KEGG   ENZYME: 3.5.1.90
Entry
EC 3.5.1.90                 Enzyme                                 

Name
adenosylcobinamide hydrolase;
CbiZ;
AdoCbi amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
adenosylcobinamide amidohydrolase
Reaction(IUBMB)
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol [RN:R05226]
Reaction(KEGG)
R05226
Substrate
adenosylcobinamide [CPD:C06508];
H2O [CPD:C00001]
Product
adenosylcobyric acid [CPD:C06507];
(R)-1-aminopropan-2-ol [CPD:C03194]
Comment
Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).
History
EC 3.5.1.90 created 2004
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
Orthology
K08260  adenosylcobinamide hydrolase
Genes
MMAI: sS8_1630
HAK: KO116_01845
HAG: BB497_14215
HVN: EI420_07430
GBI: PG2T_14225
BACI: B1NLA3E_01980
BACO: OXB_1391
BMQ: BMQ_1994
BMD: BMD_1950
BMH: BMWSH_3286
BMEG: BG04_4295
PMW: B2K_10005
PRI: PRIO_1520
PSWU: SY83_08810
ASOC: CB4_00867
SALQ: SYNTR_0853
DRM: Dred_2681
DAE: Dtox_1956
PTH: PTH_1477
HMO: HM1_1855
ELM: ELI_2045
AWO: Awo_c10360(cbiZ2)
TTE: TTE2426
TKI: TKV_c03070(cbiZ)
TPZ: Tph_c03470(cbiZ)
MIT: OCO_21870
MIA: OCU_22060
MID: MIP_03097
MYO: OEM_19770
MIR: OCQ_20980
MLP: MLM_1928A
MMM: W7S_10285
SERJ: SGUI_2139
SEN: SACE_6498
SESP: BN6_28070
KAL: KALB_7956
ACTI: UA75_27430
ACAD: UA74_26840
SAQ: Sare_4761
MIL: ML5_2591
ASE: ACPL_6861
ACTS: ACWT_6730
DEH: cbdbA637(rdhF) cbdbA87(rdhF)
DEV: DhcVS_591
DMC: btf_610(cbiZ)
DMD: dcmb_1046(cbiZ) dcmb_656(cbiZ)
DMG: GY50_0122(cbiZ) GY50_0246(cbiZ) GY50_0578(cbiZ) GY50_1354(cbiZ) GY50_1389(cbiZ)
DUC: UCH007_05720(cbiZ) UCH007_13440(rdhF)
TRA: Trad_0381
NDE: NIDE2660
NJA: NSJP_3530
MST: Msp_0437
MRU: mru_1218(cbiZ)
MSI: Msm_0825
MEB: Abm4_0754(cbiZ)
MMIL: sm9_1752(cbiZ)
MEYE: TL18_07800
MOL: YLM1_0611
MFC: BRM9_1712(cbiZ)
AFU: AF_1400
FPL: Ferp_2081
GAC: GACE_1857
GAH: GAH_01724
PFU: PF0305
PFI: PFC_00600
PHO: PH0814(PH0814)
PAB: PAB1708
PYN: PNA2_0142
TKO: TK0846
TON: TON_0689
TGA: TGAM_0516(cbiZ)
THE: GQS_01490
THA: TAM4_743
THM: CL1_2012
TLT: OCC_11919
THS: TES1_0965
TNU: BD01_0588
TEU: TEU_09185
PPAC: PAP_03150
MBAR: MSBR2_0417
MAC: MA_1623
MMA: MM_0173
MMAC: MSMAC_2488
METM: MSMTP_1142
MHOR: MSHOH_1351
MBU: Mbur_1001
MMET: MCMEM_1490
MMH: Mmah_1373
MPY: Mpsy_1883
MBG: BN140_2491(cbiZ)
MEMA: MMAB1_3351(cbiZ)
MBN: Mboo_0181
MPL: Mpal_0026
MPD: MCP_2916(cbiZ)
MEZ: Mtc_0313
RCI: RCIX826
HAL: VNG_1583C
HSL: OE_3261F(cbiZ)
HHB: Hhub_2918(cbiZ)
HAGS: JT689_07770(cbiZ)
HABO: JRZ79_06185(cbiZ)
HALH: HTSR_1763(cbiZ)
HHSR: HSR6_1829(cbiZ)
HSU: HLASF_0298(cbiZ)
HSF: HLASA_0297(cbiZ)
HMA: rrnAC1935
HHI: HAH_2444
NPH: NP_5300A(cbiZ)
NMO: Nmlp_2452(cbiZ)
HUT: Huta_2500
HMU: Hmuk_0140
HALL: LC1Hm_2696(cbiZ)
HWA: HQ_1406A(cbiZ)
HWC: Hqrw_1482(cbiZ)
HVO: HVO_0592(cbiZ)
HME: HFX_0579(cbiZ)
HLA: Hlac_0236
HDF: AArcSl_2193(cbiZ)
HTU: Htur_2838
NMG: Nmag_0992(cbiZ)
NAT: NJ7G_1620
TVO: TVG0808276(TVG0808276)
PTO: PTO0124
MARC: AR505_1296
STO: STK_02670
SOL: Ssol_2424
SSOA: SULA_2449
SSOL: SULB_2450
SSOF: SULC_2447
SID: M164_0544
SII: LD85_0555
SIH: SiH_0832
SIR: SiRe_0518
SIC: SiL_0543
MSE: Msed_1086
AHO: Ahos_1964
CMA: Cmaq_1368
TTN: TTX_1465
TUZ: TUZN_1652
VDI: Vdis_1065
VMO: VMUT_1904
 » show all
Reference
1  [PMID:14990804]
  Authors
Woodson JD, Escalante-Semerena JC
  Title
CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
  Journal
Proc Natl Acad Sci U S A 101:3591-6 (2004)
DOI:10.1073/pnas.0305939101
  Sequence
[mma:MM_0173] [hal:VNG_1583C]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.90
IUBMB Enzyme Nomenclature: 3.5.1.90
ExPASy - ENZYME nomenclature database: 3.5.1.90
BRENDA, the Enzyme Database: 3.5.1.90
CAS: 905988-16-1

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