KEGG   ENZYME: 3.4.24.80
Entry
EC 3.4.24.80                Enzyme                                 
Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763  matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA4323(MMP14)
PTR742887(MMP14)
PPS100990208(MMP14)
GGO101142469(MMP14)
PON100171646(MMP14)
PPYG129012809(MMP14)
NLE100606407(MMP14)
HMH116484897(MMP14)
SSYN129489367(MMP14)
MCC712429(MMP14)
MCF102132205(MMP14)
MTHB126958269
MNI105499628(MMP14)
CSAB103231446(MMP14)
CATY105598793(MMP14)
PANU101021138(MMP14)
TGE112629015(MMP14)
MLEU105547169(MMP14)
RRO104674133(MMP14)
RBB108523596(MMP14)
TFN117069995(MMP14)
PTEH111554785(MMP14)
CANG105503789(MMP14)
CJC100389088(MMP14)
SBQ101041075(MMP14)
CIMI108315352(MMP14)
ANAN105727007(MMP14)
CSYR103267686(MMP14)
MMUR105864715(MMP14)
LCAT123620578(MMP14)
PCOQ105814481(MMP14)
OGA100957810(MMP14)
MMU17387(Mmp14)
MCAL110309210(Mmp14)
MPAH110325048(Mmp14)
RNO81707(Mmp14)
MCOC116084514(Mmp14)
ANU117705214(Mmp14)
ASYL127691566(Mmp14)
MUN110550039(Mmp14)
CGE100689336(Mmp14)
MAUA101828511(Mmp14)
PROB127230416(Mmp14)
PLEU114708709(Mmp14)
MORG121435038(Mmp14)
MFOT126490920
AAMP119800000(Mmp14)
NGI103739479(Mmp14)
HGL101723795(Mmp14)
CPOC100732039(Mmp14)
CCAN109685808(Mmp14) 109689717
DORD105992545(Mmp14)
DSP122113480(Mmp14)
PLOP125363479(Mmp14)
NCAR124974865
MMMA107148235(Mmp14)
ITI101956123(Mmp14)
OCU100009598(MMP14)
OPI101516419(MMP14)
TUP102468813(MMP14)
GVR103585554(MMP14)
CFA403823(MMP14)
CLUD112657051(MMP14)
VVP112926491(MMP14)
VLG121493160(MMP14)
NPO129499441(MMP14)
AML100468621(MMP14)
UMR103681059(MMP14)
UAH113246072(MMP14)
UAR123795799(MMP14)
ELK111158421
LLV125104089
MPUF101689912(MMP14)
MNP131999791(MMP14)
MLK131836341(MMP14)
NVS122893172(MMP14)
ORO101369821(MMP14)
EJU114217869(MMP14)
ZCA113909394(MMP14)
MLX118003628(MMP14)
NSU110585608(MMP14)
LWW102730388(MMP14)
FCA101089776(MMP14)
PYU121031488(MMP14)
PCOO112855695(MMP14)
PBG122468871(MMP14)
PVIV125168909(MMP14)
LRUF124508807
LGF123583378(MMP14)
AJU106988210
PTG102953674(MMP14)
PPAD109255047(MMP14)
PUC125909706
PLEZ122222328(MMP14)
HHV120240441(MMP14)
BTA281915(MMP14)
BOM102281987(MMP14)
BIU109564819(MMP14)
BBUB102413520(MMP14)
BBIS104981988(MMP14)
CHX100861171(MMP14)
OAS443116(MMP14)
BTAX128053747(MMP14)
CSUM138074128(MMP14)
ODA120853412(MMP14)
CCAD122443218(MMP14)
MREE136171722(MMP14)
OVR110147730(MMP14)
MBEZ129562985(MMP14)
SSC397471(MMP14)
CFR102513570(MMP14)
CBAI105068764(MMP14)
CDK105096970(MMP14)
VPC102525752(MMP14)
BACU103003307(MMP14)
BMUS118890456(MMP14)
LVE103081188(MMP14)
OOR101284790(MMP14)
LALB132517985(MMP14)
DLE111164185(MMP14)
PCAD102987825(MMP14)
PSIU116748985(MMP14)
PPHC136118908(MMP14)
NASI112397473(MMP14)
ECB100034170(MMP14)
EPZ103556751(MMP14)
EAI106840662(MMP14)
MYB102240202(MMP14)
MYD102761559(MMP14)
MMYO118679356(MMP14)
MLF102431406(MMP14)
MDT132240293(MMP14)
MYUM139017737(MMP14)
PKL118724917(MMP14)
EFUS103301531(MMP14)
MNA107531691(MMP14)
DRO112301504(MMP14)
SHON118980961(MMP14)
AJM119037284(MMP14)
PDIC114491682(MMP14)
PHAS123820486(MMP14)
MMF118616019(MMP14)
PPAM129074125(MMP14)
HAI109393698(MMP14)
RFQ117024113(MMP14)
PALE102887003(MMP14)
PGIG120593901(MMP14)
PVP105300520(MMP14)
RAY107498042(MMP14)
MJV108400026(MMP14)
TOD119238905(MMP14)
SARA101551659(MMP14)
SFUM130042065(MMP14)
SETR126001357(MMP14)
LAV100671131(MMP14)
TMU101345768
ETF101656746(MMP14)
DNM101420058(MMP14)
MDO100030382(MMP14)
GAS123236026(MMP14)
SHR100932143(MMP14)
AFZ127551035
PCW110223023(MMP14)
TVP118830349(MMP14)
PBRV138168877(MMP14)
OAA100091029(MMP14)
TACU119921115(MMP14)
ATRC139586886
ACOE138101679(MMP14)
CCIC134055882
CBOY140645789(MMP14)
CNIC135999463(MMP14)
ASN102368749(MMP14)
AMJ102558609(MMP14)
CMY102943947(MMP14)
CCAY125622589(MMP14)
DCC119841791(MMP14)
CPIC101945719(MMP14)
MRV120380346(MMP14)
ACS100553534(mmp14)
ASAO132777648(MMP14)
PVT110087815(MMP14)
SUND121934813(MMP14)
PBI103064383(MMP14)
PMUR107295092(MMP14)
CTIG120317985(MMP14)
PGUT117658208(MMP14)
APRI131197583(MMP14)
PTEX113448731(MMP14)
NSS113422251(MMP14)
VKO123018636(MMP14)
PMUA114581663(MMP14)
PRAF128399506(MMP14)
ZVI118095008(MMP14)
HCG128329770(MMP14)
GJA107109121(MMP14)
EMC129338762(MMP14)
XLA108707025 407753(mmp14.L)
XTR594950(mmp14)
NPR108786770(MMP14)
RTEM120941067(MMP14)
ACAT141145677(MMP14)
BBUF120989035(MMP14)
BGAR122923469(MMP14)
DTC141089122(MMP14)
PWL138299725(MMP14)
MUO115456955(MMP14)
GSH117350258(MMP14)
DRE373882(mmp14a) 566945(mmp14b)
SRX107706348 107738136 107753930
SANH107668983 107691938 107704286
SGH107557973 107562471(mmp14) 107588203 107591383
CCAR109060080(mmp14a) 109064679 109111707 109111713
CAUA113044985 113105708 113119884
CGIB127933340 127951000 127962211
PTET122323463(mmp14b) 122349364(mmp14a)
LROH127168695(mmp14a) 127182330(mmp14b)
GRF141332121(mmp14a) 141343649(mmp14b)
OMC131520650(mmp14b) 131544302(mmp14a)
PPRM120462605(mmp14a) 120465105(mmp14b)
RKG130076154(mmp14b) 130102601(mmp14a)
MAMB125251639(mmp14b) 125264498(mmp14a)
CIDE127494064 127515365
CERY137002989(mmp14b) 137030204(mmp14a)
MASI127412145 127440633 127442247 127445441
TROS130553967(mmp14a) 130554170(mmp14b)
TDW130417209(mmp14b) 130428394(mmp14a)
MANU129440312(mmp14a) 129441835(mmp14b)
PDAB135730773(mmp14a) 135767376(mmp14b)
IPU108267832 108267934(mmp14a)
IFU128609516(mmp14b) 128610251(mmp14a)
PHYP113525614 113540329
SMEO124386873(mmp14b) 124387269(mmp14a)
TFD113633887(mmp14b) 113663174(mmp14a)
TVC132848324(mmp14b) 132848843(mmp14a)
CGAR128518961(mmp14b) 128524653(mmp14a)
NGRA132891900(mmp14b) 132895887(mmp14a)
TRN134311692(mmp14a) 134312203
AMEX103024760(mmp14a) 103041213(mmp14b)
CMAO118825668(mmp14a) 118825730(mmp14b)
EEE113578328 113589197(mmp14)
CHAR105895553(mmp14a) 105907068(mmp14b)
SPIL134059473(mmp14a) 134067450(mmp14b)
TRU101061607 101073560
TFS130522245(mmp14a) 130539565(mmp14b)
TNGGSTEN00015140G001 GSTEN00025878G001
LCO104927972 104932902
NCC104956583
TBEN117488121(mmp14a) 117488510(mmp14b)
CGOB115022907 115023741
PGEO117462031(mmp14b) 117463873(mmp14a)
GACU117539229(mmp14a) 117556619(mmp14b)
EMAC134865988(mmp14b) 134872261(mmp14a)
ELY117246202(mmp14a) 117272256(mmp14b)
EFO125883715(mmp14a) 125901619(mmp14b)
PLEP121952037(mmp14b) 121961947(mmp14a)
SLUC116043318(mmp14a) 116055111(mmp14b)
ECRA117934665(mmp14a) 117954333(mmp14b)
ESP116684895 116699164 116707003
PFLV114545892(mmp14) 114565145
GAT120816303(mmp14b) 120821932(mmp14a)
PPUG119209171(mmp14b) 119222503(mmp14a)
AFB129088883(mmp14b) 129093101(mmp14a)
CLUM117746697(mmp14b) 117747783(mmp14a)
PSWI130197928(mmp14b) 130211969(mmp14a)
CANA137781978(mmp14b) 137792367(mmp14a)
CVE137885909(mmp14a) 137892697(mmp14b)
MSAM119902498(mmp14b) 119912139(mmp14a)
SCHU122869956(mmp14a) 122887183(mmp14b)
CUD121504664(mmp14a) 121520493(mmp14b)
SPUL138600653(mmp14a) 138611430(mmp14b)
LMIX132958189(mmp14a) 132978742(mmp14b)
ALAT119011743(mmp14b) 119027665(mmp14a)
ASTR137590670(mmp14a) 137611984(mmp14b)
MZE101464934 101486213
ONL100691693 100695964
OAU116312338(mmp14a) 116333767(mmp14b)
OLA100125428(mmp14) 101171699
OML112147164(mmp14b) 112156455(mmp14a)
CSAI133420119(mmp14a) 133452983(mmp14b)
XMA102236291 102236856
XCO114146537 114157472
XHE116721687 116732222
PRET103475992 103478877
PFOR103138402 103145985(mmp14)
PLAI106934757 106944750
PMEI106918840(mmp14) 106926970
GAF122820067(mmp14a) 122840722(mmp14b)
PPRL129362045(mmp14b) 129379472(mmp14a)
CVG107087725 107101469(mmp14)
CTUL119773355(mmp14a) 119793328(mmp14b)
GMU124870019(mmp14b) 124881091(mmp14a)
NFU107377284(mmp14) 107384247
KMR108238671(mmp14b) 108245890(mmp14a)
ALIM106517892 106526432
NWH119408978(mmp14a) 119414992(mmp14b)
AOCE111577984(mmp14b) 111587803(mmp14a)
EJA138207401(mmp14b) 138210648(mmp14a)
BFRE138628366(mmp14b) 138632999(mmp14a)
MCEP125010467(mmp14b) 125022045(mmp14a)
CSEM103388226(mmp14) 103396588
POV109640512 109641241
SSEN122766893(mmp14a) 122778576(mmp14b)
SSOE131456700(mmp14a) 131468364(mmp14b)
HHIP117778918(mmp14b) 117779297(mmp14a)
HSP118102417(mmp14a) 118117847(mmp14b)
PPLT128430205(mmp14a) 128454880(mmp14b)
SMAU118287780(mmp14a) 118310471(mmp14b)
LCF108883931(mmp14b) 108903045(mmp14a)
SDU111223843 111235670
SLAL111647186 111666536
XGL120797566(mmp14a) 120799114(mmp14b)
HCQ109508489 109512811
SSCV125973364(mmp14a) 125984530(mmp14b)
SBIA133494704(mmp14a) 133510391(mmp14b)
PEE133397616(mmp14a) 133411425(mmp14b)
PTAO133472402(mmp14a) 133489369(mmp14b)
BPEC110170349 110172013
ENY140356204(mmp14b) 140371408(mmp14a)
MALB109962674 109974431
BSPL114844813(mmp14b) 114850074(mmp14a)
SJO128369257(mmp14b) 128384020(mmp14a)
SSCO133990320(mmp14b) 134005459(mmp14a)
GMH115529051 115549175
SASA106569443 106577791 106600280 106608848
STRU115157316 115169490 115194394 115198396
OTW112214636(mmp14a) 112226707 112235598 112260764
OMY110500495(mmp14a) 110508483(mmp14b) 110530599 110531636
OGO124008505 124009973 124014257 124041589(mmp14b)
ONE115102780 115114675 115133442 115137978
OKI109871780 109875099 109896970 109906435
OKE118368870 118392084(mmp14a) 118394992(mmp14b) 118401873
OMM135511381 135516234(mmp14a) 135558989(mmp14b)
OCLA139376259 139378922 139387194 139416020
SALP111953232 111956641 111979299 112080231
SNH120020209 120030301 120049716 120055633
CCLU121535634 121572618 121581129(mmp14b) 123482924
ELS105020567 105021572
OEP134009683(mmp14a) 134036388(mmp14b)
SFM108930930 108937864(mmp14) 114911942
PKI111837704 111854546
AANG118234064(mmp14b)
AROT135258716(mmp14a) 135260578(mmp14b)
CCOG133134789(mmp14a) 133136183(mmp14b)
PSPA121305269
ARUT117398173(mmp14b)
PSEX120524476
LCM102355301(MMP14)
HAKA140716637
LRJ133345949
BFO118403865 118407405 118407406 118410626 118418696
BBEL109479373 109480908
CIN100181633
SCLV120332934
SPU574861 576145 582797(MMP14)
LPIC129273105 129281296 129281986
AJJ139968614 139968676 139968696 139968803 139968804 139968805 139980687 139980696 139980725 139980828 139980892 139981055 139981449
APLC110985439 110990105
ARUN117290654 117303830 117303899
AAMU139938058 139939026 139944134 139952941 139952942 139953039 139953219
AFIL140140896 140160876 140164467 140168127 140170847 140171461 140171462 140171463 140171464 140171465 140171470
AJC117109985 117110040
SKO100369238
PFLL139122101 139132316 139133010 139133014 139143390 139144984 139144987 139145154 139145155
DMEDmel_CG4859(Mmp1)
DER6548508
DSE6618866
DSIDsimw501_GD24926(Dsim_GD24926)
DYADyak_GE11424
DAN6494770
DSR110182794
DPO4805299
DPE6592953
DMN108160136 117185778
DWI6640267
DMODmoj_GI19538
DAZ108616549
DNV108654324
DHE111593840
DVI6625046(Mmp1)
CCAT101460552
BOD106622068
BDR105230249
RZE108363354 108372064
AOQ129243716
ALUD128868315
TDA119679599
MDE101888990
SCAC106082756
LCQ111679245
LSQ119606779
CVJ135962505(Mmp1)
GFS119642247
ECOE129952208
CLON129611244
HIS119646152
AGA1270173
ACOZ120947394
AARA120905478
AMER121592038
ASTE118512669
AMAP126561852
AFUN125771541
AMOU128300470
AMRS128714516
AALI118463173
ACOS131267787
AAG5566822
AALB109425677
ASUA134202688 134210845
CQUCpipJ_CPIJ010856
CPII120414643
CBRI134830541
CNS116338916
BCOO119081749
ACER107993310
ALAB122710880
ADR102671973
AFLR100869155
BIM100741313
BBIF117212916
BVK117233695
BVAN117158980
BHUN126866293
BTER100647268
BAFF126926503
BPYO122571303
BPAS132908850
FVI122534048
CCAL108628386
OBB114880439
OLG117608429
MGEN117217405
NMEA116426310
CGIG122400960
SOC105198300
MPHA105835181
AEC105151121
ACEP105619997
PBAR105424383
VEM105566274
COBS139109600
TLN139810228
HST105190364
DQU106744935
CFO105255413
FEX115241861
PMEC138937953
LHU105675698(Mmp1)
PGC109858212
OBO105286124
PCF106788603
PFUC122522006
VPS122636559
VCRB124432304
VVE124956498
NVI100113893(Mmp1)
CSOL105368158
TPRE106651404
LHT122502870
LBD127282597
MDL103577460
CGLO123263452
FAS105271342
DAM107036851
AGIF122860917
CINS118074355
VCAN122417944
CCIN107270395
DSM124404461
NPT124210989
NFB124174691
NLO107223958
NVG124296925
AROA105683294
TCA657261(Mmp-1)
TMOL138132253
DPA109542402
ESIM136417169(Mmp1)
EFOR136342053(Mmp1)
SOY115889561
AGRG126740476
ATD109596135
CSET123312265
HAXR123677657 123678080 123678081 123678282 123678347
AGB108910921
LDC111512852
DVV114325910
NVL108566081
DCOR135790579
APLN108741148
PPYR116172083
OTU111424932
BMOR100144547(Mmp1)
BMAN114249403
MSEX115445748
DPLKGM_204463
BANY112043322
MJU123864465
NIQ126775635
VCD124536044
MCIX123664994
PMAC106712426
PPOT106107829
PXU106116917
BPHI137929418(Mmp1)
PRAP111002882
PBX123707644
PNAP125055885
ZCE119830077
CCRC123699336
LSIN126971371
AAGE121729864
HAW110371693
HZE124637345
TNL113492652
SLIU111353141
OFU114356670
ONU135081893
ATRA106138711
GMW113522981
PXY105396373
PGW126381824
LGLY125240997
CSTB134754628
CFUM141427700(Mmp1)
CFEL113370190
CCRN123305758
API100164006
DNX107166270
AGS114124803
RMD113560497
ACOO126840413
DVT126904256
BTAB109040286
DCI103519571
CLEC106669674
HHAL106691851
NLU111057664
HVI124359559
MQU128991305
PHUPhum_PHUM302710
FOC113213791
TPAL117643377
ZNE110840851
CSEC111866774
PAME138691068(Mmp1) 138695343 138705008 138705009 138705010 138705011
SGRE126336836
BROR134532171
IEL124161113
HAMR139700875(Mmp1)
FCD110860649
DPXDAPPUDRAFT_303785
DMK116916797
DPZ124314058
AFRA136037187
PVM113820224(Mmp1)
PJA122257686
PCHN125032121
PMOO119596927
HAME121869561
PCLA123744862(Mmp1)
CQD128706577
PTRU123501683
ESN127005132
MNZ135214873
MRJ136854040(Mmp1)
PORN139761226 139761227
HAZT108667780
EAF111708257
LSM121129741
TCF131879453
PPOI119097459
ISC8051455
DSV119443090
RSAN119388217
RMP119185118
VDE111254153
VJA111271735
GOE100907722 100908155
TUT107367240
DPTE113799701
DFR124494264
CSCU111636483
CVS136976270(Mmp1)
PTEP107450091 107450852
ABRU129963441
UDV129219355 129219910
SDM118183209 118205650
LPOL106461522 106467071
PMEO129593831
LGILOTGIDRAFT_158923
PVUL126821564
PCAN112555453
LSAX138983608
BGT106051365
GAE121376669
HRF124112473
HRJ124261822
HASI137281587
HCRA139447182 139455256 139456123 139456270
CRG105333479
CANU128180086
CVN111099717
OED125659971
MYI110459519
PMAX117342186
AIRR138308339 138331148 138331667 138332356 138335787
MCAF127737545
MMER123554940
RPHI132726857
DPOL127834476
MAEA128220403
OBI106869299
OSN115209377
LJP135479108
LAK106156796
LLON135494680
NVE5512892
MCAZ138026402 138026404 138032644 138043517
MFOO137980281 137980283 138003143 138006915 138006916
 » show all
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.80
IUBMB Enzyme Nomenclature: 3.4.24.80
ExPASy - ENZYME nomenclature database: 3.4.24.80
BRENDA, the Enzyme Database: 3.4.24.80
CAS: 161384-17-4

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