KEGG ENZYME: 3.4.24.80

ENZYME: 3.4.24.80

Entry

EC 3.4.24.80                Enzyme

Name

membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain

Comment

In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

History

EC 3.4.24.80 created 2003

Orthology

K07763

matrix metalloproteinase-14 (membrane-inserted)

Genes

HSA:	4323(MMP14)

PTR:	742887(MMP14)

PPS:	100990208(MMP14)

GGO:	101142469(MMP14)

PON:	100171646(MMP14)

NLE:	100606407(MMP14)

MCC:	712429(MMP14)

MCF:	102132205(MMP14)

CSAB:

103231446(MMP14)

CATY:

105598793(MMP14)

PANU:

101021138(MMP14)

TGE:	112629015(MMP14)

RRO:	104674133(MMP14)

RBB:	108523596(MMP14)

TFN:	117069995(MMP14)

PTEH:

111554785(MMP14)

CJC:	100389088(MMP14)

SBQ:	101041075(MMP14)

CSYR:

103267686(MMP14)

MMUR:

105864715(MMP14)

OGA:	100957810(MMP14)

MMU:	17387(Mmp14)

MCAL:

110309210(Mmp14)

MPAH:

110325048(Mmp14)

RNO:	81707(Mmp14)

MCOC:

116084514(Mmp14)

MUN:	110550039(Mmp14)

CGE:	100689336(Mmp14)

PLEU:

114708709(Mmp14)

NGI:	103739479(Mmp14)

HGL:	101723795(Mmp14)

CPOC:

100732039(Mmp14)

CCAN:

109685808(Mmp14) 109689717

DORD:

105992545(Mmp14)

DSP:	122113480(Mmp14)

OCU:	100009598(MMP14)

OPI:	101516419(MMP14)

TUP:	102468813(MMP14)

CFA:	403823(MMP14)

VVP:	112926491(MMP14)

VLG:	121493160(MMP14)

AML:	100468621(MMP14)

UMR:	103681059(MMP14)

UAH:	113246072(MMP14)

UAR:	123795799(MMP14)

ELK:

111158421

LLV:

125104089

MPUF:

101689912(MMP14)

ORO:	101369821(MMP14)

EJU:	114217869(MMP14)

ZCA:	113909394(MMP14)

MLX:	118003628(MMP14)

FCA:	101089776(MMP14)

PYU:	121031488(MMP14)

PBG:	122468871(MMP14)

PTG:	102953674(MMP14)

PPAD:

109255047(MMP14)

AJU:	106988210(MMP14)

HHV:	120240441(MMP14)

BTA:	281915(MMP14)

BOM:	102281987(MMP14)

BIU:	109564819(MMP14)

BBUB:

102413520(MMP14)

CHX:	100861171(MMP14)

OAS:	443116(MMP14)

ODA:	120853412(MMP14)

CCAD:

122443218(MMP14)

SSC:	397471(MMP14)

CFR:	102513570(MMP14)

CBAI:

105068764(MMP14)

CDK:	105096970(MMP14)

VPC:	102525752(MMP14)

BACU:

103003307(MMP14)

LVE:	103081188(MMP14)

OOR:	101284790(MMP14)

DLE:	111164185(MMP14)

PCAD:

102987825(MMP14)

PSIU:

116748985(MMP14)

ECB:	100034170(MMP14)

EPZ:	103556751(MMP14)

EAI:	106840662(MMP14)

MYB:	102240202(MMP14)

MYD:	102761559(MMP14)

MMYO:

118679356(MMP14)

MLF:	102431406(MMP14)

MNA:	107531691(MMP14)

PKL:	118724917(MMP14)

HAI:	109393698(MMP14)

DRO:	112301504(MMP14)

SHON:

118980961(MMP14)

AJM:	119037284(MMP14)

PDIC:

114491682(MMP14)

PHAS:

123820486(MMP14)

MMF:	118616019(MMP14)

RFQ:	117024113(MMP14)

PALE:

102887003(MMP14)

PGIG:

120593901(MMP14)

PVP:	105300520(MMP14)

RAY:	107498042(MMP14)

MJV:	108400026(MMP14)

TOD:	119238905(MMP14)

SARA:

101551659(MMP14)

LAV:	100671131(MMP14)

TMU:

101345768

DNM:	101420058(MMP14)

MDO:	100030382(MMP14)

GAS:	123236026(MMP14)

SHR:	100932143(MMP14)

PCW:	110223023(MMP14)

OAA:	100091029(MMP14)

LSR:

110481924

PMOA:

120512485

PHI:	102107021(MMP14)

ASN:	102368749(MMP14)

AMJ:	102558609(MMP14)

CMY:	102943947(MMP14)

CPIC:

101945719(MMP14)

CABI:

116818422(MMP14)

MRV:	120380346(MMP14)

ACS:	100553534(mmp14)

PVT:	110087815(MMP14)

SUND:

121934813(MMP14)

PBI:	103064383(MMP14)

PMUR:

107295092(MMP14)

TSR:	106550394(MMP14)

PGUT:

117658208(MMP14)

VKO:	123018636(MMP14)

PMUA:

114581663(MMP14)

ZVI:	118095008(MMP14)

GJA:	107109121(MMP14)

XLA:	108707025 407753(mmp14.L)

XTR:	594950(mmp14)

NPR:	108786770(MMP14)

RTEM:

120941067(MMP14)

BBUF:

120989035(MMP14)

BGAR:

122923469(MMP14)

DRE:	373882(mmp14a) 566945(mmp14b)

SRX:	107706348 107738136 107753930

SANH:

107668983 107669100 107691938 107704286

SGH:	107557973 107562471(mmp14) 107588203 107591383

CCAR:

109060080 109064679 109111707 109111713

CAUA:

113044985 113052124 113052125 113105708 113119884

IPU:	108267723 108267832 108267934(mmp14a)

PHYP:

113525614 113540329

SMEO:

124386873(mmp14b) 124387269(mmp14a)

AMEX:

103024760(mmp14) 103041213

EEE:	113578328 113589197(mmp14)

TRU:	101061607 101073560

TNG:	GSTEN00015140G001 GSTEN00025878G001

LCO:	104927972 104932902

NCC:	104952609 104956583

CGOB:

115022907 115023741

ELY:	117246202(mmp14a) 117272256(mmp14b)

PLEP:

121952037(mmp14b) 121961947(mmp14a)

SLUC:

116043318(mmp14a) 116055111(mmp14b)

ECRA:

117934665(mmp14a) 117954333(mmp14b)

PFLV:

114545892(mmp14) 114565145

GAT:	120816303(mmp14b) 120821932(mmp14a)

PPUG:

119209171(mmp14b) 119222503(mmp14a)

MSAM:

119902498(mmp14b) 119912139(mmp14a)

CUD:	121504664(mmp14a) 121520493(mmp14b)

MZE:	101464934 101486213

ONL:	100691693 100695964

OAU:	116312338(mmp14a) 116333767(mmp14b)

OLA:	100125428(mmp14) 101171699

OML:	112147164(mmp14b) 112156455(mmp14a)

XMA:	102236291 102236856

XCO:	114146537 114157472

XHE:	116721687 116732222

PRET:

103475992 103478877

PFOR:

103138402 103145985(mmp14)

PLAI:

106934757 106944750

PMEI:

106918840(mmp14) 106926970

GAF:	122820067(mmp14a) 122840722(mmp14b)

CVG:	107087725 107101469(mmp14)

CTUL:

119773355(mmp14a) 119793328(mmp14b)

GMU:	124870019(mmp14b) 124881091(mmp14a)

NFU:	107377284(mmp14) 107384247

KMR:	108238671(mmp14b) 108245890(mmp14a)

ALIM:

106517892 106526432 106535469

NWH:	119408978(mmp14a) 119414992(mmp14b)

AOCE:

111577984 111587803

CSEM:

103388226(mmp14) 103396588

POV:	109640512 109641241

SSEN:

122766893(mmp14a) 122778576(mmp14b)

HHIP:

117778918(mmp14b) 117779297(mmp14a)

LCF:	108883931 108903045

SDU:	111223843 111235670

SLAL:

111647186 111666536

XGL:	120797566(mmp14a) 120799114(mmp14b)

HCQ:	109508489 109512811

BPEC:

110170349 110172013

MALB:

109962674 109974431

SASA:

106569443 106577791 106600280 106608848

OTW:	112214636(mmp14a) 112226707 112235598 112260764

OMY:	110500495(mmp14a) 110508483(mmp14b) 110530599 110531636

OGO:	124008505 124009973 124014257 124041589(mmp14b)

ONE:	115102780 115114675 115133442 115137978

SALP:

111953232 111956641 111979299 112080231

SNH:	120020209 120030301 120049716 120055633

ELS:	105020567 105021572

SFM:	108930930 108937864(mmp14) 114911942

PKI:	111837704 111854546

AANG:

118234064(mmp14b)

PSPA:

121305269 121306845

ARUT:

117398173(mmp14b)

LCM:	102355301(MMP14)

BFO:	118403865 118405991 118406077 118407203 118407405 118407406 118410626 118416517 118418696 118422022 118426409 118431106

BBEL:

109462286 109465428 109467309 109468271 109468435 109474289 109479373 109480028 109480908 109486532

CIN:	100175506 100181633 100184312

SCLV:

120329469 120332934

SPU:	105436437 105439065 105441790 115919166 115921774 115923431 115924100 115924102 576018 576145 581157 581457 582797(MMP14) 583799 585680 592649 752715

APLC:

110981585 110981864 110982266 110986275 110986843 110986844 110986855 110986884 110990105

SKO:	100369238 100369384 100373845 100373999 100377895 100378191

DME:	Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)

DER:	6548508 6553563

DSE:

6618866

DSI:	Dsimw501_GD20010(Dsim_GD20010) Dsimw501_GD24926(Dsim_GD24926)

DYA:	Dyak_GE11424

DAN:

6494770

DSR:

110182794

DPO:	Dpse_GA18484

DPE:

6592953

DMN:	108160136 117185778

DWI:

6640267

DGR:	6560466 6563713

DMO:	Dmoj_GI19538

DAZ:

108616549

DNV:

108654324

DHE:

111593840

DVI:

6625046

CCAT:

101460552 101461412

BOD:	106622068 106627693

MDE:

101888990

SCAC:

106082756 106086034

LCQ:

111679245

AGA:	AgaP_AGAP006904

ACOZ:

120947394

AARA:

120897383 120905478

AAG:	5566822 5575548 5575549 5575550 5575574

AALB:

109410819 109410820 109410823 109421170 109421241 109421242 109425677 115256248 115256255 115256256 115256258 115266864 115266868 115266869

CQU:	CpipJ_CPIJ010856 CpipJ_CPIJ012497 CpipJ_CPIJ015719 CpipJ_CPIJ016690 CpipJ_CPIJ016691 CpipJ_CPIJ016692

CPII:

120414643 120414880 120421278 120421289 120421290 120421291

CNS:

116338916

ACER:

107993310

ALAB:

122710880

BIM:

100741313

BBIF:

117212916

BVK:

117233695

BVAN:

117158980

BTER:

100647268

BPYO:

122571303

CCAL:

108628386

OBB:

114880439

MGEN:

117217405

NMEA:

116426310

CGIG:

122400960 122402161

SOC:	105198300 105205971

MPHA:

105835181 105835693

AEC:

105151121

ACEP:

105619997

PBAR:

105422417 105424243 105424383 105426446

VEM:

105566274

HST:

105190364

DQU:	106744935 106748962

CFO:

105255413

FEX:

115241861

LHU:

105675698

PGC:	109858212 109861586 109861889 109861992 109862219 109863338

OBO:

105286124

PCF:

106788603

PFUC:

122522006

VPS:

122636559

NVI:	100113893(Mmp1)

CSOL:

105368158

TPRE:

106651404

MDL:

103577460

CGLO:

123263452

FAS:

105271342

DAM:

107036851

AGIF:

122847785 122860917

CCIN:

107268792 107270395 107272043

TCA:	103313084 103313085 657261(Mmp-1)

DPA:

109542402

SOY:	115889248 115889561

ATD:

109596135

CSET:

123311328 123312265 123312267

AGB:	108910021 108910921

LDC:	111512850 111512852

NVL:	108563139 108563140 108566081

APLN:

108741148 112904568

PPYR:

116163807 116172083 116172517 116182295

OTU:	111415936 111417845 111424932

BMOR:

100144547(Mmp1)

BMAN:

114249403

MSEX:

115445748 119191609 119193430

DPL:	KGM_204463

BANY:

112043322

PMAC:

106712426

PPOT:

106107829

PXU:

106116917

PRAP:

111002882

ZCE:	119830077 119830092 119830249

HAW:

110371693

TNL:

113492652

OFU:

114356670

PXY:

105396373

API:

100164006

DNX:

107166270

AGS:	114124803 114124805

RMD:

113560497

BTAB:

109040286

DCI:

103519571

CLEC:

106669674

HHAL:

106677886 106677898 106677916 106691851

NLU:	111057664 111058731

PHU:	Phum_PHUM302710

FOC:

113213791

ZNE:	110834801 110834804 110840851

CSEC:

111865495 111865497 111866716 111866774

FCD:	110860548 110860649 110860650 110860652 110860657

DPX:	DAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_316218 DAPPUDRAFT_325672 DAPPUDRAFT_325673

DMK:

116916797

PVM:

113820224

PJA:

122257686

HAME:

121869479 121869561

PCLA:

123744861 123744862 123759852

PTRU:

123501683

HAZT:

108667780

EAF:	111699680 111708257 111710507

ISC:	IscW_ISCW006136

DSV:

119443090

RSAN:

119388217

RMP:

119185118

VDE:

111254153

VJA:

111271735

TUT:

107367240

DPTE:

113799701

DFR:

124494264

CSCU:

111636483

PTEP:

107450087 107450091

SDM:	118183209 118205650

HRO:	HELRODRAFT_108967 HELRODRAFT_193602 HELRODRAFT_193603

LGI:	LOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475

PCAN:

112555453 112562988

BGT:	106051365 106074476

GAE:	121367749 121376669

HRF:	124112473 124113799 124116437 124116459 124120008

HRJ:	124253143 124256263 124261822 124277101

CRG:	105319539 105333479

MYI:	110455345 110459519 110462871

PMAX:

117342186

MMER:

123533194 123554940

OBI:	106869299 106873152 106876107 106879964

OSN:	115209377 115224271 115230377

LAK:	106152579 106152606 106155462 106156796 106163428 106164145 106168179

NVE:	5500606 5506166 5509262 5510262 5510263 5512892 5520492 5520493

EPA:	110231292 110238012 110238646 110239804 110251669 110254069

ATEN:

116286904 116289580 116302034 116302824

ADF:	107349768 107349780

AMIL:

114963032 114966306 114966308

PDAM:

113669026 113674901 113674903 113678590 113679792 113684651 113684653 113685983

SPIS:

111324455 111324555 111324941 111324943 111324944 111324945 111324968 111342087

DGT:	114517718 114522163 114542131

XEN:	124434705 124441150 124441151 124457226

HMG:	100199631 100199712 100200849(mmp) 100200988 100201138 100201778 100202503 100204953 101234798 101236912 101239608 101241586 105843571

» show all

Reference

1 [PMID:11532942]

Authors

Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.

Title

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

Journal

EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.80

IUBMB Enzyme Nomenclature:

3.4.24.80

ExPASy - ENZYME nomenclature database:

3.4.24.80

BRENDA, the Enzyme Database:

3.4.24.80

CAS:	161384-17-4

DBGET integrated database retrieval system