KEGG   ENZYME: 3.5.1.102Help
Entry
EC 3.5.1.102                Enzyme                                 

Name
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
ArfB
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase
Reaction(IUBMB)
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate [RN:R09374]
Reaction(KEGG)
Substrate
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
H2O [CPD:C00001]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
formate [CPD:C00058]
Comment
The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 3.5.4.29 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 3.5.4.25 (GTP cyclohydrolase II) catalyses both reactions.
History
EC 3.5.1.102 created 2010, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K14653  2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
Genes
MJA: MJ_0116
MFE: Mefer_0820
MVU: Metvu_0787
MFS: MFS40622_0989
MIF: Metin_0294
MIG: Metig_0986
MMP: MMP1705
MMQ: MmarC5_1701
MMX: MmarC6_0966
MMZ: MmarC7_0980
MMD: GYY_09400
MAE: Maeo_0663
MVO: Mvol_1322
MTH: MTH_651
MST: Msp_1177
MSI: Msm_0184
MRU: mru_1283(arfB)
MEB: Abm4_0796(arfB)
METH: MBMB1_0319(arfB)
MFV: Mfer_1218
 » show all
Taxonomy
Reference
1  [PMID:19309161]
  Authors
Grochowski LL, Xu H, White RH
  Title
An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin.
  Journal
Biochemistry 48:4181-8 (2009)
DOI:10.1021/bi802341p
  Sequence
[mja:MJ_0116]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.102
IUBMB Enzyme Nomenclature: 3.5.1.102
ExPASy - ENZYME nomenclature database: 3.5.1.102
BRENDA, the Enzyme Database: 3.5.1.102

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