KEGG   ENZYME: 3.5.1.131Help
Entry
EC 3.5.1.131                Enzyme                                 

Name
1-carboxybiuret hydrolase;
atzEG (gene names)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
1-carboxybiuret amidohydrolase
Reaction(IUBMB)
1-carboxybiuret + H2O = urea-1,3-dicarboxylate + NH3 [RN:R12333]
Reaction(KEGG)
Substrate
1-carboxybiuret [CPD:C22084];
H2O [CPD:C00001]
Product
urea-1,3-dicarboxylate [CPD:C22085];
NH3 [CPD:C00014]
Comment
The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex.
History
EC 3.5.1.131 created 2019
Pathway
ec00791  Atrazine degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19837  1-carboxybiuret hydrolase
Genes
HNA: Hneap_0846
BUO: BRPE64_CCDS07460
BCAI: K788_0005134
PHS: C2L64_35110
PTER: C2L65_31040
BAV: BAV2584
BHO: D560_0088
BHM: D558_0086
BHZ: ACR54_01203(atzE_1)
BGM: CAL15_12200
AXX: ERS451415_04465(gatA_6)
HYB: Q5W_18935
MPT: Mpe_A0772
LCH: Lcho_3028
THI: THI_3642
BJA: blr1041
BRA: BRADO6818
BBT: BBta_0721
BRS: S23_67650
AOL: S58_06460
RPA: RPA1469(gatA1)
RPB: RPB_4054
RPT: Rpal_1654
XAU: Xaut_4656
AZC: AZC_1515
SNO: Snov_0644
MEX: Mext_1693
MDI: METDI2366
MCH: Mchl_2012
MPO: Mpop_1125
MET: M446_2141
MOR: MOC_0819
META: Y590_08125
MAQU: Maq22A_1p30080(gatA)
BBAR: RHAL1_03705(atzE)
PLEO: OHA_1_04339(atzE)
HDI: HDIA_3392(atzE)
RBM: TEF_15430
CCR: CC_2613
CAK: Caul_3713
CSE: Cseg_1082
LABT: FIU93_18170(atzE)
SHUM: STHU_04700
AZL: AZL_a09080(gatA)
AFR: AFE_0782
ACU: Atc_m027
 » show all
Taxonomy
Reference
1  [PMID:29523689]
  Authors
Esquirol L, Peat TS, Wilding M, Liu JW, French NG, Hartley CJ, Onagi H, Nebl T, Easton CJ, Newman J, Scott C
  Title
An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.
  Journal
J Biol Chem 293:7880-7891 (2018)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.131
IUBMB Enzyme Nomenclature: 3.5.1.131
ExPASy - ENZYME nomenclature database: 3.5.1.131
BRENDA, the Enzyme Database: 3.5.1.131

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