KEGG ENZYME: 3.5.1.90

ENZYME: 3.5.1.90

Entry

EC 3.5.1.90                 Enzyme

Name

adenosylcobinamide hydrolase;
CbiZ;
AdoCbi amidohydrolase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

adenosylcobinamide amidohydrolase

Reaction(IUBMB)

adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol [RN:R05226]

Reaction(KEGG)

R05226

Substrate

adenosylcobinamide [CPD:C06508];
H2O [CPD:C00001]

Product

adenosylcobyric acid [CPD:C06507];
(R)-1-aminopropan-2-ol [CPD:C03194]

Comment

Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).

History

EC 3.5.1.90 created 2004

Pathway

ec00860

Porphyrin metabolism

ec01100

Metabolic pathways

Orthology

K08260

adenosylcobinamide hydrolase

Genes

MMAI:

sS8_1630

HAK:	KO116_01845

HAG:	BB497_14215

HBP:	HPTD01_3546

HAMS:

NF683_14615

HQN:	M0220_00840

HVN:	EI420_07430

GBI:	PG2T_14225

PCAG:

NCTC12856_00133

DYS:	G7050_13770

NDE:

NIDE2660

NJA:

NSJP_3530

BACI:

B1NLA3E_01980

BACO:

OXB_1391

BMQ:

BMQ_1994

BMD:

BMD_1950

BMH:	BMWSH_3286

BMEG:

BG04_4295

BFX:	BC359_13235

PKS:	IE339_16055

MEBZ:

LPC09_11540

BLR:	BRLA_c021790

BRW:	GOP56_03695

PJD:	Pjdr2_3347

GYM:	GYMC10_5189

PMS:	KNP414_01665

PMQ:	PM3016_1972

PMW:

B2K_10005

PLV:	ERIC2_c32630

POD:	PODO_06000

PAEF:

R50345_06380

PAEE:

R70331_06075

PAEJ:

H70737_06230

PBJ:	VN24_21395

PIH:	UB51_16105

PRI:

PRIO_1520

PXL:	BS614_11210

PSWU:

SY83_08810

PDH:	B9T62_01465

PIB:	BBD41_19985

PCX:	LPB68_07845

PVO:	PVOR_27914

PLW:	D5F53_04055

PLEN:

EIM92_20635

PLUT:

EI981_21615

PBK:	Back11_13150

PPRT:

ET464_04125

PBAC:

HUB98_23890

PRZ:	GZH47_03420

PTRI:

KDC22_06225

PCEL:

HUB94_18215

PTJ:	JRJ22_05325

PUI:	PUW25_06255

PMAH:

PTQ21_12605

PAMY:

P9222_30205

PWN:	QNH46_07280

PSPN:

L1F29_12580

PPAB:

KET34_07825

PGLU:

A3958_03615

PHEX:

L0M14_17100

PEZZ:

HW560_31105

ANX:	ACH33_02990

ASOC:

CB4_00867

ATHE:

K3F53_15945

AUD:	PO771_02445

ANEU:

PP175_22120

CCHL:

FPL14_25275

AFX:	JZ786_00050 JZ786_07515

ACUR:

JZ785_03390

TUM:	CBW65_11160

TAB:	CIG75_16875

LFB:	C1X05_13255

TVU:	AB849_007595

KPUL:

GXN76_03665

KEB:	GXN75_03785

PABS:

JIR001_25000

SALQ:

SYNTR_0853

DED:	DHBDCA_p2629

DEC:	DCF50_p2640

DRS:	DEHRE_01430 DEHRE_12855

PTH:

PTH_1477

DRM:

Dred_2681

DAE:

Dtox_1956

DKU:	Desku_2191

FWA:	DCMF_24995 DCMF_25050

TJR:	TherJR_1261

HMO:

HM1_1855

ELM:

ELI_2045

ELIM:

B2M23_17005

AWO:	Awo_c10360(cbiZ2)

ALKA:

J0B03_06030

BPRO:

PMF13cell1_01394

EHL:	EHLA_0566 EHLA_2015

TTE:

TTE2426

TKI:	TKV_c03070(cbiZ)

TPZ:	Tph_c03470(cbiZ)

DHO:	Dia5BBH33_05930

SSG:	Selsp_1207

SELE:

ADJ74_07590

MANA:

MAMMFC1_02847

STED:

SPTER_03330

PFAC:

PFJ30894_01782

MIT:

OCO_21870

MIA:

OCU_22060

MID:

MIP_03097

MYO:

OEM_19770

MCHI:

AN480_11320

MIR:

OCQ_20980

MMAL:

CKJ54_09785

MLP:

MLM_1928A

MMM:

W7S_10285

MGOR:

H0P51_08660

SERJ:

SGUI_2139

ORN:	DV701_11620

SERW:

FY030_15580

NMES:

H9L09_19745

NPI:	G7071_14490

SEN:

SACE_6498

SACG:

FDZ84_07375

SESP:

BN6_28070

KAL:

KALB_7956

KPHY:

AOZ06_28410

LED:	BBK82_07075

AHM:	TL08_23590

ACTI:

UA75_27430

ACAD:

UA74_26840

AHG:	AHOG_24745

PMAD:

BAY61_12190

SACE:

GIY23_08780

STP:	Strop_4321

SAQ:

Sare_4761

MAU:	Micau_5904

MIL:

ML5_2591

MICB:

MicB006_1949

MTUA:

CSH63_27810

MICH:

FJK98_30665

MTEM:

GCE86_24130

MCAB:

HXZ27_29450

MSAG:

GCM10017556_21530

VMA:	VAB18032_02945

VER:	HUT12_30530

MENO:

Jiend_32300

MCHL:

PVK74_19655

MFEU:

H1D33_05510

MPRN:

Q3V37_08460

MHAW:

RMN56_13175

MICF:

QQG74_29940

ASE:

ACPL_6861

ACTS:

ACWT_6730

PLAB:

C6361_10000

PLAT:

C6W10_07100

PFLA:

Pflav_067840

PSUU:

Psuf_029930

ATL:	Athai_58250

ASER:

Asera_16770

PRY:	Prubr_29620

AEY:	CDG81_03860

AYM:	YM304_06580

ATQ:	GH723_09265

AQZ:	KSP35_12315

DET:	DET0653 DET0687

DEH:	cbdbA637(rdhF) cbdbA87(rdhF)

DEB:	DehaBAV1_0102 DehaBAV1_0623

DEV:

DhcVS_591

DEG:	DehalGT_0585

DMC:	btf_610(cbiZ)

DMD:	dcmb_1046(cbiZ) dcmb_656(cbiZ)

DMG:	GY50_0122(cbiZ) GY50_0246(cbiZ) GY50_0578(cbiZ) GY50_1354(cbiZ) GY50_1389(cbiZ)

DMX:	X792_03165 X792_07260

DMY:	X793_02910

DMZ:	X794_00335 X794_02655 X794_04905 X794_06655

DUC:	UCH007_05720(cbiZ) UCH007_13440(rdhF)

DEW:	DGWBC_1178

DFO:	Dform_01406

DETH:

HX448_08550

KBB:	ccbrp13_11420

TRA:

Trad_0381

FVA:	FV113G1_31850

FNF:	BSQ88_02390

MST:

Msp_0437

METB:

AW729_04920

MRU:	mru_1218(cbiZ)

MSI:

Msm_0825

MEB:	Abm4_0754(cbiZ)

MMIL:

sm9_1752(cbiZ)

MEYE:

TL18_07800

MOL:

YLM1_0611

METV:

K4897_07370

MFC:	BRM9_1712(cbiZ)

METN:

BK008_08620

METT:

CIT01_00970

METO:

CIT02_04050

AFU:

AF_1400

AFG:	AFULGI_00015110

APO:	Arcpr_0307

AVE:	Arcve_1003

AST:	Asulf_00935

FPL:

Ferp_2081

GAC:

GACE_1857

GAH:

GAH_01724

PFU:

PF0305

PFI:

PFC_00600

PHO:	PH0814(PH0814)

PAB:

PAB1708

PYN:

PNA2_0142

PYA:	PYCH_17420

PYC:	TQ32_02265

TKO:

TK0846

TON:

TON_0689

TGA:	TGAM_0516(cbiZ)

TBA:	TERMP_00560

THE:

GQS_01490

THA:

TAM4_743

THM:

CL1_2012

TLT:

OCC_11919

THS:

TES1_0965

TNU:

BD01_0588

TEU:

TEU_09185

TGY:	X802_07720

THV:	ADU37_CDS15850

TCH:	CHITON_1275

TPEP:

A0127_02010

TPIE:

A7C91_09565

TGG:	A3K92_03405

TCE:	A3L02_03895

TBS:	A3L01_04215

THH:	CDI07_04105

TTD:	A3L14_06110

TPRF:

A3L09_09540

TRL:	A3L10_02380

TPAF:

A3L08_05950

THY:	A3L12_04860

TIC:	FH039_07865

TCQ:	TIRI35C_1092

THEM:

FPV09_01550

PPAC:

PAP_03150

MBA:	Mbar_A3636

MBY:	MSBRM_1999

MBW:	MSBRW_1096

MBAR:

MSBR2_0417

MAC:

MA_1623

MMA:

MM_0173

MMAZ:

MmTuc01_0181

MMJ:	MSMAS_1128

MMAC:

MSMAC_2488

MVC:	MSVAZ_1368

MEK:	MSKOL_1311

MLS:	MSLAZ_1097

METM:

MSMTP_1142

MEF:	MSWH1_1025

MEQ:	MSWHS_1096

MSJ:	MSSAC_1600

MSZ:	MSSIH_1189

MSW:	MSSIT_1256

MHOR:

MSHOH_1351

MBU:

Mbur_1001

MMET:

MCMEM_1490

MELO:

J7W08_06240

MMH:

Mmah_1373

MHAZ:

BHR79_06795

MEV:	Metev_2213

MZH:	Mzhil_0770

MPY:

Mpsy_1883

MZI:	HWN40_12760

MHZ:	Metho_0085

MHU:	Mhun_0271 Mhun_2543

MRTJ:

KHC33_03965

MLA:	Mlab_0705 Mlab_1672

MEM:	Memar_2352

MBG:	BN140_2491(cbiZ)

MEMA:

MMAB1_3351(cbiZ)

MCHK:

MchiMG62_00820

MSUM:

OH143_06030

MRC:	R6Y96_01515

MPI:	Mpet_0148 Mpet_2230

MEFW:

F1737_10290

MAQE:

RJ40_08495

MFK:	E2N92_08715

MANQ:

L1994_10255

MBN:

Mboo_0181

MFO:	Metfor_0011 Metfor_0922

MPL:

Mpal_0026

MPD:	MCP_2916(cbiZ)

MEZ:

Mtc_0313

RCI:

RCIX826

HAL:

VNG_1583C

HSL:	OE_3261F(cbiZ)

HANR:

LJ422_06430(cbiZ)

HDL:	HALDL1_05020

HHB:	Hhub_2918(cbiZ)

HAGS:

JT689_07770(cbiZ)

HABO:

JRZ79_06185(cbiZ)

HNO:	LT974_11365

HANX:

ABSL23_14450

HALH:

HTSR_1763(cbiZ)

HHSR:

HSR6_1829(cbiZ)

HSU:	HLASF_0298(cbiZ)

HSF:	HLASA_0297(cbiZ)

HAHS:

HSRCO_0495(cbiZ)

HALR:

EFA46_013440

HJE:	HacjB3_12800

HDO:	MUK72_06640

HALX:

M0R89_09965

HAYC:

NGM10_05725

HAXY:

NGM07_16600

SAIM:

K0C01_07375

HARA:

AArcS_2275(cbiZ)

HMA:

rrnAC1935

HHI:

HAH_2444

HHN:	HISP_12440

HAB:	SG26_04755

HTA:	BVU17_11895

HALJ:

G9465_06600

HSIN:

KDQ40_01205

NPH:	NP_5300A(cbiZ)

NMO:	Nmlp_2452(cbiZ)

NHO:	HWV23_10035

NSAL:

HWV07_14455

HUT:

Huta_2500

HALA:

Hrd1104_08195

HASV:

SVXHr_2063(cbiZ)

HABN:

HBNXHr_2051(cbiZ)

HMU:

Hmuk_0140

HALZ:

E5139_03990

HALL:

LC1Hm_2696(cbiZ)

HAZP:

GBQ70_03990

HALI:

BV210_04730

HDS:	HSR122_2341(cbiZ)

HRR:	HZS55_07810

HPEL:

HZS54_08475

HLT:	I7X12_06205

HARC:

HARCEL1_07210

SSAI:

N0B31_11610

HAAD:

MW046_07560

HWA:	HQ_1406A(cbiZ)

HWC:	Hqrw_1482(cbiZ)

HVO:	HVO_0592(cbiZ)

HALE:

G3A49_03000

HLN:	SVXHx_0544(cbiz)

HME:	HFX_0579(cbiZ)

HGI:	ABY42_02770

HLS:	KU306_07560

HBO:	Hbor_26120

HAQ:	DU484_05755

HAJ:	DU500_06225

HAER:

DU502_03885

HRA:	EI982_09780

HLM:	DV707_12480

HALM:

FCF25_09780

HLA:

Hlac_0236

HALP:

DOS48_01140

HALB:

EKH57_09575

HEZZ:

EO776_02820

HALQ:

Hrr1229_005290

HSS:	J7656_13950

HSAI:

HPS36_04800

HAZZ:

KI388_00455

SRUB:

C2R22_02855

HAE:	halTADL_2184

HALG:

HUG10_16670

HALU:

HUG12_19730

HMP:	K6T50_10895

HRE:	K6T36_10680

HRM:	K6T25_05350

HACB:

Hbl1158_02665

HDF:	AArcSl_2193(cbiZ)

HTU:

Htur_2838

HSAL:

JMJ58_14240

HAKZ:

J0X25_02365

NMG:	Nmag_0992(cbiZ)

HXA:	Halxa_2231

NAT:

NJ7G_1620

NPE:	Natpe_1092

NVR:	FEJ81_05680

NPL:	FGF80_05325

NAY:	HYG81_05245

HALY:

HYG82_06025

HJT:	DVR14_14760

HLO:	J0X27_15055

NGE:	Natgr_2766

HRU:	Halru_2358

SAWL:

NGM29_07805

HALV:

NGM15_16965

NOU:	Natoc_1890

HLR:	HALLA_15860

HLC:	CHINAEXTREME08775

NAJ:	B1756_03160

NAG:	AArcMg_2763

NAN:	AArc1_0943

NARA:

QQ977_09005

NBG:	DV706_10225

NAS:	GCU68_01840

HDA:	BB347_09760

MELU:

MTLP_08190

TVO:	TVG0808276(TVG0808276)

PTO:

PTO0124

FAC:	FACI_IFERC01G1896

TAR:	TALC_01123 TALC_01134

MAX:	MMALV_11630

MARC:

AR505_1296

STO:

STK_02670

SOH:	D1869_00840

SSO:

SSO1594

SOL:

Ssol_2424

SSOA:

SULA_2449

SSOL:

SULB_2450

SSOF:

SULC_2447

SSHI:

J5U23_01464

SIS:	LS215_1134

SIA:	M1425_0519

SIM:	M1627_0528

SID:

M164_0544

SIY:	YG5714_0493

SIN:	YN1551_2515

SII:

LD85_0555

SIH:

SiH_0832

SIR:

SiRe_0518

SIC:

SiL_0543

SULE:

GFS03_05375

SULO:

GFS33_10665

MSE:

Msed_1086

MEMJ:

MJ1HA_1214

MPRU:

DFR88_01090

MJN:	MjAS7_2093

AHO:

Ahos_1964

AMAN:

B6F84_09305

ABRI:

DFR85_05730

ASUL:

DFR86_07995

AAMB:

D1866_04820

SACD:

HS1genome_1561

SAZO:

D1868_06740

SMET:

RQ359_001368

CMA:

Cmaq_1368

TTN:

TTX_1465

TUZ:

TUZN_1652

VDI:

Vdis_1065

VMO:

VMUT_1904

LOB:	NEF87_004872

» show all

Reference

1 [PMID:14990804]

Authors

Woodson JD, Escalante-Semerena JC

Title

CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.

Journal

Proc Natl Acad Sci U S A 101:3591-6 (2004)
DOI:10.1073/pnas.0305939101

Sequence

[mma:MM_0173] [hal:VNG_1583C]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.90

IUBMB Enzyme Nomenclature:

3.5.1.90

ExPASy - ENZYME nomenclature database:

3.5.1.90

BRENDA, the Enzyme Database:

3.5.1.90

CAS:	905988-16-1

DBGET integrated database retrieval system