KEGG   ENZYME: 3.5.1.12
Entry
EC 3.5.1.12                 Enzyme                                 

Name
biotinidase;
amidohydrolase biotinidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
biotin-amide amidohydrolase
Reaction(IUBMB)
biotin amide + H2O = biotin + NH3 [RN:R01076]
Reaction(KEGG)
R01076;
(other) R01077 R06134
Substrate
biotin amide [CPD:C01893];
H2O [CPD:C00001]
Product
biotin [CPD:C00120];
NH3 [CPD:C00014]
Comment
Also acts on biotin esters.
History
EC 3.5.1.12 created 1961
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01435  biotinidase
Genes
HSA: 686(BTD)
PTR: 470760(BTD)
PPS: 100983934(BTD)
GGO: 101131296(BTD)
PON: 100458389(BTD)
NLE: 100584490(BTD)
MCC: 677722(BTD)
MCF: 101926326(BTD)
CSAB: 103241707(BTD)
CATY: 105578326(BTD)
PANU: 101018867(BTD)
RRO: 104656449(BTD)
RBB: 108535861(BTD)
TFN: 117084205(BTD)
PTEH: 111539502(BTD)
CJC: 100409568(BTD)
SBQ: 101042865(BTD)
MMUR: 105872706(BTD)
MMU: 26363(Btd)
MCAL: 110309042(Btd)
MPAH: 110325552(Btd)
RNO: 306262(Btd)
MCOC: 116084403(Btd)
MUN: 110551270(Btd)
CGE: 100755324(Btd)
PLEU: 114708166(Btd)
NGI: 103747521(Btd)
HGL: 101716226(Btd)
CPOC: 100723421(Btd)
CCAN: 109694811(Btd)
OCU: 100341187(BTD)
OPI: 101524102(BTD)
TUP: 102476912(BTD)
CFA: 477059(BTD)
VVP: 112925620(BTD)
VLG: 121478712(BTD)
AML: 100483327(BTD)
UMR: 103679387(BTD)
UAH: 113253913(BTD)
ORO: 101380238(BTD)
ELK: 111155099
MPUF: 101679447(BTD)
EJU: 114205726(BTD)
MLX: 118003387(BTD)
FCA: 101094289(BTD)
PYU: 121033648(BTD)
PBG: 122492012(BTD)
PTG: 102952175(BTD)
PPAD: 109258837(BTD)
AJU: 106971609(BTD)
HHV: 120238470(BTD)
BTA: 537669(BTD)
BOM: 102282711(BTD)
BIU: 109561800(BTD)
BBUB: 102398640(BTD)
CHX: 102179988(BTD)
OAS: 101113196(BTD)
ODA: 120880376(BTD)
CCAD: 122445508(BTD)
SSC: 100737057(BTD)
CFR: 102506341(BTD)
CBAI: 105077624(BTD)
CDK: 105096612(BTD)
BACU: 103004341(BTD)
LVE: 103080922(BTD)
OOR: 101278082(BTD)
DLE: 111168158(BTD)
PCAD: 102983963(BTD)
PSIU: 116753297(BTD)
ECB: 100063800(BTD)
EPZ: 103561484(BTD)
EAI: 106842762(BTD)
MYB: 102258405(BTD)
MYD: 102759604(BTD)
MMYO: 118668202(BTD)
MNA: 107542412(BTD)
PKL: 118715367(BTD)
HAI: 109395825(BTD)
DRO: 112309951(BTD)
SHON: 118997593(BTD)
AJM: 119048309(BTD)
PDIC: 114502076(BTD)
MMF: 118633287(BTD)
RFQ: 117037188(BTD)
PALE: 102894216(BTD)
PGIG: 120582056(BTD)
RAY: 107508454(BTD)
MJV: 108398575(VNN1) 108403192(BTD)
TOD: 119256862(BTD)
LAV: 100663934(BTD)
TMU: 101354864
MDO: 100030538(BTD)
GAS: 123249200(BTD)
SHR: 100922840(BTD)
PCW: 110209057(BTD)
OAA: 100084040(BTD)
GGA: 420639(BTD)
PCOC: 116227086(BTD) 116240276
MGP: 100540232(BTD)
CJO: 107309167(BTD)
NMEL: 110394953(BTD)
APLA: 101796688(BTD) 101798228
ACYG: 106030251(BTD)
TGU: 100226458(BTD)
LSR: 110474622(BTD)
SCAN: 103812912(BTD)
PMOA: 120502675(BTD)
OTC: 121339587(BTD)
PRUF: 121352913(BTD)
GFR: 102043957(BTD)
FAB: 101821386(BTD)
PHI: 102104565(BTD)
PMAJ: 107199918(BTD)
CCAE: 111923444(BTD)
CCW: 104689076(BTD)
ETL: 114055684(BTD)
FPG: 101914603(BTD)
FCH: 102056176(BTD)
CLV: 102085390(BTD)
EGZ: 104126131(BTD)
NNI: 104013909(BTD)
ACUN: 113476796(BTD)
PADL: 103918399(BTD)
AAM: 106483475(BTD)
AROW: 112977278(BTD)
NPD: 112957226(BTD)
DNE: 112985275(BTD)
ASN: 112549578
AMJ: 102566286(BTD)
CPOO: 109310413(BTD)
GGN: 109291601(BTD)
PSS: 102458076(BTD)
CMY: 102946514(BTD)
CPIC: 101939105(BTD)
TST: 117872360(BTD)
CABI: 116837034(BTD)
ACS: 100556978(btd)
PVT: 110072153(BTD)
SUND: 121934088(BTD)
PBI: 103068246(BTD)
PMUR: 107282909(BTD)
TSR: 106545056(BTD)
PGUT: 117655107(BTD)
VKO: 123033836(BTD)
PMUA: 114607098(BTD)
ZVI: 118092351(BTD)
XLA: 108718912(btd.L)
XTR: 100489727(btd)
NPR: 108803235(BTD)
DRE: 555376(btd)
SRX: 107732456(btd)
SANH: 107694759(btd)
SGH: 107559753
CCAR: 109080426(btd)
CAUA: 113062563 113062564
IPU: 108256913
PHYP: 113536296(btd)
AMEX: 103037138
EEE: 113590652(btd)
TRU: 101069377(btd)
TNG: GSTEN00032985G001
LCO: 104939816 109139331 109139332
NCC: 104944686 104944699(btd)
CGOB: 115015920
ELY: 117263564 117264124 117264125 117264127 117264131
PLEP: 121958319(btd)
SLUC: 116066869 116066871 118493288(btd)
ECRA: 117956338 117956339(btd)
PFLV: 114567763 114567944 114568312
GAT: 120826662(btd)
PPUG: 119218862(btd)
MSAM: 119906734 119906832 119907789
CUD: 121523277 121523334 121523416 121524115 121524298 121524362
MZE: 101466121 101475752
ONL: 100694007 102082273(btd) 109194532 109197882 109198139 109198141 109200911 109200913 109200914 109204954
OAU: 116318428 116333647 116333669(btd) 116333671
OLA: 101173953
OML: 112136498 112136509
XMA: 102233822(btd)
XCO: 114155352(btd)
XHE: 116731274(btd)
PRET: 103472253 103472511
GAF: 122843529(btd)
CVG: 107085879
CTUL: 119785857(btd)
NFU: 107383317
KMR: 108240453(btd)
ALIM: 106521953 106530461
AOCE: 111573358(btd)
CSEM: 103394637(btd)
POV: 109642670(btd)
SSEN: 122786435(btd)
HHIP: 117770677 117770876 117770877
LCF: 108877741 108877753
SDU: 111223068
SLAL: 111656913
XGL: 120786265(btd)
HCQ: 109527670(btd)
BPEC: 110175184
MALB: 109968104
SASA: 106570600 106588721 106588750
OTW: 112240210(btd) 112264467
OMY: 110489374(btd) 110496519
SALP: 112074045(btd)
SNH: 120021968 120041045
ELS: 105012460(btd)
SFM: 108933388
PKI: 111846924(btd)
AANG: 118234546 118234547 118234548 118234549 118234550
LOC: 102695279(btd)
PSPA: 121315128(btd)
ARUT: 117394718(btd)
LCM: 102358398 102358664(BTD)
CMK: 103181262(btd)
RTP: 109911552 109933343
SPU: 575770
APLC: 110985242
DGR: 6565785
HAZT: 108668034
CSCU: 111631973 111642029
PTEP: 107449055 107449061
SDM: 118201733 118203125
PMAX: 117333923
OSN: 115226121
 » show all
Reference
1  [PMID:14087327]
  Authors
KNAPPE J, BRUEMMER W, BIEDERBICK K.
  Title
[PURIFICATION AND PROPERTIES OF BIOTINIDASE FROM SWINE KIDNEY AND LACTOBACILLUS CASEI.]
  Journal
Biochem Z 338:599-613 (1963)
Reference
2  [PMID:13211594]
  Authors
THOMA RW, PETERSON WH.
  Title
The enzymatic degradation of soluble bound biotin.
  Journal
J Biol Chem 210:569-79 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.12
IUBMB Enzyme Nomenclature: 3.5.1.12
ExPASy - ENZYME nomenclature database: 3.5.1.12
BRENDA, the Enzyme Database: 3.5.1.12
CAS: 9025-15-4

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Pathway (4)   
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Chemical substance (8)   
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Gene (472)   
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