Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

N-succinyl-L-glutamate amidohydrolase

N-succinyl-L-glutamate + H2O = succinate + L-glutamate [RN:R00411]

R00411

N-succinyl-L-glutamate [CPD:C05931];
H2O [CPD:C00001]

Requires Co2+ for maximal activity [1]. N2-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).

EC 3.5.1.96 created 2006

1  [PMID:2865249]

Vander Wauven C, Stalon V.

Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia.

J Bacteriol 164:882-6 (1985)

2  [PMID:3534538]

Cunin R, Glansdorff N, Pierard A, Stalon V.

Biosynthesis and metabolism of arginine in bacteria.

Microbiol Rev 50:314-52 (1986)

3

Cunin, R., Glansdorff, N., Pierard, A. and Stalon, V.

Erratum report: Biosynthesis and metabolism of arginine in bacteria.

Microbiol Rev 51:178 (1987)

4  [PMID:9393691]

Itoh Y.

Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.

J Bacteriol 179:7280-90 (1997)
DOI:10.1128/JB.179.23.7280-7290.1997

[pae:PA0901]

5  [PMID:9696779]

Schneider BL, Kiupakis AK, Reitzer LJ.

Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.

J Bacteriol 180:4278-86 (1998)

[eco:b1744]