KEGG   ENZYME: 3.4.24.85
Entry
EC 3.4.24.85                Enzyme                                 
Name
S2P endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site DRSR_ILL_483!CVLTFLCLSFNPLTSLLQWGGA, in which the membrane-spanning segment is underlined. The residues NP (bold), 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.
Comment
Type example of peptidase family M50. The transcription factors SREBP-1 and -2 are synthesized as precursor proteins that are attached to the membranes of the endoplasmic reticulum and two cleavages are needed to release the active factor so that it can move to the nucleus. This enzyme cleaves the second of these, and is thus the "site 2 protease", S2P.
History
EC 3.4.24.85 created 2003
Orthology
K07765  S2P endopeptidase
Genes
HSA51360(MBTPS2)
PTR465532(MBTPS2)
PPS100988592(MBTPS2)
GGO101135564(MBTPS2)
PON100454671(MBTPS2)
NLE100591951(MBTPS2)
MCC696540(MBTPS2)
MCF102140645(MBTPS2)
CSAB103231700(MBTPS2)
CATY105574630(MBTPS2)
PANU100998047(MBTPS2)
TGE112615897(MBTPS2)
RRO104676699(MBTPS2)
RBB108532305(MBTPS2)
TFN117077330
PTEH111534807(MBTPS2)
CJC100406330(MBTPS2)
SBQ101045752(MBTPS2)
CSYR103251900(MBTPS2)
MMUR105882360(MBTPS2)
OGA100966464(MBTPS2)
MMU270669(Mbtps2)
MCAL110286780(Mbtps2)
MPAH110313738(Mbtps2)
RNO302705(Mbtps2)
MCOC116090057(Mbtps2)
CGE100689085(Mbtps2)
PLEU114695780(Mbtps2)
NGI103730145(Mbtps2)
HGL101726620(Mbtps2)
CPOC100713910(Mbtps2)
CCAN109694191(Mbtps2)
DORD105993256(Mbtps2)
DSP122099622(Mbtps2)
NCAR124972110
OCU100344858(MBTPS2)
OPI101534233(MBTPS2)
TUP102496221(MBTPS2)
VVP112919116(MBTPS2)
VLG121483345(MBTPS2) 121483346(YY2)
AML100465637(MBTPS2)
UMR103668263(MBTPS2)
UAH113242234(MBTPS2)
UAR123797212(MBTPS2)
ELK111150508
LLV125091683
MPUF101673050(MBTPS2)
ORO101364136(MBTPS2) 101365783
EJU114223604(MBTPS2)
ZCA113930638(MBTPS2)
MLX118007628(MBTPS2)
FCA101084262(MBTPS2)
PYU121026120(MBTPS2) 121026121(YY2)
PBG122477245(MBTPS2) 122477246(YY2)
PTG102954190(MBTPS2)
PPAD109257438(MBTPS2)
AJU106982742(MBTPS2)
HHV120224317(MBTPS2)
BTA533134(MBTPS2)
BOM102280586(MBTPS2)
BIU109555212(MBTPS2)
BBUB102399831(MBTPS2)
CHX102190948(MBTPS2)
OAS101106915(MBTPS2)
ODA120882635(MBTPS2)
CCAD122434617(MBTPS2)
SSC102165056(MBTPS2)
CFR102512896(MBTPS2)
CBAI105081166(YY2) 105081167(MBTPS2)
CDK105095321(MBTPS2)
VPC102536764(MBTPS2) 102540265(YY2)
BACU103012194
LVE103072780(MBTPS2)
OOR101272405(MBTPS2)
DLE111167499(MBTPS2)
PCAD102984850
PSIU116747392(MBTPS2)
ECB100051796(MBTPS2)
EPZ103544240 103544664
EAI106835512(MBTPS2)
MYB102251140(MBTPS2)
MYD102759985(MBTPS2)
MMYO118653996(MBTPS2)
MLF102435081(MBTPS2) 111825283(YY2)
MNA107526794(MBTPS2)
PKL118719814(MBTPS2)
HAI109395788(MBTPS2)
DRO112313356(MBTPS2)
SHON118987194(MBTPS2)
AJM119037241(MBTPS2)
PDIC114504643(MBTPS2) 114504828(YY2)
PHAS123830011(MBTPS2) 123830012(YY2)
MMF118635641(MBTPS2)
RFQ117024554(MBTPS2)
PALE102879833(MBTPS2) 102888641
PGIG120594265(YY2)
PVP105304384(YY2) 105304386(MBTPS2)
RAY107507194 107521443(MBTPS2)
MJV108396543(MBTPS2)
TOD119246281(MBTPS2) 119246283(YY2) 119250808
SARA101545687(MBTPS2)
LAV100656136(MBTPS2)
TMU101354197
DNM101443734(YY2) 101444187(MBTPS2)
MDO100011019(MBTPS2)
GAS123242411(MBTPS2)
SHR100929394(MBTPS2)
PCW110210826(MBTPS2)
OAA100083166(MBTPS2)
GGA427996(MBTPS2)
PCOC116232752(MBTPS2)
CJO107324943(MBTPS2)
NMEL110404550(MBTPS2)
APLA101791896(MBTPS2)
ACYG106037836(MBTPS2)
AFUL116489637(MBTPS2)
TGU100221191(MBTPS2)
LSR110483218(MBTPS2)
SCAN103815923(MBTPS2)
PMOA120504604(MBTPS2)
OTC121333464(MBTPS2)
PRUF121356178(MBTPS2)
GFR102036374(MBTPS2)
FAB101809571(MBTPS2)
PHI102114211(MBTPS2)
PMAJ107208240(MBTPS2)
CCAE111922783(MBTPS2)
CCW104686191(MBTPS2)
ETL114067190(MBTPS2)
ZAB102071938(MBTPS2)
FPG101923038(MBTPS2)
FCH102049253(MBTPS2)
CLV102083546(MBTPS2)
EGZ104135176(MBTPS2)
NNI104022509(MBTPS2)
TALA104360896(MBTPS2)
PADL103914502(MBTPS2)
ACHC115343766(MBTPS2)
AAM106492099(MBTPS2)
AROW112964576(MBTPS2)
NPD112958244(MBTPS2)
DNE112995636(MBTPS2)
ASN102387796(MBTPS2)
AMJ102575368(MBTPS2)
CPOO109305981(MBTPS2)
GGN109302990(MBTPS2)
PSS102444548(MBTPS2)
CMY102933913(MBTPS2)
CPIC101930956(MBTPS2)
TST117868917(MBTPS2)
CABI116825315(MBTPS2)
MRV120391502(MBTPS2)
ACS100560770(mbtps2)
PVT110076743(MBTPS2)
SUND121926743(MBTPS2)
PBI103049752(MBTPS2)
PMUR107286126(MBTPS2)
TSR106549486(MBTPS2)
PGUT117675343(MBTPS2)
VKO123029104(MBTPS2)
PMUA114596226(MBTPS2)
ZVI118085613(MBTPS2)
GJA107125646(MBTPS2)
STOW125430566(MBTPS2)
XLA108708013(mbtps2.L)
XTR549815(mbtps2)
NPR108791843(MBTPS2)
RTEM120927517(MBTPS2)
BBUF120994834(MBTPS2)
BGAR122930507(MBTPS2)
DRE334658(mbtps2)
SRX107705275 107721932
SANH107671355(mbtps2)
SGH107586733 107590223
CCAR109049930 109077056
CAUA113042393 113066185
PPRM120488375(mbtps2)
MAMB125257563(mbtps2)
IPU108256590(mbtps2)
PHYP113541172(mbtps2)
SMEO124375503(mbtps2)
TFD113646384(mbtps2)
AMEX103023831(mbtps2)
EEE113567526(mbtps2)
TRU101072394(mbtps2)
TNGGSTEN00025473G001
LCO104928761(mbtps2)
NCC104960002(mbtps2)
CGOB115025320(mbtps2)
ELY117264297(mbtps2)
PLEP121960917(mbtps2)
SLUC116048537(mbtps2)
ECRA117938272(mbtps2)
PFLV114549314(mbtps2)
GAT120811872(mbtps2)
PPUG119198876(mbtps2)
MSAM119912604(mbtps2)
CUD121526972(mbtps2)
MZE101483191(mbtps2)
ONL100703948(mbtps2)
OAU116324443(mbtps2)
OLA101156537(mbtps2)
OML112151464(mbtps2)
XMA102221158(mbtps2)
XCO114136729(mbtps2)
XHE116712025(mbtps2)
PRET103456744(mbtps2)
PFOR103140524(mbtps2)
PLAI106957979(mbtps2)
PMEI106932433(mbtps2)
GAF122823952(mbtps2)
CVG107081826(mbtps2)
CTUL119787336(mbtps2)
GMU124858332(mbtps2)
NFU107383072(mbtps2)
KMR108234732(mbtps2)
ALIM106515531(mbtps2)
NWH119426828(mbtps2)
AOCE111583051(mbtps2)
CSEM103377480(mbtps2)
POV109639643(mbtps2)
SSEN122779956(mbtps2)
HHIP117754199(mbtps2)
LCF108885097(mbtps2)
SDU111237870(mbtps2)
SLAL111645767(mbtps2)
XGL120790152(mbtps2)
HCQ109524711(mbtps2)
BPEC110161280(mbtps2)
MALB109961574(mbtps2)
SASA106590709(mbtps2)
OTW112256304
OMY110489512(mbtps2)
OGO124039421(mbtps2)
ONE115118504(mbtps2)
SALP112075585(mbtps2)
SNH120050899(mbtps2)
ELS105007360(mbtps2)
SFM108939619(mbtps2)
PKI111860977(mbtps2)
AANG118226613(mbtps2)
LOC102697603(mbtps2)
PSPA121302861(mbtps2)
ARUT117405158 117406453
LCM102362818
CMK103189988(mbtps2)
RTP109931902(mbtps2)
BFO118422803
BBEL109487319
CIN100184558
SCLV120325686 120326400
SPU582844
APLC110988215
SKO100371404
DMEDmel_CG8988(S2P)
DER6546958
DSE6608714
DSIDsimw501_GD25883(Dsim_GD25883)
DYADyak_GE13498
DAN6496245
DSR110177989
DPODpse_GA21457
DPE6600929
DMN108159953 117192968
DWI6646250
DGR6568800
DMODmoj_GI21268
DAZ108617352
DNV108654811
DHE111592195
DVI6626282
BOD106616843
MDE101898733
SCAC106082140
LCQ111688160
AGAAgaP_AGAP011819
ACOZ120958553
AARA120903737
AAG5580236
AALB109421913
CQUCpipJ_CPIJ010386
CPII120419159 120425526
CNS116340102
AME724553
ACER107996867
ALAB122720419
BIM100741651
BBIF117215080
BVK117231843
BVAN117160261
BTER100648700
BPYO122577606
CCAL108625191 108625246
OBB114882894
NMEA116431666
CGIG122401344
SOC105199823
MPHA105840084
AEC105148603
ACEP105620494
PBAR105427989
VEM105568306
HST105182172
DQU106747874
CFO105251432
FEX115240473
LHU105670511
PGC109852414
OBO105284575
PCF106784328
PFUC122513459
VPS122636839
NVI100123289(S2P)
CSOL105362181
TPRE106658951
MDL103572252
CGLO123271252
FAS105263007
DAM107038671
AGIF122854980
CCIN107272270
TCA656329
DPA109543687
SOY115883626
ATD109599456
CSET123314737
AGB108906626
LDC111508351
NVL108561796
APLN108735686
PPYR116182625
OTU111417260
BMOR101741763
BMAN114246975
MSEX115440458 119189768
DPLKGM_214515
BANY112058056
PMAC106709708
PPOT106105796
PXU106121895
PRAP110993256
ZCE119834000
HAW110376080
TNL113505775
SLIU111357386
OFU114352402
PXY105389341
API100162197
DNX107166620
AGS114130744
RMD113548146
BTAB109040122
CLEC106661245
HHAL106684514
NLU111055544
PHUPhum_PHUM599380
FOC113214407
ZNE110826742
CSEC111874529
FCD110851821
DPXDAPPUDRAFT_326128
DMK116923506
PVM113799959
PJA122259886
PCHN125037200
HAME121869180
PCLA123754029
PTRU123505017
HAZT108681364
LSM121118238
ISCIscW_ISCW019725
DSV119461142
RSAN119396399
RMP119174608
VDE111246345
VJA111272568
TUT107369971
DPTE113794715
DFR124498799
CSCU111617924 111630903
PTEP107441421
SDM118196452
CELCELE_Y56A3A.2(Y56A3A.2)
CBRCBG_13303
LOALOAG_10133
TSPTsp_11288
HROHELRODRAFT_107238
LGILOTGIDRAFT_221778
PCAN112565622
BGT106058700
GAE121371758 121391818
HRF124139020
HRJ124257974
CRG105336925
MYI110457572
PMAX117327288
MMER123551265 123551266
OBI106881390
OSN115215896
LAK106171374 106171385
SMMSmp_054310
SHXMS3_0016073
OVIT265_11944
EGLEGR_01021
NVE5512821
EPA110248167
ATEN116304403
ADF107339251
AMIL114977501
PDAM113672162
SPIS111323017
DGT114516428
XEN124442411
HMG100215228
TADTRIADDRAFT_24878
AQU100637842 105315749
ATHAT4G20310
ALY9303960
CRB17878863
CSAT104718285 104723004 104731502
EUSEUTSA_v10024898mg
BRP103858089
BNA106360760 106376465 106430281
BOE106306359
RSZ108842709
THJ104806234
CPAP110817438
CIT102620118
CICCICLE_v10015668mg
PVY116146552
MINC123219177
TCC18600480
GRA105783923
GHI107893637 107918360
GAB108461477
DZI111277328
EGR104445846
GMX100809949
GSJ114390054
PVUPHAVU_003G274600g
VRA106765870
VAR108320667
VUN114176207
CCAJ109807982
APRC113858333
MTRMTR_8g070630
CAM101493040
LJALj0g3v0230449.1(Lj0g3v0230449.1) Lj0g3v0230449.2(Lj0g3v0230449.2)
ADU107476826
AIP107626256
AHF112719703 112796232
LANG109330528 109331887
FVE101307969
RCN112168361
PPER18778320
PMUM103325623
PAVI110754841
PDUL117624582
MDM103445955
PXB103958088
ZJU107406354 107435681
MNT21393179
CSV101207924
CMO103482997
MCHA111022467
CMAX111490932
CMOS111459160
CPEP111796202
RCU8279017
JCU105636831
HBR110656436
MESC110606312
POP7497561
PEU105123146 105124115
PALZ118054370
JRE108988814
QSU112030864
QLO115967669
TWL120005535
SLY101252708 101254520
SPEN107008322 107008555
SOT102605458
CANN107877204
NTA107763671 107823653
NSY104221055 104243871
NTO104093874
NAU109225058
INI109192738
ITR115998505 116012334
SIND105179585
OEU111374992
EGT105950849 105957168 105964318
SSPL121793380 121799989
HAN110908883
ECAD122605027
LSV111887828
CCAV112526926
DCR108198862
CSIN114309296
BVG104894493
SOE110782937
CQI110727487 110729023
NNU104599827
MING122089854
TSS122652529
PSOM113289849 113309963
NCOL116260490
PDA103708318
EGU105047584
MUS103984723
DCT110105666
PEQ110033074
AOF109840737
ATR18448966
SMOSELMODRAFT_430732
CSLCOCSUDRAFT_41457
CVRCHLNCDRAFT_133196
CMECYME_CMB142C
GSLGasu_20810
CNECNF02350
CNBCNBF2350
CNGCNAG_05742
CGICGB_F3440C
TMSTREMEDRAFT_35860
TASAA1Q1_01382
TVSTRAVEDRAFT_171989
DSQDICSQDRAFT_65838
PCOPHACADRAFT_210853
SHSSTEHIDRAFT_113130
HIRHETIRDRAFT_108045
ADLAURDEDRAFT_146324 AURDEDRAFT_169972
FMEFOMMEDRAFT_144109
GTRGLOTRDRAFT_140954
LBCLACBIDRAFT_315143
MRRMoror_3027
MOREE1B28_005914
CPUTCONPUDRAFT_147066
SLASERLADRAFT_439527
WSEWALSEDRAFT_34302
WICJ056_002703
MRTMRET_3017
PGRPGTG_02405
MLRMELLADRAFT_60682
MBRMONBRDRAFT_6860
SREPTSG_09454
DDIDDB_G0275939(mbtps2)
DPPDICPUDRAFT_91002
DFADFA_01538(mbtps2)
ACANACA1_164160
SPARSPRG_01794
GTTGUITHDRAFT_108117
 » show all
Reference
1  [PMID:10693756]
  Authors
Brown MS, Ye J, Rawson RB, Goldstein JL.
  Title
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans.
  Journal
Cell 100:391-8 (2000)
DOI:10.1016/S0092-8674(00)80675-3
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.85
IUBMB Enzyme Nomenclature: 3.4.24.85
ExPASy - ENZYME nomenclature database: 3.4.24.85
BRENDA, the Enzyme Database: 3.4.24.85
CAS: 752251-31-3

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