Entry
Name
allophanate hydrolase;
allophanate lyase;
AtzF;
TrzF
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
urea-1-carboxylate amidohydrolase
Reaction(IUBMB)
urea-1-carboxylate + H2O = 2 CO2 + 2 NH3 [RN:
R00005 ]
Reaction(KEGG)
Substrate
Product
Comment
Along with EC
3.5.2.15 (cyanuric acid amidohydrolase) and EC
3.5.1.84 (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC
6.3.4.6 , urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate [6].
History
EC 3.5.1.54 created 1986, modified 2008
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K14541 urea carboxylase / allophanate hydrolase
Genes
NCS : NCAS_0B02280(NCAS0B02280)
NDI : NDAI_0C05400(NDAI0C05400)
TPF : TPHA_0L01560(TPHA0L01560)
TDL : TDEL_0B03290(TDEL0B03290)
KNG : KNAG_0A03800(KNAG0A03800)
CAL : CAALFM_C104660WA(DUR1)
YLI : YALI0E07271g YALI0E35156g
SMIN : v1.2.013193.t1(symbB.v1.2.013193.t1) v1.2.013193.t2(symbB.v1.2.013193.t2)
RTG : NCTC13098_03736(gatA_1)
REE : electrica_02560(atzF)
CLAP : NCTC11466_02329(gatA_2)
KOR : AWR26_11270(atzF) AWR26_16850(atzF)
KRD : A3780_07410 A3780_12825
KIE : NCTC12125_02717(gatA_2)
AHN : NCTC12129_02474(gatA_1) NCTC12129_02475(gatA_2)
SERA : Ser39006_007510(atzF)
SFJ : SAMEA4384070_1467(gatA_2)
SOF : NCTC11214_05515(gatA_2)
PAQU : DMB82_0010215(atzF)
PCAC : OI450_09210(atzF) OI450_17900
DIC : Dpoa569_003026(atzF)
XPH : XppCFBP6546_12170(atzF)
PST : PSPTO_1361 PSPTO_4244
PSYR : N018_05600 N018_19800
PSP : PSPPH_1242 PSPPH_3976
PSAV : PSA3335_06015 PSA3335_09725
PAVL : BKM03_07635(atzF) BKM03_23020(atzF)
PVD : CFBP1590__1310(atzF) CFBP1590__4583(atzF)
PCAB : JGS08_18980(atzF) JGS08_20565(atzF)
PCOF : POR16_05435(atzF) POR16_18395(atzF)
PTRE : I9H09_05600(atzF) I9H09_18710(atzF)
PSYI : MME58_05835(atzF) MME58_20370(atzF)
PAST : N015_04725(atzF) N015_20945(atzF)
PLUL : FOB45_03030(atzF) FOB45_19205(atzF)
MBS : MRBBS_3249 MRBBS_3260
MPQ : ABA45_15395 ABA45_15440
ABER : BSR55_14170 BSR55_16875
HMI : soil367_09325 soil367_14570(atzF) soil367_16805(atzF)
THIO : AYJ59_03325 AYJ59_04295
NAX : HC341_02810(atzF) HC341_03815(atzF)
APAC : S7S_02700 S7S_12170
CDIZ : CEDIAZO_01575(atzF)
BXB : DR64_6673(atzF) DR64_6690(atzF)
BPY : Bphyt_5227 Bphyt_5244
BFN : OI25_3648(atzF) OI25_7103(atzF)
PSPW : BJG93_20130(atzF) BJG93_33420(atzF)
PARB : CJU94_22270(atzF) CJU94_22355(atzF)
PTRO : G5S35_16565(atzF) G5S35_26065(atzF)
PDIO : PDMSB3_1720.1 PDMSB3_1738.1(atzF)
PLG : NCTC10937_01302(gatA_2)
AXX : ERS451415_05059(gatA_8)
HTN : KI616_00255(atzF) KI616_09385 KI616_25525(atzF)
HCZ : G9Q37_09040(atzF) G9Q37_14545(atzF)
HSE : Hsero_1413 Hsero_4470(gatA)
HSZ : ACP92_07095 ACP92_22320
HRB : Hrubri_1237 Hrubri_4413
HHF : E2K99_07100(atzF) E2K99_23520(atzF)
RGU : A4W93_06125 A4W93_16145
MEU : ACJ67_01995 ACJ67_03685
URU : DSM104443_03825(atzF)
ACOM : CEW83_09345(atzF) CEW83_17195(atzF)
RBS : RHODOSMS8_03365(atzF)
SFD : USDA257_c27410(gatA1)
ALF : CFBP5473_16415(atzF)
ALEG : CFBP4996_01290 CFBP4996_01350(atzF)
RET : RHE_PC00188 RHE_PE00117
RLE : RL2460 pRL100433 pRL90294
RTR : RTCIAT899_PC07775 RTCIAT899_PC08545
RHR : CKA34_26525(atzF) CKA34_31170(atzF)
RLS : HB780_09680(atzF) HB780_11915(atzF)
RSUL : N2599_29100(atzF) N2599_32365
RLW : RlegWSM1455_10020 RlegWSM1455_32805(atzF)
RRHO : PR018_18380 PR018_24730(atzF)
RTU : PR017_25555(atzF) PR017_27080
ARA : Arad_10039(atzF) Arad_9881(atzF)
RBW : RLCC275e_10145 RLCC275e_30755(atzF)
BJA : bll1044(bll1044) bll5806(bll5806)
BJU : BJ6T_10690 BJ6T_39000
BJP : RN69_05215 RN69_18925
BRAD : BF49_5027 BF49_5834
BIC : LMTR13_27670 LMTR13_36490
BRQ : CIT40_24985 CIT40_30225(atzF)
BGZ : XH91_12440(atzF) XH91_33180(atzF)
BSYM : CIT39_23950 CIT39_29330(atzF)
BVZ : BRAD3257_0587 BRAD3257_8682(atzF)
BSEP : HAP48_0012065(atzF)
BBAN : J4G43_034840(atzF) J4G43_050860(atzF)
BCAN : BcanWSM471_25765(atzF) BcanWSM471_29180 BcanWSM471_35600(atzF)
BCOU : IC761_12620(atzF) IC761_34795(atzF)
RPA : TX73_007205(atzF) TX73_007530(atzF)
VGO : GJW-30_1_01656(atzF)
TRB : HB776_09310(atzF) HB776_26120(atzF)
XDI : EZH22_13230 EZH22_24815(atzF)
MRD : Mrad2831_4565 Mrad2831_6163
MAQU : Maq22A_1p30070(gatA)
MMES : MMSR116_15635(atzF)
MTUN : MTUNDRAET4_3061(atzF)
DNP : N8A98_16455(atzF) N8A98_20545 N8A98_21305(atzF)
PLEO : OHA_1_04343(atzF) OHA_2_00069(atzF)
RLI : RLO149_c040170(atzF)
TPRO : Ga0080559_TMP452 Ga0080559_TMP462
AHT : ANTHELSMS3_01746 ANTHELSMS3_01748
LALG : LentiSH36_02104 LentiSH36_02644
LVS : LOKVESSMR4R_03018(atzF)
AZL : AZL_a09070(gatA) AZL_b03880(gatA)
AZS : E6C72_14055 E6C72_15840(atzF) E6C72_24400(atzF)
NCB : C0V82_20995(atzF) C0V82_24165(atzF)
SKT : IGS68_23155(atzF) IGS68_28350(atzF)
SMUC : JL100_022500(atzF) JL100_024780(atzF)
SROE : JL101_001070(atzF) JL101_001870(atzF)
PJD : Pjdr2_2806 Pjdr2_4924
PAEA : R70723_08810 R70723_12245
MSA : Mycsm_03320 Mycsm_04304
MADI : A7U43_15395 A7U43_22445
MNE : D174_09320 D174_15555
MYN : MyAD_09135 MyAD_15280
MTHN : 4412656_02192(gatA_2)
MDR : MDOR_12390(atzF) MDOR_20430
MAUU : NCTC10437_02946(gatA_2) NCTC10437_03799
MMAG : MMAD_20240 MMAD_29840
MTY : MTOK_48290 MTOK_60730
MPSC : MPSYJ_27500 MPSYJ_35780
MARZ : MARA_09240 MARA_20160
MPOF : MPOR_34100 MPOR_42040
MPHU : MPHO_02720(atzF) MPHO_34670
MMUC : C1S78_000815 C1S78_017060(atzF)
MSEI : MSEDJ_32450 MSEDJ_42530
MSAL : DSM43276_01421(atzF)
NFR : ERS450000_01879(gatA_2)
NSR : NS506_01455 NS506_03810
NAD : NCTC11293_01072(gatA_1)
NYA : LTV02_09925 LTV02_23590(atzF)
NSPU : IFM12276_67400(atzF)
RPY : Y013_09820 Y013_13940
RRT : 4535765_03781(gatA_7)
RCR : NCTC10994_03485(gatA_3)
GOR : KTR9_3137 KTR9_3822 KTR9_4376
GOM : D7316_00134(atzF_1) D7316_04837(atzF_2)
GAV : C5O27_08520(atzF) C5O27_11840
GOD : GKZ92_15080 GKZ92_18535(atzF)
GJI : H1R19_15225 H1R19_18450(atzF)
GAMI : IHQ52_19020 IHQ52_22535(atzF)
GMG : NWF22_00710 NWF22_03950(atzF)
TPUL : TPB0596_30080(atzF)
SCI : B446_01060 B446_34235
SPAD : DVK44_04075(atzF) DVK44_33650(atzF)
YIA : LO772_02755(atzF) LO772_07685(atzF)
CART : PA27867_0256 PA27867_2518
AAGI : NCTC2676_1_01187(gatA_3)
PSNI : NIBR502771_03895(atzF)
RAIN : Rai3103_05040(atzF)
AJA : AJAP_25725 AJAP_27500
AMYB : BKN51_03945 BKN51_05730
AORI : SD37_12365 SD37_14200
AROO : NQK81_09230(atzF) NQK81_11005
MENO : Jiend_55120 Jiend_55870
GCY : LQF76_14440(atzF) LQF76_14460
» show all
Taxonomy
Reference
1
Authors
Maitz, G.S., Haas, E.M. and Castric, P.A.
Title
Purification and properties of the allophanate hydrolase from Chlamydomonas reinhardii.
Journal
Biochim Biophys Acta 714:486-491 (1982)
Reference
Authors
Roon RJ, Levenberg B.
Title
Urea amidolyase. I. Properties of the enzyme from Candida utilis.
Journal
J Biol Chem 247:4107-13 (1972)
Reference
Authors
Sumrada RA, Cooper TG.
Title
Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast.
Journal
J Biol Chem 257:9119-27 (1982)
Reference
Authors
Kanamori T, Kanou N, Kusakabe S, Atomi H, Imanaka T
Title
Allophanate hydrolase of Oleomonas sagaranensis involved in an ATP-dependent degradation pathway specific to urea.
Journal
Reference
Authors
Cheng G, Shapir N, Sadowsky MJ, Wackett LP.
Title
Allophanate hydrolase, not urease, functions in bacterial cyanuric acid metabolism.
Journal
Reference
Authors
Shapir N, Sadowsky MJ, Wackett LP
Title
Purification and characterization of allophanate hydrolase (AtzF) from Pseudomonas sp. strain ADP.
Journal
Sequence
Reference
Authors
Shapir N, Cheng G, Sadowsky MJ, Wackett LP
Title
Purification and characterization of TrzF: biuret hydrolysis by allophanate hydrolase supports growth.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.54
ExPASy - ENZYME nomenclature database: 3.5.1.54
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.54