KEGG   ENZYME: 3.5.1.9Help
Entry
EC 3.5.1.9                  Enzyme                                 

Name
arylformamidase;
kynurenine formamidase;
formylase;
formylkynureninase;
formylkynurenine formamidase;
formamidase I;
formamidase II
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
aryl-formylamine amidohydrolase
Reaction(IUBMB)
N-formyl-L-kynurenine + H2O = formate + L-kynurenine [RN:R01959]
Reaction(KEGG)
R01959;
(other) R00988 R04911
Show
Substrate
N-formyl-L-kynurenine [CPD:C02700];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
L-kynurenine [CPD:C00328]
Comment
Also acts on other aromatic formylamines.
History
EC 3.5.1.9 created 1961
Pathway
ec00380  Tryptophan metabolism
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
Orthology
K01432  arylformamidase
K07130  arylformamidase
K14263  kynurenine formamidase
Genes
HSA: 125061(AFMID)
PTR: 740879(AFMID)
PPS: 100970897(AFMID)
GGO: 101125668(AFMID)
PON: 100445038(AFMID)
NLE: 100607651(AFMID)
MCC: 715153(AFMID)
MCF: 102119297(AFMID)
CSAB: 103243652(AFMID)
RRO: 104677020(AFMID)
RBB: 108534184(AFMID)
CJC: 100405728(AFMID)
SBQ: 101031688(AFMID)
MMU: 71562(Afmid)
RNO: 688283(Afmid)
CGE: 100773211(Afmid)
NGI: 103746016 103747284(Afmid)
HGL: 101701788(Afmid)
CCAN: 109683145(Afmid)
OCU: 103346800(AFMID)
TUP: 102487779(AFMID)
AML: 100479576(AFMID)
UMR: 103665785(AFMID)
ORO: 101367234(AFMID)
FCA: 101081096(AFMID)
PTG: 102950210(AFMID)
AJU: 106981919(AFMID)
BTA: 518864(AFMID)
BOM: 102275298(AFMID)
BIU: 109573962(AFMID)
PHD: 102344749(AFMID)
CHX: 102180346(AFMID)
OAS: 101123646(AFMID)
SSC: 110255955(AFMID)
CFR: 102511521(AFMID)
CDK: 105092158(AFMID)
BACU: 103011555(AFMID)
LVE: 103072321(AFMID)
OOR: 101288072(AFMID)
ECB: 100057858(AFMID)
EPZ: 103554046(AFMID)
EAI: 106845235(AFMID)
MYB: 102252879(AFMID)
MYD: 102766391(AFMID)
HAI: 109383641(AFMID)
RSS: 109449424(AFMID)
PALE: 102896867(AFMID)
LAV: 100664008(AFMID)
TMU: 101347908
MDO: 100031085(AFMID)
SHR: 100918127(AFMID)
OAA: 100092470(AFMID)
GGA: 769005(AFMID)
MGP: 100547285(AFMID)
CJO: 107322134(AFMID)
APLA: 101791387(AFMID)
ACYG: 106046751(AFMID)
TGU: 100226881(AFMID)
GFR: 102034312(AFMID)
FAB: 101821817(AFMID)
PHI: 102100690(AFMID)
PMAJ: 107212643(AFMID)
CCW: 104698233(AFMID)
FPG: 101917076(AFMID)
FCH: 102058767(AFMID)
CLV: 102085456(AFMID)
AAM: 106487109(AFMID)
ASN: 102382271(AFMID)
AMJ: 102560486(AFMID)
CMY: 102934783(AFMID)
CPIC: 101933108(AFMID)
ACS: 100564970(afmid)
PVT: 110090454(AFMID)
PBI: 103064600(AFMID)
GJA: 107115306(AFMID)
XLA: 108701014(afmid.L)
XTR: 100127853(afmid)
NPR: 108801439(AFMID)
DRE: 550372(afmid)
SRX: 107713249(afmid)
SANH: 107702031(afmid)
SGH: 107564564(afmid)
CCAR: 109086875(afmid)
IPU: 108271030(afmid)
AMEX: 103033615(afmid)
TRU: 101063527(afmid)
LCO: 104922272(afmid)
NCC: 104950181(afmid)
MZE: 101481480(afmid)
OLA: 101157840(afmid)
XMA: 102227043(afmid)
PRET: 103465415(afmid)
NFU: 107392382(afmid)
CSEM: 103384348(afmid)
LCF: 108875676(afmid)
HCQ: 109527424(afmid)
BPEC: 110165200(afmid)
SASA: 100196069(afmid)
ELS: 105012020(afmid)
SFM: 108930257(afmid)
LCM: 102347585(AFMID)
CMK: 103175558(afmid)
SPU: 100893038
APLC: 110987668
DME: Dmel_CG9542(KFase)
DSI: Dsimw501_GD22571(Dsim_GD22571)
MDE: 101896956
AAG: 5564939
AME: 726754
BIM: 100744961
BTER: 100652125
SOC: 105202049
AEC: 105146214
ACEP: 105623022
PBAR: 105429137
HST: 105184489
CFO: 105253611
LHU: 105667288
NVI: 100678019
NVL: 108560927
PMAC: 106719646
PRAP: 110993756
PXY: 105386122
API: 100572435
DNX: 107167870
ZNE: 110838995
CEL: CELE_D2024.2(afmd-1)
CBR: CBG05817
BMY: Bm1_24135
TSP: Tsp_03170
OBI: 106877803
SHX: MS3_08394
EPA: 110236087
HMG: 100207179
AQU: 105312956
SCE: YDR428C(BNA7)
ERC: Ecym_4070
TPF: TPHA_0D02390(TPHA0D02390)
TDL: TDEL_0A03980(TDEL0A03980)
CAL: CAALFM_C114270WA(CaO19.7237)
SPE: Spro_2366
SMAR: SM39_1824
SERF: L085_16775
ETE: ETEE_0211
PAE: PA2081(kynB)
PAEV: N297_2146(kynB)
PAEI: N296_2146(kynB)
PAU: PA14_37590(kynB)
PAP: PSPA7_3206(kynB)
PAG: PLES_32401(kynB)
PAF: PAM18_2962(kynB)
PNC: NCGM2_3061(kynB)
PAEB: NCGM1900_4400(kynB)
PAEP: PA1S_15275
PAEM: U769_14875
PAEL: T223_16555
PAEU: BN889_02277(kynB)
PAEG: AI22_18495
PAEC: M802_2143(kynB)
PAEO: M801_2145(kynB)
PFL: PFL_0752(kynB)
PPRC: PFLCHA0_c07620(kynB)
PPRO: PPC_0765(kynB)
PFS: PFLU_5199
PFC: PflA506_4492(kynB)
PFW: PF1751_v1c46500(kynB)
PFB: VO64_2041
PSES: PSCI_0278(kynB)
PSEM: TO66_03620
PSOS: POS17_0741(kynB)
PANR: A7J50_4945
PSET: THL1_1540
SWD: Swoo_1402
HCO: LOKO_00764(lip2)
PSE: NH8B_0025
RSO: RSc0760(kynB)
RSN: RSPO_c02605(kynB)
RSE: F504_780
RPI: Rpic_0710
REH: H16_A2814(h16_A2814) H16_B1997(h16_B1997)
RME: Rmet_6545
CGD: CR3_0575(kynB) CR3_3935 CR3_3941(aes)
BMA: BMA0353
BMV: BMASAVP1_A0652(kynB)
BML: BMA10229_A2487(kynB)
BMN: BMA10247_0100(kynB)
BMAL: DM55_1747(kynB)
BMAE: DM78_246(kynB)
BMAQ: DM76_1723(kynB)
BMAI: DM57_2379
BMAF: DM51_147(kynB)
BMAZ: BM44_2876(kynB)
BMAB: BM45_670(kynB)
BPS: BPSL0848
BPL: BURPS1106A_0897(kynB)
BPD: BURPS668_0894(kynB)
BPSE: BDL_1178(kynB)
BPSM: BBQ_2600(kynB)
BPSU: BBN_2723(kynB)
BPSD: BBX_3125(kynB)
BPK: BBK_658(kynB)
BPSH: DR55_272(kynB)
BPSA: BBU_1332(kynB)
BPSO: X996_3354(kynB)
BUT: X994_1888(kynB)
BTE: BTH_I0711
BTQ: BTQ_730(kynB)
BTJ: BTJ_1711(kynB)
BTZ: BTL_2990(kynB)
BTD: BTI_2973(kynB)
BTV: BTHA_3210(kynB)
BTHE: BTN_1719(kynB)
BTHM: BTRA_3305(kynB)
BTHA: DR62_1909
BTHL: BG87_3185(kynB)
BOK: DM82_237(kynB)
BOC: BG90_787(kynB)
BVE: AK36_1323(kynB)
BCN: Bcen_1966
BCJ: BCAL2790
BCEN: DM39_2661(kynB) DM39_4555
BCEW: DM40_211(kynB)
BCEO: I35_2647
BAM: Bamb_2625
BMU: Bmul_0720
BMJ: BMULJ_02540(kynB)
BMK: DM80_2388(kynB)
BMUL: NP80_2718(kynB)
BCT: GEM_0853
BCED: DM42_2492(kynB)
BDL: AK34_507(kynB)
BCON: NL30_25970
BUB: BW23_2307(kynB)
BLAT: WK25_12505
BTEI: WS51_23325
BSEM: WJ12_12945
BPSL: WS57_31665
BMEC: WJ16_13225
BSTG: WT74_13735
BGP: BGL_1c30820(kynB)
BGU: KS03_389(kynB)
BGO: BM43_779(kynB)
BUK: MYA_2343
BUE: BRPE67_ACDS22240(kynB)
BUL: BW21_3114(kynB)
BXB: DR64_2903(kynB) DR64_7822
BPH: Bphy_0508
PARB: CJU94_08810(kynB)
PHS: C2L64_02805(kynB)
PTER: C2L65_02575(kynB)
PNU: Pnuc_1645
BPA: BPP3950
BHO: D560_1936 D560_2921(kynB)
BHM: D558_1921 D558_2899(kynB)
BHZ: ACR54_00831(nlhH_2) ACR54_00832 ACR54_01357(kynB) ACR54_04153(nlhH_3)
AXX: ERS451415_00459(aes_1) ERS451415_01661(kynB)
PUT: PT7_2767
AMIM: MIM_c23410(kynB)
PNA: Pnap_3018
AAV: Aave_1157
AAA: Acav_1168
ACRA: BSY15_2537 BSY15_476(kynB)
LIM: L103DPR2_00868(kynB) L103DPR2_01180(nlhH_2)
LIH: L63ED372_01898(kynB) L63ED372_02081(nlhH_3)
MELM: C7H73_06355(kynB)
MMS: mma_2321
CFU: CFU_3321
CARE: LT85_3772
CPRA: CPter91_4079(kynB)
LCH: Lcho_2976
RGE: RGE_13230
PBH: AAW51_3796(kynB)
GSU: GSU3349
GME: Gmet_0042
GUR: Gura_0174
GBM: Gbem_3555
GEO: Geob_1077
GEM: GM21_3621
GEB: GM18_0535
DEU: DBW_0427
DMA: DMR_21530
SCL: sce1525
DBR: Deba_1497
MLO: mll5717
SMER: DU99_24720
RLG: Rleg_5000
OAH: DR92_3853
AZC: AZC_4299
SNO: Snov_2326
MET: M446_3448
MNO: Mnod_1199
MMED: Mame_00665(nlhH_1)
RBM: TEF_12375
CAK: Caul_5243
SAL: Sala_1390
SPHK: SKP52_06935(kynB)
SPHP: LH20_08390
SMAZ: LH19_12420
SPHT: K426_22659
ELI: ELI_14145
EFV: CHH26_01940(kynB)
RCE: RC1_2776
MAGN: WV31_13080
TXI: TH3_10945
NAO: Y958_24985(kynB)
NCB: C0V82_24895(kynB)
BAN: BA_2752(kynB)
BAR: GBAA_2752(kynB)
BAT: BAS2566
BAH: BAMEG_1843(kynB)
BAI: BAA_2816(kynB)
BANT: A16_27880
BANR: A16R_59510
BANS: BAPAT_2644
BANV: DJ46_1530(kynB)
BCE: BC2758
BCA: BCE_2786
BCR: BCAH187_A2807(kynB)
BCB: BCB4264_A2765(kynB)
BCU: BCAH820_2760(kynB)
BCG: BCG9842_B2527(kynB)
BCQ: BCQ_2599
BCX: BCA_2836(kynB)
BNC: BCN_2617
BCF: bcf_13475
BCER: BCK_21110
BTL: BALH_2477
BTB: BMB171_C2469(kynB)
BTT: HD73_3237
BTHI: BTK_16030
BTC: CT43_CH2746(kynB)
BTM: MC28_1952(kynB)
BTG: BTB_c28730(kynB)
BTI: BTG_05905
BTW: BF38_3927(kynB)
BWW: bwei_2271(kynB)
BMYC: DJ92_5027 DJ92_5231(kynB)
BMYO: BG05_3267(kynB)
BCL: ABC0652
BPF: BpOF4_10265(kynB)
BMQ: BMQ_3584(kynB)
BMD: BMD_3569(kynB)
BMEG: BG04_458(kynB)
BKO: CKF48_03510(kynB)
OIH: OB0755
GKA: GK2335
GEA: GARCT_02321(kynB_2)
AFL: Aflv_0977
ANM: GFC28_20 GFC28_981(kynB)
AAMY: GFC30_2536
ANL: GFC29_1605 GFC29_646(kynB)
HHD: HBHAL_4764(kynB)
VIL: CFK37_02330(kynB)
VNE: CFK40_18835(kynB)
VPN: A21D_02337(kynB)
SHU: SHYC_02060(kynB)
SAGQ: EP23_08075
MCAK: MCCS_15050(kynB_1) MCCS_15440(kynB_2)
ESI: Exig_0179
EAN: Eab7_0171(kynB)
PMW: B2K_04875
AAC: Aaci_2550
AAD: TC41_2842
SIV: SSIL_1662
SOB: CSE16_06370(kynB)
JEO: JMA_13120
SMU: SMU_1172c
CTC: CTC_01863
CACE: CACET_c22310(kynB2)
ASF: SFBM_0397
CCEL: CCDG5_0080
RBR: RBR_01420
HSC: HVS_15655(kynB)
CPY: Cphy_1894
HSD: SD1D_0997
DAE: Dtox_1259
TTE: TTE1006
THX: Thet_1484
TIT: Thit_0966
MTA: Moth_2301
CSC: Csac_0804
ATE: Athe_0573
TTM: Tthe_1639
TSH: Tsac_1611
ABRA: BN85312620
RER: RER_54650
REY: O5Y_26030
REQ: REQ_05120
RQI: C1M55_27555(kynB)
KSK: KSE_37190
ARR: ARUE_113p00090(meqF)
KAL: KALB_5909
ACTI: UA75_26985
ACAD: UA74_26400
AHG: AHOG_24315(nlhH3)
ALL: CRK56717
SYN: slr2121
SYY: SYNGTS_1482(slr2121)
SYT: SYNGTI_1482(slr2121)
SYS: SYNPCCN_1481(slr2121)
SYQ: SYNPCCP_1481(slr2121)
DEH: cbdbA626
DEV: DhcVS_581
DMC: btf_599
DMD: dcmb_645
DMG: GY50_0566
DFO: Dform_00360(kynB)
HAU: Haur_0059
PBF: CFX0092_A3059(kynB)
DRA: DR_A0340
DGE: Dgeo_1533
DGO: DGo_CA0871(kynB)
TRA: Trad_2366
TTR: Tter_1205
PNL: PNK_1420
ABAC: LuPra_03102(kynB_2)
GAU: GAU_1134
GBA: J421_2894
SRU: SRU_1503
SRM: SRM_01702
HSW: Hsw_1306
DTU: Dtur_0925
SAAL: L336_0460
MAC: MA_3747
MBAR: MSBR2_2661
MMA: MM_2825
MMAC: MSMAC_1224
METM: MSMTP_0923
MTHE: MSTHC_0901
MTHR: MSTHT_2379
MHOR: MSHOH_0818
MPY: Mpsy_0989
MTP: Mthe_0383
MCJ: MCON_1407
MEMA: MMAB1_1839
MPI: Mpet_0649
MBN: Mboo_0257
MPL: Mpal_0317
MPD: MCP_2371
MEZ: Mtc_2107
RCI: RCIX2670
MARH: Mia14_0300
 » show all
Taxonomy
Reference
1  [PMID:14907621]
  Authors
HAYAISHI O, STANIER RY.
  Title
The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway.
  Journal
J Bacteriol 62:691-709 (1951)
Reference
2  [PMID:13163050]
  Authors
JAKOBY WB.
  Title
Kynurenine formamidase from Neurospora.
  Journal
J Biol Chem 207:657-63 (1954)
Reference
3  [PMID:14794728]
  Authors
MEHLER AH, KNOX WE.
  Title
The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine.
  Journal
J Biol Chem 187:431-8 (1950)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.9
IUBMB Enzyme Nomenclature: 3.5.1.9
ExPASy - ENZYME nomenclature database: 3.5.1.9
BRENDA, the Enzyme Database: 3.5.1.9
CAS: 156229-75-3

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