KEGG   ENZYME: 3.4.24.80Help
Entry
EC 3.4.24.80                Enzyme                                 

Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763  matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA: 4323(MMP14)
PTR: 742887(MMP14)
PPS: 100990208(MMP14)
GGO: 101142469(MMP14)
PON: 100171646(MMP14)
NLE: 100606407(MMP14)
MCC: 712429(MMP14)
MCF: 102132205(MMP14)
CSAB: 103231446(MMP14)
RRO: 104674133(MMP14)
RBB: 108523596(MMP14)
CJC: 100389088(MMP14)
SBQ: 101041075(MMP14)
MMU: 17387(Mmp14)
MCAL: 110309210(Mmp14)
MPAH: 110325048(Mmp14)
RNO: 81707(Mmp14)
MUN: 110550039(Mmp14)
CGE: 100689336(Mmp14)
NGI: 103739479(Mmp14)
HGL: 101723795(Mmp14)
CCAN: 109685808(Mmp14) 109689717
OCU: 100009598(MMP14)
TUP: 102468813(MMP14)
CFA: 403823(MMP14)
VVP: 112926491(MMP14)
AML: 100468621(MMP14)
UMR: 103681059(MMP14)
UAH: 113246072(MMP14)
ORO: 101369821(MMP14)
ELK: 111158421
FCA: 101089776(MMP14)
PTG: 102953674(MMP14)
PPAD: 109255047(MMP14)
AJU: 106988210(MMP14)
BTA: 281915(MMP14)
BOM: 102281987(MMP14)
BIU: 109564819(MMP14)
BBUB: 102413520(MMP14)
CHX: 100861171(MMP14)
OAS: 443116(MMP14)
SSC: 397471(MMP14)
CFR: 102513570 102524386(MMP14)
CDK: 105096970(MMP14)
BACU: 103003307(MMP14)
LVE: 103081188(MMP14)
OOR: 101284790(MMP14)
DLE: 111164185(MMP14)
PCAD: 102987825(MMP14)
ECB: 100034170(MMP14)
EPZ: 103556751(MMP14)
EAI: 106840662(MMP14)
MYB: 102240202(MMP14)
MYD: 102761559(MMP14)
MNA: 107531691(MMP14)
HAI: 109393698(MMP14)
DRO: 112301504(MMP14)
PALE: 102887003(MMP14)
RAY: 107498042(MMP14)
MJV: 108400026(MMP14)
LAV: 100671131(MMP14)
TMU: 101345768
MDO: 100030382(MMP14)
SHR: 100932143(MMP14)
PCW: 110223023(MMP14)
OAA: 100091029(MMP14)
TGU: 115493029
LSR: 110481924
PHI: 102107021(MMP14)
ASN: 102368749(MMP14)
AMJ: 102558609(MMP14)
CMY: 102943947
CPIC: 101945719(MMP14)
ACS: 100553534(mmp14)
PVT: 110087815(MMP14)
PBI: 103064383(MMP14)
PMUR: 107295092(MMP14)
TSR: 106550394(MMP14)
PMUA: 114581663(MMP14)
GJA: 107109121(MMP14)
XLA: 108707025 407753(mmp14.L)
XTR: 594950(mmp14)
NPR: 108786770(MMP14)
DRE: 373882(mmp14a) 566945(mmp14b)
AMEX: 103024760(mmp14) 103041213
EEE: 113578328 113589197(mmp14)
OLA: 100125428(mmp14) 101171699
CVG: 107087725 107101469(mmp14)
NFU: 107377284(mmp14) 107384247
KMR: 108238671(mmp14) 108245890
CSEM: 103388226(mmp14) 103396588
LCM: 102355301(MMP14)
CMK: 103179997(prg4)
CIN: 100181633
DME: Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)
DER: 6548508
DSI: Dsimw501_GD24926(Dsim_GD24926)
DSR: 110182794
DPE: 6592953
DMN: 108160136
DWI: 6640267
DAZ: 108616549
DNV: 108654324
DHE: 111593840
MDE: 101888990
LCQ: 111679245
AAG: 5566822
BIM: 100741313
BTER: 100647268
CCAL: 108628386
OBB: 114880439
AEC: 105151121
ACEP: 105619997
VEM: 105566274
HST: 105190364
DQU: 106744935
CFO: 105255413
LHU: 105675698
OBO: 105286124
PCF: 106788603
NVI: 100113893(Mmp1)
CSOL: 105368158
MDL: 103577460
DPA: 109542402
ATD: 109596135
BMOR: 100144547(Mmp1)
BMAN: 114249403
PMAC: 106712426
HAW: 110371693
TNL: 113492652
PXY: 105396373
API: 100164006
DNX: 107166270
RMD: 113560497
BTAB: 109040286
CLEC: 106669674
PVM: 113820224
TUT: 107367240
DPTE: 113799701
CSCU: 111636483
 » show all
Taxonomy
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.80
IUBMB Enzyme Nomenclature: 3.4.24.80
ExPASy - ENZYME nomenclature database: 3.4.24.80
BRENDA, the Enzyme Database: 3.4.24.80
CAS: 161384-17-4

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