KEGG   ENZYME: 3.4.24.87Help
Entry
EC 3.4.24.87                Enzyme                                 

Name
ADAMTS13 endopeptidase;
ADAMTS VWF cleaving metalloprotease;
ADAMTS-13;
ADAMTS13;
vWF-cleaving protease;
VWF-CP;
vWF-degrading protease;
Upshaw factor;
von Willebrand factor cleaving protease;
ADAMTS13 peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the von Willebrand factor at bond Tyr842!Met843 within the A2 domain
Comment
In peptidase family M12.
History
EC 3.4.24.87 created 2009
Orthology
K08627  a disintegrin and metalloproteinase with thrombospondin motifs 13
Genes
HSA: 11093(ADAMTS13)
PTR: 473153(ADAMTS13)
PPS: 100970824 100978943
GGO: 101151958(ADAMTS13)
PON: 100459418(ADAMTS13)
NLE: 100580216(ADAMTS13)
MCC: 722202(ADAMTS13)
MCF: 102145096(ADAMTS13)
CSAB: 103239684(ADAMTS13)
RRO: 104669720(ADAMTS13)
RBB: 108513335(ADAMTS13)
CJC: 100404947(ADAMTS13)
SBQ: 101038728(ADAMTS13)
MMU: 279028(Adamts13)
MCAL: 110312498(Adamts13)
MPAH: 110317485(Adamts13)
RNO: 102554393(Adamts13)
MUN: 110557514(Adamts13)
CGE: 100770010(Adamts13)
NGI: 103742812(Adamts13)
HGL: 101713585(Adamts13)
CCAN: 109696127(Adamts13)
OCU: 100343027(ADAMTS13)
TUP: 102474078(ADAMTS13)
CFA: 100630922(ADAMTS13)
VVP: 112935883(ADAMTS13)
AML: 100481099(ADAMTS13)
UMR: 103679919(ADAMTS13)
UAH: 113266572(ADAMTS13)
ORO: 101385635(ADAMTS13)
FCA: 101086761(ADAMTS13)
PTG: 102959927(ADAMTS13)
PPAD: 109258253(ADAMTS13)
AJU: 106988263(ADAMTS13)
BTA: 532272(ADAMTS13)
BOM: 102287814(ADAMTS13)
BIU: 109565686(ADAMTS13)
BBUB: 102412616(ADAMTS13)
CHX: 102174580(ADAMTS13)
OAS: 101112214(ADAMTS13)
SSC: 100627950(ADAMTS13)
CFR: 102506864(ADAMTS13)
CDK: 105105829 105106329(ADAMTS13)
BACU: 102999611(ADAMTS13)
LVE: 103074204(ADAMTS13)
OOR: 101281877(ADAMTS13)
DLE: 111177028(ADAMTS13)
PCAD: 102996576 112065505 114485480
ECB: 100069281(ADAMTS13)
EPZ: 103565346(ADAMTS13)
EAI: 106845293(ADAMTS13)
MYB: 102240335(ADAMTS13)
MYD: 102764800(ADAMTS13)
MNA: 107524621(ADAMTS13)
HAI: 109382381
DRO: 112306578(ADAMTS13)
PALE: 102885523(ADAMTS13)
RAY: 107514854(ADAMTS13)
MJV: 108398385(ADAMTS13)
LAV: 100667919(ADAMTS13)
TMU: 101354225
MDO: 100018539(ADAMTS13)
SHR: 100924870(ADAMTS13)
PCW: 110205378(ADAMTS13)
OAA: 100077268(ADAMTS13)
GGA: 417152(ADAMTS13)
MGP: 100544155(ADAMTS13)
CJO: 107321769(ADAMTS13)
NMEL: 110406845(ADAMTS13)
APLA: 101800615(ADAMTS13)
ACYG: 106044108(ADAMTS13)
TGU: 100226372(ADAMTS13)
LSR: 110477621(ADAMTS13)
SCAN: 103819131(ADAMTS13)
GFR: 102043124(ADAMTS13)
FAB: 101809354(ADAMTS13)
PHI: 102109550(ADAMTS13)
PMAJ: 107212053(ADAMTS13)
CCAE: 111937039(ADAMTS13)
CCW: 104688336(ADAMTS13)
ETL: 114059081(ADAMTS13)
FPG: 101910275(ADAMTS13)
FCH: 102055781(ADAMTS13)
CLV: 102096762(ADAMTS13)
EGZ: 104129330(ADAMTS13)
NNI: 104023191(ADAMTS13)
ACUN: 113486351(ADAMTS13)
PADL: 103915348(ADAMTS13)
AAM: 106483743 106483751
ASN: 102379615(ADAMTS13)
AMJ: 102565959(ADAMTS13)
PSS: 102455064(ADAMTS13)
CMY: 102937118(ADAMTS13)
CPIC: 101940111(ADAMTS13)
PVT: 110079591(ADAMTS13)
PBI: 103050431(ADAMTS13)
PMUR: 107300476 107302802(ADAMTS13)
TSR: 106555726
PMUA: 114589118(ADAMTS13)
GJA: 107113557(ADAMTS13)
XLA: 108698851
XTR: 100485801(adamts13)
NPR: 108792836(ADAMTS13)
DRE: 100320289(adamts13)
SRX: 107725310 107740991(adamts13)
SANH: 107691575(adamts13) 107702807
SGH: 107548275 107565123(adamts13)
CCAR: 109085749 109087872
IPU: 108265332(adamts13)
PHYP: 113533593(adamts13)
AMEX: 103029987(adamts13)
EEE: 113578195(adamts13)
TRU: 101074374(adamts13)
TNG: GSTEN00025091G001
LCO: 104923091(adamts13)
NCC: 104945790 104954446
MZE: 101477146(adamts13)
ONL: 100696354(adamts13)
OLA: 101165315(adamts13)
XMA: 102237546(adamts13)
XCO: 114154695(adamts13)
PRET: 103470625(adamts13)
CVG: 107099575(adamts13)
NFU: 107393634(adamts13)
KMR: 108236553(adamts13)
ALIM: 106516687(adamts13)
AOCE: 111586394(adamts13)
CSEM: 103398347
POV: 109633866(adamts13)
LCF: 108878613(adamts13)
SDU: 111226862(adamts13)
SLAL: 111644942(adamts13)
HCQ: 109511597(adamts13)
BPEC: 110169902(adamts13)
MALB: 109954821(adamts13)
SASA: 106579902(adamts13)
OTW: 112262981(adamts13)
SALP: 111957513(adamts13)
ELS: 105025189(adamts13)
SFM: 108938135(adamts13)
PKI: 111858732(adamts13)
LCM: 102349966(ADAMTS13)
CMK: 103184703(adamts13)
RTP: 109922320
PVM: 113821132
CRG: 105336114
MYI: 110455596
 » show all
Taxonomy
Reference
1  [PMID:11535495]
  Authors
Fujikawa K, Suzuki H, McMullen B, Chung D
  Title
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.
  Journal
Blood 98:1662-6 (2001)
  Sequence
[hsa:11093]
Reference
2  [PMID:12393397]
  Authors
Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, Lopez JA
  Title
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.
  Journal
Blood 100:4033-9 (2002)
DOI:10.1182/blood-2002-05-1401
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.87
IUBMB Enzyme Nomenclature: 3.4.24.87
ExPASy - ENZYME nomenclature database: 3.4.24.87
BRENDA, the Enzyme Database: 3.4.24.87

  All links  
Gene (369)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (158)   
   KEGG MGENES (32)   
   RefGene (178)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (8)   
   PDBSTR (4)   
DNA sequence (10)   
   RefSeq(nuc) (9)   
   GenBank (1)   
3D Structure (2)   
   PDB (2)   
All databases (397)   

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