KEGG   ENZYME: 3.5.1.26Help
Entry
EC 3.5.1.26                 Enzyme                                 

Name
N4-(beta-N-acetylglucosaminyl)-L-asparaginase;
aspartylglucosylamine deaspartylase;
aspartylglucosylaminase;
aspartylglucosaminidase;
aspartylglycosylamine amidohydrolase;
N-aspartyl-beta-glucosaminidase;
glucosylamidase;
beta-aspartylglucosylamine amidohydrolase;
4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase
Reaction(IUBMB)
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate [RN:R03421]
Reaction(KEGG)
Substrate
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine [CPD:C04540];
H2O [CPD:C00001]
Product
N-acetyl-beta-D-glucosaminylamine [CPD:C01239];
L-aspartate [CPD:C00049]
Comment
Acts only on asparagine-oligosaccharides containing one amino acid, i.e., the asparagine has free alpha-amino and alpha-carboxyl groups [cf. EC 3.5.1.52, peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase]
History
EC 3.5.1.26 created 1972 (EC 3.5.1.37 created 1972, incorporated 1976)
Pathway
ec00511  Other glycan degradation
Orthology
K01444  N4-(beta-N-acetylglucosaminyl)-L-asparaginase
Genes
HSA: 175(AGA)
PTR: 461616(AGA)
PPS: 100991884(AGA)
GGO: 101141987(AGA)
PON: 100453921(AGA)
NLE: 100592376(AGA)
MCC: 699740(AGA)
MCF: 101866403(AGA)
CSAB: 103236570(AGA)
RRO: 104678731(AGA)
RBB: 108534035(AGA)
CJC: 100394328(AGA)
SBQ: 101047494(AGA)
MMU: 11593(Aga)
RNO: 290923(Aga)
CGE: 100754017(Aga)
NGI: 103745235(Aga)
HGL: 101721618(Aga)
CCAN: 109698217(Aga)
OCU: 100338965(AGA)
TUP: 102474114 102499422(AGA)
CFA: 475638(AGA)
AML: 100472378(AGA)
UMR: 103679378(AGA)
ORO: 101373841(AGA)
FCA: 101086138(AGA)
PTG: 102951369(AGA)
AJU: 106981492(AGA)
BTA: 511345(AGA)
BOM: 102286328(AGA)
BIU: 109553504(AGA)
PHD: 102338732(AGA)
CHX: 102190099(AGA)
OAS: 101106396(AGA)
SSC: 100152203(AGA)
CFR: 102510279(AGA)
CDK: 105084419(AGA)
BACU: 103010237(AGA)
LVE: 103090245(AGA)
OOR: 101286827(AGA)
ECB: 100060636(AGA)
EPZ: 103544136(AGA)
EAI: 106834003(AGA)
MYB: 102253028(AGA)
MYD: 102758128(AGA)
HAI: 109387669(AGA)
RSS: 109456925(AGA)
PALE: 102894840(AGA)
LAV: 100658416(AGA)
TMU: 101359772
MDO: 100017534(AGA) 103099919
SHR: 100930206(AGA)
OAA: 100087946(AGA)
GGA: 422558(AGA)
MGP: 100548334
CJO: 107313324(AGA)
APLA: 101796827(AGA)
ACYG: 106041734(AGA)
TGU: 100231883(AGA)
GFR: 102032864(AGA)
FAB: 101817078(AGA)
PHI: 102101320(AGA)
PMAJ: 107203468(AGA)
CCW: 104690852(AGA)
FPG: 101916501(AGA)
FCH: 102048549(AGA)
CLV: 102090634(AGA)
EGZ: 104129422(AGA)
AAM: 106484055(AGA)
ASN: 102378205 102380183(AGA)
AMJ: 102565336(AGA) 102575296
PSS: 102450894(AGA)
CMY: 102937597(AGA)
CPIC: 101936557(AGA)
ACS: 100565704(aga) 103279484
PVT: 110083560(AGA) 110086035
PBI: 103056632(AGA)
GJA: 107117470(AGA)
XLA: 108704291 496249(aga.L)
XTR: 100485379(aga)
NPR: 108792719(AGA)
DRE: 566517(aga) 767799(zgc:153169)
SANH: 107666437 107669106(aga)
CCAR: 109076945
IPU: 100528085(aga) 108263419
AMEX: 103033819 103034994(aga)
TRU: 101062413(aga)
LCO: 104917916(aga)
NCC: 104966467(aga)
MZE: 101465374(aga)
OLA: 101169182(aga)
XMA: 102218359(aga)
PRET: 103471837(aga)
NFU: 107379833(aga)
CSEM: 103390673(aga)
LCF: 108885184(aga)
HCQ: 109524435(aga)
BPEC: 110153730(aga)
SASA: 106604521(aga)
ELS: 105005758 105027612(aga)
SFM: 108925954(aga) 108927096
LCM: 102349860(AGA) 102352273
CMK: 103180212(aga)
CIN: 100184715
SPU: 593612
APLC: 110990315
DSI: Dsimw501_GD10667(Dsim_GD10667) Dsimw501_GD25160(Dsim_GD25160) Dsimw501_GD25331(Dsim_GD25331)
MDE: 101900755
AAG: 5571922
BIM: 100746497
BTER: 100649792
SOC: 105204737
ACEP: 105621106
PBAR: 105430803
HST: 105185089
PGC: 109861480
TCA: 663067
NVL: 108568058
BMOR: 751092
PMAC: 106715683
PRAP: 110996239
PXY: 105392134
API: 100164194
DNX: 107169380
ZNE: 110832112
FCD: 110851512
TUT: 107362717
CEL: CELE_R04B3.2(R04B3.2)
CBR: CBG02104
BMY: Bm1_03250
TSP: Tsp_01031
SHX: MS3_03789
HMG: 100205957
AQU: 100634067
ATH: AT5G61540
CRB: 17875909
BRP: 103860603
BOE: 106306661
THJ: 104818311
CPAP: 110820541
CIT: 102620322
TCC: 18605307
GRA: 105764878
DZI: 111314473
EGR: 104449888
GMX: 100527747
VRA: 106762863
VAR: 108347799
CCAJ: 109819068
CAM: 101492551
ADU: 107495363
AIP: 107605372
LJA: Lj3g3v3430150.1(Lj3g3v3430150.1) Lj3g3v3430150.2(Lj3g3v3430150.2) Lj3g3v3430150.3(Lj3g3v3430150.3)
LANG: 109346007
FVE: 101297675
PPER: 18787104
PMUM: 103333382
PAVI: 110764705
CSV: 101205920
CMO: 103494471
MCHA: 111011702
CMAX: 111483481
CMOS: 111430645
CPEP: 111809905
RCU: 8289640
JCU: 105648639
HBR: 110669605
VVI: 100855408
SLY: 101267007
SPEN: 107012263
SOT: 102588616
CANN: 107863528
NSY: 104240436
NTO: 104119684
INI: 109186648
SIND: 105179208
OEU: 111406054
HAN: 110905023
LSV: 111889936
DCR: 108197339
BVG: 104906642
SOE: 110782255
NNU: 104598446
OSA: 4336581
DOSA: Os04t0549300-01(Os04g0549300)
OBR: 102701445
BDI: 100846480
ATS: 109750018(LOC109750018)
SBI: 110436579
ZMA: 100280081
SITA: 101761688
PDA: 103698063
EGU: 105043704
MUS: 103970402
DCT: 110111178
AOF: 109839484
PPP: 112278248
APRO: F751_3423
NCR: NCU09718
NTE: NEUTE1DRAFT46478(NEUTE1DRAFT_46478)
MGR: MGG_03346
MAW: MAC_08542
MAJ: MAA_01933
SPAR: SPRG_01487
XCC: XCC2914(aspG)
XCB: XC_1195
XCA: xcc-b100_1239(aspG)
XCP: XCR_3281
XCV: XCV3222
XAX: XACM_3009
XAC: XAC3092(aspG)
XCI: XCAW_03378(aspG)
XOO: XOO1760(aspG)
XOM: XOO1660(XOO1660)
XOP: PXO_01618
XOR: XOC_3281(aga)
XAL: XALC_2229
XPH: XppCFBP6546_03060(XppCFBP6546P_03060)
SML: Smlt2173
SMT: Smal_1767
SMZ: SMD_1957
LAB: LA76x_2807(aga)
LEZ: GLE_2264
LEM: LEN_2771
CCR: CC_2359
CSE: Cseg_3153
SMAZ: LH19_07820
STAX: MC45_10240
TTF: THTE_3267
IPA: Isop_3307
SACI: Sinac_2872
SUS: Acid_0488
GBA: J421_2417
DORI: FH5T_21245
SRM: SRM_02869
RMR: Rmar_1344
CPI: Cpin_6563
FLN: FLA_5560
MUC: MuYL_3499
DFE: Dfer_2594
SLI: Slin_5698
LBY: Lbys_1666
FAE: FAES_1477
HSW: Hsw_2842
FLM: MY04_0974
GFO: GFO_0141
GFL: GRFL_1913
FJO: Fjoh_2037
FIN: KQS_02300
ZPR: ZPR_0519
MARM: YQ22_10985
CBAL: M667_07525
CBAT: M666_07560
DDO: I597_0156
ZGA: ZOBELLIA_2350(aspG)
MLT: VC82_1914
NDO: DDD_1879
POM: MED152_13284(aspG)
EAO: BD94_1211
CHZ: CHSO_1665
WIN: WPG_0929
CABY: Cabys_2441
 » show all
Taxonomy
Reference
1  [PMID:5010303]
  Authors
Kono M, Yamashina I.
  Title
Purification and properties of 4-L-aspartylglycosylamine amidohydrolase from hog kidney.
  Journal
Biochim Biophys Acta 258:600-17 (1972)
DOI:10.1016/0005-2744(72)90252-5
Reference
2  [PMID:6061403]
  Authors
Mahadevan S, Tappel AL.
  Title
Beta-aspartylglucosylamine amido hydrolase of rat liver and kidney.
  Journal
J Biol Chem 242:4568-76 (1967)
Reference
3  [PMID:5778645]
  Authors
Tarentino AL, Maley F.
  Title
The purification and properties of a beta-aspartyl N-acetylglucosylamine amidohydrolase from hen oviduct.
  Journal
Arch Biochem Biophys 130:295-303 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.26
IUBMB Enzyme Nomenclature: 3.5.1.26
ExPASy - ENZYME nomenclature database: 3.5.1.26
BRENDA, the Enzyme Database: 3.5.1.26
CAS: 9075-24-5

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