Entry |
|
Name |
ADAMTS13 endopeptidase;
ADAMTS VWF cleaving metalloprotease;
ADAMTS-13;
ADAMTS13;
vWF-cleaving protease;
VWF-CP;
vWF-degrading protease;
Upshaw factor;
von Willebrand factor cleaving protease;
ADAMTS13 peptidase
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
|
Reaction(IUBMB) |
The enzyme cleaves the von Willebrand factor at bond Tyr842!Met843 within the A2 domain
|
Comment |
In peptidase family M12.
|
History |
EC 3.4.24.87 created 2009
|
Orthology |
K08627 | a disintegrin and metalloproteinase with thrombospondin motifs 13 |
|
Genes |
» show all
|
Reference |
|
Authors |
Fujikawa K, Suzuki H, McMullen B, Chung D |
Title |
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family. |
Journal |
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Sequence |
|
Reference |
|
Authors |
Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, Lopez JA |
Title |
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.24.87 |
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