Entry
Name
HslU---HslV peptidase;
HslUV;
HslV-HslU;
HslV peptidase;
ATP-dependent HslV-HslU proteinase;
caseinolytic protease X;
caseinolytic proteinase X;
ClpXP ATP-dependent protease;
ClpXP protease;
ClpXP serine proteinase;
Escherichia coli ClpXP serine proteinase;
HslUV protease;
HslUV proteinase;
HslVU protease;
HslVU proteinase;
protease HslVU;
proteinase HslUV
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Threonine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
ATP-dependent cleavage of peptide bonds with broad specificity.
Comment
The HslU subunit of the HslU---HslV complex functions as an ATP dependent 'unfoldase'. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolysed by HslV [5]. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis [7]. In peptidase family T1.
History
EC 3.4.25.2 created 2009, modified 2010
Orthology
K01419 ATP-dependent HslUV protease, peptidase subunit HslV
Genes
PLAG : 39743019(PADL01_1231000)
PMAL : PMUG01_14064700(ClpQ)
PBRS : 92373782(MKS88_005695)
PREL : PRELSG_1446500(ClpQ)
EHX : EMIHUDRAFT_47629 EMIHUDRAFT_47636
TCR : 506275.20 510719.260
LMAT : 92510592(LSCM1_00429)
LOI : 92356447(LSCM4_00431)
ECOO : ECRM13514_5048(hslV)
ECOH : ECRM13516_4784(hslV)
ECW : EcE24377A_4468(hslV)
EDJ : ECDH1ME8569_3801(hslV)
ECOI : ECOPMV1_04331(hslV)
REE : electrica_04956(hslV)
RTG : NCTC13098_07105(hslV)
CLAP : NCTC11466_04491(hslV)
KIE : NCTC12125_03684(hslV)
BAGE : BADSM9389_40700(hslV)
AHN : NCTC12129_04830(hslV)
METY : MRY16398_55220(hslV)
PSHI : SAMEA2665130_2852(hslV)
YPG : YpAngola_A0113(hslV)
YPI : YpsIP31758_0113(hslV)
SMW : SMWW4_v1c47230(hslV)
SFJ : SAMEA4384070_4726(hslV)
SOF : NCTC11214_01531(hslV)
SSAR : SSARUM_004652(hslV)
PAQU : DMB82_0000760(hslV)
PARL : PEC302110_38330(hslV)
DIC : Dpoa569_000166(hslV)
BAPF : BUMPF009_CDS00027(hslv)
BAPG : BUMPG002_CDS00027(hslv)
BAPU : BUMPUSDA_CDS00027(hslv)
BAPW : BUMPW106_CDS00027(hslv)
TPTY : NCTC11468_03688(hslV)
PHEI : NCTC12003_03846(hslV)
PRJ : NCTC6933_03874(hslV)
LRI : NCTC12151_00102(hslV)
HIC : NTHIC486_00494(hslV)
HPIT : NCTC13334_00779(hslV)
HHZ : NCTC10839_00377(hslV)
HAEG : NCTC8502_00641(hslV)
PDAG : 4362423_01651(hslV)
ADP : NCTC12871_01606(hslV)
ALIG : NCTC10568_02110(hslV)
ASEG : NCTC10977_00548(hslV)
AVT : NCTC3438_02156(hslV)
RPNE : NCTC8284_03845(hslV)
PAET : NCTC13378_02194(hslV)
XFU : XFF4834R_chr06460(hslV)
XPH : XppCFBP6546_08445(hslV)
XHD : LMG31886_07500(hslV)
LLZ : LYB30171_02419(hslV)
VAU : VANGNB10_cI2425c(hslV)
VPL : SA104470976_00160(hslV)
PAEB : NCGM1900_5808(hslV)
PVD : CFBP1590__4927(hslV)
PPRC : PFLCHA0_c04440(hslV)
PMUD : NCTC8068_00407(hslV)
PFW : PF1751_v1c03760(hslV)
PPUU : PputUW4_00336(hslV)
PTRT : HU722_0002910(hslV)
PTW : TUM18999_56220(hslV)
PTAE : NCTC10697_04204(hslV)
MSHE : MAALD49_08030(hslV)
SCAA : TUM17387_04060(hslV)
CATE : C2869_07800 C2869_21640
SALH : HMF8227_00132(hslV)
CBS : COXBURSA331_A0074(hslV)
LLG : 44548918_02358(hslV)
LJR : NCTC11533_02447(hslV)
LCJ : NCTC11976_03115(hslV)
LWA : SAMEA4504053_0977(hslV)
LSS : NCTC12082_02321(hslV)
LADL : NCTC12735_01141(hslV)
LANT : TUM19329_08550(hslV)
MISZ : MishRS11D_31100(hslV)
TIB : THMIRHAM_04570(hslV)
TSE : THMIRHAS_04430(hslV)
TZO : THMIRHAT_19350(hslV)
RHEI : ATY27_07120 ATY27_17740
TFRI : Thiofri_04790(hslV)
TNI : TVNIR_0084(hslV_[H])
GAI : IMCC3135_00090(hslV)
THIC : TspCOW1_24370(hslV)
HAXI : HAALTHF_19370n(hslV)
HAAH : HALA3H3_590058(hslV)
ALCA : ASALC70_01713(hslV)
AEL : NCTC12917_00161(hslV)
CHJ : NCTC10426_01064(hslV)
GBI : PG2T_03475 PG2T_14810
ATY : A9R16_001925(hslV) A9R16_002290
CDIZ : CEDIAZO_00616(hslV)
ECOR : SAMEA4412678_1051(hslV)
CVI : CV_0401(hslV) CV_1999
CVC : BKX93_00230 BKX93_13445
CHRO : CXB49_09945 CXB49_21740
CHRI : DK842_07315 DK842_17080
CHRB : DK843_00205 DK843_12880
CRZ : D1345_08100 D1345_23275(hslV)
CHRM : FYK34_05840 FYK34_16670(hslV)
CHAE : CH06BL_17480 CH06BL_47860(hslV)
AQS : DKK66_01370 DKK66_08280
IOD : EJO50_01235(hslV) EJO50_02250
IFL : C1H71_03985 C1H71_04870
JEU : BJP62_08345 BJP62_17265
JES : JHS3_05690 JHS3_20440(hslV)
DEE : HQN60_02145 HQN60_08880(hslV)
DTK : K4H28_10370(hslV) K4H28_10635
CHIZ : HQ393_00580(hslV) HQ393_07225
CFON : HZU75_02705 HZU75_03440(hslV)
CHIC : N8I74_11170 N8I74_18690(hslV)
CARI : FNU76_12445(hslV) FNU76_19465
CKS : H9L41_01355(hslV) H9L41_07510
LHK : LHK_00004(hslV) LHK_02183
AQL : BXU06_02280 BXU06_14950
RPJ : N234_00785 N234_06880
REH : H16_A0199(clpY) H16_A1376(hslV)
CNC : CNE_1c01890(hslV) CNE_1c14030(hslVU)
CUH : BJN34_00915 BJN34_07015
REU : Reut_A0167 Reut_A1305
RME : Rmet_0131(hslV) Rmet_1198
CTI : RALTA_A0142(hslV) RALTA_A1296
CBW : RR42_m0213 RR42_m1491
CCUP : BKK81_03355 BKK81_12900
CUP : BKK80_02700 BKK80_13115
CUU : BKK79_09570 BKK79_19180
CPAU : EHF44_04745(hslV) EHF44_15515
COX : E0W60_11585(hslV) E0W60_16850
CCAM : M5D45_00770(hslV) M5D45_06025
CUK : KB879_00880(hslV) KB879_07090
CNAN : A2G96_02080 A2G96_07560
BMV : BMASAVP1_A2916(hslV)
BML : BMA10229_A2173(hslV)
BPL : BURPS1106A_0201(hslV)
BUE : BRPE67_ACDS27610(hslV)
PPK : U875_14385 U875_22535
PPNO : DA70_06280 DA70_15215
PPNM : LV28_15465 LV28_24420
PRB : X636_11635 X636_20395
PPUL : RO07_09505 RO07_18755
PSPU : NA29_05425 NA29_18465
PAPI : SG18_10005 SG18_17460
PVE : UC34_01300 UC34_09940
POX : MB84_05630 MB84_14260
PTX : ABW99_03440 ABW99_16230
PFG : AB870_12555 AB870_20510
PNR : AT302_09175 AT302_23880
PAND : DRB87_01160 DRB87_09175
PFIB : PI93_001115(hslV) PI93_017675
PCOM : NTU39_01520(hslV) NTU39_11105
PLG : NCTC10937_00596(hslV)
LMIR : NCTC12852_00319(hslV)
BUO : BRPE64_ACDS28300(hslV)
VTR : MYVALT_G_00580(hslV)
BTRM : SAMEA390648701384(hslV)
AXX : ERS451415_06002(hslV)
RHY : RD110_16165 RD110_24100
RHF : EUB48_11635 EUB48_18435(hslV)
VAP : Vapar_0908 Vapar_2164
VPE : Varpa_0968 Varpa_3728
VPD : VAPA_1c09610(hslV) VAPA_1c23420
VAA : AX767_00870 AX767_06970
VBO : CKY39_04555 CKY39_20185
VAM : C4F17_02925 C4F17_14630
VAZ : H7F35_16780(hslV) H7F35_26670
VAV : IG196_02940(hslV) IG196_17905
RTA : Rta_09580(hslV) Rta_18690
SMIO : CATMQ487_49490(hslV)
JAB : VN23_01560 VN23_13245
GLC : JQN73_07100(hslV) JQN73_13625
XYK : GT347_03770 GT347_18195(hslV)
XYG : R9X41_07475 R9X41_19160(hslV)
SHD : SUTH_00573 SUTH_00740
DOE : DENOEST_1534 DENOEST_2459(hslV)
URU : DSM104443_03449 DSM104443_03589(hslV)
UPL : DSM104440_02968 DSM104440_03125(hslV)
THAG : CKCBHOJB_03153(hslV)
DDZ : DSYM_24770 DSYM_27290
BEB : AEM42_13845 AEM42_14055
ERW : ERWE_CDS_08110(hslV)
ERG : ERGA_CDS_08020(hslV)
RBS : RHODOSMS8_03129(hslV)
SMEL : SM2011_c02575(hslV)
SFD : USDA257_c59190(hslV)
SAME : SAMCFNEI73_Ch0056(hslV)
AGR : AGROH133_02857(hslV)
ALF : CFBP5473_01015(hslV)
AVV : RvVAT039_16930(hslV)
AVF : RvVAR031_04050(hslV)
ASAL : CFBP5507_13190(hslV)
RPUS : CFBP5875_12815(hslV)
ALEG : CFBP4996_13210(hslV)
REC : RHECIAT_CH0000051(hslV)
REL : REMIM1_CH00049(hslV)
REP : IE4803_CH00048(hslV)
REI : IE4771_CH00049(hslV)
RTR : RTCIAT899_CH00255(hslV)
RGA : RGR602_CH00048(hslV)
RPHA : AMC79_CH00051(hslV)
RLW : RlegWSM1455_21610(hslV)
RBW : RLCC275e_22130(hslV)
NGL : RG1141_CH40310(hslV)
NEN : NCHU2750_37690(hslV)
BIO : BR141012304_10657(hslV)
BSEP : HAP48_0015400(hslV)
BCAN : BcanWSM471_01130(hslV)
VGO : GJW-30_1_01486(hslV)
BHS : BM1374165_00215(hslV)
BTX : BM1374166_00208(hslV)
BEZ : NCTC12898_00098(hslV)
MAQU : Maq22A_c06850(hslV)
MMES : MMSR116_15475(hslV)
MTUN : MTUNDRAET4_3006(hslV)
FIL : BN1229_v1_1500(hslV)
FIY : BN1229_v1_1502(hslV)
BVY : NCTC9239_03434(hslV)
TSV : DSM104635_03873(hslV)
RLI : RLO149_c041530(hslV)
PHP : PhaeoP97_03420(hslV)
PPIC : PhaeoP14_03335(hslV)
SINL : DSM14862_00091(hslV)
SPSE : SULPSESMR1_03202(hslV)
RMM : ROSMUCSMR3_02291(hslV)
AHT : ANTHELSMS3_00980(hslV)
LALG : LentiSH36_02757(hslV)
LVS : LOKVESSMR4R_03589(hslV)
AALK : LGT41_0004125(hslV)
SBIN : SBA_ch1_24600(hslV)
SPAG : sphantq_03578(hslV)
SFLA : SPHFLASMR4Y_00700(hslV)
HFL : PUV54_06300(hslV) PUV54_12250
HPO : HMPREF4655_21090(hslV)
HPX : HMPREF0462_0906(hslV)
HCL : NCTC13205_00322(hslV)
HSH : NHP194022_00840(hslV)
HPUL : NCTC13154_00654(hslV)
CJV : MTVDSCj20_0677(hslV)
CFV : CFVI03293_0758(hslV)
CAMP : CFT03427_0981(hslV)
CCOC : CCON33237_0939(hslV)
CLR : UPTC16701_0770(hslV)
CLM : UPTC16712_0774(hslV)
CAMR : CAQ16704_0784(hslV)
CHV : CHELV3228_0318(hslV)
CPIN : CPIN18020_0910(hslV)
CAMZ : CVIC12175_0785(hslV)
PPOR : JCM14722_26010(hslV)
BAZ : BAMTA208_09075(clpQ)
BSON : S101395_03118(hslV)
BSTR : QI003_08675(clpQ) QI003_12100(clpQ)
BFD : NCTC4823_02490(clpQ)
PARG : PspKH34_26200(hslV)
BLEN : NCTC4824_02676(hslV)
SAX : USA300HOU_1184(clpQ)
SUQ : HMPREF0772_11977(hslV)
SUX : SAEMRSA15_10860(hslV)
SUF : SARLGA251_11640(hslV)
SAUT : SAI1T1_2008960(clpQ)
SAUJ : SAI2T2_1008980(clpQ)
SAUK : SAI3T3_1008970(clpQ)
SAUQ : SAI4T8_1008960(clpQ)
SAUV : SAI7S6_1008970(hslV)
SAUW : SAI5S5_1008930(hslV)
SAUX : SAI6T6_1008940(hslV)
SAUY : SAI8T7_1008970(hslV)
SDP : NCTC12225_01763(hslV)
SPIC : SAMEA4384060_1683(hslV)
SSH : NCTC13712_01198(hslV)
SSIM : SAMEA4384339_1137(clpQ)
SSTE : SAMEA4384403_1558(hslV)
LMOC : LMOSLCC5850_1336(clpQ)
LMW : LMOSLCC2755_1281(clpQ)
LMX : LMOSLCC2372_1339(clpQ)
LMZ : LMOSLCC2482_1327(clpQ)
LMON : LMOSLCC2376_1229(clpQ)
LMOS : LMOSLCC7179_1248(clpQ)
LMOO : LMOSLCC2378_1293(clpQ)
LMOY : LMOSLCC2479_1338(clpQ)
LMOT : LMOSLCC2540_1329(clpQ)
LMOA : LMOATCC19117_1287(clpQ)
LGZ : NCTC10812_01684(clpQ)
BAYD : BSPP4475_08855(hslV)
PPQ : PPSQR21_019580(hslV)
PNK : AASFL403_10200(hslV)
COHN : KCTCHS21_38470(hslV)
LPW : LpgJCM5343_10560(hslV)
EFAU : EFAU085_01164(hslV)
EFU : HMPREF0351_11140(hslV)
ECEC : NCTC12421_01369(clpQ)
AMIC : Ami3637_12820(hslV)
ABUT : Ami103574_11960(hslV)
VRM : 44547418_00985(clpQ)
MANA : MAMMFC1_03904(clpQ)
LEPV : J4558_06330(hslV) J4558_14025(hslV)
MTAI : Mtai_v1c12360(hslV)
LCRE : Pla8534_56030(hslV)
BMEI : Spa11_11360(hslV) Spa11_24130(prcB)