KEGG   ENZYME: 3.5.1.118Help
Entry
EC 3.5.1.118                Enzyme                                 

Name
gamma-glutamyl hercynylcysteine S-oxide hydrolase;
EgtC
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
gamma-glutamyl-S-(hercyn-2-yl)cysteine S-oxide amidohydrolase
Reaction(IUBMB)
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate [RN:R11021]
Reaction(KEGG)
Substrate
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20995];
H2O [CPD:C00001]
Product
S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20994];
L-glutamate [CPD:C00025]
Comment
The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria.
History
EC 3.5.1.118 created 2015
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K07008  gamma-glutamyl hercynylcysteine S-oxide hydrolase
Genes
MTU: Rv3702c(egtC)
MTV: RVBD_3702c
MTC: MT3805
MRA: MRA_3738
MTF: TBFG_13733
MTB: TBMG_03745
MTK: TBSG_03769
MTZ: TBXG_003716
MTG: MRGA327_22800
MTI: MRGA423_23345
MTUR: CFBS_3923
MTD: UDA_3702c
MTUC: J113_25835
MTUE: J114_19775
MTUH: I917_25960
MTUL: TBHG_03637
MTUT: HKBT1_3907
MTUU: HKBT2_3917
MBB: BCG_3761c
MBT: JTY_3763
MBX: BCGT_3564
MAF: MAF_37100
MMIC: RN08_4082
MPA: MAP_0304c
MAO: MAP4_3567
MAVI: RC58_17725
MAVU: RE97_17755
MAV: MAV_0401
MIT: OCO_03540
MIA: OCU_03610
MID: MIP_00738
MYO: OEM_03660
MIR: OCQ_03560
MMAL: CKJ54_01710(egtC)
MUL: MUL_4286
MMC: Mmcs_4880
MKM: Mkms_4969
MJL: Mjls_5248
MMI: MMAR_5213
MMM: W7S_01740
MLI: MULP_05490(egtC)
MHAD: B586_03750
MSHG: MSG_04706(egtC)
MVA: Mvan_5484
MGI: Mflv_1317
MPHL: MPHLCCUG_00353(egtC)
MVQ: MYVA_5374
MTHN: 4412656_04307(egtC)
MHAS: MHAS_03907(egtC)
MAB: MAB_0371
MABB: MASS_0367
MCHE: BB28_01810
MSTE: MSTE_00330(egtC)
MSAL: DSM43276_00321(egtC)
MTER: 4434518_03929(egtC_2)
ASD: AS9A_2108
NFA: NFA_48850
NFR: ERS450000_05024(egtC)
NNO: NONO_c66350(egtC)
NTP: CRH09_34700(egtC)
RER: RER_43180
REY: O5Y_20235
ROP: ROP_57710
REQ: REQ_12480
RHB: NY08_2331
RFA: A3L23_00520(egtC)
RHS: A3Q41_02833(egtC)
RRZ: CS378_22370(egtC)
RHU: A3Q40_02532(egtC)
RQI: C1M55_21750(egtC)
RRT: 4535765_01116(egtC_2)
RBY: CEJ39_08080(egtC)
SCO: SCO0912(SCM1.45)
SALB: XNR_5670
SMA: SAVERM_7339(egtC)
SGR: SGR_697
SGB: WQO_31705
SCT: SCAT_4661
SFA: Sfla_0406
SBH: SBI_01720
SHY: SHJG_7893
SVE: SVEN_6868
SALS: SLNWT_7176
STRP: F750_6593
SFI: SFUL_6744
SALU: DC74_6877
SALL: SAZ_35725
STRE: GZL_01889
SLD: T261_1096
STRM: M444_29580
SAMB: SAM23877_6628(egtC)
SPRI: SPRI_0730
SRW: TUE45_00192(egtC)
SLE: sle_06850(sle_06850)
SRN: A4G23_05243(egtC)
STRD: NI25_03150
SMAL: SMALA_7431
SLAU: SLA_6649
SALJ: SMD11_0806
SLX: SLAV_06115(egtC2)
SFK: KY5_7466c
SNZ: DC008_30820(egtC)
SGE: DWG14_01146(egtC_1)
KSK: KSE_64550
STRI: C7M71_003905(egtC)
ARTP: E5206_18080(egtC)
LMOI: VV02_12410
KFL: Kfla_5161
NDA: Ndas_0639
NAL: B005_3534
NGV: CDO52_21010(egtC)
STRR: EKD16_07230(egtC)
TCU: Tcur_3639
SRO: Sros_0330
NML: Namu_1080
GOB: Gobs_0203
SEN: SACE_3824(cbiN)
SACC: EYD13_12495(egtC)
AMD: AMED_4962
AMN: RAM_25260
AMM: AMES_4903
AMZ: B737_4903
AOI: AORI_3754
AMQ: AMETH_3013(cbiN)
AMYC: CU254_17955(egtC)
PDX: Psed_3381
PSEA: WY02_03170
PSEE: FRP1_09625
PSEH: XF36_11000
PAUT: Pdca_32240(egtC)
AMI: Amir_2124
APRE: CNX65_10830(egtC)
SESP: BN6_30870
KAL: KALB_2952
ACTI: UA75_11535
ACAD: UA74_11450
AHG: AHOG_10785(egtC)
ACTA: C1701_22035(egtC)
SAQ: Sare_2258
MIL: ML5_4985
MTUA: CSH63_08015(egtC)
MICH: FJK98_16745(egtC)
ASE: ACPL_6425(cbiN)
ACTN: L083_7397
AFS: AFR_38620
ACTS: ACWT_6292
PLK: CIK06_14640(egtC)
PLAB: C6361_04530(egtC)
PLAT: C6W10_01055(egtC)
CAI: Caci_8030
SNA: Snas_5170
TBI: Tbis_2649
AEY: CDG81_09255(egtC)
 » show all
Taxonomy
Reference
1  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J Am Chem Soc 132:6632-3 (2010)
DOI:10.1021/ja101721e
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.118
IUBMB Enzyme Nomenclature: 3.5.1.118
ExPASy - ENZYME nomenclature database: 3.5.1.118
BRENDA, the Enzyme Database: 3.5.1.118

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