| Entry |
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| Name |
2-(acetamidomethylene)succinate hydrolase;
alpha-(N-acetylaminomethylene)succinic acid hydrolase
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
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| Sysname |
2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
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| Reaction(IUBMB) |
2-(acetamidomethylene)succinate + 2 H2O = acetate + succinate semialdehyde + NH3 + CO2 [RN: R01649]
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| Reaction(KEGG) |
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| Substrate |
2-(acetamidomethylene)succinate [CPD: C01215];
H2O [CPD: C00001]
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| Product |
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| Comment |
Involved in the degradation of pyridoxin in Pseudomonas.
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| History |
EC 3.5.1.29 created 1972
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K18614 | 2-(acetamidomethylene)succinate hydrolase |
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| Genes |
| MMED: | Mame_00121(fac-dex_1) |
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| Reference |
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| Authors |
Huynh MS, Snell EE. |
|---|
| Title |
Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases. |
|---|
| Journal |
J Biol Chem 260:2379-83 (1985) |
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| Reference |
|
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| Authors |
Nyns EJ, Zach D, Snell EE. |
|---|
| Title |
The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid. |
|---|
| Journal |
J Biol Chem 244:2601-5 (1969) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.1.29 |
| ExPASy - ENZYME nomenclature database: | 3.5.1.29 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 3.5.1.29 |
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