KEGG   ENZYME: 3.4.24.86
Entry
EC 3.4.24.86                Enzyme                                 
Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
History
EC 3.4.24.86 created 2003
Orthology
K06059  disintegrin and metalloproteinase domain-containing protein 17
Genes
HSA6868(ADAM17)
PTR459018(ADAM17)
PPS100988650(ADAM17)
GGO101152705(ADAM17)
PON100439426(ADAM17)
NLE100605134(ADAM17)
HMH116480211(ADAM17)
MCC694429(ADAM17)
MCF102116784(ADAM17)
MTHB126933776
MNI105486511(ADAM17)
CSAB103220846(ADAM17)
CATY105587543(ADAM17)
PANU100126726(ADAM17)
TGE112604761(ADAM17)
MLEU105528533(ADAM17)
RRO104675213(ADAM17)
RBB108516165(ADAM17)
TFN117062750(ADAM17)
PTEH111531765(ADAM17)
CANG105525335(ADAM17)
CJC100406520(ADAM17)
SBQ101049053(ADAM17)
CIMI108301849(ADAM17)
CSYR103273750(ADAM17)
MMUR105882940(ADAM17)
LCAT123636584(ADAM17)
PCOQ105806730(ADAM17)
OGA100947870(ADAM17)
MMU11491(Adam17)
MCAL110306467(Adam17)
MPAH110324376(Adam17)
RNO57027(Adam17)
MCOC116080989(Adam17)
ANU117716809(Adam17)
MUN110564190(Adam17)
CGE100684971(Adam17)
MAUA101828493(Adam17)
PROB127215298 127237593(Adam17)
PLEU114698857(Adam17)
MORG121432399(Adam17) 121438902
MFOT126501305
AAMP119807826(Adam17)
NGI103747629(Adam17)
HGL101720924(Adam17)
CPOC100732916(Adam17)
CCAN109695934(Adam17)
DORD105983695(Adam17)
DSP122108773(Adam17)
PLOP125356745(Adam17)
NCAR124962735
MMMA107137509(Adam17)
OCU100101613
OPI101532279(ADAM17)
TUP102496316(ADAM17)
GVR103610686(ADAM17)
CFA475662(ADAM17)
CLUD112664856(ADAM17)
VVP112927728(ADAM17)
VLG121491142(ADAM17)
NPO129510838(ADAM17)
AML100482770(ADAM17)
UMR103675912(ADAM17)
UAH113269710(ADAM17)
UAR123778537(ADAM17)
ELK111154187
LLV125108380
MPUF101678822(ADAM17)
MNP132021122(ADAM17)
MLK131807398(ADAM17)
NVS122915325(ADAM17)
ORO101378266(ADAM17)
EJU114205773(ADAM17)
ZCA113937386(ADAM17)
MLX118007302 118007360
NSU110587392(ADAM17)
LWW102738586(ADAM17)
FCA101089004(ADAM17)
PYU121044072(ADAM17)
PCOO112864061(ADAM17)
PBG122497481(ADAM17)
PVIV125158339(ADAM17)
LRUF124503705
PTG102948618(ADAM17)
PPAD109268814(ADAM17)
PUC125937696
AJU106982950
HHV120231128(ADAM17)
BTA517541(ADAM17)
BOM102279111(ADAM17)
BIU109566404(ADAM17)
BBUB102393245(ADAM17)
BBIS104997349(ADAM17)
CHX102188327(ADAM17)
OAS101116815(ADAM17)
BTAX128055238(ADAM17)
ODA120851888(ADAM17)
CCAD122442085(ADAM17)
MBEZ129539087(ADAM17)
SSC397343(ADAM17)
CFR102508816(ADAM17)
CBAI105076036(ADAM17)
CDK105091236(ADAM17)
VPC102542735(ADAM17)
BACU103004501(ADAM17)
BMUS118905722(ADAM17)
LVE103086820(ADAM17)
OOR101272366(ADAM17)
DLE111164496(ADAM17)
PCAD102978565(ADAM17)
PSIU116763969(ADAM17)
NASI112394765(ADAM17)
ECB100072496(ADAM17)
EPZ103543937 103560849(ADAM17)
EAI106847480(ADAM17)
MYB102256292(ADAM17)
MYD102767398(ADAM17)
MMYO118669297(ADAM17)
MLF102425078(ADAM17)
PKL118715935(ADAM17)
EFUS103305599(ADAM17)
MNA107526643(ADAM17)
DRO112297707(ADAM17)
SHON118988749(ADAM17)
AJM119053993(ADAM17)
PDIC114499294(ADAM17)
PHAS123822573(ADAM17)
MMF118630463(ADAM17)
PPAM129067690(ADAM17)
HAI109386655(ADAM17)
RFQ117032918(ADAM17)
PALE102894565(ADAM17)
PGIG120622059(ADAM17)
PVP105295437(ADAM17)
RAY107498263(ADAM17)
MJV108398652(ADAM17) 108406598
TOD119259567(ADAM17)
SARA101541255(ADAM17)
LAV100663807(ADAM17)
TMU101350544
ETF101641143(ADAM17)
DNM101418734(ADAM17)
MDO100032069(ADAM17)
GAS123237029(ADAM17)
SHR100926795(ADAM17)
AFZ127548615
PCW110212614(ADAM17)
OAA100086345(ADAM17)
GGA421931(ADAM17)
PCOC116240757(ADAM17)
MGP100549409(ADAM17)
CJO107312200(ADAM17)
TPAI128088191(ADAM17)
LMUT125689571(ADAM17)
NMEL110395713(ADAM17)
APLA101794295(ADAM17)
ACYG106030708(ADAM17)
CATA118246149(ADAM17)
AFUL116487500(ADAM17)
TGU100225922(ADAM17)
LSR110467958(ADAM17)
SCAN103820444(ADAM17)
PMOA120505304(ADAM17)
OTC121344379(ADAM17)
PRUF121359136(ADAM17)
GFR102034165(ADAM17)
FAB101814343(ADAM17)
OMA130251684(ADAM17)
PHI102106429(ADAM17)
PMAJ107201529(ADAM17)
CCAE111925944(ADAM17)
CCW104685448(ADAM17)
CBRC103622851(ADAM17)
ETL114058979(ADAM17)
ZAB102062655(ADAM17)
ZLE135445354(ADAM17)
ACHL103811209(ADAM17)
SVG106865122(ADAM17)
MMEA130576652(ADAM17)
HRT120749949(ADAM17)
FPG101924106(ADAM17)
FCH102055911(ADAM17)
CLV102098173(ADAM17)
EGZ104127159(ADAM17)
NNI104013024(ADAM17)
PCRI104031903(ADAM17)
PLET104622291(ADAM17)
PCAO104053058(ADAM17)
ACUN113478354(ADAM17)
TALA104357741(ADAM17)
PADL103924054(ADAM17)
AFOR103895885(ADAM17)
ACHC115350914(ADAM17)
HLE104831248(ADAM17)
AGEN126046408
GCL127014468
CCRI104162249(ADAM17)
CSTI104550091(ADAM17)
CMAC104484666(ADAM17)
MUI104539665(ADAM17)
BREG104638126(ADAM17)
FGA104075420(ADAM17)
GSTE104253426(ADAM17)
LDI104350533(ADAM17)
MNB103776199(ADAM17)
OHA104336253(ADAM17)
NNT104399631(ADAM17)
SHAB115609394(ADAM17)
DPUB104308101(ADAM17)
PGUU104463942(ADAM17)
ACAR104522582(ADAM17)
CPEA104390068(ADAM17)
CVF104293745(ADAM17)
RTD128906738(ADAM17)
CUCA104066457(ADAM17)
TEO104371691(ADAM17)
BRHI104492889(ADAM17)
AAM106494759(ADAM17)
AROW112976492(ADAM17)
NPD112945452(ADAM17)
TGT104576511(ADAM17)
DNE112981540(ADAM17)
SCAM104147606(ADAM17)
ASN102373202(ADAM17)
AMJ102560812(ADAM17)
CPOO109312094(ADAM17)
GGN109300145(ADAM17)
PSS102454376(ADAM17)
CMY102933390(ADAM17)
CCAY125634554(ADAM17)
DCC119853372(ADAM17)
CPIC101938160(ADAM17)
TST117875291(ADAM17)
CABI116823114(ADAM17)
MRV120401271(ADAM17)
ACS100563907(adam17)
ASAO132782703(ADAM17)
PVT110080585(ADAM17)
SUND121927898(ADAM17)
PBI103060091(ADAM17)
PMUR107295813(ADAM17)
CTIG120302866(ADAM17)
PGUT117674213(ADAM17)
APRI131195933(ADAM17)
PTEX113432968(ADAM17)
NSS113416457(ADAM17)
VKO123017146(ADAM17)
PMUA114593781(ADAM17)
PRAF128410153(ADAM17)
ZVI118082396(ADAM17)
HCG128340529(ADAM17)
GJA107112820(ADAM17)
STOW125433705(ADAM17)
EMC129333377(ADAM17)
XLA108718238(adam17.S) 733430(adam17.L)
XTR100492947(adam17)
NPR108789869(ADAM17)
RTEM120936358(ADAM17)
BBUF120997413(ADAM17)
BGAR122933687 122934891
MUO115467158(ADAM17)
GSH117356874(ADAM17)
DRE324142(adam17a) 560657(adam17b)
SRX107707689 107721298(adam17) 107752755 107756583
SANH107655315 107668236 107679802(adam17) 107693239
SGH107549102 107553270 107563905 107601850
CCAR109102614 109108207
CAUA113060579 113062863 113063206 113078559 113117279
CGIB127933475 127938250 127976588 127983609
PTET122324794(adam17b) 122361857(adam17a)
LROH127179302(adam17a) 127182844(adam17b)
OMC131523616(adam17a) 131527724(adam17b)
PPRM120476738(adam17a) 120493978(adam17b)
RKG130075457(adam17b) 130080283(adam17a)
MAMB125269329(adam17a) 125277828(adam17b)
CIDE127498026 127498187 127502958
MASI127410155 127411257 127416487 127455512
TROS130560624(adam17a) 130565599(adam17b)
TDW130434396(adam17b) 130437270(adam17a)
MANU129417404(adam17a) 129429321(adam17b)
IPU108257789(adam17b) 108270063(adam17a)
IFU128601062(adam17b) 128612996(adam17a)
PHYP113531802 113538559(adam17)
SMEO124377472(adam17b) 124390219(adam17a)
TFD113655629(adam17b) 113659686(adam17a)
TVC132843230(adam17b) 132852675(adam17a)
TRN134320106(adam17b) 134324943(adam17a)
AMEX103041369 103041996
CMAO118815633(adam17b) 118823462(adam17a)
EEE113570511 113579136(adam17)
CHAR105897061(adam17b) 105897267(adam17a)
TRU101063716(adam17) 101075639
TFS130516153(adam17b) 130539694(adam17a)
TNGGSTEN00003450G001 GSTEN00032183G001
LCO104922135 104938532
NCC104953609(adam17)
TBEN117473782(adam17a)
CGOB115027586(adam17)
PGEO117467499
GACU117549910
EMAC134877193(adam17b) 134881429(adam17a)
ELY117266979(adam17a) 117270804(adam17b)
EFO125896904(adam17b) 125900530(adam17a)
PLEP121953389(adam17a) 121955712
SLUC116035705(adam17a) 116061359
ECRA117936317(adam17a)
ESP116670032(adam17)
PFLV114546481(adam17)
GAT120815238 120833295(adam17a)
PPUG119195236 119227477(adam17a)
AFB129103252(adam17a) 129107002(adam17b)
CLUM117751347(adam17a)
PSWI130202053(adam17a)
MSAM119909392(adam17b) 119910413(adam17a)
SCHU122861718(adam17a) 122862643(adam17b)
CUD121521362(adam17b) 121526184(adam17a)
ALAT119004926(adam17a) 119012752(adam17b)
MZE101474055 101477206
ONL100692440 100700935
OAU116312411(adam17b) 116334721(adam17a)
OLA101165277 101171872
OML112149788(adam17a) 112157702(adam17b)
CSAI133461983(adam17a) 133464880(adam17b)
XMA102222153 102227287(adam17)
XCO114134256 114158418(adam17)
XHE116709412 116734229(adam17)
PRET103457157(adam17) 103458871
PFOR103144243 103146799(adam17)
PLAI106954181 106958488(adam17)
PMEI106925343(adam17) 106926881
GAF122825649(adam17b) 122846679(adam17a)
PPRL129354515(adam17b) 129374730
CVG107087577 107089571(adam17)
CTUL119784254(adam17a) 119789424(adam17b)
GMU124855404 124882393(adam17b)
NFU107377926 107392286(adam17)
KMR108236986(adam17a) 108249691(adam17b)
ALIM106521553 106530770(adam17)
NWH119418690(adam17b) 119427330(adam17a)
AOCE111565930 111587227
MCEP124998878(adam17b) 125023604(adam17a)
CSEM103377555(adam17) 103381366
POV109628009 109647613 109647706
SSEN122782844(adam17a) 122784344(adam17b)
HHIP117755872(adam17a) 117758776(adam17b)
HSP118104017(adam17b) 118116343(adam17a)
PPLT128450646(adam17a) 128460522(adam17b)
SMAU118286480(adam17a) 118289970(adam17b)
LCF108888136(adam17a) 108891569(adam17b)
SDU111225559 111236091
SLAL111644771(adam17) 111672592
XGL120788898(adam17b) 120795416(adam17a)
HCQ109526133(adam17) 109531720
SSCV125981403 125990485
SBIA133496315(adam17b) 133513442(adam17a)
PEE133412516(adam17a) 133417292(adam17b)
PTAO133468402(adam17b) 133488146(adam17a)
BPEC110155414(adam17) 110164254
MALB109955016 109974460
BSPL114847944(adam17a) 114849978(adam17b)
SJO128375934(adam17a) 128377021(adam17b)
SASA106566892 106607660 106610723
STRU115162529 115172824 115195042
OTW112217454(adam17b) 112247281 112256502(adam17a)
OMY110498110 110505320(adam17a) 110522060(adam17b)
OGO123994869(adam17b) 124001138 124046303(adam17a)
ONE115138326 115139643 115146388
OKI109866323 109894643 109903890
OKE118362310 118368488 118386674(adam17b)
SALP111963100 111968888 111972678
SNH120019620(adam17b) 120023088(adam17a) 120060189
CCLU121539398 121545088 121566828(adam17b)
ELS105016077 105017805 114829444
SFM108921884(adam17)
PKI111842019
AANG118223873 118230860(adam17b)
LOC102682214(adam17)
PSPA121315402 121317536(adam17b)
ARUT117402183(adam17a) 117411384(adam17b)
PSEX120526040(adam17b)
LCM102367618(ADAM17)
CMK103187122(adam17b)
CPLA122541365(adam17b)
HOC132834418(adam17b)
LERI129697077(adam17b)
PMRN116942526 116951388(ADAM17)
LRJ133340851 133340852 133349091
BFO118404014
BBEL109473119
CIN100175230
SCLV120332865
SPU585715
LPIC129264781
APLC110985040
AJC117103049
SKO102803736
DMEDmel_CG7908(Tace)
DER6554190
DSE6612793
DSIDsimw501_GD21492(Dsim_GD21492)
DYADyak_GE10847
DAN6501584
DSR110186406
DPO6896714
DPE6594801
DMN108155302
DWI6650344
DGR6567576
DMODmoj_GI10801
DAZ108609115
DNV108659297
DHE111596420
DVI6635224
CCAT101448581
BOD106618981
BDR105225774
RZE108361250
AOQ129239624
TDA119677694 119683338
MDE101891592 131805884
SCAC106081862
LCQ111686124
LSQ119601926
GFS119635009
ECOE129939823
CLON129607063
HIS119650619
AGA1273579
ACOZ120949087
AARA120894455
AMER121590638
ASTE118502845
AFUN125763313
AMOU128301613
AALI118457949
AAG5563722
AALB109424331
ASUA134224369
CQUCpipJ_CPIJ005931
CPII120421188
CNS116346870
BCOO119069712
AME551599
ACER108000097
ALAB122717424
ADR102674053
AFLR100868051
BIM100745543
BBIF117212151
BVK117240411
BVAN117162798
BTER100645870
BAFF126914335
BPYO122566715
BPAS132909761
FVI122527570
CCAL108623713
OBB114877479
OLG117607800
MGEN117227229
NMEA116432844
CGIG122396464
SOC105197464
MPHA105839042
AEC105143101
ACEP105623272
PBAR105427116
VEM105561144
HST105184135
DQU106750237
CFO105258924
FEX115241593
LHU105669279
PGC109861730
OBO105282848
PCF106793988
PFUC122521241
VPS122637869
VCRB124422154
VVE124956652
NVI100119121
CSOL105364600
TPRE106654176
LHT122502437
LBD127289378
MDL103578657
CGLO123270939
FAS105266951
DAM107041094
AGIF122855408
CINS118073841
VCAN122406705
CCIN107265431
DSM124408540
NPT124211666
NFB124187719
NLO107226342
NVG124298125
AROA105690398
TCA663540
DPA109537991
SOY115875020
AGRG126748933
ATD109602707
CSET123315085 123318618
AGB108914225
LDC111506628
DVV114326997
NVL108563900
APLN108738958 112904002
PPYR116161187
OTU111419993
BMOR101742406
BMAN114240363
MSEX115440097
DPLKGM_202512
BANY112051369
MJU123874356
NIQ126773170
VCD124534830
MCIX123659170
PMAC106713573
PPOT106104922
PXU106122629
PRAP111003508
PBX123706897
PNAP125050368
CCRC123698644
LSIN126967438
AAGE121734141
HAW110384278
HZE124637015
TNL113503404
SLIU111354966
OFU114352070
ATRA106129617
GMW113510798
PXY105386060
PGW126370922
LGLY125234118
CFEL113372468
CCRN123305992
API100158671
DNX107167450
AGS114130986
RMD113559354
ACOO126839611 126843026
DVT126902802
BTAB109032996
DCI103515131
CLEC106673239
HHAL106685230
NLU111053184
HVI124361784
MQU128988521
PHUPhum_PHUM024730
FOC113217343
TPAL117654419
ZNE110836194
CSEC111874896 111875197
SGRE126267245
BROR134533754
IEL124154096
FCD110845600
DPXDAPPUDRAFT_314368
DMK116925958 123470055
DPZ124340918
PVM113801174 113801176
PJA122247615 122264652
PCHN125046731 125046761
PMOO119591392 119591553
HAME121869162
PCLA123764791
CQD128696329
PTRU123504923
ESN126996497
MNZ135204219 135204236 135204237
HAZT108674819
EAF111713207
LSM121117760 121118487
TCF131877982
PPOI119100663 119100666 119100667
ISC120835932
DSV119460684
RSAN119396531
RMP119174711
VDE111247675 111248881 111249277 111249387 111250104 111250143
VJA111259527 111264350 111264356 111265748 111269090 111269228
DFR124498186 124498350
CSCU111618821
PTEP107455115
ABRU129958549
UDV129230976
SDM118180981
PMEO129589025
CELCELE_ZK154.7(adm-4)
CBRCBG_16796(Cbr-adm-4)
CRQGCK72_024847
NAINECAME_00683
BMYBM_BM7430(Bma-adm-4)
LOALOAG_03310
TSPTsp_02601
LGILOTGIDRAFT_140416 LOTGIDRAFT_218462
PVUL126831602 126832499
PCAN112559081 112559083 112559089 112559955 112560031 112560314 112561901 112570179 112577068
BGT106052851 106054305 106057281 106057282 106057867 106068788
GAE121387517 121387804
HRF124125268 124149260
HRJ124265245 124272395
CRG105322445 105330896 105338334 105338464 105348437
CVN111123307 111125232 111126918 111127133 111127575 111127576 111133224
CANU128156361 128179872 128180124 128192123 128192532
OED125668371 125680934 125681006 125681301
MYI110445809 110449224 110453479 110456857 110458138
PMAX117317391 117317665 117317752 117339393
MMER123538796 123538949
RPHI132721796 132721819
DPOL127831834 127848415
MAEA128204382 128240386 128242344 128242345 128243947 128244826 128245060
OBI106881514
OSN115220007
LJP135464594
LAK106153651
SMMSmp_175340.1
SHXMS3_00006789(ADAM17)
OVIT265_01230
EGLEGR_00581
LLON135502975 135503323
NVE5511423
EPA110250562
ATEN116292316
ADF107358831
AMIL114948654
PDAM113681067
SPIS111328065
DGT114528597
XEN124447472
HMG100210793
HSY130614752 130614753
RES135689956
TADTRIADDRAFT_58971
AQU105311941 105312617 105315908
EINEint_060290
EHEEHEL_060310
EROEROM_060290
MBRMONBRDRAFT_22131 MONBRDRAFT_22277 MONBRDRAFT_24567
SREPTSG_06305 PTSG_07102 PTSG_07278
 » show all
Reference
1  [PMID:11733179]
  Authors
Black RA.
  Title
Tumor necrosis factor-alpha converting enzyme.
  Journal
Int J Biochem Cell Biol 34:1-5 (2002)
DOI:10.1016/S1357-2725(01)00097-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.86
IUBMB Enzyme Nomenclature: 3.4.24.86
ExPASy - ENZYME nomenclature database: 3.4.24.86
BRENDA, the Enzyme Database: 3.4.24.86
CAS: 151769-16-3

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