EC                 Enzyme                                 

acyl-homoserine-lactone acylase;
acyl-homoserine lactone acylase;
N-acyl-homoserine lactone acylase;
PA2385 protein;
quorum-quenching AHL acylase;
quorum-quenching enzyme;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
N-acyl-L-homoserine-lactone amidohydrolase
an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate [RN:R09646]
N-acyl-L-homoserine lactone [CPD:C18049];
H2O [CPD:C00001]
L-homoserine lactone [CPD:C19777];
carboxylate [CPD:C00060]
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules. It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons. Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity.
EC created 2007
K07116  acyl-homoserine-lactone acylase
PLU: plu3527
PLUM: A4R40_17535
XNE: XNC1_2459 XNC1_3898
XNM: XNC2_2365 XNC2_3751
XBU: HGO23_09785
PSI: S70_12665
PSX: DR96_637(quiP)
PSTA: BGK56_15550
PRAG: EKN56_12135
XHR: XJ27_15475
PSD: DSC_07985
RBD: ALSL_1953
VTA: B0479
PAE: PA1032(quiP) PA2385(pvdQ)
PAEV: N297_1068(quiP) N297_2458(pvdQ)
PAEI: N296_1068(quiP) N296_2458(pvdQ)
PAU: PA14_33820(pvdQ) PA14_50980(pac)
PAG: PLES_29171(pvdQ) PLES_42911(quiP)
PAF: PAM18_2656(pvdQ) PAM18_4013(quiP)
PNC: NCGM2_1893(pac) NCGM2_3396(pvdQ)
PAEB: NCGM1900_1577(pac) NCGM1900_4144(pvdQ)
PAEU: BN889_01092(quiP_3) BN889_02613(pvdQ)
PAEC: M802_1065(quiP) M802_2455(pvdQ)
PAEO: M801_1068(quiP)
PMY: Pmen_1414
PMK: MDS_1470
PRE: PCA10_15830(quiP)
PPSE: BN5_2962
PCQ: PcP3B5_14340(quiP_1) PcP3B5_31380(pvdQ)
PPU: PP_1108(quiP) PP_2901(pvdQ)
PPUN: PP4_10510(quiP) PP4_29180(pvdQ)
PVD: CFBP1590__1424(quiP) CFBP1590__2019(pvdQ)
PFL: PFL_1268(quiP) PFL_2902(pvdQ)
PPRC: PFLCHA0_c13030(quiP1) PFLCHA0_c29480(pvdQ)
PPRO: PPC_1321 PPC_2934(pvdQ)
PFC: PflA506_1277(quiP) PflA506_2831(pvdQ)
PMAN: OU5_0210(pvdQ) OU5_2200(quiP)
PSA: PST_1741
PSTT: CH92_13690
PKC: PKB_1465(quiP)
PSES: PSCI_2682(pvdQ) PSCI_3059
PSEC: CCOS191_1218(quiP) CCOS191_2888(pvdQ)
PSET: THL1_1630
PALL: UYA_07420
POJ: PtoMrB4_14410(quiP) PtoMrB4_31380(pvdQ)
PMAO: PMYSY11_3080(quiP)
PALI: A3K91_2707
PSYC: DABAL43B_2798(pvdQ)
SON: SO_0918(aaiD)
SFR: Sfri_0771
SAZ: Sama_2773
SBL: Sbal_0764
SWD: Swoo_0136
SWP: swp_0947
SVO: SVI_0150
SPSW: Sps_00199
SBK: SHEWBE_4248(pvdQ)
SKH: STH12_02649(pvdQ)
SCAA: TUM17387_30790(aaiD)
PSM: PSM_A2452
PTD: PTET_a2795(pvdQ)
MAD: HP15_1139(pvdQ)
MARJ: MARI_10810(pvdQ)
AMAL: I607_09245
AMAE: I876_09605
AMAO: I634_09685
AMAD: I636_09995
AMAI: I635_10390
AMAG: I533_09560
AMAC: MASE_09200
AAUS: EP12_09825
FBL: Fbal_0230
CJA: CJA_1862
HCH: HCH_05500
ADI: B5T_00685
AXE: P40_03210
RSO: RSc2547(aac)
RSM: CMR15_10813(aac)
RSE: F504_2493
RPI: Rpic_2825
RIN: ACS15_2847(pvdQ)
RME: Rmet_4860
BGO: BM43_5357
PPUL: RO07_24060
PSPU: NA29_12810
PLG: NCTC10937_02093(pvdQ) NCTC10937_04196(quiP_2)
CABA: SBC2_45410(pvdQ)
AAV: Aave_1140
AAA: Acav_1150
ACRA: BSY15_3632
DAC: Daci_3480
JAG: GJA_1735
DOE: DENOEST_3694(aac)
DOL: Dole_2798
MXA: MXAN_2906
CCX: COCOR_04399(pvdQ) COCOR_05166(pvdQ1) COCOR_06657(aac)
HOH: Hoch_3571
PLA: Plav_0937
BMEL: DK63_3043
BMEE: DK62_2367
CAK: Caul_1171
GAK: X907_2581
HNE: HNE_0221
SAL: Sala_2388
SPHP: LH20_18455
SPHM: G432_07215
STAX: MC45_04545
SPHI: TS85_00930
SPMI: K663_03170
BLAS: BSY18_1372
SMIC: SmB9_21770
ELI: ELI_01425
KSC: CD178_00017(pvdQ)
TMO: TMO_b0330(pvdQ)
MCHE: BB28_06135
MSTE: MSTE_01210(aaiD)
MSAL: DSM43276_01102(aac_1)
SGR: SGR_6809
SGB: WQO_01105
SFA: Sfla_1468
SDV: BN159_8167(aac)
STRP: F750_5406
STRM: M444_05995
SAMB: SAM23877_0977(aac)
SRW: TUE45_00999(aac_1)
SRN: A4G23_00124(aac_1)
SALF: SMD44_00726(pvdQ)
SALJ: SMD11_5897(pvdQ)
SGE: DWG14_07803(aac)
SNF: JYK04_01263(aac_1)
SHUN: DWB77_07035(aac)
SCYG: S1361_03590(aac1) S1361_37335(aac3)
NDK: I601_2333(pvdQ)
PSIM: KR76_08305
NCX: Nocox_21850(aac)
AMD: AMED_6716
AMN: RAM_34450
AMM: AMES_6617
AMZ: B737_6617
AOI: AORI_4372
AMYY: YIM_38660(aac)
AORI: SD37_31210
AMI: Amir_3685
SAQ: Sare_2063
SYN: slr0378
SYY: SYNGTS_2134(slr0378)
SYT: SYNGTI_2133(slr0378)
SYS: SYNPCCN_2132(slr0378)
SYQ: SYNPCCP_2132(slr0378)
CYT: cce_4606
NSH: GXM_08301
CTHE: Chro_3734
DRA: DR_A0255
DGO: DGo_PA0145(aac)
ABAC: LuPra_05670(pvdQ)
GAU: GAU_3147
PSAC: PSM36_0578
SRU: SRU_1143
SRM: SRM_01323
SGN: SGRA_0910
MUC: MuYL_1085
SLI: Slin_4469
MARM: YQ22_06085
CBAT: M666_02885
MLT: VC82_1057
SPON: HME9304_01082(pvdQ)
 » show all
1  [PMID:12535081]
Lin YH, Xu JL, Hu J, Wang LH, Ong SL, Leadbetter JR, Zhang LH
Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes.
Mol Microbiol 47:849-60 (2003)
2  [PMID:16495538]
Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Camara M, Williams P, Quax WJ
Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.
Infect Immun 74:1673-82 (2006)
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