| Entry |
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| Name |
gamma-glutamyl-gamma-aminobutyrate hydrolase;
gamma-glutamyl-GABA hydrolase;
PuuD;
YcjL;
4-(gamma-glutamylamino)butanoate amidohydrolase;
4-(L-gamma-glutamylamino)butanoate amidohydrolase
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
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| Sysname |
4-(gamma-L-glutamylamino)butanoate amidohydrolase
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| Reaction(IUBMB) |
4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate [RN: R07419]
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| Reaction(KEGG) |
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| Substrate |
4-(gamma-L-glutamylamino)butanoate [CPD: C15767];
H2O [CPD: C00001]
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| Product |
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| Comment |
Forms part of a putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(gamma-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).
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| History |
EC 3.5.1.94 created 2006, modified 2011
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| Pathway |
| ec00330 | Arginine and proline metabolism |
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| Orthology |
| K09473 | gamma-glutamyl-gamma-aminobutyrate hydrolase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H. |
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| Title |
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.1.94 |
| ExPASy - ENZYME nomenclature database: | 3.5.1.94 |
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