KEGG   ENZYME: 3.5.1.131
Entry
EC 3.5.1.131                Enzyme                                 

Name
1-carboxybiuret hydrolase;
atzEG (gene names)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
1-carboxybiuret amidohydrolase
Reaction(IUBMB)
1-carboxybiuret + H2O = urea-1,3-dicarboxylate + NH3 [RN:R12333]
Reaction(KEGG)
R12333
Substrate
1-carboxybiuret [CPD:C22084];
H2O [CPD:C00001]
Product
urea-1,3-dicarboxylate [CPD:C22085];
NH3 [CPD:C00014]
Comment
The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex.
History
EC 3.5.1.131 created 2019
Pathway
ec00791  Atrazine degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19837  1-carboxybiuret hydrolase
Genes
XHY: FZ025_14215
TTU: TERTU_2008
HNA: Hneap_0846
BMEC: WJ16_29720
BUO: BRPE64_CCDS07460
BCAI: K788_0005134
PHS: C2L64_35110
PTER: C2L65_31040
PPNO: DA70_11690
PRB: X636_15140
BAV: BAV2584
BHO: D560_0088
BHM: D558_0086
BHZ: ACR54_01203(atzE_1)
AXX: ERS451415_04465(gatA_6)
HYB: Q5W_18935
MPT: Mpe_A0772
LCH: Lcho_3028
THI: THI_3642
BJA: blr1041
BRA: BRADO6818
BBT: BBta_0721
BRS: S23_67650
AOL: S58_06460
RPA: RPA1469(gatA1)
RPB: RPB_4054
RPT: Rpal_1654
XAU: Xaut_4656
AZC: AZC_1515
SNO: Snov_0644
MDI: METDI2366
MEX: Mext_1693
MCH: Mchl_2012
MPO: Mpop_1125
MET: M446_2141
MOR: MOC_0819
META: Y590_08125
MAQU: Maq22A_1p30080(gatA)
BBAR: RHAL1_03705(atzE)
PLEO: OHA_1_04339(atzE)
HDI: HDIA_3392(atzE)
RBM: TEF_15430
CCR: CC_2613
CAK: Caul_3713
CSE: Cseg_1082
LABT: FIU93_18170(atzE)
SPHI: TS85_12020
GOH: B932_0815
GXY: GLX_26950
GXL: H845_638
KSC: CD178_00377(atzE_1)
SHUM: STHU_04700
AZL: AZL_a09080(gatA)
AFR: AFE_0782
ACU: Atc_m027
KFL: Kfla_7051
NML: Namu_0017
AMQ: AMETH_4752(gatA)
PSEA: WY02_17970
PSEE: FRP1_24810
PSEH: XF36_23605
PAUT: Pdca_03620
CYA: CYA_2100
CYB: CYB_2659
LET: O77CONTIG1_01204(atzE)
HHG: XM38_037730(atzE)
AMR: AM1_2033
MAR: MAE_24190
MPK: VL20_4002
CYT: cce_3546
TER: Tery_4203
NSH: GXM_06212
CALH: IJ00_16755
NSP: BMF81_01350(atzE)
CTHE: Chro_5195
CAG: Cagg_2536
TRO: trd_0309
OBG: Verru16b_02869(atzE)
SUS: Acid_6116
 » show all
Reference
1  [PMID:29523689]
  Authors
Esquirol L, Peat TS, Wilding M, Liu JW, French NG, Hartley CJ, Onagi H, Nebl T, Easton CJ, Newman J, Scott C
  Title
An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.
  Journal
J Biol Chem 293:7880-7891 (2018)
DOI:10.1074/jbc.RA118.001996
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.131
IUBMB Enzyme Nomenclature: 3.5.1.131
ExPASy - ENZYME nomenclature database: 3.5.1.131
BRENDA, the Enzyme Database: 3.5.1.131

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