KEGG ENZYME: 3.5.1.12

ENZYME: 3.5.1.12

Entry

EC 3.5.1.12                 Enzyme

Name

biotinidase;
amidohydrolase biotinidase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

biotin-amide amidohydrolase

Reaction(IUBMB)

biotin amide + H2O = biotin + NH3 [RN:R01076]

Reaction(KEGG)

R01076;
(other) R01077 R06134

Substrate

biotin amide [CPD:C01893];
H2O [CPD:C00001]

Product

biotin [CPD:C00120];
NH3 [CPD:C00014]

Comment

Also acts on biotin esters.

History

EC 3.5.1.12 created 1961

Pathway

ec00780

Biotin metabolism

ec01100

Metabolic pathways

Orthology

K01435

biotinidase

Genes

HSA:

686(BTD)

PTR:	470760(BTD)

PPS:	100983934(BTD)

GGO:	101131296(BTD)

PON:	100458389(BTD)

NLE:	100584490(BTD)

MCC:	677722(BTD)

MCF:	101926326(BTD)

MTHB:

126946874

CSAB:

103241707(BTD)

CATY:

105578326(BTD)

PANU:

101018867(BTD)

TGE:	112617641(BTD)

RRO:	104656449(BTD)

RBB:	108535861(BTD)

TFN:	117084205(BTD)

PTEH:

111539502(BTD)

CANG:

105505755(BTD)

CJC:	100409568(BTD)

SBQ:	101042865(BTD)

CSYR:

103249273(BTD)

MMUR:

105872706(BTD)

LCAT:

123628581(BTD)

PCOQ:

105826206(BTD)

OGA:	100943917(BTD)

MMU:	26363(Btd)

MCAL:

110309042(Btd)

MPAH:

110325552(Btd)

RNO:	306262(Btd)

MCOC:

116084403(Btd)

MUN:	110551270(Btd)

CGE:	100755324(Btd)

MAUA:

101832998(Btd)

PLEU:

114708166(Btd)

MORG:

121455239(Btd)

MFOT:

126499146

AAMP:

119827426(Btd)

NGI:	103747521(Btd)

HGL:	101716226(Btd)

CPOC:

100723421(Btd)

CCAN:

109694811(Btd)

DORD:

105989900(Btd)

DSP:	122107949(Btd)

NCAR:

124968278 124968503

OCU:

100341187

OPI:	101524102(BTD)

TUP:	102476912(BTD)

GVR:	103595213(BTD)

CFA:	477059(BTD)

CLUD:

112660942(BTD)

VVP:	112925620(BTD)

VLG:	121478712(BTD)

AML:	100483327(BTD)

UMR:	103679387(BTD)

UAH:	113253913(BTD)

UAR:	123788358(BTD)

ELK:

111155099

LLV:

125104704

MPUF:

101679447(BTD)

ORO:	101380238(BTD)

EJU:	114205726(BTD)

ZCA:	113915824(BTD)

MLX:	118003387(BTD)

NSU:	110570752(BTD)

LWW:	102732709(BTD)

FCA:	101094289(BTD)

PYU:	121033648(BTD)

PBG:	122492012(BTD)

LRUF:

124526160

PTG:	102952175(BTD)

PPAD:

109258837(BTD)

AJU:	106971609(BTD)

HHV:	120238470(BTD)

BTA:	537669(BTD)

BOM:	102282711(BTD)

BIU:	109561800(BTD)

BBUB:

102398640(BTD)

BBIS:

105000736(BTD)

CHX:	102179988(BTD)

OAS:	101113196(BTD)

ODA:	120880376(BTD)

CCAD:

122445508(BTD)

SSC:	100737057(BTD)

CFR:	102506341(BTD)

CBAI:

105077624(BTD)

CDK:	105096612(BTD)

VPC:	102536252(BTD)

BACU:

103004341(BTD)

LVE:	103080922(BTD)

OOR:	101278082(BTD)

DLE:	111168158(BTD)

PCAD:

102983963(BTD)

PSIU:

116753297(BTD)

ECB:	100063800(BTD)

EPZ:	103561484(BTD)

EAI:	106842762(BTD)

MYB:	102258405(BTD)

MYD:	102759604(BTD)

MMYO:

118668202(BTD)

MLF:	102419448(BTD)

MNA:	107542412(BTD)

PKL:	118715367(BTD)

HAI:	109395825(BTD)

DRO:	112309951(BTD)

SHON:

118997593(BTD)

AJM:	119048309(BTD)

PDIC:

114502076(BTD)

PHAS:

123830655(BTD)

MMF:	118633287(BTD)

RFQ:	117037188(BTD)

PALE:

102894216(BTD)

PGIG:

120582056(BTD)

PVP:	105288551 111739437(BTD)

RAY:	107508454(BTD)

MJV:	108398575(VNN1) 108403192(BTD)

TOD:	119256862(BTD)

SARA:

101555521(BTD)

LAV:	100663934(BTD)

TMU:

101354864

ETF:	101648355(BTD)

MDO:	100030538(BTD)

GAS:	123249200(BTD)

SHR:	100922840(BTD)

PCW:	110209057(BTD)

OAA:	100084040(BTD)

GGA:	420639(BTD)

PCOC:

116227086(BTD) 116240276

MGP:	100540232(BTD)

CJO:	107309167(BTD)

NMEL:

110394953(BTD)

APLA:

101796688(BTD) 101798228

ACYG:

106030251(BTD)

AFUL:

116486767(BTD)

TGU:	100226458(BTD)

LSR:	110474622(BTD)

SCAN:

103812912(BTD)

PMOA:

120502675(BTD)

OTC:	121339587(BTD)

PRUF:

121352913(BTD)

GFR:	102043957(BTD)

FAB:	101821386(BTD)

PHI:	102104565(BTD)

PMAJ:

107199918(BTD)

CCAE:

111923444(BTD)

CCW:	104689076(BTD)

CBRC:

103614134(BTD)

ETL:	114055684(BTD)

ZAB:	102075280(BTD)

ACHL:

103797008(BTD)

FPG:	101914603(BTD)

FCH:	102056176(BTD)

CLV:	102085390(BTD)

EGZ:	104126131(BTD)

NNI:	104013909(BTD)

PLET:

104623708(BTD)

PCRI:

104036901(BTD)

PCAO:

104045793(BTD)

ACUN:

113476796(BTD)

TALA:

104359643(BTD)

PADL:

103918399(BTD)

AFOR:

103906634(BTD)

ACHC:

115339769(BTD)

HALD:

104323793(BTD)

HLE:	104843122(BTD)

AGEN:

126038078

GCL:

127013139

CCRI:

104156679(BTD)

CSTI:

104556663(BTD)

EHS:	104504847(BTD)

CMAC:

104483065(BTD)

MUI:	104542479(BTD)

FGA:	104072840(BTD)

GSTE:

104254419(BTD)

LDI:	104341838(BTD)

MNB:	103777184(BTD)

OHA:	104333320(BTD)

NNT:	104411675(BTD)

DPUB:

104307530(BTD)

PGUU:

104467522(BTD)

ACAR:

104529906(BTD)

CPEA:

104397555(BTD)

AVIT:

104273902(BTD)

CVF:	104289893(BTD)

CUCA:

104059167(BTD)

TEO:	104375118(BTD)

BRHI:

104493186(BTD)

AAM:	106483475(BTD)

AROW:

112977278(BTD)

NPD:	112957226(BTD)

TGT:	104568400(BTD)

DNE:	112985275(BTD)

SCAM:

104145078(BTD)

ASN:

112549578

AMJ:	102566286(BTD)

CPOO:

109310413(BTD)

GGN:	109291601(BTD)

PSS:	102458076(BTD)

CMY:	102946514(BTD)

CPIC:

101939105(BTD)

TST:	117872360(BTD)

CABI:

116837034(BTD)

MRV:	120398935(BTD)

ACS:	100556978(btd)

PVT:	110072153(BTD)

SUND:

121934088(BTD)

PBI:	103068246(BTD)

PMUR:

107282909(BTD)

CTIG:

120307312(BTD)

TSR:	106545056(BTD)

PGUT:

117655107(BTD)

VKO:	123033836(BTD)

PMUA:

114607098(BTD)

ZVI:	118092351(BTD)

STOW:

125441284(BTD)

XLA:	108718912(btd.L)

XTR:	100489727(btd)

NPR:	108803235(BTD)

RTEM:

120940232(BTD)

BBUF:

121002205(BTD)

BGAR:

122938308(BTD)

DRE:	555376(btd)

SRX:	107732456(btd)

SANH:

107694759(btd)

SGH:

107559753

CCAR:

109080426(btd)

CAUA:

113062563 113062564

MAMB:

125275859 125276131

IPU:	108256913(btd)

PHYP:

113536296(btd)

SMEO:

124375894(btd)

TFD:	113661654(btd)

AMEX:

103037138

EEE:	113590652(btd)

TRU:	101069377(btd)

TNG:	GSTEN00032985G001

LCO:	104939816 109139331 109139332

NCC:	104944686 104944699(btd)

CGOB:

115015920

ELY:	117263564 117264124 117264125 117264127 117264131

EFO:	125904495 125905085 125905086 125905087 125905088 125905089 125905092 125905093 125905095

PLEP:

121958319(btd)

SLUC:

116066869 116066871 118493288(btd)

ECRA:

117956338 117956339(btd)

ESP:

116701988

PFLV:

114567763 114567944 114568312

GAT:	120826662(btd)

PPUG:

119218862(btd)

MSAM:

119906734 119906832 119907789

CUD:	121523277 121523334 121523416 121524115 121524298 121524362

ALAT:

119014975 119014987

MZE:	101466121 101475752

ONL:	100694007 102082273(btd) 109194532 109197882 109198139 109198141 109200911 109200913 109200914 109204954

OAU:	116318428 116333647 116333669(btd) 116333671

OLA:

101173953

OML:	112136498 112136509

XMA:	102233822(btd)

XCO:	114155352(btd)

XHE:	116731274(btd)

PRET:

103472253 103472511

PFOR:

103134997 103135181

PLAI:

106936832(btd) 106943235

PMEI:

106922082 106922093

GAF:	122843529(btd)

CVG:

107085879

CTUL:

119785857(btd)

GMU:	124879401(btd)

NFU:

107383317

KMR:	108240453(btd)

ALIM:

106521953 106530461

NWH:	119425694(btd)

AOCE:

111573358(btd)

MCEP:

125019389(btd)

CSEM:

103394637(btd)

POV:	109642670(btd)

SSEN:

122786435(btd)

HHIP:

117770677 117770876 117770877

HSP:	118124941 118124942 118124943

LCF:	108877741 108877753

SDU:

111223068

SLAL:

111656913

XGL:	120786265(btd)

HCQ:	109527670(btd)

BPEC:

110175184

MALB:

109968104

BSPL:

114865773(btd)

SASA:

106570600 106588721 106588750

STRU:

115173883 115175361

OTW:	112240210(btd) 112264467

OMY:	110489374(btd) 110496519

OGO:	124011966 124012249 124043172

ONE:

115132671

SALP:

112074045(btd)

SNH:	120021968 120041045

CCLU:

121572271 121586635

ELS:	105012460(btd)

SFM:

108933388

PKI:	111846924(btd)

AANG:

118234546 118234547 118234548 118234549 118234550

LOC:	102695279(btd)

PSPA:

121315128(btd)

ARUT:

117394718(btd)

PSEX:

120515401(btd)

LCM:	102358398 102358664(BTD)

CMK:	103181262(btd)

RTP:	109911552 109933343

SPU:

575770

APLC:

110985242

DGR:

6565785

PTRU:

123518658

HAZT:

108668034

CSCU:

111631973 111642029

PTEP:

107449055 107449061

SDM:	118201733 118203125

PMAX:

117333923

OSN:

115226121

XEN:

124446359

» show all

Reference

1 [PMID:14087327]

Authors

KNAPPE J, BRUEMMER W, BIEDERBICK K.

Title

[PURIFICATION AND PROPERTIES OF BIOTINIDASE FROM SWINE KIDNEY AND LACTOBACILLUS CASEI.]

Journal

Biochem Z 338:599-613 (1963)

Reference

2 [PMID:13211594]

Authors

THOMA RW, PETERSON WH.

Title

The enzymatic degradation of soluble bound biotin.

Journal

J Biol Chem 210:569-79 (1954)

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.12

IUBMB Enzyme Nomenclature:

3.5.1.12

ExPASy - ENZYME nomenclature database:

3.5.1.12

BRENDA, the Enzyme Database:

3.5.1.12

CAS:

9025-15-4

DBGET integrated database retrieval system