KEGG   ENZYME: 3.5.1.129Help
Entry
EC 3.5.1.129                Enzyme                                 

Name
N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase;
N5-(cytidine 5'-diphosphoramidyl)-L-glutamine deacylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N5-(cytidine 5'-diphosphoramidyl)-L-glutamine amidohydrolase
Reaction(IUBMB)
N5-(cytidine 5'-diphosphoramidyl)-L-glutamine + H2O = cytidine 5'-diphosphoramidate + L-glutamate [RN:R12251]
Reaction(KEGG)
Substrate
N5-(cytidine 5'-diphosphoramidyl)-L-glutamine [CPD:C22033];
H2O [CPD:C00001]
Product
cytidine 5'-diphosphoramidate [CPD:C22031];
L-glutamate [CPD:C00025]
Comment
The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.
History
EC 3.5.1.129 created 2018
Orthology
K23150  N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase
Genes
DDC: Dd586_1832
VAF: D1115_22865
PMK: MDS_1829
PPU: PP_0727
PPUT: L483_03690
PMON: X969_02145
PMOT: X970_02125
PFO: Pfl01_5513
PCH: EY04_30525
PCZ: PCL1606_01890
PSEM: TO66_30420
SPL: Spea_1405
MHC: MARHY0658
HHA: Hhal_0772
AHA: AHA_4153
HHE: HH_1437
HCP: HCN_1066
WSU: WS2179
CJE: Cj1417c
CJU: C8J_0638
CJI: CJSA_1348
CJM: CJM1_0656
CJEJ: N564_01414
CJEU: N565_01454
CJEN: N755_01451
CJEI: N135_01506
CJER: H730_08040
CJY: QZ67_01552(carA_1)
CJQ: UC78_1359
CFZ: CSG_17650
CLA: CLA_0315
CCF: YSQ_05945
CCY: YSS_03095
CCOI: YSU_05595
CIS: CINS_0305
CCUN: CCUN_1304
GLO: Glov_3393
DVM: DvMF_0015
CCX: COCOR_06830(pabA)
AVI: Avi_7109
MAGX: XM1_2454
MAI: MICA_1013
NPH: NP_1950A
NMR: Nmar_0661
 » show all
Taxonomy
Reference
1  [PMID:29023101]
  Authors
Taylor ZW, Brown HA, Holden HM, Raushel FM
  Title
Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni.
  Journal
Biochemistry 56:6079-6082 (2017)
DOI:10.1021/acs.biochem.7b00905
  Sequence
[cje:Cj1417c]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.129
IUBMB Enzyme Nomenclature: 3.5.1.129
ExPASy - ENZYME nomenclature database: 3.5.1.129
BRENDA, the Enzyme Database: 3.5.1.129

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