLDRAFT_174415 BRAFLDRAFT_230518 BRAFLDRAFT_264495 BRAFLDRAFT_67465 BRAFLDRAFT_89756 BRAFLDRAFT_92283 BRAFLDRAFT_92284

CIN:

100181633

APLC:

110981585 110981864 110982266 110986275 110986843 110986844 110986855 110986884 110990105

SKO:	100366845 100369238 100369384 100373845 100377895 100378191 102807864

DME:	Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)

DER:

6548508

DSE:	Dsec_GM11800

DSI:	Dsimw501_GD24926(Dsim_GD24926)

DYA:	Dyak_GE11424

DAN:	Dana_GF11910

DSR:

110182794

DPO:	Dpse_GA18484

DPE:

6592953

DMN:

108160136

DWI:

6640267

DGR:	Dgri_GH21566

DMO:	Dmoj_GI19538

DAZ:

108616549

DNV:

108654324

DHE:

111593840

DVI:	Dvir_GJ21109

MDE:

101888990

LCQ:

111679245

AGA:	AgaP_AGAP006904

AAG:

5566822

AALB:

109425677 115256248

CQU:	CpipJ_CPIJ010856

BIM:

BTER:

CCAL:

OBB:

SOC:	105198300 105205971

MPHA:

105835181 105835693

AEC:

105151121

ACEP:

105619997

PBAR:

105422417 105424383 105426446

VEM:

HST:

DQU:

CFO:

LHU:

PGC:	109858212 109861586 109861889 109861992 109862219 109863338

OBO:

105286124

PCF:

106788603

NVI:	100113893(Mmp1)

CSOL:

105368158

MDL:

103577460

TCA:	103313084 103313085 657261(Mmp-1)

DPA:

109542402

ATD:

109596135

NVL:	108563139 108563140 108566081

BMOR:

100144547(Mmp1)

BMAN:

114249403

DPL:	KGM_204463

PMAC:

PRAP:

HAW:

TNL:

PXY:

API:

DNX:

AGS:	114124803 114124805

RMD:

113560497

BTAB:

109040286

CLEC:

106669674

PHU:	Phum_PHUM302710

ZNE:	110834801 110834804 110840851

FCD:	110860548 110860649 110860650 110860652 110860657

DPX:	DAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_316218 DAPPUDRAFT_325672 DAPPUDRAFT_325673

PVM:

113820224

ISC:	IscW_ISCW006136

TUT:

107367240

DPTE:

113799701

CSCU:

111636483

PTEP:

107450087 107450091 107450852 107454725

HRO:	HELRODRAFT_108967 HELRODRAFT_193602 HELRODRAFT_193603

LGI:	LOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475

PCAN:

112555453 112562988

CRG:	105319539 105333479 105338896

MYI:	110455345 110459519 110462871

OBI:	106869299 106873152 106876107 106879964

LAK:	106152579 106152606 106155462 106156796 106163428 106164145 106168179

NVE:	NEMVE_v1g166550

EPA:	110231292 110238012 110238646 110239804 110251669

ADF:	107349768 107349780

AMIL:

114963032 114966302 114966306 114966308

PDAM:

113669026 113674901 113678590 113679792 113684651 113684653 113685983

SPIS:

111324455 111324941 111324943 111324944 111324945 111324968 111342087

DGT:	114517718 114518429 114522163 114542131

» show all

Reference

1 [PMID:11532942]

Authors

Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.

Title

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

Journal

EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.80

IUBMB Enzyme Nomenclature:

3.4.24.80

ExPASy - ENZYME nomenclature database:

3.4.24.80

BRENDA, the Enzyme Database:

3.4.24.80

CAS:	161384-17-4

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Gene (6072)   
   KEGG ORTHOLOGY (1)   
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Protein sequence (78)   
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