KEGG   ENZYME: 3.5.1.89Help
Entry
EC 3.5.1.89                 Enzyme                                 

Name
N-acetylglucosaminylphosphatidylinositol deacetylase;
N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase;
N-acetylglucosaminylphosphatidylinositol de-N-acetylase;
GlcNAc-PI de-N-acetylase;
GlcNAc-PI deacetylase;
acetylglucosaminylphosphatidylinositol deacetylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase
Reaction(IUBMB)
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate [RN:R03482 R05917]
Reaction(KEGG)
Substrate
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD:C01288];
H2O [CPD:C00001]
Product
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD:C04248];
acetate [CPD:C00033]
Comment
Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in yeast). In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group.
History
EC 3.5.1.89 created 1992 as EC 3.1.1.69, transferred 2002 to EC 3.5.1.89, modified 2002
Pathway
ec00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ec01100  Metabolic pathways
Orthology
K03434  N-acetylglucosaminylphosphatidylinositol deacetylase
Genes
HSA: 9487(PIGL)
PTR: 468371(PIGL)
PPS: 100986317(PIGL)
GGO: 101144089(PIGL)
PON: 100450550(PIGL)
NLE: 100598552(PIGL)
MCC: 696605(PIGL)
MCF: 102118394(PIGL)
CSAB: 103242452 103242566
RRO: 104681437(PIGL)
RBB: 108522160(PIGL)
CJC: 100415215(PIGL)
SBQ: 101046118(PIGL)
MMU: 327942(Pigl)
RNO: 192263(Pigl)
CGE: 100752487(Pigl)
NGI: 103726063(Pigl)
HGL: 101703262(Pigl)
CCAN: 109692378(Pigl)
OCU: 100339176(PIGL)
TUP: 102486610(PIGL)
CFA: 479514(PIGL)
AML: 100483189(PIGL)
UMR: 103658516(PIGL)
ORO: 101372356(PIGL)
FCA: 101095055(PIGL)
PTG: 102950977(PIGL)
AJU: 106981433(PIGL)
BTA: 507080(PIGL)
BOM: 102267257(PIGL)
BIU: 109573401(PIGL)
PHD: 102331893(PIGL)
CHX: 102178568(PIGL)
OAS: 101117518(PIGL)
SSC: 100523821(PIGL)
CFR: 102516594(PIGL)
CDK: 105085083(PIGL)
BACU: 102998131(PIGL)
LVE: 103077014(PIGL)
OOR: 101287111(PIGL)
ECB: 100073146(PIGL)
EPZ: 103543984 103560480(PIGL)
EAI: 106838863(PIGL)
MYB: 102250124(PIGL)
MYD: 102766905(PIGL)
HAI: 109382180(PIGL)
RSS: 109461286(PIGL)
PALE: 102893644(PIGL)
LAV: 100674275(PIGL)
TMU: 101359452
MDO: 100021142(PIGL)
SHR: 100914581(PIGL)
OAA: 100078091(PIGL)
GGA: 417600(PIGL)
MGP: 100546427(PIGL)
CJO: 107322415(PIGL)
APLA: 101805021(PIGL)
ACYG: 106045784(PIGL)
TGU: 100218498(PIGL)
GFR: 102038000(PIGL)
FAB: 101819705(PIGL)
PHI: 102109608(PIGL)
PMAJ: 107212778(PIGL)
CCW: 104691180(PIGL)
FPG: 101912638(PIGL)
FCH: 102055774(PIGL)
CLV: 102083477(PIGL)
EGZ: 104121860(PIGL)
AAM: 106493758(PIGL)
ASN: 102367899(PIGL)
AMJ: 102564394(PIGL)
PSS: 102460170(PIGL)
CMY: 102936569(PIGL)
CPIC: 101946503(PIGL)
PVT: 110087404(PIGL)
PBI: 103058331(PIGL)
GJA: 107119552(PIGL)
XLA: 108707935(pigl.L)
XTR: 100495759(pigl)
NPR: 108800136(PIGL)
DRE: 561471(pigl)
IPU: 108259871(pigl)
AMEX: 103035262(pigl)
TRU: 101063673(pigl)
LCO: 104923434(pigl)
NCC: 104963937(pigl)
MZE: 101469666(pigl)
OLA: 101171602(pigl)
XMA: 102218960(pigl)
PRET: 103476038(pigl)
NFU: 107386643(pigl)
CSEM: 103394906(pigl)
LCF: 108893224(pigl)
HCQ: 109531124(pigl)
BPEC: 110165145(pigl)
SASA: 100196068(pigl)
ELS: 105027553(pigl)
SFM: 108936196(pigl)
LCM: 102348270(PIGL)
CMK: 103180539(pigl)
CIN: 104266429
SPU: 100893824
APLC: 110986240
SKO: 100377567
DSI: Dsimw501_GD20086(Dsim_GD20086)
MDE: 101889913
AAG: 5564160
AME: 724648
BIM: 100744041
BTER: 100651477
SOC: 105195159
AEC: 105148343
ACEP: 105626316
PBAR: 105432330
HST: 105188524
CFO: 105250348
LHU: 105679654
PGC: 109852494
NVI: 100122783
TCA: 660665
DPA: 109543753
NVL: 108566534
BMOR: 101746769
PMAC: 106714524
PRAP: 110993300
PXY: 105388117
API: 100167541
DNX: 107172365
ZNE: 110826862
FCD: 110862038
TUT: 107370939
CEL: CELE_Y52B11C.1(Y52B11C.1)
CBR: CBG07954
BMY: Bm1_48430
MYI: 110455343
OBI: 106871685
LAK: 106178096
SHX: MS3_02228
EPA: 110254092
ADF: 107340845
HMG: 100200643
AQU: 105312184
THJ: 104822320
CIT: 102615400
TCC: 18611788
GRA: 105780528
DZI: 111293471
EGR: 104433400
VRA: 106752828
VAR: 108319347
CCAJ: 109813222
CAM: 101500559
ADU: 107481686
AIP: 107631546
LJA: Lj4g3v0286240.1(Lj4g3v0286240.1) Lj4g3v0286240.2(Lj4g3v0286240.2) Lj6g3v0030120.2(Lj6g3v0030120.2) Lj6g3v0030120.3(Lj6g3v0030120.3)
LANG: 109350924
PPER: 18777426
PMUM: 103337156
PAVI: 110757117
MDM: 103440777
ZJU: 107419488
CSV: 101217265
CMO: 103494031
MCHA: 111007488
CMAX: 111485360
CMOS: 111429838
CPEP: 111779943
RCU: 8266989
JCU: 105637339
HBR: 110658374
POP: 7485181
VVI: 100855158
NSY: 104210665
NTO: 104109323
SIND: 105158225
OEU: 111412222
HAN: 110911683
LSV: 111890830
DCR: 108192926
BVG: 104902233
SOE: 110801269
NNU: 104610190
OSA: 4337416
DOSA: Os04t0678800-01(Os04g0678800)
OBR: 102720790
BDI: 100825685
ATS: 109751895(LOC109751895)
SITA: 101763343
PDA: 103698060
EGU: 105058989
MUS: 104000505
DCT: 110115193
AOF: 109848368
ATR: 18424082
PPP: 112290847
CRE: CHLREDRAFT_188921(PIA1)
MNG: MNEG_9538
SCE: YMR281W(GPI12)
ERC: Ecym_4617
KMX: KLMA_80045(GPI12)
NCS: NCAS_0C00380(NCAS0C00380)
NDI: NDAI_0K00330(NDAI0K00330)
TPF: TPHA_0I00280(TPHA0I00280)
TBL: TBLA_0B03300(TBLA0B03300)
TDL: TDEL_0B00520(TDEL0B00520)
KAF: KAFR_0B03960(KAFR0B03960)
PIC: PICST_30247(GPI12)
CAL: CAALFM_C110320WA(CaO19.4903)
CAUR: QG37_02247
SLB: AWJ20_2149(GPI12)
NCR: NCU09510
NTE: NEUTE1DRAFT80698(NEUTE1DRAFT_80698)
MGR: MGG_05020
CMT: CCM_08051
MBE: MBM_03823
ANI: AN0049.2
ANG: ANI_1_910124(An14g06640)
ABE: ARB_03399
TVE: TRV_08084
PTE: PTT_15068
SPO: SPAPB2B4.01c(gpi12)
CNE: CNC00580
CNB: CNBC6650
ABP: AGABI1DRAFT118528(AGABI1DRAFT_118528)
ABV: AGABI2DRAFT183645(AGABI2DRAFT_183645)
MGL: MGL_0955
DDI: DDB_G0293136(pigL)
DFA: DFA_12225(pigL)
EHI: EHI_015270(52.t00009)
PYO: PY17X_1125000(PY06379)
PCB: PCHAS_112310(PC001117.02.0)
TAN: TA10880
TPV: TP04_0615
BBO: BBOV_III007080(17.m07624)
NGD: NGA_2035300(PIGL)
SPAR: SPRG_10910
LMA: LMJF_09_0040(GPI12)
LIF: LINJ_09_0060(GPI12)
 » show all
Taxonomy
Reference
1  [PMID:2525555]
  Authors
Doering TL, Masterson WJ, Englund PT, Hart GW.
  Title
Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine.
  Journal
J Biol Chem 264:11168-73 (1989)
Reference
2  [PMID:9188481]
  Authors
Nakamura N, Inoue N, Watanabe R, Takahashi M, Takeda J, Stevens VL, Kinoshita T.
  Title
Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase.
  Journal
J Biol Chem 272:15834-40 (1997)
DOI:10.1074/jbc.272.25.15834
  Sequence
[rno:192263]
Reference
3  [PMID:10085243]
  Authors
Watanabe R, Ohishi K, Maeda Y, Nakamura N, Kinoshita T.
  Title
Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis.
  Journal
Biochem J 339 ( Pt 1):185-92 (1999)
  Sequence
[sce:YMR281W] [rno:192263] [hsa:9487]
Reference
4  [PMID:11432820]
  Authors
Smith TK, Crossman A, Borissow CN, Paterson MJ, Dix A, Brimacombe JS, Ferguson MA.
  Title
Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.
  Journal
EMBO J 20:3322-32 (2001)
DOI:10.1093/emboj/20.13.3322
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.89
IUBMB Enzyme Nomenclature: 3.5.1.89
ExPASy - ENZYME nomenclature database: 3.5.1.89
BRENDA, the Enzyme Database: 3.5.1.89
CAS: 122191-30-4

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