KEGG   ENZYME: 3.4.24.89Help
Entry
EC 3.4.24.89                Enzyme                                 

Name
Pro-Pro endopeptidase;
metalloprotease CD2830
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme catalyses the hydrolytic cleavage of peptide bonds between two proline residues
Comment
This metalloprotease, which is secreted by the bacterium Peptoclostridium difficile, contains zinc.
History
EC 3.4.24.89 created 2015
Orthology
K20109  Pro-Pro endopeptidase
Genes
BTM: MC28_G104
BTHU: YBT1518_32677
BMYO: BG05_5545 BG05_5615
BIF: N288_16355
BMET: BMMGA3_10250 BMMGA3_15165
GST: HW35_02855
BSM: BSM4216_2256
BSJ: UP17_14375
BON: A361_18835
BFX: BC359_13255
GKA: GK1777
GTN: GTNG_1672
ANM: GFC28_853
AAMY: GFC30_2091
ANL: GFC29_773
 » show all
Taxonomy
Reference
1  [PMID:24303041]
  Authors
Cafardi V, Biagini M, Martinelli M, Leuzzi R, Rubino JT, Cantini F, Norais N, Scarselli M, Serruto D, Unnikrishnan M
  Title
Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins.
  Journal
PLoS One 8:e81306 (2013)
DOI:10.1371/journal.pone.0081306
  Sequence
Reference
2  [PMID:24623589]
  Authors
Hensbergen PJ, Klychnikov OI, Bakker D, van Winden VJ, Ras N, Kemp AC, Cordfunke RA, Dragan I, Deelder AM, Kuijper EJ, Corver J, Drijfhout JW, van Leeuwen HC
  Title
A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.
  Journal
Mol Cell Proteomics 13:1231-44 (2014)
DOI:10.1074/mcp.M113.034728
  Sequence
Reference
3  [PMID:26522134]
  Authors
Hensbergen PJ, Klychnikov OI, Bakker D, Dragan I, Kelly ML, Minton NP, Corver J, Kuijper EJ, Drijfhout JW, van Leeuwen HC
  Title
Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831.
  Journal
FEBS Lett 589:3952-8 (2015)
DOI:10.1016/j.febslet.2015.10.027
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.89
IUBMB Enzyme Nomenclature: 3.4.24.89
ExPASy - ENZYME nomenclature database: 3.4.24.89
BRENDA, the Enzyme Database: 3.4.24.89

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