KEGG   ENZYME: 3.5.1.12Help
Entry
EC 3.5.1.12                 Enzyme                                 

Name
biotinidase;
amidohydrolase biotinidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
biotin-amide amidohydrolase
Reaction(IUBMB)
biotin amide + H2O = biotin + NH3 [RN:R01076]
Reaction(KEGG)
R01076;
(other) R01077 R06134
Show
Substrate
biotin amide [CPD:C01893];
H2O [CPD:C00001]
Product
biotin [CPD:C00120];
NH3 [CPD:C00014]
Comment
Also acts on biotin esters.
History
EC 3.5.1.12 created 1961
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01435  biotinidase
Genes
HSA: 686(BTD)
PTR: 470760(BTD)
PPS: 100983934(BTD)
GGO: 101131296(BTD)
PON: 100458389(BTD)
NLE: 100584490(BTD)
MCC: 677722(BTD)
MCF: 101926326(BTD)
CSAB: 103241707(BTD)
RRO: 104656449(BTD)
RBB: 108535861(BTD)
CJC: 100409568(BTD)
SBQ: 101042865(BTD)
MMU: 26363(Btd)
RNO: 306262(Btd)
CGE: 100755324(Btd)
NGI: 103747521(Btd)
HGL: 101716226(Btd)
CCAN: 109694811(Btd)
OCU: 100341187(BTD)
TUP: 102476912(BTD)
CFA: 477059(BTD)
AML: 100483327(BTD)
UMR: 103679387(BTD)
ORO: 101380238(BTD)
FCA: 101094289(BTD)
PTG: 102952175(BTD)
AJU: 106971609(BTD)
BTA: 537669(BTD)
BOM: 102282711(BTD)
BIU: 109561800(BTD)
PHD: 102323994(BTD)
CHX: 102179988(BTD)
OAS: 101113196(BTD)
SSC: 100737057(BTD)
CFR: 102506341(BTD)
CDK: 105096612(BTD)
BACU: 103004341(BTD)
LVE: 103080922(BTD)
OOR: 101278082(BTD)
ECB: 100063800(BTD)
EPZ: 103561484(BTD)
EAI: 106842762(BTD)
MYB: 102258405(BTD)
MYD: 102759604(BTD)
HAI: 109395825(BTD)
RSS: 109444518(BTD)
PALE: 102894216(BTD)
LAV: 100663934(BTD)
TMU: 101354864
MDO: 100030538(BTD)
SHR: 100922840(BTD)
OAA: 100084040(BTD)
GGA: 420639(BTD)
MGP: 100540232(BTD)
CJO: 107309167(BTD)
APLA: 101796688(BTD)
ACYG: 106030251(BTD)
TGU: 100223229 100226458(BTD)
SCAN: 103812912(BTD)
GFR: 102043957(BTD)
FAB: 101821386(BTD)
PHI: 102104565(BTD)
PMAJ: 107199918(BTD)
CCAE: 111923444(BTD)
CCW: 104689076(BTD)
FPG: 101914603(BTD)
FCH: 102056176(BTD)
CLV: 102085390(BTD)
EGZ: 104126131(BTD)
NNI: 104013909(BTD)
ACUN: 113476796(BTD)
AAM: 106483475(BTD)
ASN: 102370218 112549578
AMJ: 102566286(BTD)
PSS: 102458076(BTD)
CMY: 102946514(BTD)
CPIC: 101939105(BTD)
ACS: 100556978(btd)
PVT: 110072153(BTD)
PBI: 103068246(BTD)
PMUR: 107282909(BTD)
GJA: 107126169(BTD)
XLA: 108718912(btd.L)
XTR: 100489727(btd)
NPR: 108803235(BTD)
DRE: 555376(btd)
SRX: 107732456(btd)
SANH: 107694759(btd)
SGH: 107559753
CCAR: 109080426(btd)
IPU: 108256913
PHYP: 113536296(btd)
AMEX: 103037138
EEE: 113590652(btd)
TRU: 101069377(Biotinase)
TNG: GSTEN00032985G001
LCO: 104939816 109139331 109139332
NCC: 104944686 104944699(btd)
MZE: 101466121 101475752
OLA: 101173953
XMA: 102233822(btd)
PRET: 103472253 103472511
NFU: 107383317
KMR: 108240453(btd)
CSEM: 103394637(btd)
LCF: 108877741 108877753
SDU: 111223068
HCQ: 109527670(btd)
BPEC: 110175184
MALB: 109968104
SASA: 106570600 106588721 106588750
OTW: 112240210 112264467
SALP: 112068324 112074045(btd)
ELS: 105012460(btd)
SFM: 108933388
PKI: 111846924(btd)
LCM: 102358398 102358664(BTD)
CMK: 103181262(btd)
DME: Dmel_CG32754
DPO: Dpse_GA17117
DER: 6551340
DPE: 6603113
DSE: Dsec_GM12589
DSI: Dsimw501_GD16207(Dsim_GD16207)
DWI: 6652898
DYA: Dyak_GE16478
DGR: Dgri_GH24839
DMO: Dmoj_GI16173
DVI: Dvir_GJ16663
BIM: 100740669
BTER: 100647835
DPA: 109541661
PRAP: 111001601 111001849
API: 100165187
DNX: 107162221
DPX: DAPPUDRAFT_311789
 » show all
Taxonomy
Reference
1  [PMID:14087327]
  Authors
KNAPPE J, BRUEMMER W, BIEDERBICK K.
  Title
[PURIFICATION AND PROPERTIES OF BIOTINIDASE FROM SWINE KIDNEY AND LACTOBACILLUS CASEI.]
  Journal
Biochem Z 338:599-613 (1963)
Reference
2  [PMID:13211594]
  Authors
THOMA RW, PETERSON WH.
  Title
The enzymatic degradation of soluble bound biotin.
  Journal
J Biol Chem 210:569-79 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.12
IUBMB Enzyme Nomenclature: 3.5.1.12
ExPASy - ENZYME nomenclature database: 3.5.1.12
BRENDA, the Enzyme Database: 3.5.1.12
CAS: 9025-15-4

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (7)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (340)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (151)   
   KEGG MGENES (15)   
   RefGene (173)   
Protein sequence (23)   
   UniProt (6)   
   SWISS-PROT (5)   
   RefSeq(pep) (12)   
DNA sequence (18)   
   RefSeq(nuc) (13)   
   GenBank (3)   
   EMBL (2)   
Protein domain (2)   
   Pfam (1)   
   PROSITE(DOC) (1)   
All databases (402)   

Download RDF
DBGET integrated database retrieval system