Entry
Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763 matrix metalloproteinase-14 (membrane-inserted)
Genes
CCAN : 109685808(Mmp14) 109689717
XLA : 108707025 407753(mmp14.L)
DRE : 373882(mmp14a) 566945(mmp14b)
SRX : 107706348 107738136 107753930
SANH : 107668983 107691938 107704286
SGH : 107557973 107562471(mmp14) 107588203 107591383
CCAR : 109060080(mmp14a) 109064679 109111707 109111713
CAUA : 113044985 113105708 113119884
CGIB : 127933340 127951000 127962211
PTET : 122323463(mmp14b) 122349364(mmp14a)
LROH : 127168695(mmp14a) 127182330(mmp14b)
GRF : 141332121(mmp14a) 141343649(mmp14b)
OMC : 131520650(mmp14b) 131544302(mmp14a)
PPRM : 120462605(mmp14a) 120465105(mmp14b)
RKG : 130076154(mmp14b) 130102601(mmp14a)
MAMB : 125251639(mmp14b) 125264498(mmp14a)
CIDE : 127494064 127515365
CERY : 137002989(mmp14b) 137030204(mmp14a)
MASI : 127412145 127440633 127442247 127445441
TROS : 130553967(mmp14a) 130554170(mmp14b)
TDW : 130417209(mmp14b) 130428394(mmp14a)
MANU : 129440312(mmp14a) 129441835(mmp14b)
PDAB : 135730773(mmp14a) 135767376(mmp14b)
IPU : 108267832 108267934(mmp14a)
IFU : 128609516(mmp14b) 128610251(mmp14a)
PHYP : 113525614 113540329
SMEO : 124386873(mmp14b) 124387269(mmp14a)
TFD : 113633887(mmp14b) 113663174(mmp14a)
TVC : 132848324(mmp14b) 132848843(mmp14a)
CGAR : 128518961(mmp14b) 128524653(mmp14a)
NGRA : 132891900(mmp14b) 132895887(mmp14a)
TRN : 134311692(mmp14a) 134312203
AMEX : 103024760(mmp14a) 103041213(mmp14b)
CMAO : 118825668(mmp14a) 118825730(mmp14b)
EEE : 113578328 113589197(mmp14)
CHAR : 105895553(mmp14a) 105907068(mmp14b)
SPIL : 134059473(mmp14a) 134067450(mmp14b)
TFS : 130522245(mmp14a) 130539565(mmp14b)
TNG : GSTEN00015140G001 GSTEN00025878G001
TBEN : 117488121(mmp14a) 117488510(mmp14b)
CGOB : 115022907 115023741
PGEO : 117462031(mmp14b) 117463873(mmp14a)
GACU : 117539229(mmp14a) 117556619(mmp14b)
EMAC : 134865988(mmp14b) 134872261(mmp14a)
ELY : 117246202(mmp14a) 117272256(mmp14b)
EFO : 125883715(mmp14a) 125901619(mmp14b)
PLEP : 121952037(mmp14b) 121961947(mmp14a)
SLUC : 116043318(mmp14a) 116055111(mmp14b)
ECRA : 117934665(mmp14a) 117954333(mmp14b)
ESP : 116684895 116699164 116707003
PFLV : 114545892(mmp14) 114565145
GAT : 120816303(mmp14b) 120821932(mmp14a)
PPUG : 119209171(mmp14b) 119222503(mmp14a)
AFB : 129088883(mmp14b) 129093101(mmp14a)
CLUM : 117746697(mmp14b) 117747783(mmp14a)
PSWI : 130197928(mmp14b) 130211969(mmp14a)
CANA : 137781978(mmp14b) 137792367(mmp14a)
CVE : 137885909(mmp14a) 137892697(mmp14b)
MSAM : 119902498(mmp14b) 119912139(mmp14a)
SCHU : 122869956(mmp14a) 122887183(mmp14b)
CUD : 121504664(mmp14a) 121520493(mmp14b)
SPUL : 138600653(mmp14a) 138611430(mmp14b)
LMIX : 132958189(mmp14a) 132978742(mmp14b)
ALAT : 119011743(mmp14b) 119027665(mmp14a)
ASTR : 137590670(mmp14a) 137611984(mmp14b)
OAU : 116312338(mmp14a) 116333767(mmp14b)
OLA : 100125428(mmp14) 101171699
OML : 112147164(mmp14b) 112156455(mmp14a)
CSAI : 133420119(mmp14a) 133452983(mmp14b)
PRET : 103475992 103478877
PFOR : 103138402 103145985(mmp14)
PLAI : 106934757 106944750
PMEI : 106918840(mmp14) 106926970
GAF : 122820067(mmp14a) 122840722(mmp14b)
PPRL : 129362045(mmp14b) 129379472(mmp14a)
CVG : 107087725 107101469(mmp14)
CTUL : 119773355(mmp14a) 119793328(mmp14b)
GMU : 124870019(mmp14b) 124881091(mmp14a)
NFU : 107377284(mmp14) 107384247
KMR : 108238671(mmp14b) 108245890(mmp14a)
ALIM : 106517892 106526432
NWH : 119408978(mmp14a) 119414992(mmp14b)
AOCE : 111577984(mmp14b) 111587803(mmp14a)
EJA : 138207401(mmp14b) 138210648(mmp14a)
BFRE : 138628366(mmp14b) 138632999(mmp14a)
MCEP : 125010467(mmp14b) 125022045(mmp14a)
CSEM : 103388226(mmp14) 103396588
SSEN : 122766893(mmp14a) 122778576(mmp14b)
SSOE : 131456700(mmp14a) 131468364(mmp14b)
HHIP : 117778918(mmp14b) 117779297(mmp14a)
HSP : 118102417(mmp14a) 118117847(mmp14b)
PPLT : 128430205(mmp14a) 128454880(mmp14b)
SMAU : 118287780(mmp14a) 118310471(mmp14b)
LCF : 108883931(mmp14b) 108903045(mmp14a)
SLAL : 111647186 111666536
XGL : 120797566(mmp14a) 120799114(mmp14b)
SSCV : 125973364(mmp14a) 125984530(mmp14b)
SBIA : 133494704(mmp14a) 133510391(mmp14b)
PEE : 133397616(mmp14a) 133411425(mmp14b)
PTAO : 133472402(mmp14a) 133489369(mmp14b)
BPEC : 110170349 110172013
ENY : 140356204(mmp14b) 140371408(mmp14a)
MALB : 109962674 109974431
BSPL : 114844813(mmp14b) 114850074(mmp14a)
SJO : 128369257(mmp14b) 128384020(mmp14a)
SSCO : 133990320(mmp14b) 134005459(mmp14a)
SASA : 106569443 106577791 106600280 106608848
STRU : 115157316 115169490 115194394 115198396
OTW : 112214636(mmp14a) 112226707 112235598 112260764
OMY : 110500495(mmp14a) 110508483(mmp14b) 110530599 110531636
OGO : 124008505 124009973 124014257 124041589(mmp14b)
ONE : 115102780 115114675 115133442 115137978
OKI : 109871780 109875099 109896970 109906435
OKE : 118368870 118392084(mmp14a) 118394992(mmp14b) 118401873
OMM : 135511381 135516234(mmp14a) 135558989(mmp14b)
OCLA : 139376259 139378922 139387194 139416020
SALP : 111953232 111956641 111979299 112080231
SNH : 120020209 120030301 120049716 120055633
CCLU : 121535634 121572618 121581129(mmp14b) 123482924
OEP : 134009683(mmp14a) 134036388(mmp14b)
SFM : 108930930 108937864(mmp14) 114911942
AROT : 135258716(mmp14a) 135260578(mmp14b)
CCOG : 133134789(mmp14a) 133136183(mmp14b)
BFO : 118403865 118407405 118407406 118410626 118418696
BBEL : 109479373 109480908
SPU : 574861 576145 582797(MMP14)
LPIC : 129273105 129281296 129281986
AJJ : 139968614 139968676 139968696 139968803 139968804 139968805 139980687 139980696 139980725 139980828 139980892 139981055 139981449
APLC : 110985439 110990105
ARUN : 117290654 117303830 117303899
AAMU : 139938058 139939026 139944134 139952941 139952942 139953039 139953219
AFIL : 140140896 140160876 140164467 140168127 140170847 140171461 140171462 140171463 140171464 140171465 140171470
PFLL : 139122101 139132316 139133010 139133014 139143390 139144984 139144987 139145154 139145155
DSI : Dsimw501_GD24926(Dsim_GD24926)
ASUA : 134202688 134210845
HAXR : 123677657 123678080 123678081 123678282 123678347
PAME : 138691068(Mmp1) 138695343 138705008 138705009 138705010 138705011
PORN : 139761226 139761227
PTEP : 107450091 107450852
LPOL : 106461522 106467071
HCRA : 139447182 139455256 139456123 139456270
AIRR : 138308339 138331148 138331667 138332356 138335787
MCAZ : 138026402 138026404 138032644 138043517
MFOO : 137980281 137980283 138003143 138006915 138006916
» show all
Taxonomy
Reference
Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.80