KEGG   ENZYME: 3.4.24.80
Entry
EC 3.4.24.80                Enzyme                                 
Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763  matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA4323(MMP14)
PTR742887(MMP14)
PPS100990208(MMP14)
GGO101142469(MMP14)
PON100171646(MMP14)
NLE100606407(MMP14)
MCC712429(MMP14)
MCF102132205(MMP14)
CSAB103231446(MMP14)
CATY105598793(MMP14)
PANU101021138(MMP14)
TGE112629015(MMP14)
RRO104674133(MMP14)
RBB108523596(MMP14)
TFN117069995(MMP14)
PTEH111554785(MMP14)
CJC100389088(MMP14)
SBQ101041075(MMP14)
CSYR103267686(MMP14)
MMUR105864715(MMP14)
OGA100957810(MMP14)
MMU17387(Mmp14)
MCAL110309210(Mmp14)
MPAH110325048(Mmp14)
RNO81707(Mmp14)
MCOC116084514(Mmp14)
MUN110550039(Mmp14)
CGE100689336(Mmp14)
PLEU114708709(Mmp14)
NGI103739479(Mmp14)
HGL101723795(Mmp14)
CPOC100732039(Mmp14)
CCAN109685808(Mmp14) 109689717
DORD105992545(Mmp14)
DSP122113480(Mmp14)
OCU100009598(MMP14)
OPI101516419(MMP14)
TUP102468813(MMP14)
CFA403823(MMP14)
VVP112926491(MMP14)
VLG121493160(MMP14)
AML100468621(MMP14)
UMR103681059(MMP14)
UAH113246072(MMP14)
UAR123795799(MMP14)
ELK111158421
LLV125104089
MPUF101689912(MMP14)
ORO101369821(MMP14)
EJU114217869(MMP14)
ZCA113909394(MMP14)
MLX118003628(MMP14)
FCA101089776(MMP14)
PYU121031488(MMP14)
PBG122468871(MMP14)
PTG102953674(MMP14)
PPAD109255047(MMP14)
AJU106988210(MMP14)
HHV120240441(MMP14)
BTA281915(MMP14)
BOM102281987(MMP14)
BIU109564819(MMP14)
BBUB102413520(MMP14)
CHX100861171(MMP14)
OAS443116(MMP14)
ODA120853412(MMP14)
CCAD122443218(MMP14)
SSC397471(MMP14)
CFR102513570(MMP14)
CBAI105068764(MMP14)
CDK105096970(MMP14)
VPC102525752(MMP14)
BACU103003307(MMP14)
LVE103081188(MMP14)
OOR101284790(MMP14)
DLE111164185(MMP14)
PCAD102987825(MMP14)
PSIU116748985(MMP14)
ECB100034170(MMP14)
EPZ103556751(MMP14)
EAI106840662(MMP14)
MYB102240202(MMP14)
MYD102761559(MMP14)
MMYO118679356(MMP14)
MLF102431406(MMP14)
MNA107531691(MMP14)
PKL118724917(MMP14)
HAI109393698(MMP14)
DRO112301504(MMP14)
SHON118980961(MMP14)
AJM119037284(MMP14)
PDIC114491682(MMP14)
PHAS123820486(MMP14)
MMF118616019(MMP14)
RFQ117024113(MMP14)
PALE102887003(MMP14)
PGIG120593901(MMP14)
PVP105300520(MMP14)
RAY107498042(MMP14)
MJV108400026(MMP14)
TOD119238905(MMP14)
SARA101551659(MMP14)
LAV100671131(MMP14)
TMU101345768
DNM101420058(MMP14)
MDO100030382(MMP14)
GAS123236026(MMP14)
SHR100932143(MMP14)
PCW110223023(MMP14)
OAA100091029(MMP14)
LSR110481924
PMOA120512485
PHI102107021(MMP14)
ASN102368749(MMP14)
AMJ102558609(MMP14)
CMY102943947(MMP14)
CPIC101945719(MMP14)
CABI116818422(MMP14)
MRV120380346(MMP14)
ACS100553534(mmp14)
PVT110087815(MMP14)
SUND121934813(MMP14)
PBI103064383(MMP14)
PMUR107295092(MMP14)
TSR106550394(MMP14)
PGUT117658208(MMP14)
VKO123018636(MMP14)
PMUA114581663(MMP14)
ZVI118095008(MMP14)
GJA107109121(MMP14)
XLA108707025 407753(mmp14.L)
XTR594950(mmp14)
NPR108786770(MMP14)
RTEM120941067(MMP14)
BBUF120989035(MMP14)
BGAR122923469(MMP14)
DRE373882(mmp14a) 566945(mmp14b)
SRX107706348 107738136 107753930
SANH107668983 107669100 107691938 107704286
SGH107557973 107562471(mmp14) 107588203 107591383
CCAR109060080 109064679 109111707 109111713
CAUA113044985 113052124 113052125 113105708 113119884
IPU108267723 108267832 108267934(mmp14a)
PHYP113525614 113540329
SMEO124386873(mmp14b) 124387269(mmp14a)
AMEX103024760(mmp14) 103041213
EEE113578328 113589197(mmp14)
TRU101061607 101073560
TNGGSTEN00015140G001 GSTEN00025878G001
LCO104927972 104932902
NCC104952609 104956583
CGOB115022907 115023741
ELY117246202(mmp14a) 117272256(mmp14b)
PLEP121952037(mmp14b) 121961947(mmp14a)
SLUC116043318(mmp14a) 116055111(mmp14b)
ECRA117934665(mmp14a) 117954333(mmp14b)
PFLV114545892(mmp14) 114565145
GAT120816303(mmp14b) 120821932(mmp14a)
PPUG119209171(mmp14b) 119222503(mmp14a)
MSAM119902498(mmp14b) 119912139(mmp14a)
CUD121504664(mmp14a) 121520493(mmp14b)
MZE101464934 101486213
ONL100691693 100695964
OAU116312338(mmp14a) 116333767(mmp14b)
OLA100125428(mmp14) 101171699
OML112147164(mmp14b) 112156455(mmp14a)
XMA102236291 102236856
XCO114146537 114157472
XHE116721687 116732222
PRET103475992 103478877
PFOR103138402 103145985(mmp14)
PLAI106934757 106944750
PMEI106918840(mmp14) 106926970
GAF122820067(mmp14a) 122840722(mmp14b)
CVG107087725 107101469(mmp14)
CTUL119773355(mmp14a) 119793328(mmp14b)
GMU124870019(mmp14b) 124881091(mmp14a)
NFU107377284(mmp14) 107384247
KMR108238671(mmp14b) 108245890(mmp14a)
ALIM106517892 106526432 106535469
NWH119408978(mmp14a) 119414992(mmp14b)
AOCE111577984 111587803
CSEM103388226(mmp14) 103396588
POV109640512 109641241
SSEN122766893(mmp14a) 122778576(mmp14b)
HHIP117778918(mmp14b) 117779297(mmp14a)
LCF108883931 108903045
SDU111223843 111235670
SLAL111647186 111666536
XGL120797566(mmp14a) 120799114(mmp14b)
HCQ109508489 109512811
BPEC110170349 110172013
MALB109962674 109974431
SASA106569443 106577791 106600280 106608848
OTW112214636(mmp14a) 112226707 112235598 112260764
OMY110500495(mmp14a) 110508483(mmp14b) 110530599 110531636
OGO124008505 124009973 124014257 124041589(mmp14b)
ONE115102780 115114675 115133442 115137978
SALP111953232 111956641 111979299 112080231
SNH120020209 120030301 120049716 120055633
ELS105020567 105021572
SFM108930930 108937864(mmp14) 114911942
PKI111837704 111854546
AANG118234064(mmp14b)
PSPA121305269 121306845
ARUT117398173(mmp14b)
LCM102355301(MMP14)
BFO118403865 118405991 118406077 118407203 118407405 118407406 118410626 118416517 118418696 118422022 118426409 118431106
BBEL109462286 109465428 109467309 109468271 109468435 109474289 109479373 109480028 109480908 109486532
CIN100175506 100181633 100184312
SCLV120329469 120332934
SPU105436437 105439065 105441790 115919166 115921774 115923431 115924100 115924102 576018 576145 581157 581457 582797(MMP14) 583799 585680 592649 752715
APLC110981585 110981864 110982266 110986275 110986843 110986844 110986855 110986884 110990105
SKO100369238 100369384 100373845 100373999 100377895 100378191
DMEDmel_CG4859(Mmp1) Dmel_CG7056(HHEX)
DER6548508 6553563
DSE6618866
DSIDsimw501_GD20010(Dsim_GD20010) Dsimw501_GD24926(Dsim_GD24926)
DYADyak_GE11424
DAN6494770
DSR110182794
DPODpse_GA18484
DPE6592953
DMN108160136 117185778
DWI6640267
DGR6560466 6563713
DMODmoj_GI19538
DAZ108616549
DNV108654324
DHE111593840
DVI6625046
CCAT101460552 101461412
BOD106622068 106627693
MDE101888990
SCAC106082756 106086034
LCQ111679245
AGAAgaP_AGAP006904
ACOZ120947394
AARA120897383 120905478
AAG5566822 5575548 5575549 5575550 5575574
AALB109410819 109410820 109410823 109421170 109421241 109421242 109425677 115256248 115256255 115256256 115256258 115266864 115266868 115266869
CQUCpipJ_CPIJ010856 CpipJ_CPIJ012497 CpipJ_CPIJ015719 CpipJ_CPIJ016690 CpipJ_CPIJ016691 CpipJ_CPIJ016692
CPII120414643 120414880 120421278 120421289 120421290 120421291
CNS116338916
ACER107993310
ALAB122710880
BIM100741313
BBIF117212916
BVK117233695
BVAN117158980
BTER100647268
BPYO122571303
CCAL108628386
OBB114880439
MGEN117217405
NMEA116426310
CGIG122400960 122402161
SOC105198300 105205971
MPHA105835181 105835693
AEC105151121
ACEP105619997
PBAR105422417 105424243 105424383 105426446
VEM105566274
HST105190364
DQU106744935 106748962
CFO105255413
FEX115241861
LHU105675698
PGC109858212 109861586 109861889 109861992 109862219 109863338
OBO105286124
PCF106788603
PFUC122522006
VPS122636559
NVI100113893(Mmp1)
CSOL105368158
TPRE106651404
MDL103577460
CGLO123263452
FAS105271342
DAM107036851
AGIF122847785 122860917
CCIN107268792 107270395 107272043
TCA103313084 103313085 657261(Mmp-1)
DPA109542402
SOY115889248 115889561
ATD109596135
CSET123311328 123312265 123312267
AGB108910021 108910921
LDC111512850 111512852
NVL108563139 108563140 108566081
APLN108741148 112904568
PPYR116163807 116172083 116172517 116182295
OTU111415936 111417845 111424932
BMOR100144547(Mmp1)
BMAN114249403
MSEX115445748 119191609 119193430
DPLKGM_204463
BANY112043322
PMAC106712426
PPOT106107829
PXU106116917
PRAP111002882
ZCE119830077 119830092 119830249
HAW110371693
TNL113492652
OFU114356670
PXY105396373
API100164006
DNX107166270
AGS114124803 114124805
RMD113560497
BTAB109040286
DCI103519571
CLEC106669674
HHAL106677886 106677898 106677916 106691851
NLU111057664 111058731
PHUPhum_PHUM302710
FOC113213791
ZNE110834801 110834804 110840851
CSEC111865495 111865497 111866716 111866774
FCD110860548 110860649 110860650 110860652 110860657
DPXDAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_316218 DAPPUDRAFT_325672 DAPPUDRAFT_325673
DMK116916797
PVM113820224
PJA122257686
HAME121869479 121869561
PCLA123744861 123744862 123759852
PTRU123501683
HAZT108667780
EAF111699680 111708257 111710507
ISCIscW_ISCW006136
DSV119443090
RSAN119388217
RMP119185118
VDE111254153
VJA111271735
TUT107367240
DPTE113799701
DFR124494264
CSCU111636483
PTEP107450087 107450091
SDM118183209 118205650
HROHELRODRAFT_108967 HELRODRAFT_193602 HELRODRAFT_193603
LGILOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475
PCAN112555453 112562988
BGT106051365 106074476
GAE121367749 121376669
HRF124112473 124113799 124116437 124116459 124120008
HRJ124253143 124256263 124261822 124277101
CRG105319539 105333479
MYI110455345 110459519 110462871
PMAX117342186
MMER123533194 123554940
OBI106869299 106873152 106876107 106879964
OSN115209377 115224271 115230377
LAK106152579 106152606 106155462 106156796 106163428 106164145 106168179
NVE5500606 5506166 5509262 5510262 5510263 5512892 5520492 5520493
EPA110231292 110238012 110238646 110239804 110251669 110254069
ATEN116286904 116289580 116302034 116302824
ADF107349768 107349780
AMIL114963032 114966306 114966308
PDAM113669026 113674901 113674903 113678590 113679792 113684651 113684653 113685983
SPIS111324455 111324555 111324941 111324943 111324944 111324945 111324968 111342087
DGT114517718 114522163 114542131
XEN124434705 124441150 124441151 124457226
HMG100199631 100199712 100200849(mmp) 100200988 100201138 100201778 100202503 100204953 101234798 101236912 101239608 101241586 105843571
 » show all
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.80
IUBMB Enzyme Nomenclature: 3.4.24.80
ExPASy - ENZYME nomenclature database: 3.4.24.80
BRENDA, the Enzyme Database: 3.4.24.80
CAS: 161384-17-4

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