KEGG   ENZYME: 3.5.1.130
Entry
EC 3.5.1.130                Enzyme                                 

Name
[amino group carrier protein]-lysine hydrolase;
lysK (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
[amino group carrier protein]-C-terminal-gamma-L-lysyl-L-glutamate amidohydrolase
Reaction(IUBMB)
[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-lysine
Reaction(KEGG)
(other) R09779
Substrate
[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate;
H2O [CPD:C00001]
Product
[amino group carrier protein]-C-terminal-L-glutamate;
L-lysine [CPD:C00047]
Comment
The enzyme participates in an L-lysine biosynthetic pathways in certain species of archaea and bacteria. In some organisms the enzyme also catalyses the activity of EC 3.5.1.132, [amino group carrier protein]-ornithine hydrolase.
History
EC 3.5.1.130 created 2019
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
Orthology
K05831  [amino group carrier protein]-lysine/ornithine hydrolase
Genes
MSD: MYSTI_01363
CCX: COCOR_02071(lysK)
CTH: Cthe_2568
CTX: Clo1313_0154
SFA: Sfla_0118
STRP: F750_6906
SPAV: Spa2297_32330
SALJ: SMD11_6705
KIT: CFP65_3951
SESP: BN6_56690
CAI: Caci_6288
RCA: Rcas_3459
CAU: Caur_1204
CAG: Cagg_2180
HAU: Haur_3310
TRO: trd_1520
STI: Sthe_0214
ATM: ANT_12370(lysK)
CAP: CLDAP_41050(lysK)
DRA: DR_1413
DGE: Dgeo_1391
DDR: Deide_17960(lysK)
DFC: DFI_03165
DGA: DEGR_27060(lysK)
TRA: Trad_1404
TTH: TT_C1396
TTJ: TTHA1757
TAQ: TO73_0259
MRB: Mrub_0027
TTR: Tter_0317
TAI: Taci_0451
TLI: Tlie_1473
PTO: PTO1468
FAI: FAD_0509(lysK)
CDIV: CPM_0544
PFU: PF1686
PFI: PFC_10175
PHO: PH1715(PH1715)
PAB: PAB0294(argE)
PYN: PNA2_0325
PYS: Py04_1632
TKO: TK0274
THS: TES1_0511
HHB: Hhub_3652(argE)
HALH: HTSR_0668(argE)
HHSR: HSR6_0694(argE)
HSU: HLASF_2141(argE2)
HSF: HLASA_2175(argE2)
HMA: rrnAC2674(gltCP)
HHI: HAH_3079(argE1)
NPH: NP_5266A(argE)
NMO: Nmlp_1239(argE)
HUT: Huta_1498
HTI: HTIA_1543
HMU: Hmuk_0776
HALL: LC1Hm_3292(argE3)
HWA: HQ_3718A(argE2)
HWC: Hqrw_4133(argE2)
HVO: HVO_0042(argE)
HME: HFX_0042(argE)
HLA: Hlac_2612
HDF: AArcSl_0039(argE)
HTU: Htur_0324
NMG: Nmag_1757(argE)
NAT: NJ7G_0259
SALI: L593_07905
APE: APE_1467.1(lysK)
ACJ: ACAM_0925(lysK)
IHO: Igni_0664
IIS: EYM_06525
IAG: Igag_1750
STO: STK_01900(lysK)
SSO: SSO0162
SOL: Ssol_1139
SSOA: SULA_1175
SSOL: SULB_1176
SSOF: SULC_1174
SAI: Saci_0756
SID: M164_1984
SII: LD85_2239
SIH: SiH_1922
SIR: SiRe_1849
SIC: SiL_1831
MSE: Msed_0170
MCN: Mcup_1903
AHO: Ahos_0889
STEP: IC006_1908
PAI: PAE2798
PIS: Pisl_1394
PCL: Pcal_1259
PAS: Pars_0867
PYR: P186_1739
POG: Pogu_1471
TNE: Tneu_1861
CMA: Cmaq_1676
TTN: TTX_0118(lysK_argE)
TUZ: TUZN_1280
VDI: Vdis_0199
VMO: VMUT_1537
NMR: Nmar_1296
NCT: NMSP_0392
NGA: Ngar_c14550(lysK)
NVN: NVIE_002650(lysK)
NEV: NTE_01581
TAA: NMY3_02229(dapE_2)
NFN: NFRAN_2991(dapE)
NCV: NCAV_1408
NBV: T478_1051
NDV: NDEV_1631
KCR: Kcr_0814
BARB: AOA66_0023
CCAI: NAS2_0273
 » show all
Reference
1  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M.
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1396]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.130
IUBMB Enzyme Nomenclature: 3.5.1.130
ExPASy - ENZYME nomenclature database: 3.5.1.130
BRENDA, the Enzyme Database: 3.5.1.130

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