KEGG   ENZYME: 3.5.1.29
Entry
EC 3.5.1.29                 Enzyme                                 
Name
2-(acetamidomethylene)succinate hydrolase;
alpha-(N-acetylaminomethylene)succinic acid hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
Reaction(IUBMB)
2-(acetamidomethylene)succinate + 2 H2O = acetate + succinate semialdehyde + NH3 + CO2 [RN:R01649]
Reaction(KEGG)
R01649;
(other) R06134
Substrate
2-(acetamidomethylene)succinate [CPD:C01215];
H2O [CPD:C00001]
Product
acetate [CPD:C00033];
succinate semialdehyde [CPD:C00232];
NH3 [CPD:C00014];
CO2 [CPD:C00011]
Comment
Involved in the degradation of pyridoxin in Pseudomonas.
History
EC 3.5.1.29 created 1972
Pathway
ec00750  Vitamin B6 metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K18614  2-(acetamidomethylene)succinate hydrolase
Genes
MLO: mlr6787
MLN: A9174_14015
MAM: Mesau_02079
MESP: C1M53_04630
MHUA: MCHK_0409
MJR: EB229_14130
MERD: EB233_10980
OST: ABWH87_14830
MLG: CWB41_10060
MEY: TM49_03755
MMED: Mame_00121(fac-dex_1)
AUZ: Sa4125_23950
STRC: AA958_31270
MIX: AB663_000684
CPHY: B5808_02065
HUM: DVJ78_00590
LDN: H9L06_08505
HEA: HL652_14730
NAEI: GCM126_31120
 » show all
Reference
1  [PMID:3972793]
  Authors
Huynh MS, Snell EE.
  Title
Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases.
  Journal
J Biol Chem 260:2379-83 (1985)
Reference
2  [PMID:5769993]
  Authors
Nyns EJ, Zach D, Snell EE.
  Title
The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid.
  Journal
J Biol Chem 244:2601-5 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.29
IUBMB Enzyme Nomenclature: 3.5.1.29
ExPASy - ENZYME nomenclature database: 3.5.1.29
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.29
BRENDA, the Enzyme Database: 3.5.1.29
CAS: 37289-09-1

  All links  
Gene (14)   
   MGENES (14)   
Protein sequence (156)   
   UniProt (138)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (271)   
   RefSeq(nuc) (40)   
   GenBank (118)   
   EMBL (113)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (442)   

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