KEGG   ENZYME: 3.5.1.132
Entry
EC 3.5.1.132                Enzyme                                 

Name
[amino group carrier protein]-ornithine hydrolase;
lysK (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
[amino group carrier protein]-C-terminal-gamma-L-ornithyl-L-glutamate amidohydrolase
Reaction(IUBMB)
[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-ornithine
Reaction(KEGG)
(other) R10933
Substrate
[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate;
H2O [CPD:C00001]
Product
[amino group carrier protein]-C-terminal-L-glutamate;
L-ornithine [CPD:C00077]
Comment
The enzyme participates in an L-arginine biosynthetic pathways in certain species of archaea and bacteria. In all cases known so far the enzyme also catalyses the activity of EC 3.5.1.130, [amino group carrier protein]-lysine hydrolase.
History
EC 3.5.1.132 created 2019
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K05831  [amino group carrier protein]-lysine/ornithine hydrolase
Genes
MSD: MYSTI_01363
MFB: MFUL124B02_07570
CCX: COCOR_02071(lysK)
AVM: JQX13_36415
CTH: Cthe_2568
CTX: Clo1313_0154
GEK: kuro4_23300
SFA: Sfla_0118
STRP: F750_6906
SPAV: Spa2297_32330
SALJ: SMD11_6705
SESP: BN6_56690
CAI: Caci_6288
RCA: Rcas_3459
CAU: Caur_1204
CAG: Cagg_2180
HAU: Haur_3310
TRO: trd_1520
STI: Sthe_0214
ATM: ANT_12370(lysK)
CAP: CLDAP_41050(lysK)
TTR: Tter_0317
DRA: DR_1413
DGE: Dgeo_1391
DDR: Deide_17960(lysK)
DFC: DFI_03165
DGA: DEGR_27060(lysK)
TRA: Trad_1404
TTH: TT_C1396
TTJ: TTHA1757(TTHA1757)
TAQ: TO73_0259
MRB: Mrub_0027
TAI: Taci_0451
TLI: Tlie_1473
PFU: PF1686
PFI: PFC_10175
PHO: PH1715(PH1715)
PAB: PAB0294(argE)
PYN: PNA2_0325
PYS: Py04_1632
TKO: TK0274
THS: TES1_0511
HHB: Hhub_3652(argE)
HALH: HTSR_0668(argE)
HHSR: HSR6_0694(argE)
HSU: HLASF_2141(argE2)
HSF: HLASA_2175(argE2)
HMA: rrnAC2674(gltCP)
HHI: HAH_3079(argE1)
NPH: NP_5266A(argE)
NMO: Nmlp_1239(argE)
HUT: Huta_1498
HTI: HTIA_1543
HMU: Hmuk_0776
HALL: LC1Hm_3292(argE3)
HWA: HQ_3718A(argE2)
HWC: Hqrw_4133(argE2)
HVO: HVO_0042(argE)
HME: HFX_0042(argE)
HLA: Hlac_2612
HDF: AArcSl_0039(argE)
HTU: Htur_0324
NMG: Nmag_1757(argE)
NAT: NJ7G_0259
SALI: L593_07905
PTO: PTO1468
FAI: FAD_0509(lysK)
CDIV: CPM_0544
APE: APE_1467.1(lysK)
ACJ: ACAM_0925(lysK)
IHO: Igni_0664
IIS: EYM_06525
IAG: Igag_1750
STO: STK_01900(lysK)
SSO: SSO0162
SOL: Ssol_1139
SSOA: SULA_1175
SSOL: SULB_1176
SSOF: SULC_1174
SAI: Saci_0756
SID: M164_1984
SII: LD85_2239
SIH: SiH_1922
SIR: SiRe_1849
SIC: SiL_1831
MSE: Msed_0170
MCN: Mcup_1903
AHO: Ahos_0889
STEP: IC006_1908
PAI: PAE2798
PIS: Pisl_1394
PCL: Pcal_1259
PAS: Pars_0867
PYR: P186_1739
POG: Pogu_1471
TNE: Tneu_1861
CMA: Cmaq_1676
TTN: TTX_0118(lysK_argE)
TUZ: TUZN_1280
VDI: Vdis_0199
VMO: VMUT_1537
NMR: Nmar_1296
NCT: NMSP_0392
NGA: Ngar_c14550(lysK)
NVN: NVIE_002650(lysK)
NEV: NTE_01581
TAA: NMY3_02229(dapE_2)
NFN: NFRAN_2991(dapE)
NCV: NCAV_1408
NBV: T478_1051
NDV: NDEV_1631
CCAI: NAS2_0273
KCR: Kcr_0814
BARB: AOA66_0023
 » show all
Reference
1  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_0756]
Reference
2  [PMID:27566549]
  Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
  Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
  Journal
J Biol Chem 291:21630-21643 (2016)
DOI:10.1074/jbc.M116.743021
  Sequence
[tko:TK0274]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.132
IUBMB Enzyme Nomenclature: 3.5.1.132
ExPASy - ENZYME nomenclature database: 3.5.1.132
BRENDA, the Enzyme Database: 3.5.1.132

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