KEGG   ENZYME: 3.5.1.102
Entry
EC 3.5.1.102                Enzyme                                 
Name
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
ArfB
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase
Reaction(IUBMB)
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate [RN:R09374]
Reaction(KEGG)
R09374
Substrate
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
H2O [CPD:C00001]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
formate [CPD:C00058]
Comment
The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 3.5.4.29 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 3.5.4.25 (GTP cyclohydrolase II) catalyses both reactions.
History
EC 3.5.1.102 created 2010, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K14653  2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
Genes
CANTNCTC13489_01337
MJAMJ_0116
MFEMefer_0820
MVUMetvu_0787
MFSMFS40622_0989
MIFMetin_0294
MJHJH146_0752
MESGMLAUSG7_0005(arfB)
MESAMLASG1_1031(arfB)
MIGMetig_0986
MMPMMP1705
MMQMmarC5_1701
MMXMmarC6_0966
MMZMmarC7_0980
MMDGYY_09400
MMAKMMKA1_19390
MMAOMMOS7_18200
MMADMMJJ_11230
MAEMaeo_0663
MVNMevan_1007
MVOMvol_1322
MOKMetok_1397
METFCFE53_03480
MTHMTH_651
MMGMTBMA_c10310
MWOMWSIV6_1023(arfB)
MTEEMTTB_06250
METCMTCT_0578
METEtca_00621
METZMETMT2_0415
METKFVF72_08315(arfB)
MTHMFZP57_04875(arfB)
METJFZP68_05315(arfB)
MSTMsp_1177
METBAW729_09880
MRUmru_1283(arfB)
MSIMsm_0184
MEBAbm4_0796(arfB)
MMILsm9_0867(arfB)
MEYETL18_05910
MOLYLM1_0795
MAROMarbSA_02670
METVK4897_01380(arfB)
MELMetbo_2103
MEWMSWAN_0504
METHMBMB1_0319(arfB)
MFCBRM9_1950(arfB)
MFIDSM1535_0138(arfB)
MCUBMCBB_0517(arfB)
MSUBBK009_11770
METNBK008_07405
METTCIT01_00865
METOCIT02_05255
MEMEHYG87_02460(arfB)
MFVMfer_1218
 » show all
Reference
1  [PMID:19309161]
  Authors
Grochowski LL, Xu H, White RH
  Title
An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin.
  Journal
Biochemistry 48:4181-8 (2009)
DOI:10.1021/bi802341p
  Sequence
[mja:MJ_0116]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.102
IUBMB Enzyme Nomenclature: 3.5.1.102
ExPASy - ENZYME nomenclature database: 3.5.1.102
BRENDA, the Enzyme Database: 3.5.1.102

DBGET integrated database retrieval system